Protein Alignment Zir and Dock10

DIOPT Version :9

• Sequence 1: NP_608489.2
• Gene: Zir / 33165
• FlyBaseID: FBgn0031216
• Length: 2064
• Species: Drosophila melanogaster
• Sequence 2: XP_008765532.2
• Gene: Dock10 / 301556
• RGDID: 1561963
• Length: 2227
• Species: Rattus norvegicus
• Alignment Length: 2352
• Identity: 636/2352 - (27%)
• Similarity: 1021/2352 - (43%)
• Gaps: 571/2352 - (24%)

  Fly    46 EPLDYEEFLSQHMNIINRDPLKHILDFPQGDVTVKIIPRKIRTVDHVVPNENLSDLPHH-----V 105
            ||||||..:.:.......|.|:.:|.||..|.:...:...|||:...||.|    ..|.     |
  Rat    62 EPLDYETVIEELEKTYRDDALQDLLFFPSDDFSTATVSWDIRTLYSTVPEE----AEHRAESLLV 122

  Fly   106 QECVNCYTRPWKVVEYAQRHLSSSCYIRERIDRGTISPSAY-QQEFEI-------DKDFSS---- 158
            :|....|:..|.||.|.....|..  ||: :.|....|... ...||:       |:|.:|
  Rat   123 KEACKFYSSQWYVVNYKYEQYSGD--IRQ-LPRAEHKPEKLPSHSFEVDHEDADKDEDTTSHSSS 184

  Fly   159 -----------FEEAFAYKSE-SCTPSSRQSIASLAS---------------------------- 183
                       |:..:.||.. :.|.::..::.|...
  Rat   185 KGGGGAGGTGVFKSGWLYKGNFNSTVNNTVTVRSFKKRYFQLTQLPDNSYIMNFYKDEKISKEPK 249

  Fly   184 ----VSSCT---------------------------DTLTPRGSW-------------------A 198
                :.|||                           :|.:....|                   .
  Rat   250 GCIFLDSCTGVVQNNRLRKYAFELKMNDLTYFVLAAETESDMDEWIHTLNRILQISPEGPLQGRK 314

  Fly   199 SFDLRRSVNDPLIPNLLDNVPPEHIDQSN------------------EARRQQDRQMALFSLYPE 245
            |.:|.....|||..::......|..|.|.                  :..|..|| :.||||.|:
  Rat   315 SAELAELGLDPLDNSVACECTLEETDSSENSLHPDFAKYLTETEDTVKTTRNTDR-LNLFSLDPD 378

  Fly   246 SEA-----EENIERRLLAEIPVEHMGHRIQVNCLQLRLELE-------------VEPIFASMAIY 292
            .:.     .:..|...:.:...|....||.:.|..|.|.|:             :||.|.|:|:|
  Rat   379 IDTLKLQKRDLFEHEFMIKPFEEKAAKRIMIICRALNLNLQGCVTENENDPVTNIEPFFVSVALY 443

  Fly   293 DAKERQKISENFYFDMNADSLKRMLSS---HVQCADI-------STQSH-------------SAI 334
            |.::.:|||.:|:.|:|..::::|||.   .::..:|       |.:.|             .||
  Rat   444 DLRDNRKISADFHTDLNHPAVRQMLSGAPPALENGNIDPGTLRQSEEPHIKGLPEEWLKFPKQAI 508

  Fly   335 FEISYPSNDLFLVIRLEKVLQGDINNSVEPYLKE-DKDKYREKVKSNAVDYCERLGKYRMPFAWT 398
            |.:|.|.:::.||.::||||.|:|.:..|||:|. |.:|:.:|:..:...:|.:||||||||||.
  Rat   509 FSVSDPHSEIVLVAKVEKVLMGNIGSGTEPYIKNPDSNKFAQKILKSNRQFCSKLGKYRMPFAWA 573

  Fly   399 GIYLTNVFNGDNFESKDAGAAERDSFGNACGSSLGTAPSSNSLDRKSSTSSFDQLRRKANDMSGT 463
               :.:||              :|:.||              :||.|
  Rat   574 ---VRSVF--------------KDNQGN--------------VDRDS------------------ 589

  Fly   464 LTRRGSLERKEKHRSWSPDDFANVVENFRPITITVPSFFKQEADKMKDEDLYKILPELKRPSSVM 528
                                      .|.|:       ::||::|:..|||.:::.:.:|...:
  Rat   590 --------------------------RFSPL-------YRQESNKISSEDLLRLVSDYRRADRI- 620

  Fly   529 KKYKCIPGSIKLEISPCVEEAKNALTPELAPINP-----QSADNVRPVKEILEFPQSAIYN---- 584
            .|.:.||||:.:.:.....|..|.:|....|:.|     ||    .|..|:.||    ||:
  Rat   621 SKMQTIPGSLDIVVDNIPLEQPNCVTSSFIPVKPFDVMAQS----EPTVEVEEF----IYDSTKH 677

  Fly   585 --PHYSYRNLLFVSPKELNFSSRA--GSARNIAVRVQLM----AGETPKDAVNAIYGKSSCPKFS 641
              |:..|:|.::|.||.|.:.|:.  ..||||.|.::..    .|..|   :..||||...|.|:
  Rat   678 CRPYRVYKNQIYVYPKHLKYDSQKCFNKARNITVCIEFKNSDDDGARP---MKCIYGKPGGPLFT 739

  Fly   642 TEAFTAVNYHNKCPSFYDEIKIALPASIKQHHHLLFTIYHVSCQ---KKPQDLQPSVETPIGYTW 703
            :.|:|||.:|::.|.|.||:||.||..:...|||||:.||::|.   |.....:.::||.:||.|
  Rat   740 SAAYTAVLHHSQNPDFSDEVKIELPTQLHGKHHLLFSFYHITCDINAKANAKKKEALETSVGYAW 804

  Fly   704 LPLLEDGKLKFGEFNLPVMVESPPENYSFI--PPNVHLPG--IKWLDNHRAVFSINVEAVTAIHT 764
            |||::..::...|:|:|:....|| ||..|  |.:....|  |||:|..:.:|.::...|:.::|
  Rat   805 LPLMKHDQIASQEYNIPIATTLPP-NYLSIQDPASAKHGGSDIKWVDGGKPLFKVSTFVVSTVNT 868

  Fly   765 LDSFLDRFFLICEYLDTRNIPSHIGENNIETELKKC--LLDIEYANREPLVRHLPLVLDKLIELL 827
            .|..::.||..|:..:     ..:.::...:.::.|  ||:::..:  .::..||::|::|.::|
  Rat   869 QDPHVNAFFRQCQKRE-----KDMSQSPTSSFVRACKNLLNVDKIH--SIMSFLPIILNQLFKIL 926

  Fly   828 VVTHKVGGQAMSLGSTVFEVLCLVSSLLSILNDDQYDQYGRQSLLSTYVHFQCKIPHPFQSKQRL 892
                 |..:...:..||..||   :.:::..:::|.|.     .:.:|:.|..|
  Rat   927 -----VQNEEDEITGTVTRVL---ADIVAKCHEEQLDH-----SVQSYIKFVFK----------- 967

  Fly   893 TCSRSTTEDLQLSESYTIYDNVLASGRSLDRKELSIDVLHSMAARDVQVRLLHEELALHWVVASG 957
                                                       .|..:.|.:|||||.:
  Rat   968 -------------------------------------------TRSYKERTIHEELAKN------ 983

  Fly   958 KAADLAMSN-----------SWFLFELIVKSMIEHLHCSNTLNGPRKHRFPHQFNDDLSTLVHLV 1011
             .:||..||           |||.|.:|:|||.:||..::.:..||..|||..:..:|..||..:
  Rat   984 -LSDLLKSNDSTIVKHVLKHSWFFFAIILKSMAQHLIDTDKIQLPRAQRFPESYQSELDNLVMGL 1047

  Fly  1012 TTKVVGYHSNEPKLAQSLNASLGFFIFDILSIMDRGFVFGLIKTYTKVLISKNASIPDLMNYKID 1076
            ...|:....:..:..:..|.|:..|:....:.|||||||.::..|..:..|  .....|..||.|
  Rat  1048 CDHVIWKCKDALEETKRANHSVARFLKRCFTFMDRGFVFKMVNNYVSMFSS--GEFKTLCQYKFD 1110

  Fly  1077 FLRIVCSHEHFVALNLPFGTSYTMVTAPCSPTPSTTSSNSQTSCGSLERALHA------DLSQEF 1135
            ||:.||.||||:.|.||       :.:...|.|.|.|.:.|        .|||      .::.||
  Rat  1111 FLQEVCQHEHFIPLCLP-------IRSANIPDPLTPSESIQ--------ELHASDMPEYSVTNEF 1160

  Fly  1136 LQQHFLVGLVLSDLAAVMEVPNPQLHGKAIRCIRNLMTSHDLDARYSETDARARVAALYIPLLSI 1200
            .::|||:|::|.::...:: .:..:...|:..::|||..|..|.||.|...:|::|:||:||..:
  Rat  1161 CRKHFLIGILLREVGFALQ-EDQDIRHLALAVLKNLMAKHSFDDRYREPRKQAQIASLYMPLYGM 1224

  Fly  1201 VMDCIPQLHQHGL-----------EQDRLQQIGQLEDYQG-PHQT-------------------I 1234
            ::|.:|:::...|           .:|.|...|..:.... .|.|                   |
  Rat  1225 LLDNMPRIYLKDLYPFTVNTSNQGSRDDLSTNGGFQTQTSMKHATSVDTSFSKDVLNSIAAFSSI 1289

  Fly  1235 TASTIN---PEVAFAISGSRPYS--YLNEQVKN--KLP--------------LSSENTRHLLVCF 1278
            ..||:|   ...:.|...|.|.:  ..:|:..|  |:|              |....||.||:||
  Rat  1290 AISTVNHADSRASLASLDSNPSTAEKSSEKTDNCEKIPRPLSLIGSTLRFDKLDQAETRSLLMCF 1354

  Fly  1279 LWVLKNL-ERNVLYRWLMDLSPHRVHQMLQGVNVCLKTFEYTGQKNV-----------------A 1325
            |.::|.: :..::..|....|| .|......::|||:.|.|.|::|:                 .
  Rat  1355 LHIMKTISDETLIAYWQRAPSP-EVSDFFSILDVCLQNFRYLGKRNIIRKIAAAFKFVQSTQNNG 1418

  Fly  1326 TLKRTNTQSFRKTGSTDVKEKLEECIRGTNSARYDLINRRKDRNSTEKFRWRKDQM--PYRSQYA 1388
            |||.:|.       |......|.:.:..|:...    ..::.|:.|......|:.:  |...|..
  Rat  1419 TLKGSNP-------SCQTSGLLPQWMHTTSGHE----GHKQHRSQTLPIIRGKNALSNPKLLQML 1472

  Fly  1389 D-AVGKSEHELELSHFI--EGSLATEVALVLLDTLEII--VH----AAANLYHNLLGTVLKVLLH 1444
            | .:..:.:|:::.|.:  |.::||||.|.:||.|.:.  ||    ..::..::|:..|....:.
  Rat  1473 DNTMNSNSNEIDIVHHVDTEANIATEVCLTILDLLSLFTQVHQRQLQQSDCQNSLMRRVFDTYML 1537

  Fly  1445 SLSRNQSVLALQNLFASQRALIFKFPNLLFDDETDICADLCLILLKHCGSLLPGIRSQAAASLYL 1509
            ....|||..||:::|||.|..:.|||:..|....|:|...|..:||.|.......:.:|:|.||.
  Rat  1538 FFQVNQSASALKHVFASLRLFVCKFPSAFFQGPADLCGSFCYEVLKCCNHRSRLTQMEASALLYF 1602

  Fly  1510 LMRQNFEIG--NNFARVKMQVTMSLSSLVGTSSVFSEQSLRRALKTVLVYAESDSDLQDTSFPEQ 1572
            .||:|||..  .:..|..:|:..::|.|:..:.:...: .:.:|.....:|..|..:::::||.:
  Rat  1603 FMRKNFEFNKQKSIVRSHLQLIKAVSQLIADAGIGGSR-FQHSLAITNNFANGDKQMKNSNFPAE 1666

  Fly  1573 VQDLLFNLHMILSDTVKMKEYQEDPEMLLDLMNRIAKGYQNNPDLRLTWLENMAKKHRERANHTE 1637
            |:||...:..:|..|.:|||:::|||||:||...:|..|.:.|:||.||||:|||.|....:.:|
  Rat  1667 VKDLTKRIRTVLMATAQMKEHEKDPEMLVDLQYSLANSYASTPELRRTWLESMAKIHARNGDLSE 1731

  Fly  1638 AAMCYVHAASLVSEYLS--------------MLESQKH----------------LPVGAVSFQRI 1672
            |||||:|.|:|::|||.              :|....|                ..:|..:|..|
  Rat  1732 AAMCYIHIAALIAEYLKRKGYWKMEKICTPPLLPEDTHPCDSNLLLTTPGGGSMFSMGWPAFLSI 1796

  Fly  1673 SPNTLMESAVSDDVLSPGEDGICLGNHFTETGLKALLEEASNSFQVAGMYEAMNEVYKILIPICE 1737
            :||...|.|:.:|  |..:|     ..:.|..|...|.........:..||.:.:|.|.:|.:.|
  Rat  1797 TPNIKEEGAMKED--SGMQD-----TPYNENILVEQLYMCVEFLWKSERYELIADVNKPIIAVFE 1854

  Fly  1738 ANRDFQKLSKVHGKLQEAFNRISQL--QGKRVFGTYFRVGFYG---GKFGDLDQQEFIYKEPTLT 1797
            ..|||:|||.::..:..::.:::::  ..||:||.|:||.|||   |.|.:.:.:|:|||||.||
  Rat  1855 KQRDFKKLSDLYYDIHRSYLKVAEVVNSEKRLFGRYYRVAFYGQAVGFFEEEEGKEYIYKEPKLT 1919

  Fly  1798 KLPEIFSRLQNFYTERFGPDSVHIIKDSNTVDINSLDPDKAYIQITYVEPYFETYEMRHRETYFE 1862
            .|.||..||...|.::||.|:|.||:|||.|:...|||..||||:|||.|:||..|:..|:|.||
  Rat  1920 GLSEISQRLLKLYADKFGADNVKIIQDSNKVNPKDLDPKYAYIQVTYVTPFFEEKEIEDRKTDFE 1984

  Fly  1863 RNFNIKRFIYATPFTKNGKAHGELNEQCKRKTILTTANHFPYVKTRIMVISRQQIVLEPIEVAIE 1927
            .:.||.||::.||||.:||.||.:.|||||:|:|||::.|||||.||.|||:....|.||||||:
  Rat  1985 MHHNINRFVFETPFTLSGKKHGGVAEQCKRRTVLTTSHLFPYVKKRIQVISQSSTELNPIEVAID 2049

  Fly  1928 DIQKKTLELAAATNQEPADPKILQMVLQGCIGTTVNQGPMEMASVFLSNLSDGTTVPTKHQNKLR 1992
            ::.||..||......|..|...||:.|||.:...||.|||..|..||.. ::....|......|:
  Rat  2050 EMSKKVSELNQLCTTEEVDMIRLQLKLQGSVSVKVNAGPMAYARAFLEE-TNAKKYPDNQVKLLK 2113

  Fly  1993 LCFREFSKRCADALKKNRNLILSDQKDYQRELERNNDRFIERLTPF------------------- 2038
            ..||:|:..|..||..|..||..||.:||.||..:....:..|:..
  Rat  2114 EIFRQFADACGQALDVNERLIKEDQLEYQEELRSHYKDMLGELSAIMNEQLCRGPCLYSFCSSVS 2178

  Fly  2039 -ITLTSVQNHGV 2049
             |:|::|...|:
  Rat  2179 SISLSTVSKSGM 2190

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Zir	NP_608489.2	DUF3398	59..151	CDD:288711	25/97 (26%)
		C2_Dock-C	589..769	CDD:176078	68/192 (35%)
		DHR-2	1549..2037	CDD:284365	201/522 (39%)
Dock10	XP_008765532.2	DUF3398	58..168	CDD:403173	33/112 (29%)
		PH_DOCK-D	195..315	CDD:270087	10/119 (8%)
		C2_Dock-D	684..873	CDD:176079	68/192 (35%)
		DHR2_DOCK10	1709..2156	CDD:212572	178/454 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D20156at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010