|
Fly 46 EPLDYEEFLSQHMNIINRDPLKHILDFPQGDVTVKIIPRKIRTVDHVVP---NENLSDLPHHVQE 107
||||||..:.|....|..|.|:.:|.||..|....|:.|:.|.:...|| .|....| .|.|
Human 61 EPLDYENVIVQKKTQILNDCLREMLLFPYDDFQTAILRRQGRYICSTVPAKAEEEAQSL--FVTE 123
Fly 108 CVNCYTRPWKVVEYAQRHLSSSCYIRE------RIDRGTISPSAYQQEFEIDKD----------- 155
|:..|...|.:|.|.....|.. .|: ::|: :....|:.:.|:|||
Human 124 CIKTYNSDWHLVNYKYEDYSGE--FRQLPNKVVKLDK--LPVHVYEVDEEVDKDEDAASLGSQKG 184
Fly 156 --------------------FSSFEEAF--------------AYKSESCTPSSRQSIASLASVSS 186
..||:..| .||.|..:...:.|| .:.|
Human 185 GITKHGWLYKGNMNSAISVTMRSFKRRFFHLIQLGDGSYNLNFYKDEKISKEPKGSI----FLDS 245
Fly 187 C---------------------------TDTLTPRGSW-------------ASFDLRR---SVND 208
| .|:......| |:...:| |..|
Human 246 CMGVVQNNKVRRFAFELKMQDKSSYLLAADSEVEMEEWITILNKILQLNFEAAMQEKRNGDSHED 310
Fly 209 PLIPNL------LDNVPPEHIDQSNEA--RRQQDRQMALFSLYPE------SEAEENIERRLLAE 259
.....| ||:..||....:.|| :.:.:.::.||.|.|: |.||..::..
Human 311 DEQSKLEGSGSGLDSYLPELAKSAREAEIKLKSESRVKLFYLDPDAQKLDFSSAEPEVKSF---- 371
Fly 260 IPVEHMGHRIQVNCLQLRLELE-------------VEPIFASMAIYDAKERQKISENFYFDMNAD 311
.|..|.||.|.|..|...|: |||.|.:::::|.|..:|||.:|:.|:|..
Human 372 --EEKFGKRILVKCNDLSFNLQCCVAENEEGPTTNVEPFFVTLSLFDIKYNRKISADFHVDLNHF 434
Fly 312 SLKRML-SSHVQCADISTQS--------HSA--------IFEISYPSNDLFLVIRLEKVLQGDIN 359
|:::|| ::.....:.|.|| |.| ||.::.|..|:|||.|:||||||.|.
Human 435 SVRQMLATTSPALMNGSGQSPSVLKGILHEAAMQYPKQGIFSVTCPHPDIFLVARIEKVLQGSIT 499
Fly 360 NSVEPYLK-EDKDKYREKVKSNAVDYCERLGKYRMPFAWTGIYLTNVFNGDNFESKDAGAAERDS 423
:..|||:| .|..|..:||..||...|:|||:||||||| |.|..
Human 500 HCAEPYMKSSDSSKVAQKVLKNAKQACQRLGQYRMPFAW---------------------AARTL 543
Fly 424 FGNACGSSLGTAPSSNSLDRKSSTSSFDQLRRKANDMSGTLTRRGSLERKEKHRSWSPDDFANVV 488
|.:|.| :||:.:..|
Human 544 FKDASG----------NLDKNARFS---------------------------------------- 558
Fly 489 ENFRPITITVPSFFKQEADKMKDEDLYKILPELKRPSSVMKKYKCIPGSIKLEISPCVEEAKNAL 553
:.::|:::|:.::|:.|:|.:.::|.. |.|...|.|::.:.|.....:..|.:
Human 559 -----------AIYRQDSNKLSNDDMLKLLADFRKPEK-MAKLPVILGNLDITIDNVSSDFPNYV 611
Fly 554 TPELAPINPQSADNVRPVK-EILEF----PQSAIYNPHYSYRNLLFVSPKELNFSSRA--GSARN 611
.....|.......:..|:. |:.|| |:.. .|:..|.|.|:|.||.|.:.|:. ..|||
Human 612 NSSYIPTKQFETCSKTPITFEVEEFVPCIPKHT--QPYTIYTNHLYVYPKYLKYDSQKSFAKARN 674
Fly 612 IAVRVQLM-AGETPKDAVNAIYGKSSCPKFSTEAFTAVNYHNKCPSFYDEIKIALPASIKQHHHL 675
||:.::.. :.|.....:..|||:...|.|:..||.||.:|::.|.|||||||.||..:.:.|||
Human 675 IAICIEFKDSDEEDSQPLKCIYGRPGGPVFTRSAFAAVLHHHQNPEFYDEIKIELPTQLHEKHHL 739
Fly 676 LFTIYHVSCQK------KPQDLQPSVETPIGYTWLPLLEDGKLKFGEFNLPVMVESPPE--NYSF 732
|.|.:||||.. |.:|: |||.:||:|||||:||::...|.::||....|.. .|..
Human 740 LLTFFHVSCDNSSKGSTKKRDV---VETQVGYSWLPLLKDGRVVTSEQHIPVSANLPSGYLGYQE 801
Fly 733 IPPNVHL-PGIKWLDNHRAVFSINVEAVTAIHTLDSFLDRFFLICEYLDTRNIPSHIGENNIETE 796
:....|. |.|||:|..:.:..|:...|:.::|.|..|..||..|:..:: |...:..|
Human 802 LGMGRHYGPEIKWVDGGKPLLKISTHLVSTVYTQDQHLHNFFQYCQKTES-------GAQALGNE 859
Fly 797 LKKCLLDIEYANREPLVRHLPLVLDKLIELL--VVTHKVGGQAMSLGSTVFEVLCLVSSLLSILN 859
|.|.|..:.......::..||.:|::|..:| ....:| |:::...:..|:.
Human 860 LVKYLKSLHAMEGHVMIAFLPTILNQLFRVLTRATQEEV---AVNVTRVIIHVVA---------- 911
Fly 860 DDQYDQYGRQSLLSTYVHFQCKIPHPFQSKQRLTCSRSTTEDLQLSESYTIYDNVLASGRSLDRK 924
|..:.|.:|.|.:||.:..| :|.| :||
Human 912 --QCHEEGLESHLRSYVKYAYK-----------------------AEPY------VAS------- 938
Fly 925 ELSIDVLHSMAARDVQVRLLHEELALHWVVASGKAADLAMSN-----SWFLFELIVKSMIEHLHC 984
:.:.:||||..........:||...|| |||.|::::|||.:||..
Human 939 ---------------EYKTVHEELTKSMTTILKPSADFLTSNKLLKYSWFFFDVLIKSMAQHLIE 988
Fly 985 SNTLNGPRKHRFPHQFNDDLSTLVHLVTTKVVGYHSNEPKLAQSLNASLGFFIFDILSIMDRGFV 1049
::.:...|..|||..::..:.|:|:::...:.....:.|:.:::.|.||..||....:.||||||
Human 989 NSKVKLLRNQRFPASYHHAVETVVNMLMPHITQKFRDNPEASKNANHSLAVFIKRCFTFMDRGFV 1053
Fly 1050 FGLIKTYTKVLISKNASIPDLMNYKIDFLRIVCSHEHFVALNL--PFGTSYTMVTAPCSPTPSTT 1112
|..|..|.......:.. .|..||.:|||:||:|||::.||| |||.
Human 1054 FKQINNYISCFAPGDPK--TLFEYKFEFLRVVCNHEHYIPLNLPMPFGK---------------- 1100
Fly 1113 SSNSQTSCGSLER----ALHADLSQEFLQQHFLVGLVLSDL-AAVMEVPNPQLHGKAIRCIRNLM 1172
|.::| .|...|:.||.:.||||||:|.:: .|:.|....:| .||..::||:
Human 1101 --------GRIQRYQDLQLDYSLTDEFCRNHFLVGLLLREVGTALQEFREVRL--IAISVLKNLL 1155
Fly 1173 TSHDLDARYSETDARARVAALYIPLLSIVMDCIPQLHQHGLE----------QDRLQQIGQLEDY 1227
..|..|.||:....:||:|.||:||..::::.:.:::...:. :|....:..:...
Human 1156 IKHSFDDRYASRSHQARIATLYLPLFGLLIENVQRINVRDVSPFPVNAGMTVKDESLALPAVNPL 1220
Fly 1228 QGPHQTITA-STINPEVAFAISG-SRPY-----------------SYLNEQVKNKLP-------- 1265
..|.:..|. ::::.::..|||| :.|| |.::....|.||
Human 1221 VTPQKGSTLDNSLHKDLLGAISGIASPYTTSTPNINSVRNADSRGSLISTDSGNSLPERNSEKSN 1285
Fly 1266 --------------------LSSENTRHLLVCFLWVLKNLERNVLYRWLMDLSPHRVHQMLQGVN 1310
|.....:.||:|||::||::..:.|:.:....|...:........
Human 1286 SLDKHQQSSTLGNSVVRCDKLDQSEIKSLLMCFLYILKSMSDDALFTYWNKASTSELMDFFTISE 1350
Fly 1311 VCLKTFEYTGQKNVATLKRTNTQSF------RKTGSTDVKEKLEECIRGTNSARYDLINRRKDRN 1369
|||..|:|.|::.:| .|.:.. ||:.:..| .||
Human 1351 VCLHQFQYMGKRYIA----RNQEGLGPIVHDRKSQTLPV-----------------------SRN 1388
Fly 1370 STEKFRWRKDQ-------MPYRSQYADAVGKSEHELELSHFIEGSLATEVALVLLDTLEIIVHAA 1427
.|.....|..| :.:...| |.|:.::.....:|.::||||.|..||||.:...|.
Human 1389 RTGMMHARLQQLGSLDNSLTFNHSY----GHSDADVLHQSLLEANIATEVCLTALDTLSLFTLAF 1449
Fly 1428 ANLY-----HN-LLGTVLKVLLHSLSRNQSVLALQNLFASQRALIFKFPNLLFDDETDICADLCL 1486
.|.. || |:..|..|.|..|.::||..||:|:|.:.|:||:|||:..::...|:||.||.
Human 1450 KNQLLADHGHNPLMKKVFDVYLCFLQKHQSETALKNVFTALRSLIYKFPSTFYEGRADMCAALCY 1514
Fly 1487 ILLKHCGSLLPGIRSQAAASLYLLMRQNFEI--GNNFARVKMQVTMSLSSLVGTSSVFSEQSLRR 1549
.:||.|.|.|..||::|:..||.|||.||:. ..:|.|..:||.:|:|.|:...........::
Human 1515 EILKCCNSKLSSIRTEASQLLYFLMRNNFDYTGKKSFVRTHLQVIISVSQLIADVVGIGGTRFQQ 1579
Fly 1550 ALKTVLVYAESDSDLQDTSFPEQVQDLLFNLHMILSDTVKMKEYQEDPEMLLDLMNRIAKGYQNN 1614
:|..:...|.||..::.|||...|:||...:..:|..|.:|||::.|||||:||...:||.|.:.
Human 1580 SLSIINNCANSDRLIKHTSFSSDVKDLTKRIRTVLMATAQMKEHENDPEMLVDLQYSLAKSYAST 1644
Fly 1615 PDLRLTWLENMAKKHRERANHTEAAMCYVHAASLVSEYLSMLESQKHLP---------------- 1663
|:||.|||::||:.|.:..:.:||||||||..:||:|||:..|:.:..|
Human 1645 PELRKTWLDSMARIHVKNGDLSEAAMCYVHVTALVAEYLTRKEAVQWEPPLLPHSHSACLRRSRG 1709
Fly 1664 ----VGAVSFQRISPNTLMESAVSDDVLSPGEDGICLGNHFTETGLKALLEEASNSFQVAGMYEA 1724
.|..:|:.|:||...|:::.:|| |...: ||.|..|..|||:.::....|..||.
Human 1710 GVFRQGCTAFRVITPNIDEEASMMEDV---GMQDV----HFNEDVLMELLEQCADGLWKAERYEL 1767
Fly 1725 MNEVYKILIPICEANRDFQKLSKVHGKLQEAFNRISQL--QGKRVFGTYFRVGFYG--------- 1778
:.::||::|||.|..|||::|:.::..|..|::::::: .|:|:.||||||.|:|
Human 1768 IADIYKLIIPIYEKRRDFERLAHLYDTLHRAYSKVTEVMHSGRRLLGTYFRVAFFGQAAQYQFTD 1832
Fly 1779 ------GKFGDLDQQEFIYKEPTLTKLPEIFSRLQNFYTERFGPDSVHIIKDSNTVDINSLDPDK 1837
|.|.|.|.:|:|||||.||.|.||..||...|:::||.::|.:|:||..|:...||...
Human 1833 SETDVEGFFEDEDGKEYIYKEPKLTPLSEISQRLLKLYSDKFGSENVKMIQDSGKVNPKDLDSKY 1897
Fly 1838 AYIQITYVEPYFETYEMRHRETYFERNFNIKRFIYATPFTKNGKAHGELNEQCKRKTILTTANHF 1902
||||:|:|.|:|:..|::.|:|.|||:.||:||::..|||:.||..|.:.|||||:||||..:.|
Human 1898 AYIQVTHVIPFFDEKELQERKTEFERSHNIRRFMFEMPFTQTGKRQGGVEEQCKRRTILTAIHCF 1962
Fly 1903 PYVKTRIMVISRQQIVLEPIEVAIEDIQKKTLELAAATNQEPADPKILQMVLQGCIGTTVNQGPM 1967
||||.||.|:.:....|.||||||:::.||..||....:....|...||:.|||.:...||.||:
Human 1963 PYVKKRIPVMYQHHTDLNPIEVAIDEMSKKVAELRQLCSSAEVDMIKLQLKLQGSVSVQVNAGPL 2027
Fly 1968 EMASVFLSNLSDGTTVPTKHQNKLRL---CFREFSKRCADALKKNRNLILSDQKDYQRELERN-- 2027
..|..|| |.|.......||::| .||:|.:.|..||..|..||..||.:||.|::.|
Human 2028 AYARAFL----DDTNTKRYPDNKVKLLKEVFRQFVEACGQALAVNERLIKEDQLEYQEEMKANYR 2088
Fly 2028 ------NDRFIERLTPFITLTSVQNHGVVKANAYNNKST 2060
::...|::.|....|||..:.:...||.:...|
Human 2089 EMAKELSEIMHEQICPLEEKTSVLPNSLHIFNAISGTPT 2127
| 
