DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Zir and DOCK1

DIOPT Version :9

Sequence 1:NP_608489.2 Gene:Zir / 33165 FlyBaseID:FBgn0031216 Length:2064 Species:Drosophila melanogaster
Sequence 2:NP_001364472.1 Gene:DOCK1 / 1793 HGNCID:2987 Length:1919 Species:Homo sapiens


Alignment Length:2115 Identity:380/2115 - (17%)
Similarity:701/2115 - (33%) Gaps:672/2115 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   199 SFDLRRSVNDPLIPNLLDNVPPEHIDQSNEA--RRQQDRQMALFSLYPES---------EAEENI 252
            ::|.|.:  |.|...:.|.|   ||.::.|.  |....|:.:...::|.|         |.:...
Human    19 NYDARGA--DELSLQIGDTV---HILETYEGWYRGYTLRKKSKKGIFPASYIHLKEAIVEGKGQH 78

  Fly   253 ERRLLAEIPVEHMGHRIQVNCLQLRLELEVEPIFASMAIYDAKERQKISENFYFDMNADSLKRML 317
            |..:..::|:      ||.....||   |...|:..:.:.|.:|..:...:..:|: .:...::|
Human    79 ETVIPGDLPL------IQEVTTTLR---EWSTIWRQLYVQDNREMFRSVRHMIYDL-IEWRSQIL 133

  Fly   318 SSHVQCADISTQSHSAIFEISYPSN--DLFLVIRLE--KVLQGDINNS-------------VEPY 365
            |..:...::.........:|.|.:.  ||.||:|.|  .:|..::.::             ||..
Human   134 SGTLPQDELKELKKKVTAKIDYGNRILDLDLVVRDEDGNILDPELTSTISLFRAHEIASKQVEER 198

  Fly   366 LKEDKDKYREKVKSNAVDYCERLGKY-RMPFAWTGIYLTNVFNG------------DNFESKDAG 417
            |:|:|.: ::.:..|      |..|: ..|.....:.|.||...            |..|||.. 
Human   199 LQEEKSQ-KQNIDIN------RQAKFAATPSLALFVNLKNVVCKIGEDAEVLMSLYDPVESKFI- 255

  Fly   418 AAERDSFGNACGSSLGTAPSSNSLDRKSST---SSFDQLRRKANDMSGTLTRRGSLERKEKHRSW 479
                               |.|.|.|.||:   ...|:|    :::....|..||.:.|.:..|:
Human   256 -------------------SENYLVRWSSSGLPKDIDRL----HNLRAVFTDLGSKDLKREKISF 297

  Fly   480 SPDDFANVVENFRPITITVPSFFKQEADKMKDEDLYKILPELKRP--SSVMKKYKCIPGSIK--- 539
                              |....:....:::|.:..|:...|:||  .:||.....|.|.:.   
Human   298 ------------------VCQIVRVGRMELRDNNTRKLTSGLRRPFGVAVMDVTDIINGKVDDED 344

  Fly   540 ----LEISPCVEE-------------AKNA--------LTPELAPIN--------PQSADNVRPV 571
                :...|...|             ||..        :|.:|.|.:        |...|....|
Human   345 KQHFIPFQPVAGENDFLQTVINKVIAAKEVNHKGQGLWVTLKLLPGDIHQIRKEFPHLVDRTTAV 409

  Fly   572 KEILEFPQSAIYNPHYSYRNLLFVSPKELNFSSRAGS---ARNIAVRVQLMAGETPKDAVNAIYG 633
            .....||:  |..|. ..||.::|:..:.:|..  ||   |:|:.|.|.:. .|..|...:.|: 
Human   410 ARKTGFPE--IIMPG-DVRNDIYVTLVQGDFDK--GSKTTAKNVEVTVSVY-DEDGKRLEHVIF- 467

  Fly   634 KSSCPKFSTEAF----TAVNYHNKCPSFYDEIKIALPASIKQHHHLLFTIYHVSCQKKPQDLQPS 694
                |....||.    :.:.|..|.|.:::.:|:|:|.......||.||..|    :..||.:..
Human   468 ----PGAGDEAISEYKSVIYYQVKQPRWFETVKVAIPIEDVNRSHLRFTFRH----RSSQDSKDK 524

  Fly   695 VETPIGYTWLPLLE-DG-KLKFGEFNLPVMVESPPENYSFIPPNVHLPGIKWLDNHRAVFSINVE 757
            .|......::.|:. || .|:.||.:| ::.::..:........:.||..| .:......|...:
Human   525 SEKIFALAFVKLMRYDGTTLRDGEHDL-IVYKAEAKKLEDAATYLSLPSTK-AELEEKGHSATGK 587

  Fly   758 AVTAIHTLDSFLDRF---FLICEYLDTRNIP----------SHIGENNIETELKKCLLDIEYANR 809
            ::.::.:.....|.|   .|:|....|:|:.          :.:.:.|:...:|        .:.
Human   588 SMQSLGSCTISKDSFQISTLVCSTKLTQNVDLLGLLKWRSNTSLLQQNLRQLMK--------VDG 644

  Fly   810 EPLVRHLPLVLDKLIELLVVTHKVGGQAMSLGSTVFEVLCLVSSLLSILNDDQYDQYGRQSLLST 874
            ..:|:.|...||.|..:::    ...::.:..:.||:.|..:..|::   |.::..:  ..:|.|
Human   645 GEVVKFLQDTLDALFNIMM----ENSESETFDTLVFDALVFIIGLIA---DRKFQHF--NPVLET 700

  Fly   875 YVHFQCKIPHPFQSKQRLTCSRSTTEDLQLSESYTIYDNVLASGRSLDRKELSIDVLHSMAARDV 939
            |:            |:..:.:.:.|:..::.::|.  |.....|.: ::...::..|.|:....|
Human   701 YI------------KKHFSATLAYTKLTKVLKNYV--DGAEKPGVN-EQLYKAMKALESIFKFIV 750

  Fly   940 QVRLLHEELALHWVVASGKAADLAMSNSWFLFELIVKSMIEHLHCSNTLNGPRKHRFPHQFNDDL 1004
            :.|:|..:|..:    .|:|.             .|:|:::..               ...||.:
Human   751 RSRILFNQLYEN----KGEAD-------------FVESLLQLF---------------RSINDMM 783

  Fly  1005 STLVHLVTTKVVGYHSNEPKLAQSLNASLGF---FIFDILSIMDRGFVFGLIKTYTKVLISKNAS 1066
            |::.. .|.:|.|             |:|.:   .:.|:..:.|..   .|.|.:|:.:      
Human   784 SSMSD-QTVRVKG-------------AALKYLPTIVNDVKLVFDPK---ELSKMFTEFI------ 825

  Fly  1067 IPDLMNYKIDFLRIVCSHEHFVALNLPFGTSYTMVTAPCSPTPSTTSSNSQTSCGSL-------E 1124
                                   ||:|.|. .|:....|......:...:|..|..:       :
Human   826 -----------------------LNVPMGL-LTIQKLYCLIEIVHSDLFTQHDCREILLPMMTDQ 866

  Fly  1125 RALHADLSQEF-----LQQHFL-------VGLVLSDLAAVMEVPNPQLHGKAIRCIRNLMTSHDL 1177
            ...|.:..::.     |..|.|       ||.....:..:||        |.:|.:...:.|...
Human   867 LKYHLERQEDLEACCQLLSHILEVLYRKDVGPTQRHVQIIME--------KLLRTVNRTVISMGR 923

  Fly  1178 DARYSETDARARVAALYIPLLSIVMDCIPQLHQHGLEQDRLQQIGQLEDYQGPHQTITASTINPE 1242
            |:.                |:...:.|:..:            :.|:|||...|...|...:..:
Human   924 DSE----------------LIGNFVACMTAI------------LRQMEDYHYAHLIKTFGKMRTD 960

  Fly  1243 VAFAISGSRPYSYLNEQV--------KNKLPLSSENTRHLLVCFLWVLKNLERNVLYRWLMDLSP 1299
            |.         .:|.|..        ||..|            |.||:.|:.:|.::        
Human   961 VV---------DFLMETFIMFKNLIGKNVYP------------FDWVIMNMVQNKVF-------- 996

  Fly  1300 HRVHQMLQGVNVCLKTFEYTGQKNVATLKRTN------TQSFRKTGSTDVKEKLEECIRGTNSA- 1357
                  |:.:|      :|....|...|.:.|      ...|....:...:|.|:  :...:|| 
Human   997 ------LRAIN------QYADMLNKKFLDQANFELQLWNNYFHLAVAFLTQESLQ--LENFSSAK 1047

  Fly  1358 RYDLINRRKDRNSTEKFRWRKDQMPYRSQYADAVGKSEHELE-----LSHFIEGSLATEVAL--- 1414
            |..::|:..|......|..|  .|.|        ...:|:::     :...:|.:|..|..|   
Human  1048 RAKILNKYGDMRRQIGFEIR--DMWY--------NLGQHKIKFIPEMVGPILEMTLIPETELRKA 1102

  Fly  1415 ---VLLDTLEIIVHAAANLYHNLLGTVLKVLLHSLSRNQSVLALQNLFASQRALIFKFPNLLFDD 1476
               :..|.::...|:..:.              .:..|:.:..|.:.....|.          |:
Human  1103 TIPIFFDMMQCEFHSTRSF--------------QMFENEIITKLDHEVEGGRG----------DE 1143

  Fly  1477 ETDICADLCLILLKHCGSLLPGIRSQAAASLYLLMRQNFEIGNNFARVKMQVTMSLSSLVGTSSV 1541
            :..:..|  .|||:||           ....||.     :.|..|  ||:.|             
Human  1144 QYKVLFD--KILLEHC-----------RKHKYLA-----KTGETF--VKLVV------------- 1175

  Fly  1542 FSEQSLRRALKTVLVYAESDSDLQDTSFPEQVQDLLFNLHMILSDTVKMKEYQEDPEMLLDLMNR 1606
                   |.::.:|.|.....|              .|....:|.||.:..:.::.|        
Human  1176 -------RLMERLLDYRTIMHD--------------ENKENRMSCTVNVLNFYKEIE-------- 1211

  Fly  1607 IAKGYQNNPDLRLTWLENMAKKHRERANHTEAAMCYVHAASLV--SEYLSMLESQKHLPVGAVSF 1669
                   ..::.:.:|..:...|:|..|:||||...:..|.|:  ||.:.:    .|| .....:
Human  1212 -------REEMYIRYLYKLCDLHKECDNYTEAAYTLLLHAKLLKWSEDVCV----AHL-TQRDGY 1264

  Fly  1670 QRISPNTLMESAVSDDVLSPGEDGICLGNHFTETGLKALLEEA-SNSFQVAGMYEAMNEVYKILI 1733
            |..:...|.|....:.:            |:.:.|  .:.||| :...::|..||  ||::    
Human  1265 QATTQGQLKEQLYQEII------------HYFDKG--KMWEEAIALGKELAEQYE--NEMF---- 1309

  Fly  1734 PICEANRDFQKLSKVHGKLQEAFNRISQLQGKRVFGTYFRVGFYGGKFGD-LDQQEFIYKEPTLT 1797
                   |:::||::..|..:.:..|.::  .|....||.||:||..|.. |..:.|||:.....
Human  1310 -------DYEQLSELLKKQAQFYENIVKV--IRPKPDYFAVGYYGQGFPTFLRGKVFIYRGKEYE 1365

  Fly  1798 KLPEIFSRLQNFYTERFGPDSVHIIKDSNTVDINSLDPDKAYIQITYVEP--------------- 1847
            :..:..:||...:     |::..:...|...|.....|.: |||...|:|               
Human  1366 RREDFEARLLTQF-----PNAEKMKTTSPPGDDIKNSPGQ-YIQCFTVKPKLDLPPKFHRPVSEQ 1424

  Fly  1848 ---------------------------YFETYE------------MRH-----RETYFERNFNIK 1868
                                       :|...|            ||.     |...|.|...::
Human  1425 IVRGLKQIVTLRAFSDAVVSFAVEACLHFSAGEKSVSVSPRPALCMRKACLVPRPRSFYRVNEVQ 1489

  Fly  1869 RFIYATPFTKNGK-AHGELNEQCKRKTILTTANHFPYVKTRIMVISRQQIVLEPIEVAIEDIQKK 1932
            ||.|:.|..|..| ...|.......:||.|||...|.:.....|.|...:.:.|:|.|||.:|..
Human  1490 RFEYSRPIRKGEKNPDNEFANMWIERTIYTTAYKLPGILRWFEVKSVFMVEISPLENAIETMQLT 1554

  Fly  1933 TLELAAATNQEPADPKI----LQMVLQGCIGTTVNQGPMEMASVFLSN----------------- 1976
            ..::.:...|...||.:    |.|:|.|.:...|..|.......|.::                 
Human  1555 NDKINSMVQQHLDDPSLPINPLSMLLNGIVDPAVMGGFANYEKAFFTDRYLQEHPEAHEKIEKLK 1619

  Fly  1977 ---------LSDGTTVPTKHQNKLRLCFREFSKRCADALKKNRNLILSDQKDYQREL------ER 2026
                     |::|..:   |.:|:....|.|.:|.....|:.:..:   :|:|...:      :|
Human  1620 DLIAWQIPFLAEGIRI---HGDKVTEALRPFHERMEACFKQLKEKV---EKEYGVRIMPSSLDDR 1678

  Fly  2027 NNDRFIERLTPFITLTSVQNHGVVKANAYNNKSTP 2061
            ...|....:..|...:|.:...|...::.::.|||
Human  1679 RGSRPRSMVRSFTMPSSSRPLSVASVSSLSSDSTP 1713

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ZirNP_608489.2 DUF3398 59..151 CDD:288711
C2_Dock-C 589..769 CDD:176078 41/188 (22%)
DHR-2 1549..2037 CDD:284365 114/587 (19%)
DOCK1NP_001364472.1 SH3_DOCK1_5_A 13..68 CDD:212984 13/53 (25%)
DOCK_N 72..416 CDD:406558 72/402 (18%)
C2_Dock-A 424..619 CDD:176076 47/208 (23%)
DHR2_DOCK 1214..1666 CDD:414667 102/497 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1997
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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