DRSC/TRiP Functional Genomics Resources

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Protein Alignment Zir and DOCK11

DIOPT Version :9

Sequence 1:NP_608489.2 Gene:Zir / 33165 FlyBaseID:FBgn0031216 Length:2064 Species:Drosophila melanogaster
Sequence 2:XP_005262425.1 Gene:DOCK11 / 139818 HGNCID:23483 Length:2086 Species:Homo sapiens


Alignment Length:2259 Identity:663/2259 - (29%)
Similarity:1043/2259 - (46%) Gaps:444/2259 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 RSFVQKVSKQ-SAADVRKNVSGCHLSKAMDPSLCGSSISPTEPLDYEEFLSQHMNIINRDPLKHI 69
            |.|.:::||. :||::|::|     |:|:..|:........||||||..::|....|..|||:.:
Human     5 RKFTKRLSKPGTAAELRQSV-----SEAVRGSVVLEKAKVVEPLDYENVIAQRKTQIYSDPLRDL 64

  Fly    70 LDFPQGDVTVKIIPRKIRTVDHVVPNE---NLSDLPHHVQECVNCYTRPWKVVEYAQRHLSSSCY 131
            |.||..|:::.:|.|:.|||...||.:   ....|  .|:||:..|:..|.||.|.....|... 
Human    65 LMFPMEDISISVIGRQRRTVQSTVPEDAEKRAQSL--FVKECIKTYSTDWHVVNYKYEDFSGDF- 126

  Fly   132 IRERIDRGTISPSAYQQE-FEIDKDFSSFEEAF-------------------------------- 163
              ..:...::.|...... ||||:|....|::.                                
Human   127 --RMLPCKSLRPEKIPNHVFEIDEDCEKDEDSSSLCSQKGGVIKQGWLHKANVNSTITVTMKVFK 189

  Fly   164 -----------------AYKSESCTPSSRQSIASLASVSSCTDTL-TPRGSWASFDLRR------ 204
                             :||.|..:..|:..|    .:.:|.|.: .|:....:|:|:.      
Human   190 RRYFYLTQLPDGSYILNSYKDEKNSKESKGCI----YLDACIDVVQCPKMRRHAFELKMLDKYSH 250

  Fly   205 ---------------------SVN-DPLIPNLLDNVPPEHIDQSNEARRQQDRQMAL-FSLYPE- 245
                                 .:| |.|:....:.|.....|:::...:.::...:| .|::|| 
Human   251 YLAAETEQEMEEWLITLKKIIQINTDSLVQEKKETVETAQDDETSSQGKAENIMASLERSMHPEL 315

  Fly   246 ----SEAEE------------------NIERRLLAEI-----PVEH-MGHRIQVNCLQLRLEL-- 280
                .|.|:                  .::|...:.|     |.|. ...|..|||..|...:  
Human   316 MKYGRETEQLNKLSRGDGRQNLFSFDSEVQRLDFSGIEPDIKPFEEKCNKRFLVNCHDLTFNILG 380

  Fly   281 -----------EVEPIFASMAIYDAKERQKISENFYFDMNADSLKRML--SSHVQCADISTQSHS 332
                       .|||.|.::|::|.|...|||.:|:.|:|..|::.||  ||....:|.|.:..|
Human   381 QIGDNAKGPPTNVEPFFINLALFDVKNNCKISADFHVDLNPPSVREMLWGSSTQLASDGSPKGSS 445

  Fly   333 ------------------AIFEISYPSNDLFLVIRLEKVLQGDINNSVEPYLK-EDKDKYREKVK 378
                              .||.::.|..::|||.|:||||||:|.:..|||:| .|..|..:||.
Human   446 PESYIHGIAESQLRYIQQGIFSVTNPHPEIFLVARIEKVLQGNITHCAEPYIKNSDPVKTAQKVH 510

  Fly   379 SNAVDYCERLGKYRMPFAWTGIYLTNVFNGDNFESKDAGAAERDSFGNACGSSLGTAPSSNSLDR 443
            ..|...|.|||:|||||||                     |.|..|.:..||.            
Human   511 RTAKQVCSRLGQYRMPFAW---------------------AARPIFKDTQGSL------------ 542

  Fly   444 KSSTSSFDQLRRKANDMSGTLTRRGSLERKEKHRSWSPDDFANVVENFRPITITVPSFFKQEADK 508
                           |:.|                           .|.|:       :||::.|
Human   543 ---------------DLDG---------------------------RFSPL-------YKQDSSK 558

  Fly   509 MKDEDLYKILPELKRPSSVMKKYKCIPGSIKLEISPCVEEAKNALTPELAPINP--QSADNVRPV 571
            :..||:.|:|.|.|:|...  |.:.|||.:.:.:.....:..|.:|....|:.|  ::..|:  .
Human   559 LSSEDILKLLSEYKKPEKT--KLQIIPGQLNITVECVPVDLSNCITSSYVPLKPFEKNCQNI--T 619

  Fly   572 KEILEF-PQSAIY-NPHYSYRNLLFVSPKELNFSSRA--GSARNIAVRVQLM-AGETPKDAVNAI 631
            .|:.|| |:...| .|...|:|.|:|.|.:|.:.|:.  ..||||||.|:.. :.|:...|:..|
Human   620 VEVEEFVPEMTKYCYPFTIYKNHLYVYPLQLKYDSQKTFAKARNIAVCVEFRDSDESDASALKCI 684

  Fly   632 YGKSSCPKFSTEAFTAVNYHNKCPSFYDEIKIALPASIKQHHHLLFTIYHVSCQ---KKPQDLQP 693
            |||.:...|:|.|:..|::||:.|.|||||||.||..:.|.||||||.|||||:   |.....|.
Human   685 YGKPAGSVFTTNAYAVVSHHNQNPEFYDEIKIELPIHLHQKHHLLFTFYHVSCEINTKGTTKKQD 749

  Fly   694 SVETPIGYTWLPLLEDGKLKFGEFNLPVMVESPP------ENYSFIPPNVHLPGIKWLDNHRAVF 752
            :||||:|:.|:|||:||::...|..|||....||      :..|....||   .|||:|..:.:.
Human   750 TVETPVGFAWVPLLKDGRIITFEQQLPVSANLPPGYLNLNDAESRRQCNV---DIKWVDGAKPLL 811

  Fly   753 SINVEAVTAIHTLDSFLDRFFLICEYLDTRNIPSHIGENNIETELKKCLLDIEYANREPLVRHLP 817
            .|.....:.|:|.|..:.:||..|:.:.:       |...:..||.|.|..:.....:.:::.||
Human   812 KIKSHLESTIYTQDLHVHKFFHHCQLIQS-------GSKEVPGELIKYLKCLHAMEIQVMIQFLP 869

  Fly   818 LVLDKLIELLV-VTHKVGGQAMSLGSTVFEVLCLVSSLLSILNDDQYDQYGRQSLLSTYVHFQCK 881
            ::|.:|..:|. :||:   ..:.:..|:.        ||.|::  :..:.|..|.|.:::.:..:
Human   870 VILMQLFRVLTNMTHE---DDVPINCTMV--------LLHIVS--KCHEEGLDSYLRSFIKYSFR 921

  Fly   882 IPHPFQSKQRLTCSRSTTEDLQLSESYTIYDNVLASGRSLDRKELSIDVLHSMAARDVQVRLLHE 946
            ...|...                                                   |.:|:||
Human   922 PEKPSAP---------------------------------------------------QAQLIHE 935

  Fly   947 ELALHWVVASGKAADLAMSN-----SWFLFELIVKSMIEHLHCSNTLNGPRKHRFPHQFNDDLST 1006
            .||...:....::||....|     |||.||:|.|||..:|...|.:..||..|||..::..|.:
Human   936 TLATTMIAILKQSADFLSINKLLKYSWFFFEIIAKSMATYLLEENKIKLPRGQRFPETYHHVLHS 1000

  Fly  1007 LVHLVTTKVVGYHSNEPKLAQSLNASLGFFIFDILSIMDRGFVFGLIKTYTKVLISKNASIPDLM 1071
            |:..:...|...::..|..::::|.||..|:...|::|||||:|.||..|......|:..:  |.
Human  1001 LLLAIIPHVTIRYAEIPDESRNVNYSLASFLKRCLTLMDRGFIFNLINDYISGFSPKDPKV--LA 1063

  Fly  1072 NYKIDFLRIVCSHEHFVALNLPFGTSYTMVTAPCSPTPSTTSSNSQTSCGSLERALHADLSQEFL 1136
            .||.:||:.:|:|||::.||||..     ...|.........|.:.....|::..|...||.|:.
Human  1064 EYKFEFLQTICNHEHYIPLNLPMA-----FAKPKLQRVQDFFSFAVDRLTSVDSNLEYSLSDEYC 1123

  Fly  1137 QQHFLVGLVLSDLAAVMEVPNPQLHGKAIRCIRNLMTSHDLDARYSETDARARVAALYIPLLSIV 1201
            :.||||||:|.:.:..:: .|.::...||..|:||:..|..|.||...:.:|::|.||:|.:.::
Human  1124 KHHFLVGLLLRETSIALQ-DNYEIRYTAISVIKNLLIKHAFDTRYQHKNQQAKIAQLYLPFVGLL 1187

  Fly  1202 MDCIPQL-----------------------------HQHGLEQDRLQQIGQLEDYQGPHQTITAS 1237
            ::.|.:|                             ::..|..|:....|..::..|..:..:..
Human  1188 LENIQRLAGRDTLYSCAAMPNSASRDEFPCGFTSPANRGSLSTDKDTAYGSFQNGHGIKREDSRG 1252

  Fly  1238 TINPEVA--FAISGSRPYSYLNEQVKNKLP----LSSENTRHLLVCFLWVLKNLERNVLYRWLMD 1296
            ::.||.|  |...|:...:......::.:.    |.....|.||:|:|:::|.:..:.|..:...
Human  1253 SLIPEGATGFPDQGNTGENTRQSSTRSSVSQYNRLDQYEIRSLLMCYLYIVKMISEDTLLTYWNK 1317

  Fly  1297 LSPHRVHQMLQGVNVCLKTFEYTGQKNVATLKRTNTQSFRKTGSTDVKEKLEECIRGTNSARYDL 1361
            :||..:..:|..:.|||..|.|.|::|:|   |.:.....|....|.|.:....:|.        
Human  1318 VSPQELINILILLEVCLFHFRYMGKRNIA---RVHDAWLSKHFGIDRKSQTMPALRN-------- 1371

  Fly  1362 INRRKDRNSTEKFRWRKDQMPYRSQYADAVGKS---EH-----ELELSH--FIEGSLATEVALVL 1416
                           |...|..|.|:..::..|   .|     |.::.|  .:||:.||||:|.:
Human  1372 ---------------RSGVMQARLQHLSSLESSFTLNHSSTTTEADIFHQALLEGNTATEVSLTV 1421

  Fly  1417 LDTLEIIVHA-----AANLYHN-LLGTVLKVLLHSLSRNQSVLALQNLFASQRALIFKFPNLLFD 1475
            |||:......     ..|..|| |:..|..:.|..|...||.::|:::|||.||.|.|||:..|.
Human  1422 LDTISFFTQCFKTQLLNNDGHNPLMKKVFDIHLAFLKNGQSEVSLKHVFASLRAFISKFPSAFFK 1486

  Fly  1476 DETDICADLCLILLKHCGSLLPGIRSQAAASLYLLMRQNFEI--GNNFARVKMQVTMSLSSLVGT 1538
            ...::||..|..:||.|.|.:...|::|:|.||||||.|||.  ...|.|..:|:.:::|.|:..
Human  1487 GRVNMCAAFCYEVLKCCTSKISSTRNEASALLYLLMRNNFEYTKRKTFLRTHLQIIIAVSQLIAD 1551

  Fly  1539 SSVFSEQSLRRALKTVLVYAESDSDLQDTSFPEQVQDLLFNLHMILSDTVKMKEYQEDPEMLLDL 1603
            .::......:.:|..:..:|.||..::.|:||.:|:||...:..:|..|.:|||:::|||||:||
Human  1552 VALSGGSRFQESLFIINNFANSDRPMKATAFPAEVKDLTKRIRTVLMATAQMKEHEKDPEMLIDL 1616

  Fly  1604 MNRIAKGYQNNPDLRLTWLENMAKKHRERANHTEAAMCYVHAASLVSEYLSMLESQKHLPVGAVS 1668
            ...:||.|.:.|:||.|||::|||.|.:..:.:||||||||.|:||:|:   |..:|..|.|..:
Human  1617 QYSLAKSYASTPELRKTWLDSMAKIHVKNGDFSEAAMCYVHVAALVAEF---LHRKKLFPNGCSA 1678

  Fly  1669 FQRISPNTLMESAVSDDVLSPGEDGICLGNHFTETGLKALLEEASNSFQVAGMYEAMNEVYKILI 1733
            |::|:||...|.|:.       ||...:..|::|..|..|||:..:....|..||.::|:.|:::
Human  1679 FKKITPNIDEEGAMK-------EDAGMMDVHYSEEVLLELLEQCVDGLWKAERYEIISEISKLIV 1736

  Fly  1734 PICEANRDFQKLSKVHGKLQEAFNRISQLQ--GKRVFGTYFRVGFYGGK-FGDLDQQEFIYKEPT 1795
            ||.|..|:|:||::|:..|..|:.:|.::.  .||:.||:|||.|||.. |.:.|.:|:|||||.
Human  1737 PIYEKRREFEKLTQVYRTLHGAYTKILEVMHTKKRLLGTFFRVAFYGQSFFEEEDGKEYIYKEPK 1801

  Fly  1796 LTKLPEIFSRLQNFYTERFGPDSVHIIKDSNTVDINSLDPDKAYIQITYVEPYFETYEMRHRETY 1860
            ||.|.||..||...|.|:||.::|.||:||:.|:...|||..|:||:|||:|||:..|:..|:|.
Human  1802 LTGLSEISLRLVKLYGEKFGTENVKIIQDSDKVNAKELDPKYAHIQVTYVKPYFDDKELTERKTE 1866

  Fly  1861 FERNFNIKRFIYATPFTKNGKAHGELNEQCKRKTILTTANHFPYVKTRIMVISRQQIVLEPIEVA 1925
            ||||.||.||::..|:|.:||..|.:.|||||:|||||:|.|||||.||.:...|||.|:||:||
Human  1867 FERNHNISRFVFEAPYTLSGKKQGCIEEQCKRRTILTTSNSFPYVKKRIPINCEQQINLKPIDVA 1931

  Fly  1926 IEDIQKKTLELAAATNQEPADPKILQMVLQGCIGTTVNQGPMEMASVFLSNLSDGTTVPTKHQNK 1990
            .::|:.||.||....:....|...||:.||||:...||.||:..|..|| |.|..:..|.|..::
Human  1932 TDEIKDKTAELQKLCSSTDVDMIQLQLKLQGCVSVQVNAGPLAYARAFL-NDSQASKYPPKKVSE 1995

  Fly  1991 LRLCFREFSKRCADALKKNRNLILSDQKDYQRELERNNDRFIERLTPFI 2039
            |:..||:|.:.|:.||:.|..||..||.:|...|:.|....::.|:..|
Human  1996 LKDMFRKFIQACSIALELNERLIKEDQVEYHEGLKSNFRDMVKELSDII 2044

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ZirNP_608489.2 DUF3398 59..151 CDD:288711 26/95 (27%)
C2_Dock-C 589..769 CDD:176078 78/191 (41%)
DHR-2 1549..2037 CDD:284365 209/490 (43%)
DOCK11XP_005262425.1 DUF3398 54..145 CDD:288711 26/95 (27%)
PH_DOCK-D 161..284 CDD:270087 13/126 (10%)
PH 166..271 CDD:278594 10/108 (9%)
C2_Dock-D 639..828 CDD:176079 78/191 (41%)
DHR2_DOCK11 1628..2040 CDD:212573 183/422 (43%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165149365
Domainoid 1 1.000 61 1.000 Domainoid score I10448
eggNOG 1 0.900 - - E1_KOG1997
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG55633
OrthoDB 1 1.010 - - D20156at2759
OrthoFinder 1 1.000 - - FOG0000340
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100358
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X255
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
109.660

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