DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Zir and Dock5

DIOPT Version :9

Sequence 1:	NP_608489.2	Gene:	Zir / 33165	FlyBaseID:	FBgn0031216	Length:	2064	Species:	Drosophila melanogaster
Sequence 2:	NP_001358941.1	Gene:	Dock5 / 305987	RGDID:	1306872	Length:	1868	Species:	Rattus norvegicus

Alignment Length:	1850	Identity:	341/1850 - (18%)
Similarity:	598/1850 - (32%)	Gaps:	638/1850 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   437 SSNSLDRKSSTSSFDQLRRKAN------DMSGT------------LTRRGSLERKE--KHRSWSP 481
            |.|.|.|..|.....::.:..|      |:|.|            :.|.|.:|.||  ||.....
  Rat   255 SENYLIRWGSNGMPKEIEKLNNLQAVFTDLSSTDLIRPRISLVCQIVRVGRMELKEGKKHTCGLR 319

  Fly   482 DDFANVVENFRPITITVPSFFKQEADKMKDEDLYKILP--ELKRPSSVMKKYKCIPGSIKLEISP 544
                      ||..:.|.........|:.||:....:|  ::...:.:.::        :|.:||
  Rat   320 ----------RPFGVAVMDISDIVHGKVDDEEKQHFIPFQQIAMETYIRQR--------QLIMSP 366

  Fly   545 CVEEAKNALTPELAPINPQSADNVRPVKEILEFPQSAIYNPHYSYRNLLFVSPKEL--------- 600
            .:   .:.:..|..|:. ...:.|...||:....|.            |:||.|.|
  Rat   367 LI---TSHVIGENEPLT-SVLNKVIAAKEVNHKGQG------------LWVSLKLLPGDLTQVQK 415

  Fly   601 NFSSRAGSARNIAVRVQLMAGETPKDAVNAIY----------GKSSCPK--------FS------ 641
            |||.....:..||.::.......|.|..|.||          ||...||        |.
  Rat   416 NFSHLVDRSTAIARKMGFPEIILPGDVRNDIYVTLIHGEFDKGKKKTPKNVEVTMSVFDEEGNLL 480

  Fly   642 -------------TEAFTAVNYHNKCPSFYDEIKIALPASIKQHHHLLFTIYHVSCQKKPQDLQP 693
                         :|..:.|.|..|.|.:|:.:|:.:........|:.||..|    :..|:.:.
  Rat   481 EKAIHPGAGYEGVSEYKSVVYYQVKQPCWYETVKVFIAIEEVTRCHIRFTFRH----RSSQESRD 541

  Fly   694 SVETPIGYTWLPLLE-DG-KLKFGEFNLPVMVESPPENYSFIPPNVHLPGIK-WLDNHRAVFSIN 755
            ..|...|..::.|:. || .|:.|..:| |:.:...:........:.|||.| .|:......|.|
  Rat   542 KSERAFGVAFVKLMNADGTTLQDGRHDL-VVYKGDNKKMEDAKYYLTLPGTKAELEEKELQASKN 605

  Fly   756 VEAVTAIHTLDSFLDRF---FLICEYLDTRNIPS------HIGENNIETELKKCLLDIEYANREP 811
            ....|.  :.||..|.|   .|||....|:|:..      .....||:..||| |::::...
  Rat   606 PSVFTP--SKDSTKDSFQIATLICSTKLTQNVDLLGLLNWRSNSQNIKHNLKK-LMEVDGGE--- 664

  Fly   812 LVRHLPLVLDKLIELLVVTHKVGGQAMSLGST----VFEVLCLVSSLLSILNDDQYDQYGRQSLL 872
            :|:.|...||.|..:::        .||...|    ||:.|..:   :|::.|.::..:  ..:|
  Rat   665 IVKFLQDTLDALFNIMM--------EMSDNETYDFLVFDALVFI---ISLIGDIKFQHF--NPVL 716

  Fly   873 STYV--HFQCKIPHPFQSKQRLTCSRSTTEDLQLSESYTIYDNVLASGRSLDRKELSIDVLHSMA 935
            .||:  ||...:.|                 ::||:....|   :|:.....:.||....|.::.
  Rat   717 ETYIYKHFSATLAH-----------------VKLSKVLNFY---VANAEDPSKTELLFAALKALK 761

  Fly   936 ARDVQVRLLHEELALHWVVASGKAADLAMSNSWFLFELIVKSMIEHLHCSNTLNGPRKHRFPHQF 1000
                                             :||..|::|.:.:|            ||..|.
  Rat   762 ---------------------------------YLFRFIIQSRVLYL------------RFYGQS 781

  Fly  1001 NDDLSTLVHLVTTKVVGYHSNEPKLAQSLNASLGFFIFDILSIMDRGF-----VFGLIKTYTKVL 1060
            .|                       ....|.|:........::|||..     :.|....|...:
  Rat   782 ED-----------------------GDEFNNSIRQLFLAFNTLMDRPLEEAVKIKGAALKYLPSI 823

  Fly  1061 ISKNASIPDLMNYKIDFLRIVCSHEHFVALNLPFGTSYTMVTAPCSPTPSTTSSNSQTSCGSLER 1125
            |:....:.|.|...:.|.:.:.|                        .|.......:.:|  :.:
  Rat   824 INDVKLVFDPMELSVLFCKFIQS------------------------IPDNQLVRQKLNC--MTK 862

  Fly  1126 ALHADLSQEFLQQHFLVGLVLSDLAAVMEVPNPQLHGKAIRCIRNLMTSHDLDARYSETDARARV 1190
            .:.:.|.|:...:..|:.| |:|          ||.|:             ||...::.|..|.
  Rat   863 IVESSLFQQAECREVLLPL-LTD----------QLSGQ-------------LDDHSTKPDHEAS- 902

  Fly  1191 AALYIPLLSIVMDCIPQ-------LHQHGLEQDRLQQIGQL---EDYQGPHQTITASTINPEVAF 1245
                ..|||.:::.:.:       .|...:.:..|::|.:.   ...|.||       |...||.
  Rat   903 ----SQLLSNILEVLDRTDVGPTSAHVQMIMERLLRRINRTVIGMSRQSPH-------IGSFVAC 956

  Fly  1246 AISGSRPYSYLNEQVKNKLPLSSENTRHLLVCFLWVLKNLERNVLYRWLMDLSPHRVHQMLQGVN 1310
            .|:..|..    |.....|.:|:..||..::.||     :|..::::.|:            |.|
  Rat   957 MIAVLRQM----EDSHYSLYISTFKTRQDIIDFL-----METFIMFKDLI------------GKN 1000

  Fly  1311 VCLKTFEYTGQKNVATLKRTNTQSFRKTGSTDVKEKLEECIRGTNSARYDLINRRKDRNSTEKFR 1375
            |..|.:        ..:..|.::.|               :|..|.....|.....|:.|.|...
  Rat  1001 VYAKDW--------MVMNMTQSRVF---------------LRAINQFAEVLTKSFMDQTSFELQL 1042

  Fly  1376 WRKDQMPYRSQYADAVGKSEHE-LELSHFIE----------GSLATEVALVLLDTLEIIVHAAAN 1429
            |       .:.:..||....|| |:|..|.|          |.:..|:...:.|
  Rat  1043 W-------NNYFHLAVAFLTHESLQLETFSEAKRNKIVKKYGDMRKEIGFRIRD----------- 1089

  Fly  1430 LYHNL-----------LGTVLKVLL---------------------HSLSRNQSVLALQNLFASQ 1462
            :::||           :|.:|:|.|                     .:||.|      .|....:
  Rat  1090 MWYNLGPHKIKFIPSMVGPILEVTLTPEVELRKATIPIFFDMMQCEFNLSGN------GNFHMFE 1148

  Fly  1463 RALIFKFPNLLFDDETDICADLCL--ILLKHCGSLLPGIRSQAAASLYLLMRQNFEIGNNFARVK 1525
            ..||.|....:.....|....:.|  :||:||                   |::..:.::.....
  Rat  1149 NELITKLDQEVEGGRGDEQYKVLLEKLLLEHC-------------------RKHKYLSSSGEVFA 1194

  Fly  1526 MQVTMSLSSLVGTSSVFSEQSLRRALKTVLVYAESDSDLQDTSFPEQVQDLLFNLHMILSDTVKM 1590
            :.|:..|.:|:.             .:|::::.||..:.                   :|.||.:
  Rat  1195 LLVSSLLENLLD-------------YRTIIMHDESKENR-------------------MSCTVNV 1227

  Fly  1591 KEYQEDPEMLLDLMNRIAKGYQNNPDLRLTWLENMAKKHRERANHTEAAMCYVHAASLVSEYLSM 1655
            ..:.::               :...|:.:.:|..:...||:..|:||||            |..:
  Rat  1228 LNFYKE---------------KKREDIYIRYLYKLRDLHRDCENYTEAA------------YTLL 1265

  Fly  1656 LESQKHLPVGAVSFQRISPNTLMESAVSDDVLSPGEDGICLGNHFTETGLKALLEEASNSFQVAG 1720
            |.::                           |....|..|:.:         ||:.  :|:.|..
  Rat  1266 LHAE---------------------------LLQWSDKPCMPH---------LLQR--DSYYVYT 1292

  Fly  1721 MYEAMNEVYKILIPICEANRDFQKLSKVHGKLQEAF-NRISQLQG------KRVF---------- 1768
            ..|...::|:.:|...:..:.::|..|:..:|.|.: :::...:|      ||..
  Rat  1293 QQELKEKLYQEIISYFDKGKMWEKAIKLSKELAETYESKVFDYEGLGSLLKKRALFYENIIKAMR 1357

  Fly  1769 --GTYFRVGFYGGKFGD-LDQQEFIYKEPTLTKLPEIFSRLQNFYTERFGPDSVHIIKDSNTV-- 1828
              ..||.||:||..|.. |..:.|||:.....:..:...||...:     |::.   |.::|.
  Rat  1358 PQPEYFAVGYYGQGFPSFLRNKIFIYRGKEYERREDFSLRLLTQF-----PNAE---KMTSTTPP 1414

  Fly  1829 --DINSLDPDKAYIQITYVEP-------YFETYEMRHRETYFERNFNIKRFIYATPFTKNGK-AH 1883
              ||.|  ..|.|:|...|:|       |.:.........|:..| .:::|.|:.||.|..| ..
  Rat  1415 GEDIRS--SPKQYLQCFTVKPVMSLPPSYKDKPVPEQILNYYRAN-EVQQFRYSRPFRKGEKDPE 1476

  Fly  1884 GELNEQCKRKTILTTANHFPYVKT--RIMVISRQQIVLEPIEVAIEDIQKKTLELAAATNQEPAD 1946
            .|.......:|..|||..||.:..  .:..||.::|  .|:|.|||.::.....::....|...|
  Rat  1477 NEFATMWIERTTYTTAYTFPGILKWFEVKHISTEEI--SPLENAIETMELTNERVSNCVQQHAWD 1539

  Fly  1947 PKI----LQMVLQGCIGTTVNQGPMEMASVFLSN--------------------------LSDGT 1981
            ..:    |.|:|.|.:...|..|.......|.:.                          |::|.
  Rat  1540 HSLSVHPLSMLLNGIVDPAVMGGFSNYEKAFFTEKYLQAHPEDQEKVELLKRLIALQIPLLAEGI 1604

  Fly  1982 TVPTKHQNKL---------RL--CFREFSKRCADALKKNRNLILSDQKDYQRELERNNDRFIERL 2035
            .:   |..||         ||  ||||..::    ::|...:|.......:|:..|.....:..:
  Rat  1605 RI---HGEKLTEQLKPLHDRLSSCFRELKEK----VEKLYGVITLPPSMTERKPSRAGSMVLPYI 1662

  Fly  2036 TPF----ITLTSVQNHGVVKANAYNNKSTP 2061
            .|.    :::|||.: .||..::.::.:.|
  Rat  1663 LPSTLRRLSVTSVAS-SVVSTSSNSSDNAP 1691

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zir	NP_608489.2	DUF3398	59..151	CDD:288711
		C2_Dock-C	589..769	CDD:176078	51/228 (22%)
		DHR-2	1549..2037	CDD:284365	106/562 (19%)
Dock5	NP_001358941.1	SH3_DOCK1_5_A	12..67	CDD:212984
		DOCK_N	75..434	CDD:374409	42/212 (20%)
		C2	442..637	CDD:387358	46/201 (23%)
		DHR2_DOCK5	1238..1637	CDD:212581	97/468 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343242
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840