DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Zir and Dock3

DIOPT Version :9

Sequence 1:NP_608489.2 Gene:Zir / 33165 FlyBaseID:FBgn0031216 Length:2064 Species:Drosophila melanogaster
Sequence 2:XP_038937508.1 Gene:Dock3 / 315992 RGDID:1306677 Length:2077 Species:Rattus norvegicus


Alignment Length:2078 Identity:391/2078 - (18%)
Similarity:698/2078 - (33%) Gaps:697/2078 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   119 VEYAQRHLSSSCYIRERIDRGT------ISPSAYQQEFE-IDKDFSSFEEAFAYKSESCTPSSRQ 176
            |...:||      |..|:|.|.      :.|   :::|| :|.|..|..:  .||...   ||||
  Rat   139 VREVKRH------ITVRLDWGNEHLGLDLVP---RKDFEVVDSDQISVSD--LYKMHL---SSRQ 189

  Fly   177 SIASLASVSSCTDTLTPRGSWASFDLRRSVNDPLIPNLLDNVPPEHIDQSNEARRQQDRQMALFS 241
            |:   ...:|..||:.||..       .:...|:         |.|.               .||
  Rat   190 SV---QQSTSQVDTMRPRHG-------ETCRMPV---------PHHF---------------FFS 220

  Fly   242 LYPESEAEENIERRLLAEIPVEHMGHRIQVNCLQLRLELEVEPIFASMAIYDAKERQKISENFYF 306
                           |.......:|              |...:|.|  :||.:|.::|||.|..
  Rat   221 ---------------LKSFTYNTIG--------------EDSDVFFS--LYDMREGKQISERFLV 254

  Fly   307 DM-------NADSLKRMLSSHVQCA---DISTQSHSAIFEISYPSNDLFL---VIRLEKVLQGDI 358
            .:       |.:.::||      ||   |:|::.         ...||::   |||:.::|..|.
  Rat   255 RLNKNGGPRNPEKIERM------CALFTDLSSKD---------MKRDLYIVAHVIRIGRMLLNDS 304

  Fly   359 NNSV------EPY----------------LKEDKD---------------KYREKV--KSNAVDY 384
            ....      .||                |||:||               :..|.:  ||:.   
  Rat   305 KKGPAHLHYRRPYGCAVLSILDVLQSLTELKEEKDFVLKVYTCNNESEWTQIHENIIRKSST--- 366

  Fly   385 CERLGKYRMPFAWTGIYLT-NVFNGDNFESKDAGAAERDSFGNACGSSLGTAPSSNSLDRKSSTS 448
                 ||..|.|..|:.:: .:|.||                                       
  Rat   367 -----KYSAPSASHGLIISLQLFRGD--------------------------------------- 387

  Fly   449 SFDQLRRKANDMSGTLTRRGSLERKEKHRSWSPDDFANVVENFRPITITVPSFFKQEADKMKDED 513
             .:|:||: |.|   :..||                         :.||         .|:...|
  Rat   388 -MEQIRRE-NPM---IFNRG-------------------------LAIT---------RKLGFPD 413

  Fly   514 LYKILPELKRPSSVMKKYKCIPGSIKLEISPCVEEAKNALTPELAPINPQSADNVRPVKEILEFP 578
            :  |:||:|                   |..|                                 
  Rat   414 V--IMPEMK-------------------IVGC--------------------------------- 424

  Fly   579 QSAIYNPHYSYRNLLFVSPKELNFSSRAGSA--RNIAVRVQLM--AGETPKDAVNAIYGKSSCPK 639
                     ..||.|:::.::.:| .|.|.:  :||.|.:.::  .||..||.::  .|.....:
  Rat   425 ---------DIRNDLYLTLEKGDF-ERGGKSVQKNIEVTMYVLYADGEILKDCIS--LGSGEPNR 477

  Fly   640 FSTEAFTAVNYHNKCPSFYDEIKIALPASIKQHHHLLFTIYHVSCQKKPQDLQPSVETPIGYTWL 704
            .|..:|  |.||:..|.:.:.||:.:|....:..||.|...|.|.:.|.:      :...|:::.
  Rat   478 SSYHSF--VLYHSNSPRWGEIIKLPIPIDRFRGSHLRFEFRHCSTKDKGE------KKLFGFSFS 534

  Fly   705 PLLEDGKLKFGEFNLPVMVESPPENYSFIPPNVH-----LPGIKWLDNHRAVFSINVEAVTAIHT 764
            ||:.|......:....:.|....||.:|   |.|     ||..|  :::....:|....:....|
  Rat   535 PLMRDDGTTLSDDIHELYVYKCDENSTF---NNHALYLGLPCCK--EDYNGCPNIPSSLIFQRST 594

  Fly   765 LDSFLDRFFLICEYLDTRNIPSHIGENNIETELKKC------LLDI----EYANREPLVRHLPLV 819
            .:||         ::.|:...:.:.:|.....|.|.      ::||    .:.:.|.:|:.|..:
  Rat   595 KESF---------FISTQLSSTKLTQNVDLLALLKWKAFPDRIMDILGRLRHVSGEEIVKFLQDI 650

  Fly   820 LDKLIELLVVTHKVGGQAMSLGSTVFEVLCLVSSLLSILNDDQYDQYGRQSLLSTYV--HFQCKI 882
            ||.|..:|      .......|..||:.|..:   :::|.|.:|..:  :.::.||:  ||...:
  Rat   651 LDTLFVIL------DDNTEKYGLLVFQSLVFI---INLLRDIKYFHF--RPVMDTYIQKHFAGAL 704

  Fly   883 PHPFQSKQRLTCSRSTTEDLQLSESYTIYDNVLASGRSLDRKELSIDVLHSMAARDVQVRLLHEE 947
            .:    |:.:.|.:..   :..|......|::..:.|:|:.....|          ||.|:|:..
  Rat   705 AY----KELIRCLKWY---MDCSAELIRQDHIQEAMRALEYLFKFI----------VQSRILYSR 752

  Fly   948 LALHWVVASGKAADLAMSNSWFLFELIVKSMIEHLHCSNTL---NGPRKHRFPHQFNDDLSTLVH 1009
                  ...|...:...|:...||:.|...:......|.||   .....:.||..|::    |:.
  Rat   753 ------ATCGMEEEQFRSSIQELFQSIRFVLSLDSRNSETLLFTQAALLNSFPTIFDE----LLQ 807

  Fly  1010 LVTTKVVGYHSNEPKLAQSLNASLGFF--IFDILSIMDRGFVFGLIKTYTKVLISKNASIPDLMN 1072
            :.|.:         ::|:.:..:||..  ...|...||...:..:.:|....|.|.:.|      
  Rat   808 MFTVQ---------EVAEFVRGTLGSMPSTVHIGQSMDVVKLQSIARTVDSRLFSFSES------ 857

  Fly  1073 YKIDFLRIVCSHEHFVALNLPFGTSYTMVTAPCSPTPSTTSSNSQTSCGSLERALHADLSQEF-L 1136
             :...|.:|..|.|   |:|.......:    ||....:..|..:||      :|.||:.:|. :
  Rat   858 -RRILLPVVLHHIH---LHLRQQKELLI----CSGILGSIFSIVKTS------SLEADVMEEVEM 908

  Fly  1137 QQHFLVGLVLSDLAAVMEVPNPQLHGKAIRCIRNLMTSHDLDARYSETDARARVAALYIP-LLSI 1200
            ....|:.::|..|..:|...:.|...:..||                ....|.:...|:. |||:
  Rat   909 MVESLLDVLLQTLLTIMSKSHAQEAVRGQRC----------------PQCTAEITGEYVSCLLSL 957

  Fly  1201 VMDCIPQLHQHGLEQDRLQQIGQLEDYQGPHQTITASTINPEVAFAISGSRPYSYLNEQVKNKLP 1265
            :.......:||.|:                                          |.|.|::| 
  Rat   958 LRQMCDTHYQHLLD------------------------------------------NFQSKDEL- 979

  Fly  1266 LSSENTRHLLVCFLWVLKNLERNVLY--RWLMDLSPHRVHQMLQGVNVCLKTFEYTGQKNVATLK 1328
                  :..|:....|.:||.:..::  .|:       |.::|.. |:.:.|.:|..    :.|.
  Rat   980 ------KEFLLKIFCVFRNLMKMSVFPRDWM-------VMRLLTS-NIIVTTVQYLS----SALH 1026

  Fly  1329 RTNTQSFRKTGSTDVKEK-------LEECIRGTNSARYDLINRRKDRNSTEKFRWRKDQMPYR-- 1384
            :..|:       ||...|       |........|.:.::|...|.:...:|:...:..|.|.  
  Rat  1027 KNFTE-------TDFDFKVWNSYFSLAVLFINQPSLQLEIITSAKRKKILDKYGDMRVMMAYELF 1084

  Fly  1385 SQYADAVGKSEHELELSHFIEGSLATEVALVLLDTLEIIVHAAANLYHNLLGTVLKVLLHSLSRN 1449
            |.:.:.   .||::   |||.|.:...:.:.|:...|:         .|::..:...::....|.
  Rat  1085 SMWQNL---GEHKI---HFIPGMIGPFLGVTLVPQPEV---------RNIMIPIFHDMMDWEQRK 1134

  Fly  1450 QSVLALQNLFASQRALIFKFPNLLFDDETDICADLCLILLKHCGSLLPGIRSQAAASLYLLMRQN 1514
            ..     |....:..||.|..:::.:.:.|                      ::...|:.|:.|.
  Rat  1135 NG-----NFKQVESELIDKLDSMVSEGKGD----------------------ESYRELFSLLTQL 1172

  Fly  1515 FEIGNNFARVKMQVTMSLSSLVGTSSVFSEQSLRRALKTVLVYAESDSDLQDTSFPEQVQDLLFN 1579
            |   ..:..:..:|........|.|.|   .|:.|.::.:|.|                      
  Rat  1173 F---GPYPSLLEKVEQETWRETGISFV---TSVTRLMERLLDY---------------------- 1209

  Fly  1580 LHMILSDTVKMKEYQEDPEM--LLDLMNRIAKGYQNNPDLRLTWLENMAKKHRERANHTEAAMCY 1642
                 .|.:|.:| .|:.::  .::||| ..|...|..::.:.::..:...|.:..|:||||...
  Rat  1210 -----RDCMKGEE-TENKKVGCTVNLMN-FYKSEINKEEMYIRYIHKLCDMHLQAENYTEAAFTL 1267

  Fly  1643 VHAASLVSEYLSMLESQKHLPVGAVSFQRISPNTLMESAVSDDVLSPGEDGICLGNHFTETGLKA 1707
            :....|:......|....|.| ....:||                   ::|:|          :.
  Rat  1268 LLYCELLQWEDRPLREFLHYP-SQTEWQR-------------------KEGLC----------RK 1302

  Fly  1708 LLEEASNSFQVAGMYEAMNEVYKILIPIC-------EANRDFQKLSKVHGKLQEAF--NRISQLQ 1763
            ::.           |....:.::..||:|       |:..|:|.||.:. |::.::  |.|.|  
  Rat  1303 IIH-----------YFNKGKSWEFGIPLCRELACQYESLYDYQSLSWIR-KMEASYYDNIIEQ-- 1353

  Fly  1764 GKRVFGTYFRVGFYGGKFG-DLDQQEFIYKEPTLTKLPEIFSRLQNFYTERFGPDSVHIIKDSNT 1827
             :|:...:|||||||.||. .|..:|::.:.....:|.....|:.:.:     |.:| .::..|.
  Rat  1354 -QRLEPEFFRVGFYGRKFPFFLRNKEYVCRGHDYERLEAFQQRMLSEF-----PQAV-AMQHPNH 1411

  Fly  1828 VDINSLDPDKAYIQITYVEP---YFETYEMRH---RETYFERNFNIKRFIYATPFTKNGK-AHGE 1885
            .|...|..|..|:||..|.|   |.:..:|..   |...|.|..|:::|.|..||.|..| ...|
  Rat  1412 PDDAILQCDAQYLQIYAVTPIPDYVDVLQMDRVPDRVKSFYRVNNVRKFRYDRPFHKGPKDKDNE 1476

  Fly  1886 LNEQCKRKTILTTANHFPYVKTRIMVISRQQIVLEPIEVAIEDIQKKTLELAAATNQEP-----A 1945
            .......:|.||..:..|.:.....|..|:.:.:.|:|.||:.::.|..||.|..:|..     .
  Rat  1477 FKSLWIERTTLTLTHSLPGISRWFEVERRELVEVSPLENAIQVVENKNQELRALISQYQHKQVHG 1541

  Fly  1946 DPKILQMVLQGCIGTTVNQGPMEMASVFLSNLSDGTTVPTKHQ------NKLRLCFREFSKRCAD 2004
            :..:|.|.|.|.|...||.|.......|...     ...|||.      ::|:...:|.......
  Rat  1542 NINLLSMCLNGVIDAAVNGGIARYQEAFFDK-----DYITKHPGDAEKISQLKELMQEQVHVLGV 1601

  Fly  2005 ALKKNRNLILSDQKDYQRELERNNDRF-------------IERLTPFITLTSVQNHGVVKANA 2054
            .|..:...:..:.:...::|   .|:|             :::|:|..:.||.....|:.:::
  Rat  1602 GLAVHEKFVHPEMRPLHKKL---IDQFQMMRASLYHEFPCLDKLSPACSGTSTPRGNVLASHS 1661

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ZirNP_608489.2 DUF3398 59..151 CDD:288711 8/37 (22%)
C2_Dock-C 589..769 CDD:176078 45/188 (24%)
DHR-2 1549..2037 CDD:284365 111/530 (21%)
Dock3XP_038937508.1 SH3_DOCK3_B 10..65 CDD:212981
DOCK_N 69..412 CDD:406558 84/452 (19%)
C2_Dock-B 426..615 CDD:176077 48/213 (23%)
DHR2_DOCK3 1241..1632 CDD:212577 98/449 (22%)
Atrophin-1 1757..>2064 CDD:397323
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166343236
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1997
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.740

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