Protein Alignment Zir and Dock11

DIOPT Version :10

• Sequence 1: NP_608489.2
• Gene: Zir / 33165
• FlyBaseID: FBgn0031216
• Length: 2064
• Species: Drosophila melanogaster
• Sequence 2: NP_001420976.1
• Gene: Dock11 / 313438
• RGDID: 1564707
• Length: 2086
• Species: Rattus norvegicus
• Alignment Length: 2277
• Identity: 670/2277 - (29%)
• Similarity: 1046/2277 - (45%)
• Gaps: 480/2277 - (21%)

  Fly     6 RSFVQKVSKQ-SAADVRKNVSGCHLSKAMDPSLCGSSISPTEPLDYEEFLSQHMNIINRDPLKHI 69
            |.|.:::||. :||::|::|     |:|:..|:........||||||..::|....|..|||:.:
  Rat     5 RKFTKRLSKPGTAAELRQSV-----SEAVRGSVVLEKAKLVEPLDYENVITQRKTQIYSDPLRDL 64

  Fly    70 LDFPQGDVTVKIIPRKIRTVDHVVPNE---NLSDLPHHVQECVNCYTRPWKVVEYAQRHLSSSCY 131
            |.||..|:::.:|.|::|||...||.:   ....|  .|:||:..|:..|.||.|.....|...
  Rat    65 LMFPMEDISLSVIGRQLRTVQSTVPEDAEKRAQSL--FVKECIKTYSTDWHVVNYKYEDFSGDF- 126

  Fly   132 IRERIDRGTISPSAYQQE-FEIDKDFSSFEEAF-------------------------------- 163
              ..:...::.|...... ||||:|....|::.
  Rat   127 --RMLPCKSLRPEKIPNHVFEIDEDCEKDEDSSSLCSQKGGVIKQGWLHKANVNSTITVTMKVFK 189

  Fly   164 -----------------AYKSESCTPSSRQSIASLASVSSCTDTL-TPRGSWASFDLRR------ 204
                             :||.|..:..|:..|    .:.:|.|.: .|:....:|:|:.
  Rat   190 RRYFYLTQLPDGSYILNSYKDEKNSKESKGCI----YLDACIDVVQCPKMRRHAFELKMLDKYSH 250

  Fly   205 ---------------------SVN-DPLIPNLLDNVP-------------------------PE- 221
                                 .:| |.|:....:.|.                         ||
  Rat   251 YLAAETEQEMEEWLITLKKIIQINTDSLVQEKKETVEAIQEEETSSQGKAENIMASLERSMHPEL 315

  Fly   222 -----HIDQSNEARRQQDRQMALFSLYPESEA-------------EENIERRLLAEIPVEHMGHR 268
                 ..:|.|:..|...|| .|||...|.:.             ||...:|.|
  Rat   316 MKYGRETEQLNKLSRGDGRQ-NLFSFDSEVQRLDFSGIEPDVKPFEEKCNKRFL----------- 368

  Fly   269 IQVNCLQLRLEL-------------EVEPIFASMAIYDAKERQKISENFYFDMNADSLKRML-SS 319
              |||..|...:             .|||.|.::|::|.|...|||.:|:.|:|..|::.|| ..
  Rat   369 --VNCHDLTFNILGHIGDNAKGPPTNVEPFFITLALFDVKNNCKISADFHVDLNPPSVREMLWGM 431

  Fly   320 HVQCA-DISTQSHS------------------AIFEISYPSNDLFLVIRLEKVLQGDINNSVEPY 365
            ..|.| |.:|:..|                  .||.::.|..::|||:|:||||||:|.:..|||
  Rat   432 STQLANDGNTKGSSPESLIHGIAESRLCYIRQGIFSVTNPHPEIFLVVRIEKVLQGNITHCAEPY 496

  Fly   366 LK-EDKDKYREKVKSNAVDYCERLGKYRMPFAWTGIYLTNVFNGDNFESKDAGAAERDSFGNACG 429
            :| .|..|..:||...|...|.|||:|||||||                     |.|..|
  Rat   497 IKNSDPIKTAQKVHRTAKQVCSRLGQYRMPFAW---------------------AARPIF----- 535

  Fly   430 SSLGTAPSSNSLDRKSSTSSFDQLRRKANDMSGTLTRRGSLERKEKHRSWSPDDFANVVENFRPI 494
                                        .|:.|:|...|                     .|.|:
  Rat   536 ----------------------------KDLQGSLDLDG---------------------KFSPL 551

  Fly   495 TITVPSFFKQEADKMKDEDLYKILPELKRPSSVMKKYKCIPGSIKLEISPCVEEAKNALTPELAP 559
                   :||::.|:.:||:.|:|.|.|:|...  |.:.|||.:.:.:.....:..|.:|....|
  Rat   552 -------YKQDSSKLSNEDILKLLSEYKKPEKT--KLQIIPGQLNITVECVPVDLPNCITSSYVP 607

  Fly   560 INP--QSADNVRPVKEILEF-PQSAIY-NPHYSYRNLLFVSPKELNFSSRA--GSARNIAVRVQL 618
            :.|  ::..|:  ..|:.|| |:...| .|...|:|.|:|.|.:|.:.|:.  ..||||||.|:.
  Rat   608 LKPFEKNCQNI--TVEVEEFVPEMTKYCYPFTIYKNHLYVYPLQLKYDSQKSFAKARNIAVCVEF 670

  Fly   619 M-AGETPKDAVNAIYGKSSCPKFSTEAFTAVNYHNKCPSFYDEIKIALPASIKQHHHLLFTIYHV 682
            . :.|:...|:..||||.:...|:|.|:..|::||:.|.|||||||.||..:.|.||||||.|||
  Rat   671 RDSDESDTSALKCIYGKPAGSVFTTNAYAVVSHHNQNPEFYDEIKIELPIHLHQKHHLLFTFYHV 735

  Fly   683 SCQ---KKPQDLQPSVETPIGYTWLPLLEDGKLKFGEFNLPVMVESPPENYSFIPPNVH------ 738
            ||:   |.....|.:||||:|:.|:|||:||::...|..|||....||   .::  ||:
  Rat   736 SCEINTKGTTKKQDTVETPVGFAWVPLLKDGRVTTLEQQLPVSANLPP---GYL--NVNDAESRR 795

  Fly   739 --LPGIKWLDNHRAVFSINVEAVTAIHTLDSFLDRFFLICEYLDTRNIPSHIGENNIETELKKCL 801
              ...|||:|..:.:..|.....:.|:|.|..:.:||..|:.:.:       |...:..||.|.|
  Rat   796 QSNADIKWVDGAKPLLKIKTHLESTIYTQDLHVHKFFHHCQLIQS-------GSKEVPGELIKYL 853

  Fly   802 LDIEYANREPLVRHLPLVLDKLIELLV-VTHKVGGQAMSLGSTVFEVLCLVSSLLSILNDDQYDQ 865
            ..:.....:.:::.||::|.:|..:|. :||:   ..:.:..|:.        ||.|::  :..:
  Rat   854 KCLHAMEIQVMIQFLPVILMQLFRVLTNMTHE---DDVPINCTMV--------LLHIVS--KCHE 905

  Fly   866 YGRQSLLSTYVHFQCKIPHPFQSKQRLTCSRSTTEDLQLSESYTIYDNVLASGRSLDRKELSIDV 930
            .|.:|.|.:::.:..:...|           ||
  Rat   906 EGLESYLRSFIKYSFRPEKP-----------ST-------------------------------- 927

  Fly   931 LHSMAARDVQVRLLHEELALHWVVASGKAADLAMSN-----SWFLFELIVKSMIEHLHCSNTLNG 990
                    :|.:|:||.||...:....::||....|     |||.||:|.|||..:|...|.:..
  Rat   928 --------LQAQLIHETLATTMIAILKQSADFLAINKLLKYSWFFFEIIAKSMATYLLEENKIKL 984

  Fly   991 PRKHRFPHQFNDDLSTLVHLVTTKVVGYHSNEPKLAQSLNASLGFFIFDILSIMDRGFVFGLIKT 1055
            ||..|||..::..|.:|:..:...|...::..|..::::|.||..|:...|::|||||||.||..
  Rat   985 PRGQRFPEAYHHILHSLLLAIIPHVTIRYAEIPDESRNVNYSLASFLKRCLTLMDRGFVFNLIND 1049

  Fly  1056 YTKVLISKNASIPDLMNYKIDFLRIVCSHEHFVALNLPFGTSYTMVTAPCSPTPSTTSSNSQTSC 1120
            |......|:..:  |..||.:||:.:|:|||::.||||..     ...|.........|.:....
  Rat  1050 YISGFSPKDPKV--LAEYKFEFLQTICNHEHYIPLNLPMA-----FAKPKLQRVQDFFSFAVDRL 1107

  Fly  1121 GSLERALHADLSQEFLQQHFLVGLVLSDLAAVMEVPNPQLHGKAIRCIRNLMTSHDLDARYSETD 1185
            .|::..|...||.|:.:.||||||:|.:.:..:: .|.::...||..|:||:..|..|.||...:
  Rat  1108 TSVDSNLEYSLSDEYCKHHFLVGLLLRETSIALQ-DNYEIRYTAISVIKNLLIKHAFDTRYQHKN 1171

  Fly  1186 ARARVAALYIPLLSIVMDCIPQL-----------------------------HQHGLEQDRLQQI 1221
            .:|::|.||:|.:.::::.|.:|                             .:..|..|:....
  Rat  1172 QQAKIAQLYLPFVGLLLENIQRLAGRDTLYSCAAMPNSASRDEFPCGFVSPTSRGSLATDKEPAY 1236

  Fly  1222 GQLEDYQGPHQTITASTINPEVA--FAISGSRPYSYLNEQVKNKLPLSSEN------TRHLLVCF 1278
            |..::..|..:..:..::.||.|  |...||...:  ..|..::..:|..|      .|:||:|:
  Rat  1237 GSFQNGHGIKREDSRGSLIPEGATGFPDPGSTGEN--TRQSSSRTSVSQYNRLDQYEIRNLLMCY 1299

  Fly  1279 LWVLKNLERNVLYRWLMDLSPHRVHQMLQGVNVCLKTFEYTGQKNVATLKRTNTQSFRKTGSTDV 1343
            |:::|.:..:.|..:...:||..:..:|..:.|||..|.|.|::|:|   |.:.....|....|.
  Rat  1300 LYIVKMISEDTLLTYWNKVSPQELINILVLLEVCLFHFRYMGKRNIA---RVHDAWLSKHFGIDR 1361

  Fly  1344 KEKLEECIRGTNSARYDLINRRKDRNSTEKFRWRKDQMPYRSQYADAVGKS---EH-----ELEL 1400
            |.:....:|.                       |...|..|.|:..::..|   .|     |.::
  Rat  1362 KSQTMPALRN-----------------------RSGVMQARLQHLSSLESSFTLNHSSATTEADI 1403

  Fly  1401 SH--FIEGSLATEVALVLLDTLEIIVHA-----AANLYHN-LLGTVLKVLLHSLSRNQSVLALQN 1457
            .|  .:||:.||||:|.:|||:......     ..|..|| |:..|..:.|..|...||.::|::
  Rat  1404 FHQALLEGNTATEVSLTVLDTISFFTQCFKSQLLNNDGHNPLMKKVFDIHLAFLKNGQSEVSLKH 1468

  Fly  1458 LFASQRALIFKFPNLLFDDETDICADLCLILLKHCGSLLPGIRSQAAASLYLLMRQNFEI--GNN 1520
            :|||.|:.|.|||:..|....::||..|..:||.|.|.:...|::|:|.||||||.|||.  ...
  Rat  1469 VFASLRSFISKFPSAFFKGRVNMCAAFCYEVLKCCTSKISSTRNEASALLYLLMRNNFEYTKRKT 1533

  Fly  1521 FARVKMQVTMSLSSLVGTSSVFSEQSLRRALKTVLVYAESDSDLQDTSFPEQVQDLLFNLHMILS 1585
            |.|..:|:.:::|.|:...::......:.:|..:..:|.||..::.|:||.:|:||...:..:|.
  Rat  1534 FLRTHLQIIIAVSQLIADVALSGGSRFQESLFIINNFANSDRPMKATAFPTEVKDLTKRIRTVLM 1598

  Fly  1586 DTVKMKEYQEDPEMLLDLMNRIAKGYQNNPDLRLTWLENMAKKHRERANHTEAAMCYVHAASLVS 1650
            .|.:|||:::|||||:||...:||.|.:.|:||.|||::|||.|.:..:.:||||||||.|:||:
  Rat  1599 ATAQMKEHEKDPEMLIDLQYSLAKSYASTPELRKTWLDSMAKIHIKNGDFSEAAMCYVHVAALVA 1663

  Fly  1651 EYLSMLESQKHLPVGAVSFQRISPNTLMESAVSDDVLSPGEDGICLGNHFTETGLKALLEEASNS 1715
            |:   |..:|..|.|..:|::|:||...|.|:.       ||...:..|::|..|..|||:..:.
  Rat  1664 EF---LHRKKLFPSGCSAFKKITPNIDEEGAMK-------EDAGMMDVHYSEEVLLELLEQCVDG 1718

  Fly  1716 FQVAGMYEAMNEVYKILIPICEANRDFQKLSKVHGKLQEAFNRISQLQ--GKRVFGTYFRVGFYG 1778
            ...|..||.::|:.|::|||.|..|:|:||::|:..|..|:.:|.::.  .||:.||:|||.|||
  Rat  1719 LWKAERYEVISEISKLIIPIYEKRREFEKLTQVYRTLHGAYTKILEVMHTKKRLLGTFFRVAFYG 1783

  Fly  1779 GK-FGDLDQQEFIYKEPTLTKLPEIFSRLQNFYTERFGPDSVHIIKDSNTVDINSLDPDKAYIQI 1842
            .. |.:.|.:|:|||||.||.|.||..||...|.|:||.:::.||:||:.|:...|||..|:||:
  Rat  1784 QSFFEEEDGKEYIYKEPKLTGLSEISFRLVKLYGEKFGTENIKIIQDSDKVNAKELDPKFAHIQV 1848

  Fly  1843 TYVEPYFETYEMRHRETYFERNFNIKRFIYATPFTKNGKAHGELNEQCKRKTILTTANHFPYVKT 1907
            |||:|||:..|:..|:|.||||.||.||::..|:|.:||..|.:.|||||:|||||:|.|||||.
  Rat  1849 TYVKPYFDDKELTERKTEFERNHNINRFVFEAPYTLSGKKQGCIEEQCKRRTILTTSNSFPYVKK 1913

  Fly  1908 RIMVISRQQIVLEPIEVAIEDIQKKTLELAAATNQEPADPKILQMVLQGCIGTTVNQGPMEMASV 1972
            ||.:...||:.|:||:||.::|:.||.||....:....|...||:.||||:...||.||:..|..
  Rat  1914 RIPITCEQQVNLKPIDVATDEIKDKTAELHKLCSSADVDMIQLQLKLQGCVSVQVNAGPLAYARA 1978

  Fly  1973 FLSNLSDGTTVPTKHQNKLRLCFREFSKRCADALKKNRNLILSDQKDYQRELERNNDRFIERLTP 2037
            || |.|.....|.|..|:|:..||:|.:.|:.||:.|..||..||.:|...|:.|....::.|:.
  Rat  1979 FL-NESQANKYPPKKVNELKDMFRKFIQACSIALELNERLIKEDQIEYHEGLKSNFRDMVKELSD 2042

  Fly  2038 FI 2039
            .|
  Rat  2043 II 2044

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Zir	NP_608489.2	DOCK_C-D_N	46..153	CDD:463380	35/110 (32%)
		C2_Dock-C	589..769	CDD:176078	77/193 (40%)
		DHR2_DOCK_C	1614..2035	CDD:212568	183/423 (43%)
Dock11	NP_001420976.1	DOCK_C-D_N	38..147	CDD:463380	35/113 (31%)
		PH_DOCK-D	161..284	CDD:270087	13/126 (10%)
		C2_Dock-D	639..828	CDD:176079	77/193 (40%)
		DHR2_DOCK11	1628..2040	CDD:212573	183/422 (43%)