DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Zir and DOCK9

DIOPT Version :9

Sequence 1:NP_608489.2 Gene:Zir / 33165 FlyBaseID:FBgn0031216 Length:2064 Species:Drosophila melanogaster
Sequence 2:XP_006719985.1 Gene:DOCK9 / 23348 HGNCID:14132 Length:2141 Species:Homo sapiens


Alignment Length:2314 Identity:653/2314 - (28%)
Similarity:1019/2314 - (44%) Gaps:546/2314 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    46 EPLDYEEFLSQHMNIINRDPLKHILDFPQGDVTVKIIPRKIRTVDHVVP---NENLSDLPHHVQE 107
            ||||||..:.|....|..|.|:.:|.||..|....|:.|:.|.:...||   .|....|  .|.|
Human    61 EPLDYENVIVQKKTQILNDCLREMLLFPYDDFQTAILRRQGRYICSTVPAKAEEEAQSL--FVTE 123

  Fly   108 CVNCYTRPWKVVEYAQRHLSSSCYIRE------RIDRGTISPSAYQQEFEIDKD----------- 155
            |:..|...|.:|.|.....|..  .|:      ::|:  :....|:.:.|:|||           
Human   124 CIKTYNSDWHLVNYKYEDYSGE--FRQLPNKVVKLDK--LPVHVYEVDEEVDKDEDAASLGSQKG 184

  Fly   156 --------------------FSSFEEAF--------------AYKSESCTPSSRQSIASLASVSS 186
                                ..||:..|              .||.|..:...:.||    .:.|
Human   185 GITKHGWLYKGNMNSAISVTMRSFKRRFFHLIQLGDGSYNLNFYKDEKISKEPKGSI----FLDS 245

  Fly   187 C---------------------------TDTLTPRGSW-------------ASFDLRR---SVND 208
            |                           .|:......|             |:...:|   |..|
Human   246 CMGVVQNNKVRRFAFELKMQDKSSYLLAADSEVEMEEWITILNKILQLNFEAAMQEKRNGDSHED 310

  Fly   209 PLIPNL------LDNVPPEHIDQSNEA--RRQQDRQMALFSLYPE------SEAEENIERRLLAE 259
            .....|      ||:..||....:.||  :.:.:.::.||.|.|:      |.||..::..    
Human   311 DEQSKLEGSGSGLDSYLPELAKSAREAEIKLKSESRVKLFYLDPDAQKLDFSSAEPEVKSF---- 371

  Fly   260 IPVEHMGHRIQVNCLQLRLELE-------------VEPIFASMAIYDAKERQKISENFYFDMNAD 311
              .|..|.||.|.|..|...|:             |||.|.:::::|.|..:|||.:|:.|:|..
Human   372 --EEKFGKRILVKCNDLSFNLQCCVAENEEGPTTNVEPFFVTLSLFDIKYNRKISADFHVDLNHF 434

  Fly   312 SLKRML-SSHVQCADISTQS--------HSA--------IFEISYPSNDLFLVIRLEKVLQGDIN 359
            |:::|| ::.....:.|.||        |.|        ||.::.|..|:|||.|:||||||.|.
Human   435 SVRQMLATTSPALMNGSGQSPSVLKGILHEAAMQYPKQGIFSVTCPHPDIFLVARIEKVLQGSIT 499

  Fly   360 NSVEPYLK-EDKDKYREKVKSNAVDYCERLGKYRMPFAWTGIYLTNVFNGDNFESKDAGAAERDS 423
            :..|||:| .|..|..:||..||...|:|||:|||||||                     |.|..
Human   500 HCAEPYMKSSDSSKVAQKVLKNAKQACQRLGQYRMPFAW---------------------AARTL 543

  Fly   424 FGNACGSSLGTAPSSNSLDRKSSTSSFDQLRRKANDMSGTLTRRGSLERKEKHRSWSPDDFANVV 488
            |.:|.|          :||:.:..|                                        
Human   544 FKDASG----------NLDKNARFS---------------------------------------- 558

  Fly   489 ENFRPITITVPSFFKQEADKMKDEDLYKILPELKRPSSVMKKYKCIPGSIKLEISPCVEEAKNAL 553
                       :.::|:::|:.::|:.|:|.:.::|.. |.|...|.|::.:.|.....:..|.:
Human   559 -----------AIYRQDSNKLSNDDMLKLLADFRKPEK-MAKLPVILGNLDITIDNVSSDFPNYV 611

  Fly   554 TPELAPINPQSADNVRPVK-EILEF----PQSAIYNPHYSYRNLLFVSPKELNFSSRA--GSARN 611
            .....|.......:..|:. |:.||    |:..  .|:..|.|.|:|.||.|.:.|:.  ..|||
Human   612 NSSYIPTKQFETCSKTPITFEVEEFVPCIPKHT--QPYTIYTNHLYVYPKYLKYDSQKSFAKARN 674

  Fly   612 IAVRVQLM-AGETPKDAVNAIYGKSSCPKFSTEAFTAVNYHNKCPSFYDEIKIALPASIKQHHHL 675
            ||:.::.. :.|.....:..|||:...|.|:..||.||.:|::.|.|||||||.||..:.:.|||
Human   675 IAICIEFKDSDEEDSQPLKCIYGRPGGPVFTRSAFAAVLHHHQNPEFYDEIKIELPTQLHEKHHL 739

  Fly   676 LFTIYHVSCQK------KPQDLQPSVETPIGYTWLPLLEDGKLKFGEFNLPVMVESPPE--NYSF 732
            |.|.:||||..      |.:|:   |||.:||:|||||:||::...|.::||....|..  .|..
Human   740 LLTFFHVSCDNSSKGSTKKRDV---VETQVGYSWLPLLKDGRVVTSEQHIPVSANLPSGYLGYQE 801

  Fly   733 IPPNVHL-PGIKWLDNHRAVFSINVEAVTAIHTLDSFLDRFFLICEYLDTRNIPSHIGENNIETE 796
            :....|. |.|||:|..:.:..|:...|:.::|.|..|..||..|:..::       |...:..|
Human   802 LGMGRHYGPEIKWVDGGKPLLKISTHLVSTVYTQDQHLHNFFQYCQKTES-------GAQALGNE 859

  Fly   797 LKKCLLDIEYANREPLVRHLPLVLDKLIELL--VVTHKVGGQAMSLGSTVFEVLCLVSSLLSILN 859
            |.|.|..:.......::..||.:|::|..:|  ....:|   |:::...:..|:.          
Human   860 LVKYLKSLHAMEGHVMIAFLPTILNQLFRVLTRATQEEV---AVNVTRVIIHVVA---------- 911

  Fly   860 DDQYDQYGRQSLLSTYVHFQCKIPHPFQSKQRLTCSRSTTEDLQLSESYTIYDNVLASGRSLDRK 924
              |..:.|.:|.|.:||.:..|                       :|.|      :||       
Human   912 --QCHEEGLESHLRSYVKYAYK-----------------------AEPY------VAS------- 938

  Fly   925 ELSIDVLHSMAARDVQVRLLHEELALHWVVASGKAADLAMSN-----SWFLFELIVKSMIEHLHC 984
                           :.:.:||||..........:||...||     |||.|::::|||.:||..
Human   939 ---------------EYKTVHEELTKSMTTILKPSADFLTSNKLLKYSWFFFDVLIKSMAQHLIE 988

  Fly   985 SNTLNGPRKHRFPHQFNDDLSTLVHLVTTKVVGYHSNEPKLAQSLNASLGFFIFDILSIMDRGFV 1049
            ::.:...|..|||..::..:.|:|:::...:.....:.|:.:::.|.||..||....:.||||||
Human   989 NSKVKLLRNQRFPASYHHAVETVVNMLMPHITQKFRDNPEASKNANHSLAVFIKRCFTFMDRGFV 1053

  Fly  1050 FGLIKTYTKVLISKNASIPDLMNYKIDFLRIVCSHEHFVALNL--PFGTSYTMVTAPCSPTPSTT 1112
            |..|..|.......:..  .|..||.:|||:||:|||::.|||  |||.                
Human  1054 FKQINNYISCFAPGDPK--TLFEYKFEFLRVVCNHEHYIPLNLPMPFGK---------------- 1100

  Fly  1113 SSNSQTSCGSLER----ALHADLSQEFLQQHFLVGLVLSDL-AAVMEVPNPQLHGKAIRCIRNLM 1172
                    |.::|    .|...|:.||.:.||||||:|.:: .|:.|....:|  .||..::||:
Human  1101 --------GRIQRYQDLQLDYSLTDEFCRNHFLVGLLLREVGTALQEFREVRL--IAISVLKNLL 1155

  Fly  1173 TSHDLDARYSETDARARVAALYIPLLSIVMDCIPQLHQHGLE----------QDRLQQIGQLEDY 1227
            ..|..|.||:....:||:|.||:||..::::.:.:::...:.          :|....:..:...
Human  1156 IKHSFDDRYASRSHQARIATLYLPLFGLLIENVQRINVRDVSPFPVNAGMTVKDESLALPAVNPL 1220

  Fly  1228 QGPHQTITA-STINPEVAFAISG-SRPY-----------------SYLNEQVKNKLP-------- 1265
            ..|.:..|. ::::.::..|||| :.||                 |.::....|.||        
Human  1221 VTPQKGSTLDNSLHKDLLGAISGIASPYTTSTPNINSVRNADSRGSLISTDSGNSLPERNSEKSN 1285

  Fly  1266 --------------------LSSENTRHLLVCFLWVLKNLERNVLYRWLMDLSPHRVHQMLQGVN 1310
                                |.....:.||:|||::||::..:.|:.:....|...:........
Human  1286 SLDKHQQSSTLGNSVVRCDKLDQSEIKSLLMCFLYILKSMSDDALFTYWNKASTSELMDFFTISE 1350

  Fly  1311 VCLKTFEYTGQKNVATLKRTNTQSF------RKTGSTDVKEKLEECIRGTNSARYDLINRRKDRN 1369
            |||..|:|.|::.:|    .|.:..      ||:.:..|                       .||
Human  1351 VCLHQFQYMGKRYIA----RNQEGLGPIVHDRKSQTLPV-----------------------SRN 1388

  Fly  1370 STEKFRWRKDQ-------MPYRSQYADAVGKSEHELELSHFIEGSLATEVALVLLDTLEIIVHAA 1427
            .|.....|..|       :.:...|    |.|:.::.....:|.::||||.|..||||.:...|.
Human  1389 RTGMMHARLQQLGSLDNSLTFNHSY----GHSDADVLHQSLLEANIATEVCLTALDTLSLFTLAF 1449

  Fly  1428 ANLY-----HN-LLGTVLKVLLHSLSRNQSVLALQNLFASQRALIFKFPNLLFDDETDICADLCL 1486
            .|..     || |:..|..|.|..|.::||..||:|:|.:.|:||:|||:..::...|:||.||.
Human  1450 KNQLLADHGHNPLMKKVFDVYLCFLQKHQSETALKNVFTALRSLIYKFPSTFYEGRADMCAALCY 1514

  Fly  1487 ILLKHCGSLLPGIRSQAAASLYLLMRQNFEI--GNNFARVKMQVTMSLSSLVGTSSVFSEQSLRR 1549
            .:||.|.|.|..||::|:..||.|||.||:.  ..:|.|..:||.:|:|.|:...........::
Human  1515 EILKCCNSKLSSIRTEASQLLYFLMRNNFDYTGKKSFVRTHLQVIISVSQLIADVVGIGGTRFQQ 1579

  Fly  1550 ALKTVLVYAESDSDLQDTSFPEQVQDLLFNLHMILSDTVKMKEYQEDPEMLLDLMNRIAKGYQNN 1614
            :|..:...|.||..::.|||...|:||...:..:|..|.:|||::.|||||:||...:||.|.:.
Human  1580 SLSIINNCANSDRLIKHTSFSSDVKDLTKRIRTVLMATAQMKEHENDPEMLVDLQYSLAKSYAST 1644

  Fly  1615 PDLRLTWLENMAKKHRERANHTEAAMCYVHAASLVSEYLSMLESQKHLP---------------- 1663
            |:||.|||::||:.|.:..:.:||||||||..:||:|||:..|:.:..|                
Human  1645 PELRKTWLDSMARIHVKNGDLSEAAMCYVHVTALVAEYLTRKEAVQWEPPLLPHSHSACLRRSRG 1709

  Fly  1664 ----VGAVSFQRISPNTLMESAVSDDVLSPGEDGICLGNHFTETGLKALLEEASNSFQVAGMYEA 1724
                .|..:|:.|:||...|:::.:||   |...:    ||.|..|..|||:.::....|..||.
Human  1710 GVFRQGCTAFRVITPNIDEEASMMEDV---GMQDV----HFNEDVLMELLEQCADGLWKAERYEL 1767

  Fly  1725 MNEVYKILIPICEANRDFQKLSKVHGKLQEAFNRISQL--QGKRVFGTYFRVGFYG--------- 1778
            :.::||::|||.|..|||::|:.::..|..|:::::::  .|:|:.||||||.|:|         
Human  1768 IADIYKLIIPIYEKRRDFERLAHLYDTLHRAYSKVTEVMHSGRRLLGTYFRVAFFGQAAQYQFTD 1832

  Fly  1779 ------GKFGDLDQQEFIYKEPTLTKLPEIFSRLQNFYTERFGPDSVHIIKDSNTVDINSLDPDK 1837
                  |.|.|.|.:|:|||||.||.|.||..||...|:::||.::|.:|:||..|:...||...
Human  1833 SETDVEGFFEDEDGKEYIYKEPKLTPLSEISQRLLKLYSDKFGSENVKMIQDSGKVNPKDLDSKY 1897

  Fly  1838 AYIQITYVEPYFETYEMRHRETYFERNFNIKRFIYATPFTKNGKAHGELNEQCKRKTILTTANHF 1902
            ||||:|:|.|:|:..|::.|:|.|||:.||:||::..|||:.||..|.:.|||||:||||..:.|
Human  1898 AYIQVTHVIPFFDEKELQERKTEFERSHNIRRFMFEMPFTQTGKRQGGVEEQCKRRTILTAIHCF 1962

  Fly  1903 PYVKTRIMVISRQQIVLEPIEVAIEDIQKKTLELAAATNQEPADPKILQMVLQGCIGTTVNQGPM 1967
            ||||.||.|:.:....|.||||||:::.||..||....:....|...||:.|||.:...||.||:
Human  1963 PYVKKRIPVMYQHHTDLNPIEVAIDEMSKKVAELRQLCSSAEVDMIKLQLKLQGSVSVQVNAGPL 2027

  Fly  1968 EMASVFLSNLSDGTTVPTKHQNKLRL---CFREFSKRCADALKKNRNLILSDQKDYQRELERN-- 2027
            ..|..||    |.|.......||::|   .||:|.:.|..||..|..||..||.:||.|::.|  
Human  2028 AYARAFL----DDTNTKRYPDNKVKLLKEVFRQFVEACGQALAVNERLIKEDQLEYQEEMKANYR 2088

  Fly  2028 ------NDRFIERLTPFITLTSVQNHGVVKANAYNNKST 2060
                  ::...|::.|....|||..:.:...||.:...|
Human  2089 EMAKELSEIMHEQICPLEEKTSVLPNSLHIFNAISGTPT 2127

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ZirNP_608489.2 DUF3398 59..151 CDD:288711 25/100 (25%)
C2_Dock-C 589..769 CDD:176078 72/191 (38%)
DHR-2 1549..2037 CDD:284365 203/535 (38%)
DOCK9XP_006719985.1 DUF3398 74..165 CDD:288711 24/96 (25%)
PH_DOCK-D 181..304 CDD:270087 13/126 (10%)
PH 186..291 CDD:278594 12/108 (11%)
C2_Dock-D 650..839 CDD:176079 72/191 (38%)
DHR2_DOCK9 1646..2097 CDD:212571 176/461 (38%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165149361
Domainoid 1 1.000 61 1.000 Domainoid score I10448
eggNOG 1 0.900 - - E1_KOG1997
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG55633
OrthoDB 1 1.010 - - D20156at2759
OrthoFinder 1 1.000 - - FOG0000340
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100358
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X255
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
109.660

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