Protein Alignment Zir and F46H5.4

DIOPT Version :9

• Sequence 1: NP_608489.2
• Gene: Zir / 33165
• FlyBaseID: FBgn0031216
• Length: 2064
• Species: Drosophila melanogaster
• Sequence 2: NP_509219.1
• Gene: F46H5.4 / 180988
• WormBaseID: WBGene00018520
• Length: 2018
• Species: Caenorhabditis elegans
• Alignment Length: 2167
• Identity: 682/2167 - (31%)
• Similarity: 1080/2167 - (49%)
• Gaps: 297/2167 - (13%)

  Fly     2 SSAQRSFVQKVSKQSAADVRKNV-SGCHLSKAMDPSLCGSSIS-----------PTEPLDYEEFL 54
            :..:|:||:|.||.:|::|||:| ||.|....:.....|..::           |..|:|.|..|
 Worm     4 ADGKRAFVKKRSKVTASEVRKHVISGLHPIHRLSEGDNGLDLAVSMMEKIQFTEPVPPVDVEALL 68

  Fly    55 SQH-----MNIINRDPLKHILDFPQGDVTVKIIPRKIRTVDH---VVPNENLSDLPHHVQECVNC 111
            .|.     .:|.:....|.:.::...||.|..| |:....||   .:||     :.:||::....
 Worm    69 DQRKTCLLYSISSPKSSKPLFEYVSDDVEVTTI-RQDGLTDHNYTTIPN-----IENHVRDICGF 127

  Fly   112 YTRPWKVV--EYAQRHLSSSCYIRER--IDRGTISPSAYQQEFE-----IDKDFSSFEEAFAYKS 167
            |...:.:|  :|||.....   |::|  :::.|...|...|.|.     :|::
 Worm   128 YCDNFSLVNRKYAQLGTED---IKDRWNLEKLTALRSLRPQIFHNGLRIMDRE------------ 177

  Fly   168 ESCTPSSRQSIASLASVSSCTDTLTPRGSWASFDLRRSVNDPLIPNLLDNVPPEHIDQSN--EAR 230
                ||:       .|:..        ||:.:.|..:...:....::|..   ..||::.  .:.
 Worm   178 ----PST-------ISIDG--------GSFDTIDPTKCATEQFYVSMLKK---SAIDKNTLLYSM 220

  Fly   231 RQQDRQMALFSLYPESEAEENIERRLLAEIPVEHMGHRIQVNCLQLRLELEVEPIFASMAIYDAK 295
            ..::|.....:...|.|.....|:|.:..:|.:....::.|...:...:...||:||||||||.|
 Worm   221 LSKNRVKHFMNCINEEEKSWKWEKRGVPRLPEQEETPKLFVKVEKAAADPFFEPLFASMAIYDIK 285

  Fly   296 ERQKISENFYFDMNADSLKRMLSSHVQCADISTQSHSAIFEISYPSNDLFLVIRLEKVL-QGDIN 359
            .|||::|:.||::.......||.||.  .:........:|.::....|:|||:::|||| |.|:.
 Worm   286 NRQKVTESMYFNIADHDKLDMLGSHQ--PNFINNYMQVLFNVTGKLEDMFLVVKIEKVLQQNDVF 348

  Fly   360 NSVEPYLKEDKDKYREKVKSNAVDYCERLGKYRMPFAW-----TGIYLTNVFNGDNFESKDAGAA 419
            .:.|||.....:...|:::..|...|:|||.||.|..:     ..||..||..|.:...:.....
 Worm   349 ENSEPYTGTKDENNMERLERAAEKNCQRLGAYRSPLGFQVIDLQRIYKANVSTGASSFDRRTDPM 413

  Fly   420 ERDSFGNACGSSLGTAPSSNSLDRKSSTSSFDQLRRKANDMSGTLTRRGS----------LERKE 474
            .......|.|:.|.||  ..|.|.:.|.:|.|  |.....|..||.|.||          :....
 Worm   414 MMSQCTTASGAVLTTA--GQSQDDQCSITSAD--RTSIASMGSTLRRFGSGTSAATVFSRVRTPL 474

  Fly   475 KHRSWSP-------DDFANVVENFRPITITVPSFFKQEADKMKDEDLYKILPELKRPSSVMKKYK 532
            ..|.::|       .:....:||.....:...||.:||.||..|||:|:|..|::|.:..:.|..
 Worm   475 TKRKFAPVSNLPTSQEVPENIENMPSCNLKFSSFIRQEGDKTSDEDIYRICSEMRRTNGKVHKKM 539

  Fly   533 CIPGSIKLEISPCVEEAKNALTPELAPINPQ----------SADNVRPVKEILEFPQSAIYNP-- 585
            .   :.:||::             ||..|..          :.::.|.:.|.:|.|   ||..
 Worm   540 F---NFELELT-------------LAGSNKSKEYQSHGSNLTLNSERVIHEAMEIP---IYQASL 585

  Fly   586 HYSYRNLLFVSPKELNFSSRAGSARNIAVRVQLM-AGETPKDAVNAIYGKSSCPKFSTEAFTAVN 649
            :.||:|::||.||.:|.|:|.|:||||.::::|| |.||.::.|  ....|:...|.|.|.|:|.
 Worm   586 NKSYKNVIFVYPKHINLSNRTGNARNIMIKIELMDANETAQEVV--FENGSTRMSFLTSAKTSVI 648

  Fly   650 YHNKCPSFYDEIKIALPASIKQHHHLLFTIYHVSCQKKPQDLQPSVETPIGYTWLPLLEDGKLKF 714
            |||:.|.|.||||::||..:...||||||:||:||::....   |.|:|||||||||..:|||:.
 Worm   649 YHNRTPHFTDEIKLSLPCDLNDGHHLLFTVYHISCKEGDSS---STESPIGYTWLPLYRNGKLRS 710

  Fly   715 GEFNLPVMVESPPENYSFIPPNVHLPGIKWLDNHRAVFSINVEAVTAIHTLDSFLDRFFLICEYL 779
            |.|:|||..|.||..|.::..|..||.:||:|||:.:||.:.|.::::|..|.||:.|......|
 Worm   711 GNFHLPVCGEKPPPRYGYLDANNALPNLKWVDNHKPIFSCSTEVISSVHAQDEFLENFLAGVASL 775

  Fly   780 ---DTRNIPSHIGENNIETELKKCLLDIEYANREPLVRHLPLVLDKLIELLVVTHKVGGQAMSLG 841
               |.|..|  :|    ||:|.:.|..:.....:.|:..:..::.:|:.|:.........:|...
 Worm   776 SSNDPRKPP--VG----ETQLIRSLEGLCKTEPKKLIAFIHFIMSRLLFLIANPPYSDELSMKAF 834

  Fly   842 STVFEVLCLVSSLLSILNDDQYDQYGRQSLLSTYVHFQCKIPHPFQSKQRLTCSR--STTEDLQL 904
            ..:.|:|.|.|::|.:    ..|.:.|..||.::|.::         ||....|:  |....::|
 Worm   835 EYIGELLKLFSNVLHL----DLDAHQRNMLLVSFVKYR---------KQAAQESKPHSNIRPVEL 886

  Fly   905 SESYTIYDNVLASGRSLDRKELSIDVLHSMAARDVQVRLLHEELALHWVVASGKAADLAMSNSWF 969
            ..|.|  ||.|.|. .::..|.:    ||......:...|||.|...|:.|.|...|:::.:|||
 Worm   887 KSSPT--DNSLISS-MIEHVERT----HSAVNTGTKNIRLHECLLEVWLRARGSLRDVSLVHSWF 944

  Fly   970 LFELIVKSMIEHLHCSNTLNGPRKHRFPHQFNDDLSTLVHLVTTKVVGYHSNEPKLAQSLNASLG 1034
            |.|:|:||..|:|..:..::.|||.||..||..:|.|||.::..:|:..|:|:|..|:.::.|||
 Worm   945 LLEIILKSCSEYLTMTGRIHSPRKSRFEEQFLKNLETLVDILAQEVIIRHTNDPDKARMISNSLG 1009

  Fly  1035 FFIFDILSIMDRGFVFGLIKTY-------TKVLISKNASIPDLMNYKIDFLRIVCSHEHFVALNL 1092
            :|:.|..|||||.||..|:..|       .:.|:..|    :|::.||||:|:|||:||::.:|:
 Worm  1010 YFLRDCFSIMDRTFVMKLVHKYLIAFAESMRKLVHSN----ELLSIKIDFVRVVCSYEHYLIVNI 1070

  Fly  1093 -----PFGTSYTMVTAPCSPTPSTTSSNSQTSCGSLERALHADLSQEFLQQHFLVGLVLSDLAAV 1152
                 |.|.     |...:..|::..|.::|...||......|:|:   ..|:|.|.||||:...
 Worm  1071 LSDLKPSGN-----TNGGAVPPASFLSGNRTKSSSLTSWTLNDISR---STHYLSGQVLSDMKDS 1127

  Fly  1153 MEVPNPQLHGKAIRCIRNLMTSHDLDARYSETDARARVAALYIPLLSIVMDCIPQLHQHGLEQDR 1217
            :......|..|||..::.|:.|||||.|..|.::.|:||.:|.||::||:|.|..||...:...
 Worm  1128 IISGKTTLCAKAIETVKELLQSHDLDDRIVEGESLAQVANIYKPLVTIVLDNIECLHSGSVRNS- 1191

  Fly  1218 LQQIGQLEDYQGPHQTITASTINPEVAFAISG---SRPYSYLNEQVKNKLPLSSENTRHLLVCFL 1279
                   .|....: :....|...:|..||:|   :.|.....:| :..||:    |:.:|.|..
 Worm  1192 -------TDVSSTN-SFVEQTQRQDVMAAIAGKLRNSPDPTFGKQ-QMDLPM----TKTILCCVF 1243

  Fly  1280 WVLKNLERNVLYRWLMDLSPHRVHQMLQGVNVCLKTFEYTGQKNVATLKRTNTQSFRKTGSTDVK 1344
            |||:|::|..|..|:..|....:.:||..:...:.:||.  :.:.|:.:|    |..||..|.:.
 Worm  1244 WVLRNIDREDLKHWIRSLDNENMLKMLHILFHTMTSFEI--KDDPASARR----SPDKTSLTKLD 1302

  Fly  1345 EKLEECIRGTNSARYDLINRRKDRNSTEKFRWRKDQMPYRSQYADAVGKSEHELELSHFIEGSLA 1409
            |:.|                      ..:.:||...........|.:...|   .||.  :..::
 Worm  1303 EEPE----------------------PGQVKWRAQSSETCETKVDQISTLE---ALSS--DAIVS 1340

  Fly  1410 TEVALVLLDTLEIIVHAAA---NLYHNLLGTVLKVLLHSLSRNQSVLALQNLFASQRALIFKFPN 1471
            .||.:.:::.::.|:..|.   |...::|..:..:::|.||.|.|...|:.:||:|:..:.|||:
 Worm  1341 CEVFMCVIEVVDNIIAVATDPKNAQFHILPMIFPIIMHGLSCNASDQVLEVIFAAQQNFLAKFPD 1405

  Fly  1472 LLFDDETDICADLCLILLKHCGSL-LPGIRSQAAASLYLLMRQNFEIGNNFARVKMQVTMSLSSL 1535
            ::.:...::||:|...:|:||.|. |..:|:.|..|||..:|:||::..|..|.:..::.:||:|
 Worm  1406 MILEQNPELCAELSQQILRHCSSTRLENVRTMATVSLYHFLRENFKLYRNLTRARTFLSTALSTL 1470

  Fly  1536 VGTS---SVF-SEQSLRRALKTVLVYAESDSDLQDT-------SFPEQVQDLLFNLHMILSDTVK 1589
            :..|   .:| :::.:.|:|:.....|..|    ||       ...||:|:|..||..|:..||:
 Worm  1471 LSGSCGIDIFVNDEFMIRSLEIANQLAAED----DTFDIAAKKKLTEQMQELTANLQKIMLSTVR 1531

  Fly  1590 MKEYQEDPEMLLDLMNRIAKGYQNNPDLRLTWLENMAKKHRERANHTEAAMCYVHAASLVSEYLS 1654
            |:|:..|.||.:|||.::.:||.||||||:|||.|||::|.::.|..|||..|:.|::||.||::
 Worm  1532 MREHVNDYEMTIDLMYQLVEGYSNNPDLRITWLLNMAERHEKQRNLCEAAHSYLQASALVFEYIA 1596

  Fly  1655 M------LESQKHLPVGAVSFQRISPNTLMESAVSDDVLSPGE-DGICLGNHFTETGLKALLEEA 1712
            .      .||:     ||.:|..|:||.:.||..:.:.|...: :......||||.|:..:||:|
 Worm  1597 QKDQNLSFESK-----GAATFSEITPNAIKESKTNFNSLKNADSENHIQSYHFTEAGVIKILEKA 1656

  Fly  1713 SNSFQVAGMYEAMNEVYKILIPICEANRDFQKLSKVHGKLQEAFNR---------------ISQL 1762
            ....:.|.:||.:....||::....|.:.:.::|..|.:|..|.::               ||.|
 Worm  1657 FALLEKAQLYELLFPFSKIILKYYHATKSYSRVSHTHKRLGIAADQIKETGEYYENQSDAWISPL 1721

  Fly  1763 QG--KRVFGTYFRVGFYGGKFGDLDQQEFIYKEPTLTKLPEIFSRLQNFYTERFGPDSVHIIKDS 1825
            .|  ||.||::|||.|||..||.|:..||:|||...:||.||.:||:.|||..:|..:|.::|||
 Worm  1722 PGIDKRCFGSFFRVAFYGKLFGALNNAEFVYKESAFSKLNEISNRLETFYTNMYGEGNVVVLKDS 1786

  Fly  1826 NTVDINSLDPDKAYIQITYVEPYFETYEMRHRETYFERNFNIKRFIYATPFTKNGKAHGELNEQC 1890
            ..|.:..|:|:|||||||:|:.|....|...|.|||.|..|:.||.:..|:|..|:|.|||..|.
 Worm  1787 KPVQLEKLNPEKAYIQITFVDVYLSDNEKMERTTYFTRRNNVNRFYFEAPYTMEGRAQGELAAQY 1851

  Fly  1891 KRKTILTTANHFPYVKTRIMVISRQQIVLEPIEVAIEDIQKKTLELAAATNQEPADPKILQMVLQ 1955
            |::||||..|.|||:|||:.|::|......|||||||||:|||.||:||...:  :||:|.|.:|
 Worm  1852 KKRTILTVENSFPYIKTRLQVVNRSVKDFSPIEVAIEDIEKKTRELSAAAQHK--NPKMLSMFIQ 1914

  Fly  1956 GCIGTTVNQGPMEMASVFLSN--LSDGTTVPTKHQNKLRLCFREFSKRCADALKKNRNLILSDQK 2018
            |.|||||||||:|:|:|||:|  |.|......:.||||||.||....:..:|::..|.||..|||
 Worm  1915 GSIGTTVNQGPLEIANVFLANAMLDDRGRPVDRLQNKLRLSFRHLQCKAMEAIELCRQLIGEDQK 1979

  Fly  2019 DYQRELERNNDRFIERLTPFIT 2040
            :|||.:|.|.:.|:..|.|.::
 Worm  1980 EYQRNVEENFESFVTHLKPMLS 2001

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Zir	NP_608489.2	DUF3398	59..151	CDD:288711	23/98 (23%)
		C2_Dock-C	589..769	CDD:176078	83/180 (46%)
		DHR-2	1549..2037	CDD:284365	217/520 (42%)
F46H5.4	NP_509219.1	DUF3398	88..167	CDD:288711	21/87 (24%)
		C2_Dock-C	589..765	CDD:176078	83/180 (46%)
		DHR-2	1488..1998	CDD:284365	217/520 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166523
Domainoid	1	1.000	386	1.000	Domainoid score	I425
eggNOG	1	0.900	-	-		E1_KOG1997
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H23566
Inparanoid	1	1.050	904	1.000	Inparanoid score	I191
Isobase	1	0.950	-	0	Normalized mean entropy	S4471
OMA	1	1.010	-	-		QHG55633
OrthoDB	1	1.010	-	-		D14993at33208
OrthoFinder	1	1.000	-	-		FOG0000340
OrthoInspector	1	1.000	-	-		oto19189
orthoMCL	1	0.900	-	-		OOG6_100358
Panther	1	1.100	-	-	LDO	PTHR23317
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5567
SonicParanoid	1	1.000	-	-		X255
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	17.750