Protein Alignment Zir and DOCK3

DIOPT Version :9

• Sequence 1: NP_608489.2
• Gene: Zir / 33165
• FlyBaseID: FBgn0031216
• Length: 2064
• Species: Drosophila melanogaster
• Sequence 2: XP_005264971.1
• Gene: DOCK3 / 1795
• HGNCID: 2989
• Length: 2071
• Species: Homo sapiens
• Alignment Length: 1935
• Identity: 366/1935 - (18%)
• Similarity: 653/1935 - (33%)
• Gaps: 606/1935 - (31%)

  Fly   119 VEYAQRHLSSSCYIRERIDRGT------ISPSAYQQEFE-IDKDFSSFEEAFAYKSESCTPSSRQ 176
            |...:||      |..|:|.|.      :.|   :::|| :|.|..|..:  .||...   ||||
Human   139 VREVKRH------ITVRLDWGNEHLGLDLVP---RKDFEVVDSDQISVSD--LYKMHL---SSRQ 189

  Fly   177 SIASLASVSSCTDTLTPRGSWASFDLRRSVNDPLIPNLLDNVPPEHIDQSNEARRQQDRQMALFS 241
            |:   ...:|..||:.||..       .:...|:         |.|...|
Human   190 SV---QQSTSQVDTMRPRHG-------ETCRMPV---------PHHFFLS--------------- 220

  Fly   242 LYPESEAEENIERRLLAEIPVEHMGHRIQVNCLQLRLELEVEPIFASMAIYDAKERQKISENFYF 306
                           |.......:|              |...:|.|  :||.:|.::|||.|..
Human   221 ---------------LKSFTYNTIG--------------EDTDVFFS--LYDMREGKQISERFLV 254

  Fly   307 DM-------NADSLKRMLSSHVQCA---DISTQSHSAIFEISYPSNDLFL---VIRLEKVLQGDI 358
            .:       |.:.::||      ||   |:|::.         ...||::   |||:.::|..|
Human   255 RLNKNGGPRNPEKIERM------CALFTDLSSKD---------MKRDLYIVAHVIRIGRMLLND- 303

  Fly   359 NNSVEPYLKEDKDKYREKVKSNAVDYCERLGKYRMPFAWTGIYLTNVFNGDNFESKDAGAAERDS 423
            :....|:|                       .||.|:....:.:.:|     .:|......|:|.
Human   304 SKKGPPHL-----------------------HYRRPYGCAVLSILDV-----LQSLTEVKEEKDF 340

  Fly   424 FGN--ACGSSLGTAPSSNSLDRKSSTSSFDQLRRKANDMSGTL-----TRRGSLERKEKHRSWSP 481
            ...  .|.:....:....::.||||.      :..|...|..|     ..||.:|:..:
Human   341 VLKVYTCNNESEWSQIHENIIRKSSA------KYSAPSASHGLIISLQLLRGDMEQIRR------ 393

  Fly   482 DDFANVVENFRPITITVPSFFKQEADKMKDEDLYKILPELKRPSSVMKKYKCIPGSIKLEISPCV 546
                   ||        |..|.:.         ..|..:|..|..:|      ||.|
Human   394 -------EN--------PMIFNRG---------LAITRKLGFPDVIM------PGDI-------- 420

  Fly   547 EEAKNALTPELAPINPQSADNVRPVKEILEFPQSAIYNPHYSYRNLLFVSPKELNFSSRAGSA-- 609
                                                       ||.|:::.::.:| .|.|.:
Human   421 -------------------------------------------RNDLYLTLEKGDF-ERGGKSVQ 441

  Fly   610 RNIAVRVQLM--AGETPKDAVNAIYGKSSCPKFSTEAFTAVNYHNKCPSFYDEIKIALPASIKQH 672
            :||.|.:.::  .||..||.::  .|.....:.|..:|  |.||:..|.:.:.||:.:|....:.
Human   442 KNIEVTMYVLYADGEILKDCIS--LGSGEPNRSSYHSF--VLYHSNSPRWGEIIKLPIPIDRFRG 502

  Fly   673 HHLLFTIYHVSCQKKPQDLQPSVETPIGYTWLPLLEDGKLKFGEFNLPVMVESPPENYSFIPPNV 737
            .||.|...|.|.:.|.:      :...|:.:..|:.|......:....:.|....||.:|   |.
Human   503 SHLRFEFRHCSTKDKGE------KKLFGFAFSTLMRDDGTTLSDDIHELYVYKCDENSTF---NN 558

  Fly   738 H-----LPGIKWLDNHRAVFSINVEAVTAIHTLDSFLDRFFLICEYLDTRNIPSHIGENNIETEL 797
            |     ||..|  :::....:|....:....|.:||         ::.|:...:.:.:|.....|
Human   559 HALYLGLPCCK--EDYNGCPNIPSSLIFQRSTKESF---------FISTQLSSTKLTQNVDLLAL 612

  Fly   798 KKC------LLDI----EYANREPLVRHLPLVLDKLIELLVVTHKVGGQAMSLGSTVFEVLCLVS 852
            .|.      ::|:    .:.:.|.:|:.|..:||.|..:|      .......|..||:.|..:
Human   613 LKWKAFPDRIMDVLGRLRHVSGEEIVKFLQDILDTLFVIL------DDNTEKYGLLVFQSLVFI- 670

  Fly   853 SLLSILNDDQYDQYGRQSLLSTYV--HFQCKIPHPFQSKQRLTCSRSTTEDLQLSESYTIYDNVL 915
              :::|.|.:|..:  :.::.||:  ||...:.:    |:.:.|.:..   :..|......|::.
Human   671 --INLLRDIKYFHF--RPVMDTYIQKHFAGALAY----KELIRCLKWY---MDCSAELIRQDHIQ 724

  Fly   916 ASGRSLDRKELSIDVLHSMAARDVQVRLLHEELALHWVVASGKAADLAMSNSWFLFELIVKSMIE 980
            .:.|:|:.....|          ||.|:|:..      ...|...:...|:...||:.|...:..
Human   725 EAMRALEYLFKFI----------VQSRILYSR------ATCGMEEEQFRSSIQELFQSIRFVLSL 773

  Fly   981 HLHCSNTL---NGPRKHRFPHQFNDDLSTLVHLVTTKVVGYHSNEPKLAQSLNASLGFF--IFDI 1040
            ....|.||   .....:.||..|::    |:.:.|.:         ::|:.:..:||..  ...|
Human   774 DSRNSETLLFTQAALLNSFPTIFDE----LLQMFTVQ---------EVAEFVRGTLGSMPSTVHI 825

  Fly  1041 LSIMDRGFVFGLIKTYTKVLISKNASIPDLMNYKIDFLRIVCSHEHFVALNLPFGTSYTMVTAPC 1105
            ...||...:..:.:|....|.|.:.|       :...|.:|..|.|   |:|.......:    |
Human   826 GQSMDVVKLQSIARTVDSRLFSFSES-------RRILLPVVLHHIH---LHLRQQKELLI----C 876

  Fly  1106 SPTPSTTSSNSQTSCGSLERALHADLSQEF-LQQHFLVGLVLSDLAAVMEVPNPQLHGKAIRCIR 1169
            |....:..|..:||      :|.||:.:|. :....|:.::|..|..:|...:.|...:..||
Human   877 SGILGSIFSIVKTS------SLEADVMEEVEMMVESLLDVLLQTLLTIMSKSHAQEAVRGQRC-- 933

  Fly  1170 NLMTSHDLDARYSETDARARVAALYIP-LLSIVMDCIPQLHQHGLEQDRLQQIGQLEDYQGPHQT 1233
                          ....|.:...|:. |||::........||.|:
Human   934 --------------PQCTAEITGEYVSCLLSLLRQMCDTHFQHLLD------------------- 965

  Fly  1234 ITASTINPEVAFAISGSRPYSYLNEQVKNKLPLSSENTRHLLVCFLWVLKNLERNVLY--RWLMD 1296
                                   |.|.|::|       :..|:....|.:||.:..::  .|:
Human   966 -----------------------NFQSKDEL-------KEFLLKIFCVFRNLMKMSVFPRDWM-- 998

  Fly  1297 LSPHRVHQMLQGVNVCLKTFEYTGQKNVATLKRTNTQSFRKTGSTDVKEK-------LEECIRGT 1354
                 |.::|.. |:.:.|.:|..    :.|.:..|:       ||...|       |.......
Human   999 -----VMRLLTS-NIIVTTVQYLS----SALHKNFTE-------TDFDFKVWNSYFSLAVLFINQ 1046

  Fly  1355 NSARYDLINRRKDRNSTEKFRWRKDQMPYR--SQYADAVGKSEHELELSHFIEGSLATEVALVLL 1417
            .|.:.::|...|.:...:|:...:..|.|.  |.:.:.   .||::   |||.|.:...:.:.|:
Human  1047 PSLQLEIITSAKRKKILDKYGDMRVMMAYELFSMWQNL---GEHKI---HFIPGMIGPFLGVTLV 1105

  Fly  1418 DTLEIIVHAAANLYHNLLGTVLKVLLHSLSRNQSVLALQNLFASQRALIFKFPNLLFDDETDICA 1482
            ...|:         .|::..:...::....|...     |....:..||.|..:::.:.:.|
Human  1106 PQPEV---------RNIMIPIFHDMMDWEQRKNG-----NFKQVEAELIDKLDSMVSEGKGD--- 1153

  Fly  1483 DLCLILLKHCGSLLPGIRSQAAASLYLLMRQNFEIGNNFARVKMQVTMSLSSLVGTSSVFSEQSL 1547
                               ::...|:.|:.|.|   ..:..:..:|........|.|.|   .|:
Human  1154 -------------------ESYRELFSLLTQLF---GPYPSLLEKVEQETWRETGISFV---TSV 1193

  Fly  1548 RRALKTVLVYAESDSDLQDTSFPEQVQDLLFNLHMILSDTVKMKEYQEDPEM--LLDLMNRIAKG 1610
            .|.::.:|.|                           .|.:|.:| .|:.::  .::||| ..|.
Human  1194 TRLMERLLDY---------------------------RDCMKGEE-TENKKIGCTVNLMN-FYKS 1229

  Fly  1611 YQNNPDLRLTWLENMAKKHRERANHTEAAMCYVHAASLVSEYLSMLESQKHLPVGAVSFQRISPN 1675
            ..|..::.:.::..:...|.:..|:||||...:....|:......|....|.| ....:||
Human  1230 EINKEEMYIRYIHKLCDMHLQAENYTEAAFTLLLYCELLQWEDRPLREFLHYP-SQTEWQR---- 1289

  Fly  1676 TLMESAVSDDVLSPGEDGICLGNHFTETGLKALLEEASNSFQVAGMYEAMNEVYKILIPIC---- 1736
                           ::|:|          :.::.           |....:.::..||:|
Human  1290 ---------------KEGLC----------RKIIH-----------YFNKGKSWEFGIPLCRELA 1318

  Fly  1737 ---EANRDFQKLSKVHGKLQEAFNRISQLQGKRVFGTYFRVGFYGGKFG-DLDQQEFIYKEPTLT 1797
               |:..|:|.||.:.......::.|.:.|  |:...:|||||||.||. .|..:|::.:.....
Human  1319 CQYESLYDYQSLSWIRKMEASYYDNIMEQQ--RLEPEFFRVGFYGRKFPFFLRNKEYVCRGHDYE 1381

  Fly  1798 KLPEIFSRLQNFYTERFGPDSVHIIKDSNTVDINSLDPDKAYIQITYVEP---YFETYEMRH--- 1856
            :|.....|:.:.:     |.:| .::..|..|...|..|..|:||..|.|   |.:..:|..
Human  1382 RLEAFQQRMLSEF-----PQAV-AMQHPNHPDDAILQCDAQYLQIYAVTPIPDYVDVLQMDRVPD 1440

  Fly  1857 RETYFERNFNIKRFIYATPFTKNGK-AHGELNEQCKRKTILTTANHFPYVKTRIMVISRQQIVLE 1920
            |...|.|..|:::|.|..||.|..| ...|.......:|.||..:..|.:.....|..|:.:.:.
Human  1441 RVKSFYRVNNVRKFRYDRPFHKGPKDKENEFKSLWIERTTLTLTHSLPGISRWFEVERRELVEVS 1505

  Fly  1921 PIEVAIEDIQKKTLELAAATNQEP-----ADPKILQMVLQGCIGTTVNQG 1965
            |:|.||:.::.|..||.:..:|..     .:..:|.|.|.|.|...||.|
Human  1506 PLENAIQVVENKNQELRSLISQYQHKQVHGNINLLSMCLNGVIDAAVNGG 1555

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Zir	NP_608489.2	DUF3398	59..151	CDD:288711	8/37 (22%)
		C2_Dock-C	589..769	CDD:176078	44/188 (23%)
		DHR-2	1549..2037	CDD:284365	97/439 (22%)
DOCK3	XP_005264971.1	SH3_DOCK3_B	10..65	CDD:212981
		DOCK_N	69..412	CDD:292790	81/431 (19%)
		C2_Dock-B	420..609	CDD:176077	48/264 (18%)
		DHR2_DOCK3	1235..1626	CDD:212577	85/370 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149360
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1997
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740