Protein Alignment Zir and F22G12.5

DIOPT Version :9

• Sequence 1: NP_608489.2
• Gene: Zir / 33165
• FlyBaseID: FBgn0031216
• Length: 2064
• Species: Drosophila melanogaster
• Sequence 2: NP_001300393.1
• Gene: F22G12.5 / 173181
• WormBaseID: WBGene00009065
• Length: 2338
• Species: Caenorhabditis elegans
• Alignment Length: 2465
• Identity: 559/2465 - (22%)
• Similarity: 939/2465 - (38%)
• Gaps: 712/2465 - (28%)

  Fly    45 TEPLDYEEFLSQHMNIINRDPLKHILDFPQGDVTVKIIPRKIRT-VDHVVPNENLSDLPHHVQEC 108
            :||::||:|:::....:..||.:.|:.||:.|:......:...| |..|.||:.........:|.
 Worm    81 SEPVNYEKFINERSIQLENDPQREIVLFPRDDIEESSTQQTCETAVPMVKPNDIKQAKWLLTREA 145

  Fly   109 VNCYTRPWKVV---------EYAQRHLSSSCYIRERIDRGTISPSAYQQEFEIDKD--------- 155
            :..||...:.:         :|:..:.||:      |:..|:|...::.:..::.:
 Worm   146 LRFYTTAHRSIVFNYSKFSGDYSANNTSSA------IENETLSSLVFESDMALEDERAAFGASSN 204

  Fly   156 ---------------------FSSFEEAFA---------YKSESCTPSSRQ-------------S 177
                                 |.:.:.:.|         ::...||...|:             |
 Worm   205 GAVGVVKEGNLNVLKSDPPTLFDNLKSSSAKRRYCILRRHEGGECTFEIRKTAQEAPKMLPLKVS 269

  Fly   178 IASLASVSSCTDTLTPRGS-------------------W--------------------ASFDLR 203
            .|.:.|.......|..|||                   |                    :..|.:
 Worm   270 AAQIKSTKKGKTVLEIRGSDADKAAILLESEETQMLEEWLVALHTAIALANKEDAISICSELDTK 334

  Fly   204 RSVNDPLIPNLLD------------------NVPPEHI---DQSNE--------------ARRQQ 233
            .:.:     .|||                  ....|.|   |.||.              ||..|
 Worm   335 GTGS-----KLLDVNAAATSSSTSVGGGRSKGADTESIGSEDSSNSRTSEMQPWRGRNSAARALQ 394

  Fly   234 ----DRQMALFSLY------PESEAEE------NIERRLLAEIPV----------------EHMG 266
                ||: .:||||      |:|..|.      |..:|..|:.|:                :..|
 Worm   395 PPIVDRR-NMFSLYYRLQPLPQSPHESSTILPGNSSKRGSADAPIFSSMSPVKMRKTSGSLKRNG 458

  Fly   267 HR--------------IQVNCLQLRLE------LEVEPIFASMAIYDAKERQKISENFYFDMNAD 311
            .:              :..:.|.|||.      .::||.|....::||.|.::..|.|...:|.|
 Worm   459 AQSSLISSTGTPFLISLDFHGLHLRLPNLSGVLQQIEPFFVRFFVFDALEARRACEEFQILVNGD 523

  Fly   312 SL----------------KRMLSSHVQCADISTQSHSAIFEI---SYPSNDLFLVIRLEKVLQGD 357
            .|                :|.|.       :...:..|:.::   :....||::|.|::::|..|
 Worm   524 ELHLTEPVFDSSCKVNGIRRSLL-------VDRAASRALLQLPPTTVNHRDLWIVCRVDRILSAD 581

  Fly   358 INNSVEPYL--KEDKD-KYREKVKSNAVDYCERLGKYRMPFAWTGIYLTNVFNGDNFESKDAGAA 419
              .:.|.|:  :...| |...|::........||..:|..||||.
 Worm   582 --TAAELYMNSRSSSDPKAVAKLQKTVSMSLTRLAGHRQRFAWTA-------------------- 624

  Fly   420 ERDSFGNACGSSLGTAPSSNSLDRKSSTSSFDQLRRKANDMSGTLTRRGSLERKEKHRSWSPDDF 484
             :..|.....:...|..|:.|....||||:          :||                ||...
 Worm   625 -KPLFPELRSNDSSTISSTTSPMLSSSTST----------LSG----------------WSKSG- 661

  Fly   485 ANVVENFRPITITVPSFFKQEADKMKDEDLYKILPE---LKRPSSVMKKYKCIPG---SIKLEIS 543
            |:.::           .::.|.::..|.||.|.|.|   |:|.|.::     ||.   |:.:...
 Worm   662 ADALQ-----------LYRCEGNRYSDGDLQKNLMEFNKLERQSKMI-----IPNATVSVSVNTR 710

  Fly   544 PCVEEAKNALTPELAPINPQSADN---VRPVKEILEFPQSAIYNPHYSYRNLLFVSPKELNFSSR 605
            ..|.:..|.:.|.|.|:||...::   ..||.::..|.... ..||.|..|||::.|..|.:.|:
 Worm   711 ASVIDYLNRVNPSLYPLNPWKPEDPSMTPPVFQLQSFGDQP-SQPHTSLTNLLYIYPLALKYDSQ 774

  Fly   606 A--GSARNIAVRVQLMAGE--TPKDAVNAIYGKSSCPKFSTEAFTAVNYHNKCPSFYDEIKIALP 666
            .  ..||||:..|:.:.||  .|:.|:  :...|:...:...:..||.:|.:.|.|.:|:|..||
 Worm   775 KAFSKARNISCTVRFVRGEEAIPEKAM--VDRMSAAGPYCISSTCAVQHHQQNPVFGEEMKAQLP 837

  Fly   667 ASIKQHHHLLFTIYHVSCQKKPQ-DLQPSVETPIGYTWLPL--------LEDGKLKFGEFNLPVM 722
            .::....||||:..|:|...... ....|.||||||:||||        :|:.:   .||.|||.
 Worm   838 LNLTTSDHLLFSFSHISVAGNSNLKASESTETPIGYSWLPLVWKKDRLVMENDE---QEFALPVA 899

  Fly   723 VESPPENYSFIPPNV-----HLPGIKWLDNHRAVFSINVEAVTAIHTLDSFLDRFFLICEYLDTR 782
            ::.||..|...|..:     .|..::|:| .:.:|.:.:..|:::.|.|:.|..||..|:.|..:
 Worm   900 IDLPPNYYRSKPTGMGKGDETLSEVRWVD-QKPLFRVRLRLVSSVFTTDAKLQTFFQACDRLSAK 963

  Fly   783 NI-------------------PSHI---------------GENNIE-----TELKKCLLDIEYAN 808
            .|                   ||.:               ..:::|     ..:|..|..|...:
 Worm   964 GIIGDAADSLKRMVKSKSSSPPSDLLHHPRSCSPIADSLQRSHSLEDPDQNPHMKHLLQSIRLLS 1028

  Fly   809 REP---LVRHLPLVLDKLIELLVVTHKVGGQAMSLGSTVFEVLCLVS--SLLSILNDDQYDQYGR 868
            ..|   |:.:||:||.:|..:|       .||.:      |.|.:.:  |::||.  |...|.|:
 Worm  1029 DVPFDRLLVYLPIVLGRLFAIL-------PQAPT------EQLAIATLRSIISIC--DMCCQNGK 1078

  Fly   869 QSLLSTYV--HFQCKIPHPFQSKQRLTCSRSTTEDLQLSESYTIYDNVLASGRSLDRKELSIDVL 931
            ..::..:|  ||                |.|...:..:|...|||..:.....:|.|:
 Worm  1079 PQVVRRFVKSHF----------------SDSVAREQFVSHETTIYSAICRHLPTLMRE------- 1120

  Fly   932 HSMAARDVQVRLLHEELALHWVVASGKAADLAMSNSWFLFELIVKSMIEHLHCSNTLN-GPRKHR 995
              :.:...|:..|:.:|                   |.|.:.::|||.:.: ||..|| ..::.|
 Worm  1121 --LQSEPEQLAQLYLQL-------------------WVLTDAVIKSMAQTM-CSEQLNKTSQRDR 1163

  Fly   996 FPHQFNDDLSTLVHLVTTKVVGYHSNEPKLAQSLNASLGFFIFDILSIMDRGFVFGLIKTYTKVL 1060
            ||.:..:.:..::.:...::|..|....:.::..|.:|.:|....:|.:|||.||..|..|...|
 Worm  1164 FPQEILEQMGQVLEVGVPQIVLKHKEMREESRCANLALAYFTRFAMSFVDRGVVFRWIHFYISRL 1228

  Fly  1061 ISKNASIPDLMNYKIDFLRIVCSHEHFVALNLPF---------------GTSYT-MVTAPCS--- 1106
              .:.....|.:||.|.|.|:|.|||.|.||||.               |...| |.|...|
 Worm  1229 --DDTDYRALRDYKTDLLEILCLHEHHVPLNLPVLINAAAQIQRLNYSGGVVDTQMQTTNASGSG 1291

  Fly  1107 ------------PTPSTTSSNSQTSCGSLERALHADLSQEFLQQHFLVGLVLSDLAAVMEVPNPQ 1159
                        ||..|..::...||..     ...||..|.|.||:|||::.:|.|.:. ....
 Worm  1292 FLSRFFNQIFNTPTLETNETDRYASCSG-----EWHLSPAFAQNHFIVGLLMQELVACIR-ETKD 1350

  Fly  1160 LHGKAIRCIRNLMTSHDLDARYSETDARARVAALYIPLLSIVMDCIPQLHQHGLEQDRLQQI--- 1221
            ...:.|..:|||:..|..|.||.:...:.|:|.||.|:|:..:|     |.|..:.:.:..:
 Worm  1351 YRKRPISLLRNLLAKHSFDKRYGDMTIQRRIAMLYAPVLTFALD-----HLHEFDSEDIDDVDAT 1410

  Fly  1222 -----------GQLEDYQGPHQTITA-STIN------------------PEVAFAISGSRPYSYL 1256
                       |.|.......:|::. .|:|                  |..:...:.|||
 Worm  1411 PTGYRSFPTSGGPLPPSSSTTKTLSKWRTVNRYTDVQQFSRGSPIRTSSPVPSTQTTPSRP---- 1471

  Fly  1257 NEQVKNKLP-------------------LSSENTRHLLVCFLWVLKNLERNVLYRWLMDLSPHRV 1302
             .|:....|                   |:.:..:.:|:|.:::|:.:.:.:|.....:......
 Worm  1472 -PQMPPPPPASGKTIPPPPSSSTPLVEKLTEDEIQDILICCVFILQRMPKRILAALWTENDGANA 1535

  Fly  1303 HQMLQGVNVCLKTFEYTGQKNVATLKRT------------NTQSFRKTGSTDVKEKLEECIRGTN 1355
            .:|::.:.:.:..|.|.|:::  .|:||            |..|...:|||..:...|..:..
 Worm  1536 EKMIRLLELIVDVFRYRGKEH--ALRRTAANSKTRSLFTLNLPSRISSGSTPNRISAEMMMAA-- 1596

  Fly  1356 SARYDLINRRKDRNSTEKFRWRKDQMPYRSQYADAVGKSEHELELSHFIEGSLATEVALVLLDTL 1420
            .|..|      |.||:    ...:.:|:|            .|:|.     :|:.||||::||..
 Worm  1597 GAGED------DPNSS----GTTNPIPFR------------VLQLV-----NLSQEVALIVLDVA 1634

  Fly  1421 EIIVHAAAN------------LYHNLLGTVLK---------VLLHSLSRNQSVLAL-QNLFASQR 1463
            :...|..|:            |:|:||...|:         |.||.::.    ||| .|||   |
 Worm  1635 QTFAHQLASSQRHRHCPQSDALFHSLLALHLRLADEHWSETVRLHVIAG----LALFVNLF---R 1692

  Fly  1464 ALIFKFPNLLFDDETDICADLCLILLK---HCGSLLPGIRSQAAASLYLLMRQNFEIGNNF---- 1521
            |.:|         |......|.:::.|   ...|.||.:::.|||.|.|::|..:|:...:
 Worm  1693 ARLF---------EGGPLEPLYMLIEKVLIQMASRLPAVQAAAAALLQLILRNGYEVAQGYFASQ 1748

  Fly  1522 ----------------------------ARVKMQVTMSLSSLVGTSSVFSEQ-SLRRALKTVLVY 1557
                                        .|...|..::|:.|:|..||.|.. :..|.|..|...
 Worm  1749 VLAQSVSPSSSKINQQAATRKGVSSERLGRPGSQTGVALARLLGFQSVLSNSAAFERGLAAVEAL 1813

  Fly  1558 AESDSDLQDTSFPEQVQDLLFNLHMILSDTVKMKEYQEDPEMLLDLMNRIAKGYQNNPDLRLTWL 1622
            .::   .:.|||...|.|||..|..:::.||.:|:...||..|.||..::|..|:.:..||..|.
 Worm  1814 VDT---RKATSFDLAVLDLLRQLRGVMTATVALKDAANDPIRLADLHLQLADSYRGSAALRSAWF 1875

  Fly  1623 ENMAKKHRERANHTEAAMCYVHAASLVSEYLSMLESQKHLPVGAVSFQRISPNTLMESAVSDDVL 1687
            :.:|:.:.:.....||::|:.|:.::::.   .||.:|.|.|....|..|: |.:.|:..|..
 Worm  1876 DTLAEIYEQDRWFAEASVCHAHSVAIIAR---ELEERKELEVDWRVFDWIN-NRIAETEQSQG-- 1934

  Fly  1688 SPGEDGICLGNHFTETGLKALLEEASNSFQVAGMYEAMNEVYKILIPICEANRDFQKLSKVHGKL 1752
              |:.|......||...|.|.:::.:.:..:|..:||:..:|::::|:.|.|.:|..|..|:.:|
 Worm  1935 --GDAGSVQPAGFTTDNLGAKIDKTAAALMLAERFEAVGPLYRLIVPVLEKNMNFTSLVSVYAEL 1997

  Fly  1753 QEAFNRISQLQ--GKRVFGTYFRVGFYGGK-FGDLDQQEFIYKEPTLTKLPEIFSRLQNFYTERF 1814
            |:.::|.::::  |||..|.||||.|.|.: ||.....::||:|..||.|......::.....:.
 Worm  1998 QQTYSRAAEVRSSGKRHLGAYFRVRFNGERHFGSEHNTDWIYREAGLTSLAAFALEIKEKCQRQV 2062

  Fly  1815 GPDSVHIIKDSNTVDINSLDPDKAYIQITYVEPYFET---YEMRHRETYFERNFNIKRFIYATPF 1876
            |.|.|. |:.:..:|::.:||..||:|||:|||....   ...:||..:.... |:..|.|....
 Worm  2063 GHDRVQ-IEANEQLDLSKIDPTVAYVQITHVEPSIPAAAGIADQHRNDFLVHT-NLSEFSYECAT 2125

  Fly  1877 TKNGKAHGE---LNEQCKRKTIL-----------TTANHFPYVKTRIMVISRQQIVLEPIEVAIE 1927
            .:|.:...:   ::|||.::|:|           ..|..||..:.|:.|||.......|:|.|.:
 Worm  2126 IENERKVSKEPAIHEQCLKRTVLRVSPSPVSEDSRAATGFPATRRRLPVISVHFEQFSPLEFACQ 2190

  Fly  1928 DIQKKTLE----LAAATNQEPADPKILQMVLQGCIGTTVNQGPMEMASVFLSNLSDGTTVPTKHQ 1988
            .:..|..:    |.||:|....|.|.||::|||.:..|||.||:..|.||           ||.:
 Worm  2191 KLNTKAEQIRKTLNAASNGRQLDVKGLQLLLQGAVLPTVNAGPLAYAEVF-----------TKEE 2244

  Fly  1989 N----------KLRLCFREFSKRCADALKKNRNLILSDQKDYQRELERNNDRFIERLTPF 2038
            .          |||..||.....|..|::.|.:.|.|||:.|...|..:.|...|||..|
 Worm  2245 QRERYGDDGLVKLRESFRNLMNSCQLAIEANASAIGSDQQTYHEVLVSSFDAMHERLQTF 2304

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Zir	NP_608489.2	DUF3398	59..151	CDD:288711	20/101 (20%)
		C2_Dock-C	589..769	CDD:176078	59/197 (30%)
		DHR-2	1549..2037	CDD:284365	152/521 (29%)
F22G12.5	NP_001300393.1	DUF3398	79..189	CDD:371776	25/113 (22%)
		PH-like	208..326	CDD:388408	13/117 (11%)
		C2	760..947	CDD:387358	58/192 (30%)
		DHR-2	1805..2303	CDD:369137	152/521 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55633
OrthoDB	1	1.010	-	-		D20156at2759
OrthoFinder	1	1.000	-	-		FOG0000340
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100358
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X255
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.830