DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Zir and Dock3

DIOPT Version :9

Sequence 1:NP_608489.2 Gene:Zir / 33165 FlyBaseID:FBgn0031216 Length:2064 Species:Drosophila melanogaster
Sequence 2:XP_011241171.1 Gene:Dock3 / 208869 MGIID:2429763 Length:2071 Species:Mus musculus


Alignment Length:2079 Identity:387/2079 - (18%)
Similarity:691/2079 - (33%) Gaps:705/2079 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   119 VEYAQRHLSSSCYIRERIDRGT------ISPSAYQQEFE-IDKDFSSFEEAFAYKSESCTPSSRQ 176
            |...:||      |..|:|.|.      :.|   :::|| :|.|..|..:  .||...   ||||
Mouse   139 VREVKRH------ITVRLDWGNEHLGLDLVP---RKDFEVVDSDQISVSD--LYKMHL---SSRQ 189

  Fly   177 SIASLASVSSCTDTLTPRGSWASFDLRRSVNDPLIPNLLDNVPPEHIDQSNEARRQQDRQMALFS 241
            |:   ...:|..||:.||..       .:...|:         |.|.               .||
Mouse   190 SV---QQSTSQVDTMRPRHG-------ETCRMPV---------PHHF---------------FFS 220

  Fly   242 LYPESEAEENIERRLLAEIPVEHMGHRIQVNCLQLRLELEVEPIFASMAIYDAKERQKISENFYF 306
                           |.......:|              |...:|.|  :||.:|.::|||.|..
Mouse   221 ---------------LKSFTYNTIG--------------EDSDVFFS--LYDMREGKQISERFLV 254

  Fly   307 DM-------NADSLKRMLSSHVQCA---DISTQSHSAIFEISYPSNDLFL---VIRLEKVLQGDI 358
            .:       |.:.::||      ||   |:|::.         ...||::   |||:.::|..|.
Mouse   255 RLNKNGGPRNPEKIERM------CALFTDLSSKD---------MKRDLYIVAHVIRIGRMLLNDS 304

  Fly   359 NNSV------EPY----------------LKEDKD---------------KYREKV--KSNAVDY 384
            ....      .||                |||:||               :..|.:  ||:.   
Mouse   305 KKGPAHLHYRRPYGCAVLSILDVLQSLTELKEEKDFVLKVYTCNNESEWTQIHENIIRKSST--- 366

  Fly   385 CERLGKYRMPFAWTGIYLT-NVFNGDNFESKDAGAAERDSFGNACGSSLGTAPSSNSLDRKSSTS 448
                 ||..|.|..|:.:: .:|.||                                       
Mouse   367 -----KYSAPSASHGLIISLQLFRGD--------------------------------------- 387

  Fly   449 SFDQLRRKANDMSGTLTRRG-SLERKEKHRSWSPDDFANVVENFRPITITVPSFFKQEADKMKDE 512
             .:|:||: |.|   :..|| ::.||                                       
Mouse   388 -MEQIRRE-NPM---IFNRGLAITRK--------------------------------------- 408

  Fly   513 DLYKILPELKRPSSVMKKYKCIPGSIKLEISPCVEEAKNALTPELAPINPQSADNVRPVKEILEF 577
                    |..|..:|      ||.|                                       
Mouse   409 --------LGFPDVIM------PGDI--------------------------------------- 420

  Fly   578 PQSAIYNPHYSYRNLLFVSPKELNFSSRAGSA--RNIAVRVQLM--AGETPKDAVNAIYGKSSCP 638
                        ||.|:::.::.:| .|.|.:  :||.|.:.::  .||..||.::  .|.....
Mouse   421 ------------RNDLYLTLEKGDF-ERGGKSVQKNIEVTMYVLYADGEILKDCIS--LGSGEPN 470

  Fly   639 KFSTEAFTAVNYHNKCPSFYDEIKIALPASIKQHHHLLFTIYHVSCQKKPQDLQPSVETPIGYTW 703
            :.|..:|  |.||:..|.:.:.||:.:|....:..||.|...|.|.:.|.:      :...|:.:
Mouse   471 RSSYHSF--VLYHSNSPRWGEIIKLPIPIDRFRGSHLRFEFRHCSTKDKGE------KKLFGFAF 527

  Fly   704 LPLLEDGKLKFGEFNLPVMVESPPENYSFIPPNVH-----LPGIKWLDNHRAVFSINVEAVTAIH 763
            .||:.|......:....:.|....||.:|   |.|     ||..|  :::....:|....:....
Mouse   528 SPLMRDDGTTLSDDIHELYVYKCDENSTF---NNHALYLGLPCCK--EDYNGCPNIPSSLIFQRS 587

  Fly   764 TLDSFLDRFFLICEYLDTRNIPSHIGENNIETELKKC------LLDI----EYANREPLVRHLPL 818
            ..:||         ::.|:...:.:.:|.....|.|.      ::||    .:.:.|.:|:.|..
Mouse   588 AKESF---------FISTQLSSTKLTQNVDLLALLKWKAFPDRIMDILGRLRHVSGEEIVKFLQD 643

  Fly   819 VLDKLIELLVVTHKVGGQAMSLGSTVFEVLCLVSSLLSILNDDQYDQYGRQSLLSTYV--HFQCK 881
            :||.|..:|      .......|..||:.|..:   :::|.|.:|..:  :.::.||:  ||...
Mouse   644 ILDTLFVIL------DDNTEKYGLLVFQSLVFI---INLLRDIKYFHF--RPVMDTYIQKHFAGA 697

  Fly   882 IPHPFQSKQRLTCSRSTTEDLQLSESYTIYDNVLASGRSLDRKELSIDVLHSMAARDVQVRLLHE 946
            :.:    |:.:.|.:..   :..|......|::..:.|:|:.....|          ||.|:|:.
Mouse   698 LAY----KELIRCLKWY---MDCSAELIRQDHIQEAMRALEYLFKFI----------VQSRILYS 745

  Fly   947 ELALHWVVASGKAADLAMSNSWFLFELIVKSMIEHLHCSNTL---NGPRKHRFPHQFNDDLSTLV 1008
            .      ...|...:...|:...||:.|...:......|.||   .....:.||..|::    |:
Mouse   746 R------ATCGMEEEQFRSSIQELFQSIRFVLSLDSRNSETLLFTQAALLNSFPTIFDE----LL 800

  Fly  1009 HLVTTKVVGYHSNEPKLAQSLNASLGFF--IFDILSIMDRGFVFGLIKTYTKVLISKNASIPDLM 1071
            .:.|.:         ::|:.:..:||..  ...|...||...:..:.:|....|.|.:.|     
Mouse   801 QMFTVQ---------EVAEFVRGTLGSMPSTVHIGQSMDVVKLQSIARTVDSRLFSFSES----- 851

  Fly  1072 NYKIDFLRIVCSHEHFVALNLPFGTSYTMVTAPCSPTPSTTSSNSQTSCGSLERALHADLSQEF- 1135
              :...|.:|..|.|   |:|.......:    ||....:..|..:||      :|.||:.:|. 
Mouse   852 --RRILLPVVLHHIH---LHLRQQKELLI----CSGILGSIFSIVKTS------SLEADVMEEVE 901

  Fly  1136 LQQHFLVGLVLSDLAAVMEVPNPQLHGKAIRCIRNLMTSHDLDARYSETDARARVAALYIP-LLS 1199
            :....|:.::|..|..:|...:.|...:..||                ....|.:...|:. |||
Mouse   902 MMVESLLDVLLQTLLTIMSKSHAQEAVRGQRC----------------PQCTAEITGEYVSCLLS 950

  Fly  1200 IVMDCIPQLHQHGLEQDRLQQIGQLEDYQGPHQTITASTINPEVAFAISGSRPYSYLNEQVKNKL 1264
            ::........||.|:                                          |.|.|::|
Mouse   951 LLRQMCDTHFQHLLD------------------------------------------NFQSKDEL 973

  Fly  1265 PLSSENTRHLLVCFLWVLKNLERNVLY--RWLMDLSPHRVHQMLQGVNVCLKTFEYTGQKNVATL 1327
                   :..|:....|.:||.:..::  .|:       |.::|.. |:.:.|.:|..    :.|
Mouse   974 -------KEFLLKIFCVFRNLMKMSVFPRDWM-------VMRLLTS-NIIVTTVQYLS----SAL 1019

  Fly  1328 KRTNTQSFRKTGSTDVKEK-------LEECIRGTNSARYDLINRRKDRNSTEKFRWRKDQMPYR- 1384
            .:..|:       ||...|       |........|.:.::|...|.:...:|:...:..|.|. 
Mouse  1020 HKNFTE-------TDFDFKVWNSYFSLAVLFINQPSLQLEIITSAKRKKILDKYGDMRVMMAYEL 1077

  Fly  1385 -SQYADAVGKSEHELELSHFIEGSLATEVALVLLDTLEIIVHAAANLYHNLLGTVLKVLLHSLSR 1448
             |.:.:.   .:|::   |||.|.:...:.:.|:...|:         .|::..:...::....|
Mouse  1078 FSMWQNL---GDHKI---HFIPGMIGPFLGVTLVPQPEV---------RNIMIPIFHDMMDWEQR 1127

  Fly  1449 NQSVLALQNLFASQRALIFKFPNLLFDDETDICADLCLILLKHCGSLLPGIRSQAAASLYLLMRQ 1513
            ...     |....:..||.|..:::.:.:.|                      ::...|:.|:.|
Mouse  1128 KNG-----NFKQVEAELIDKLDSMVSEGKGD----------------------ESYRELFGLLTQ 1165

  Fly  1514 NFEIGNNFARVKMQVTMSLSSLVGTSSVFSEQSLRRALKTVLVYAESDSDLQDTSFPEQVQDLLF 1578
            .|   ..:..:..:|........|.|.|   .|:.|.::.:|.|                     
Mouse  1166 LF---GPYPSLLEKVEQETWRETGISFV---TSVTRLMERLLDY--------------------- 1203

  Fly  1579 NLHMILSDTVKMKEYQEDPEM--LLDLMNRIAKGYQNNPDLRLTWLENMAKKHRERANHTEAAMC 1641
                  .|.:|.:| .|:.::  .::||| ..|...|..::.:.::..:...|.:..|:||||..
Mouse  1204 ------RDCMKGEE-TENKKVGCTVNLMN-FYKSEINKEEMYIRYIHKLCDMHLQAENYTEAAFT 1260

  Fly  1642 YVHAASLVSEYLSMLESQKHLPVGAVSFQRISPNTLMESAVSDDVLSPGEDGICLGNHFTETGLK 1706
            .:....|:......|....|.| ....:||                   ::|:|          :
Mouse  1261 LLLYCELLQWEDRPLREFLHYP-SQTEWQR-------------------KEGLC----------R 1295

  Fly  1707 ALLEEASNSFQVAGMYEAMNEVYKILIPIC-------EANRDFQKLSKVHGKLQEAF--NRISQL 1762
            .::.           |....:.::..||:|       |:..|:|.||.:. |::.::  |.|.| 
Mouse  1296 KIIH-----------YFNKGKSWEFGIPLCRELACQYESLYDYQSLSWIR-KMEASYYDNIIEQ- 1347

  Fly  1763 QGKRVFGTYFRVGFYGGKFG-DLDQQEFIYKEPTLTKLPEIFSRLQNFYTERFGPDSVHIIKDSN 1826
              :|:...:|||||||.||. .|..:|::.:.....:|.....|:.:.:     |.:| .::..|
Mouse  1348 --QRLEPEFFRVGFYGRKFPFFLRNKEYVCRGHDYERLEAFQQRMLSEF-----PQAV-AMQHPN 1404

  Fly  1827 TVDINSLDPDKAYIQITYVEP---YFETYEMRH---RETYFERNFNIKRFIYATPFTKNGK-AHG 1884
            ..|...|..|..|:||..|.|   |.:..:|..   |...|.|..|:::|.|..||.|..| ...
Mouse  1405 HPDDAILQCDAQYLQIYAVTPIPDYVDVLQMDRVPDRVKSFYRVNNVRKFRYDRPFHKGPKDKDN 1469

  Fly  1885 ELNEQCKRKTILTTANHFPYVKTRIMVISRQQIVLEPIEVAIEDIQKKTLELAAATNQEP----- 1944
            |.......:|.||..:..|.:.....|..|:.:.:.|:|.||:.::.|..||.|..:|..     
Mouse  1470 EFKSLWIERTTLTLTHSLPGISRWFEVERRELVEVSPLENAIQVVENKNQELRALISQYQHKQVH 1534

  Fly  1945 ADPKILQMVLQGCIGTTVNQGPMEMASVFLSNLSDGTTVPTKHQ------NKLRLCFREFSKRCA 2003
            .:..:|.|.|.|.|...||.|.......|...     ...|||.      ::|:...:|......
Mouse  1535 GNINLLSMCLNGVIDAAVNGGIARYQEAFFDK-----DYITKHPGDAEKISQLKELMQEQVHVLG 1594

  Fly  2004 DALKKNRNLILSDQKDYQRELERNNDRF-------------IERLTPFITLTSVQNHGVVKANA 2054
            ..|..:...:..:.:...::|   .|:|             :::|:|..:.||.....|:.:::
Mouse  1595 VGLAVHEKFVHPEMRPLHKKL---IDQFQMMRASLYHEFPGLDKLSPACSGTSTPRGNVLASHS 1655

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ZirNP_608489.2 DUF3398 59..151 CDD:288711 8/37 (22%)
C2_Dock-C 589..769 CDD:176078 44/188 (23%)
DHR-2 1549..2037 CDD:284365 111/530 (21%)
Dock3XP_011241171.1 SH3_DOCK3_B 10..65 CDD:212981
DOCK_N 69..412 CDD:374409 84/465 (18%)
C2_Dock-B 420..609 CDD:176077 48/264 (18%)
DHR2_DOCK3 1235..1626 CDD:212577 98/449 (22%)
Atrophin-1 1751..>2058 CDD:367360
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167839419
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1997
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.740

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