DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Zir and Dock1

DIOPT Version :9

Sequence 1:NP_608489.2 Gene:Zir / 33165 FlyBaseID:FBgn0031216 Length:2064 Species:Drosophila melanogaster
Sequence 2:NP_001137330.1 Gene:Dock1 / 309081 RGDID:1566072 Length:1864 Species:Rattus norvegicus


Alignment Length:2049 Identity:381/2049 - (18%)
Similarity:699/2049 - (34%) Gaps:594/2049 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   199 SFDLRRSVNDPLIPNLLDNVPPEHIDQSNEA--RRQQDRQMALFSLYPES---------EAEENI 252
            ::|.|.:  |.|...:.|.|   ||.::.|.  |....|:.:...::|.|         |.:...
  Rat    19 NYDARGA--DELSLQIGDTV---HILETYEGWYRGYTLRKKSKKGIFPASYIHLKEAIVEGKGQH 78

  Fly   253 ERRLLAEIPVEHMGHRIQVNCLQLRLELEVEPIFASMAIYDAKERQKISENFYFDMNADSLKRML 317
            |..:..::|:      ||.....||   |...|:..:.:.|.:|..:...:..:|: .:...::|
  Rat    79 ETVIPGDLPL------IQEVTTTLR---EWSTIWRQLYVQDNREMFRSVRHMIYDL-IEWRSQIL 133

  Fly   318 SSHVQCADISTQSHSAIFEISYPSN--DLFLVIRLEKVLQGDINNSVEPYLKEDKDKYR-EKVKS 379
            |..:...::.........:|.|.:.  ||.||:|.|.      .|.::|.|......:| .:|.|
  Rat   134 SGTLPQDELKELKKKVTAKIDYGNRILDLDLVVRDED------GNILDPELTSTISLFRAHEVAS 192

  Fly   380 NAVDYCERLGKYRMPFAWTGIYLTNVFNGD-NFESKDAGAAERDSFGN----ACGSSLGTAP--- 436
            ..|:  |||.:.:          :...|.| |.::|.|.......|.|    .|  .:|...   
  Rat   193 KQVE--ERLQEEK----------SQKQNMDINRQAKFAATPSLALFVNLKNVVC--KIGEDAEVL 243

  Fly   437 ------------SSNSLDRKSST---SSFDQLRRKANDMSGTLTRRGSLERKEKHRSWSPDDFAN 486
                        |.|.|.|.||:   ...|:|    :::....|..||.:.|.:..|:       
  Rat   244 MSLYDPVESKFISENYLVRWSSSGLPKDIDRL----HNLRAVFTDLGSKDLKREKISF------- 297

  Fly   487 VVENFRPITITVPSFFKQEADKMKDEDLYKILPELKRP--SSVMKKYKCIPGSIK-------LEI 542
                       |....:....:::|.:..|:...|:||  .:||.....|.|.:.       :..
  Rat   298 -----------VCQIVRVGRMELRDSNTRKLTSGLRRPFGVAVMDVTDIINGKVDDEDKQHFIPF 351

  Fly   543 SPCVEE-------------AKNA--------LTPELAPIN--------PQSADNVRPVKEILEFP 578
            .|...|             ||..        :|.:|.|.:        |...|....|.....||
  Rat   352 QPVAGENDFLQTVINKVIAAKEVNHKGQGLWVTLKLLPGDIHQIRKEFPHLVDRTTAVARKTGFP 416

  Fly   579 QSAIYNPHYSYRNLLFVSPKELNFSSRAGS---ARNIAVRVQLMAGETPKDAVNAIYGKSSCPKF 640
            :  |..|. ..||.::|:..:.:|..  ||   |:|:.|.|.:. .|..|...:.|:     |..
  Rat   417 E--IIMPG-DVRNDIYVTLVQGDFDK--GSKTTAKNVEVTVSVY-DEDGKRLEHVIF-----PGA 470

  Fly   641 STEAF----TAVNYHNKCPSFYDEIKIALPASIKQHHHLLFTIYHVSCQKKPQDLQPSVETPIGY 701
            ..||.    :.:.|..|.|.:::.:|:|:|.......||.||..|    :..||.:...|.....
  Rat   471 GDEAISEYKSVIYYQVKQPRWFETLKVAIPIEDVNRSHLRFTFRH----RSSQDSKDKSEKIFAL 531

  Fly   702 TWLPLLE-DG-KLKFGEFNLPVMVESPPENYSFIPPNVHLPGIKWLDNHRAVFSINVEAVTAIHT 764
            .::.|:. || .|:.||.:| ::.::..:........:.||..|. :......|...:.:.::.:
  Rat   532 AFVKLMRYDGTTLRDGEHDL-IVYKAEAKKLEDAATYLSLPSTKG-ELEEKGHSATGKGMQSLGS 594

  Fly   765 LDSFLDRF---FLICEYLDTRNIPS------HIGENNIETELKKCLLDIEYANREPLVRHLPLVL 820
            .....|.|   .|:|....|:|:..      ....|.::..|:: |:.::...   :|:.|...|
  Rat   595 CTISKDSFQISTLVCSTKLTQNVDLLGLLKWRSNTNLLQQNLRQ-LMKVDGGE---VVKFLQDTL 655

  Fly   821 DKLIELLVVTHKVGGQAMSLGSTVFEVLCLVSSLLSILNDDQYDQYGRQSLLSTYV--HFQCKIP 883
            |.|..:::    ...::.:..:.||:.|..:..|::   |.::..:  ..:|.||:  ||...: 
  Rat   656 DALFNIMM----ENSESETFDTLVFDALVFIIGLIA---DRKFQHF--NPVLETYIKKHFSATL- 710

  Fly   884 HPFQSKQRLTCSRSTTEDLQLSESYTIYDNVLAS-GRSLDRKELSIDVLHSMAARD------VQV 941
                                   :||....||.: ..|.::..::..:..::.|.:      |:.
  Rat   711 -----------------------AYTKLTKVLRTYVASAEKPGINEQLYKAIKALEYIFKFIVRS 752

  Fly   942 RLLHEELALHWVVASGKAADLAMSNSWFLFELIVKSMIEHLHCSNTLNGPRKHRFPHQFNDDLST 1006
            |:|..:|..:    .|:|.             .|:|:::..               ...||.:|:
  Rat   753 RVLFNQLYEN----KGEAD-------------FVESLLQLF---------------RSINDMMSS 785

  Fly  1007 LVHLVTTKVVGYHSNEPKLAQSLNASLGF---FIFDILSIMDRGFVFGLIKTYTKVLISKNASIP 1068
            :..| |.:|.|             |:|.:   .:.|:..:.|..   .|.|.:|:.:        
  Rat   786 MSEL-TVRVKG-------------AALKYLPTIVNDVKLVFDPK---ELSKMFTEFI-------- 825

  Fly  1069 DLMNYKIDFLRIVCSHEHFVALNLPFGTSYTMVTAPCSPTPSTTSSNSQTSCGSLERALHAD-LS 1132
                                 ||:|.|. .|:....|......:...:|..|..:...:..| |.
  Rat   826 ---------------------LNVPVGL-LTVQKLYCLIEIVHSDLFTQHDCREILLPMMTDQLK 868

  Fly  1133 QEFLQQHFLVGL--VLSDLAAVM---EVPNPQLHGKAI-----RCIRNLMTSHDLDARYSETDAR 1187
            ....:|..|...  :||::..|:   :|...|.|.:.|     |.:...:.|...|:.       
  Rat   869 YHLERQEDLEACCQLLSNILEVLYRKDVGPTQRHVQIIMEELLRTVNRTVISMGRDSE------- 926

  Fly  1188 ARVAALYIPLLSIVMDCIPQLHQHGLEQDRLQQIGQLEDYQGPHQTITASTINPEVAFAISGSRP 1252
                     |:...:.|:..:            :.|:||:...|...|...:..:|.        
  Rat   927 ---------LIGNFVACMTAI------------LRQMEDFHYAHLIKTFGKMRTDVV-------- 962

  Fly  1253 YSYLNEQV--------KNKLPLSSENTRHLLVCFLWVLKNLERNVLYRWLMDLSPHRVHQMLQGV 1309
             .:|.|..        ||..|            |.||:.|..:|.::              |:.:
  Rat   963 -DFLMETFIMFKNLIGKNVYP------------FDWVIMNTMQNKVF--------------LRAI 1000

  Fly  1310 NVCLKTFEYTGQKNVATLKRTN------TQSFRKTGSTDVKEKLEECIRGTNSA-RYDLINRRKD 1367
            |      :|....|...|.:.|      ...|....:...:|.|:  :...:|| |..::|:..|
  Rat  1001 N------QYADMLNKKFLDQANFELQLWNNYFHLAVAFLTQESLQ--LENFSSAKRAKILNKYGD 1057

  Fly  1368 RNSTEKFRWRKDQMPYRSQYADAVGKSEHELE-----LSHFIEGSLATEVAL------VLLDTLE 1421
            ......|..|  .|.|        ...:|:::     :...:|.:|..|..|      :..|.::
  Rat  1058 MRRQIGFEIR--DMWY--------NLGQHKIKFIPEMVGPILEMTLIPETELRKATLPIFFDMMQ 1112

  Fly  1422 IIVHAAANLYHNLLGTVLKVLLHSLSRNQSVLALQNLFASQRALIFKFPNLLFDDETDICADLCL 1486
            ...|:..:.              .:..|:.:..|.:.....|.          |::..:..|  .
  Rat  1113 CEFHSTRSF--------------QMFENEIITKLDHEVEGGRG----------DEQYKVLFD--K 1151

  Fly  1487 ILLKHCGSLLPGIRSQAAASLYLLMRQNFEIGNNFARVKMQVTMSLSSLVGTSSVFSEQSLRRAL 1551
            |||:||           ....||.     :.|..|  ||:.|.:                :.|.|
  Rat  1152 ILLEHC-----------RKHKYLA-----KTGETF--VKLVVRL----------------MERLL 1182

  Fly  1552 KTVLVYAESDSDLQDTSFPEQVQDLLFNLHMILSDTVKMKEYQEDPEMLLDLMNRIAKGYQNNPD 1616
            ....:..:.:.|.:                  :|.||.:..:.::.|               ..:
  Rat  1183 DYRTIMHDENKDNR------------------MSCTVNVLNFYKEIE---------------REE 1214

  Fly  1617 LRLTWLENMAKKHRERANHTEAAMCYVHAASLVSEYLSMLESQKHLPVGAVSFQRISPNTLMESA 1681
            :.:.:|..:...|:|..|:||||...:..|.|:.  .|......|| :....||..:...|.|..
  Rat  1215 MYIRYLYKLCDLHKECDNYTEAAYTLLLHAKLLK--WSEDACAAHL-IQRDGFQATTQGQLKEQL 1276

  Fly  1682 VSDDVLSPGEDGICLGNHFTETGLKALLEEA-SNSFQVAGMYEAMNEVYKILIPICEANRDFQKL 1745
            ..:.:            |:.:.|  .:.||| :...::|..||  .|::           |:::|
  Rat  1277 YQEII------------HYFDKG--KMWEEAIALGKELAEQYE--TELF-----------DYEQL 1314

  Fly  1746 SKVHGKLQEAFNRISQLQGKRVFGTYFRVGFYGGKFGD-LDQQEFIYKEPTLTKLPEIFSRLQNF 1809
            |::..|..:.:..|.::  .|....||.||:||..|.. |..:.|||:.....:..:..:||...
  Rat  1315 SELLKKQAQFYENIVKV--IRPKPDYFAVGYYGQGFPSFLRGKVFIYRGKEYERREDFEARLLTQ 1377

  Fly  1810 YTERFGPDSVHIIKDSNTVDINSLDPDKAYIQITYVEPYFETYEMRHRE-----TYFERNFNIKR 1869
            :     |::..:...|...|.....|.: |||...|:|..:.....||.     ..|.|...::|
  Rat  1378 F-----PNAEKMKTTSPPGDDIKTSPGQ-YIQCFTVKPKLDLPPKFHRPVSEQIVSFYRVNEVQR 1436

  Fly  1870 FIYATPFTKNGK-AHGELNEQCKRKTILTTANHFPYVKTRIMVISRQQIVLEPIEVAIEDIQKKT 1933
            |.|:.|..|..| ...|.......:||.|||...|.:.....|.|...:.:.|:|.|||.:|...
  Rat  1437 FEYSRPIRKGEKNPDNEFANMWIERTIYTTAYKLPGILRWFEVKSVFMVEISPLENAIETMQLTN 1501

  Fly  1934 LELAAATNQEPADPKI----LQMVLQGCIGTTVNQGPMEMASVFLSN------------------ 1976
            .::::...|...||.:    |.|:|.|.:...|..|.......|.::                  
  Rat  1502 DKISSMIQQHLDDPGLPINPLSMLLNGIVDPAVMGGFANYEKAFFTDRYLQEHPEAHGQIEKLKD 1566

  Fly  1977 --------LSDGTTVPTKHQNKLRLCFREFSKRCADALKKNRNLILSDQKDY-QREL-----ERN 2027
                    |::|..:   |.:|:....|.|.:|.....|:.:..:   :|.| .|.:     :|.
  Rat  1567 LIAWQIPFLAEGIRI---HGDKVTEALRPFHERMEACFKQLKEKV---EKQYGVRTMPSGLDDRR 1625

  Fly  2028 NDRFIERLTPFITLTSVQNHGVVKANAYNNKSTP 2061
            ..|....:..|...:|.:...|...:::::.|||
  Rat  1626 GSRPRSMVRSFTMPSSSRPLSVASVSSFSSDSTP 1659

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ZirNP_608489.2 DUF3398 59..151 CDD:288711
C2_Dock-C 589..769 CDD:176078 41/188 (22%)
DHR-2 1549..2037 CDD:284365 109/531 (21%)
Dock1NP_001137330.1 SH3_DOCK1_5_A 13..68 CDD:212984 13/53 (25%)
DOCK_N 72..416 CDD:292790 74/395 (19%)
C2_Dock-A 424..619 CDD:176076 47/208 (23%)
DHR2_DOCK 1214..1612 CDD:297424 98/441 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1997
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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