DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Zir and Dock9

DIOPT Version :9

Sequence 1:	NP_608489.2	Gene:	Zir / 33165	FlyBaseID:	FBgn0031216	Length:	2064	Species:	Drosophila melanogaster
Sequence 2:	XP_006518407.1	Gene:	Dock9 / 105445	MGIID:	106321	Length:	2142	Species:	Mus musculus

Alignment Length:	2345	Identity:	662/2345 - (28%)
Similarity:	1022/2345 - (43%)	Gaps:	558/2345 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 SAADVRKNVSGCHLSKAMDPSLCGSSISPTEPLDYEEFLSQHMNIINRDPLKHILDFPQGDVTVK 80
            |..|...:::.| |:|   |.|       .||||||..:.|....|..|.|:.:|.||..|....
Mouse    42 SKEDSELSIAFC-LAK---PKL-------IEPLDYENVIVQKKTQILNDCLREMLLFPYDDFQTA 95

  Fly    81 IIPRKIRTVDHVVP---NENLSDLPHHVQECVNCYTRPWKVVEYAQRHLSSSCYIRE------RI 136
            |:.|:.|.:...||   .|....|  .|.||:..|...|.:|.|.....|..  .|:      ::
Mouse    96 ILRRQGRYLRSTVPANAEEEAQSL--FVTECIKTYNSDWHLVTYKYEDYSGE--FRQLPNKVPKL 156

  Fly   137 DRGTISPSAYQQEFEIDKD-------------------------------FSSFEEAF------- 163
            |:  :....|:.:.|.|||                               ..||:..|
Mouse   157 DK--LPVHVYEVDEEADKDEDAASLGSQKGGITKHGWLYKGNMNSAISVTMRSFKRRFFHLIQLG 219

  Fly   164 -------AYKSESCTPSSRQSIASLASVSSCTDTL-TPRGSWASFDLRRS--------------- 205
                   .||.|..:...:.||    .:.||...: ..|....:|:|:..
Mouse   220 DGSYNLNFYKDEKISKEPKGSI----FLDSCMGVIQNNRVRRFAFELKMQDKSSYLLAADSEAEM 280

  Fly   206 ------VNDPLIPNL---------------------------LDNVPPEHIDQSNEA--RRQQDR 235
                  :|..|..|.                           ||:..||....:.||  :.:.:.
Mouse   281 EEWVTVLNKILQLNFEAAMQEKRNGDPHEDDEQSKLEGSGSGLDSYLPELAKSTREAEIKLKSES 345

  Fly   236 QMALFSLYPE------SEAEENIERRLLAEIPVEH-MGHRIQVNCLQLRLELE------------ 281
            ::.||.|.|:      |.||..::       |.|. .|.||.|.|..|...|:
Mouse   346 RVKLFYLDPDTQKLDFSSAEPEVK-------PFEEKFGKRILVKCNDLSFNLQCCVAENEEGPTT 403

  Fly   282 -VEPIFASMAIYDAKERQKISENFYFDMNADSLKRMLSSHVQCADISTQS--------HSA---- 333
             |||.|.:::::|.|..:|||.:|:.|:|..|:::||:..........||        |:|
Mouse   404 NVEPFFVTLSLFDIKYNRKISADFHVDLNHFSVRQMLTPTSPALMNGGQSPPAFQDALHTAMQYP 468

  Fly   334 ---IFEISYPSNDLFLVIRLEKVLQGDINNSVEPYLK-EDKDKYREKVKSNAVDYCERLGKYRMP 394
               ||.::.|..|:|||.|:||||||.|.:..|||:: .|..|..:||..||...|:|||:||||
Mouse   469 KQGIFSVTCPHPDIFLVARIEKVLQGSITHCAEPYMRSSDSSKVAQKVLKNAKQACQRLGQYRMP 533

  Fly   395 FAWTGIYLTNVFNGDNFESKDAGAAERDSFGNACGSSLGTAPSSNSLDRKSSTSSFDQLRRKAND 459
            |||                     |.|..|                                 .|
Mouse   534 FAW---------------------AARTLF---------------------------------KD 544

  Fly   460 MSGTLTRRGSLERKEKHRSWSPDDFANVVENFRPITITVPSFFKQEADKMKDEDLYKILPELKRP 524
            .||.|         :|:..:|                   :.::|:::|:.::|:.|:|.:.::|
Mouse   545 TSGNL---------DKNARFS-------------------AIYRQDSNKLSNDDMLKLLADFRKP 581

  Fly   525 SSVMKKYKCIPGSIKLEISPCVEEAKNALTPELAPINPQSADNVRPVK-EILEF----PQSAIYN 584
            .. |.|...|.|::.:.|.....:..|.|.....|:......:..|:. |:.||    |:..  .
Mouse   582 EK-MAKLPVILGNLDITIDSVSCDFPNYLNSSYIPMRQFETCSKSPITFEVEEFVPCIPKHT--Q 643

  Fly   585 PHYSYRNLLFVSPKELNFSSRA--GSARNIAVRVQLM-AGETPKDAVNAIYGKSSCPKFSTEAFT 646
            |:..|.|.|:|.||.|.:.|:.  ..|||||:.::.. :.|.....:..|||:...|.|:..|..
Mouse   644 PYTVYSNHLYVYPKYLKYDSQKSFAKARNIAICIEFKDSDEEDSQPLKCIYGRPGGPVFTRSALA 708

  Fly   647 AVNYHNKCPSFYDEIKIALPASIKQHHHLLFTIYHVSCQK------KPQDLQPSVETPIGYTWLP 705
            ||.:|.:.|.|||||||.|||.:.:.||||||.:||||..      |.:|   :|||.:|::|||
Mouse   709 AVLHHQQNPEFYDEIKIELPAQLHERHHLLFTFFHVSCDNSTKGSTKKKD---AVETQVGFSWLP 770

  Fly   706 LLEDGKLKFGEFNLPVMVESPPE--NYSFIPPNVHL-PGIKWLDNHRAVFSINVEAVTAIHTLDS 767
            ||:||::...|.::||....|..  .|..:....|. |.:||::..:.:..|:...|:.::|.|.
Mouse   771 LLKDGRVLTSEQHIPVSANLPSGYLGYQELGMGRHYGPEVKWVEGGKPLLKISTHLVSTVYTQDQ 835

  Fly   768 FLDRFFLICEYLDTRNIPSHIGENNIETELKKCLLDIEYANREPLVRHLPLVLDKLIELL--VVT 830
            .|..||..|:..::       |.....:||.|.|..:.......::..||.:|::|..:|  ...
Mouse   836 HLHNFFQYCQKTES-------GAQASGSELVKYLKSLHAMEGHVMIAFLPTILNQLFRVLTRATQ 893

  Fly   831 HKVGGQAMSLGSTVFEVLCLVSSLLSILNDDQYDQYGRQSLLSTYVHFQCKIPHPFQSKQRLTCS 895
            .:|   |:::...:..|:.            |..:.|.:|.|.:||.|..|
Mouse   894 EEV---AVNVTRVIIHVVA------------QCHEEGLESHLRSYVKFAYK-------------- 929

  Fly   896 RSTTEDLQLSESYTIYDNVLASGRSLDRKELSIDVLHSMAARDVQVRLLHEELALHWVVASGKAA 960
                     :|.|      :||                      :.:.:||||..........:|
Mouse   930 ---------AEPY------VAS----------------------EYKTVHEELTKSMTTILKPSA 957

  Fly   961 DLAMSN-----SWFLFELIVKSMIEHLHCSNTLNGPRKHRFPHQFNDDLSTLVHLVTTKVVGYHS 1020
            |...||     |||.|::::|||.:||..:|.:...|..|||..::..:.|:|:::...:.....
Mouse   958 DFLTSNKLLKYSWFFFDVLIKSMAQHLIENNKVKLLRNQRFPASYHHAVETVVNMLMPHITQKFR 1022

  Fly  1021 NEPKLAQSLNASLGFFIFDILSIMDRGFVFGLIKTYTKVLISKNASIPDLMNYKIDFLRIVCSHE 1085
            :.|:.:::.|.||..||....:.|||||||..|..|.......:..  .|..||.:|||:||:||
Mouse  1023 DNPEASKNANHSLAVFIKRCFTFMDRGFVFKQINNYISCFAPGDPK--TLFEYKFEFLRVVCNHE 1085

  Fly  1086 HFVALNL--PFGTSYTMVTAPCSPTPSTTSSNSQTSCGSLER----ALHADLSQEFLQQHFLVGL 1144
            |::.|||  |||.                        |.::|    .|...|:.||.:.||||||
Mouse  1086 HYIPLNLPMPFGK------------------------GRIQRYQDLQLDYSLTDEFCRNHFLVGL 1126

  Fly  1145 VLSDLAAVMEVPNPQLHGKAIRCIRNLMTSHDLDARYSETDARARVAALYIPLLSIVMDCIPQLH 1209
            :|.::...:: ...::...||..::||:..|..|.||:....:||:|.||:||..::::.:.:::
Mouse  1127 LLREVGTALQ-EFREVRVIAISMLKNLLIKHSFDDRYNSRSHQARIATLYLPLFGLLIENVQRIN 1190

  Fly  1210 -------------------------------------QHGLEQDRLQQIGQLEDYQGPHQTITAS 1237
                                                 .|.|.:|.|   |.:.....|:   |||
Mouse  1191 VRDVSPFPVNPGSIVKDEALAVPAGNPLMTPQKGNTLDHSLHKDLL---GAISGIASPY---TAS 1249

  Fly  1238 T--------------------------INPEVAFAISGSRPYSYLNEQVKNKLPLSSENTRHLLV 1276
            |                          .|||.:.::...:....|...|.....|.....:.||:
Mouse  1250 TPNINSVRNADSRGSLISTDSGNSLPDRNPEKSNSLDKQQQSGMLGNSVVRCDKLDQSEIKSLLM 1314

  Fly  1277 CFLWVLKNLERNVLYRWLMDLSPHRVHQMLQGVNVCLKTFEYTGQKNVATLKRTNTQSFRKTGST 1341
            |||:|||::..:.|:.:....|...:........|||..|:|.|::.:|    .|.:.....|..
Mouse  1315 CFLYVLKSMSDDALFTYWNKASTAELMDFFTISEVCLHQFQYMGKRYIA----RNQEGLGPIGHD 1375

  Fly  1342 DVKEKLEECIRGTNSARYDLINRRKDRNSTEKFRWRKDQM-------PYRSQYADAVGKSEHELE 1399
            ...:.|.                 ..||.|.....|..|:       .:...|    |.||.::.
Mouse  1376 RKSQTLP-----------------VSRNRTGMMHARLQQLGSLDNSVTFNHSY----GHSEADVV 1419

  Fly  1400 LSHFIEGSLATEVALVLLDTLEIIVHAAANLY-----HN-LLGTVLKVLLHSLSRNQSVLALQNL 1458
            ....:|.::||||.|..||||.:...|..|..     || |:..|..|.|..|.::||.:||:|:
Mouse  1420 HQSLLEANIATEVCLTALDTLSLFTLAFKNQLLADHGHNPLMKKVFDVYLCFLQKHQSEMALKNV 1484

  Fly  1459 FASQRALIFKFPNLLFDDETDICADLCLILLKHCGSLLPGIRSQAAASLYLLMRQNFEI--GNNF 1521
            |.:.|:||:|||:..::...|:||.||..:||.|.|.|..||::|:..||.|||.||:.  ..:|
Mouse  1485 FTALRSLIYKFPSAFYEGRADMCASLCYEVLKCCNSKLSSIRTEASQLLYFLMRNNFDYTGKKSF 1549

  Fly  1522 ARVKMQVTMSLSSLVGTSSVFSEQSLRRALKTVLVYAESDSDLQDTSFPEQVQDLLFNLHMILSD 1586
            .|..:||.:|:|.|:...........:::|..:...|.||..::.|||...|:||...:..:|..
Mouse  1550 VRTHLQVIISVSQLIADVVGIGGTRFQQSLSIINNCANSDRIIKHTSFSSDVKDLTKRIRTVLMA 1614

  Fly  1587 TVKMKEYQEDPEMLLDLMNRIAKGYQNNPDLRLTWLENMAKKHRERANHTEAAMCYVHAASLVSE 1651
            |.:|||::.|||||:||...:||.|.:.|:||.|||::||:.|.:..:.:||||||||..:||:|
Mouse  1615 TAQMKEHENDPEMLVDLQYSLAKSYASTPELRKTWLDSMARIHVKNGDLSEAAMCYVHVTALVAE 1679

  Fly  1652 YLSMLES----QKHLPV-------------------GAVSFQRISPNTLMESAVSDDVLSPGEDG 1693
            ||:..|:    |:..|.                   |..:|:.|:||...|:::.:||   |...
Mouse  1680 YLTRKEADLALQREPPAFPYSHSTCQRKSWGGMFRQGCTAFRVITPNIDEEASMMEDV---GMQD 1741

  Fly  1694 ICLGNHFTETGLKALLEEASNSFQVAGMYEAMNEVYKILIPICEANRDFQKLSKVHGKLQEAFNR 1758
            :    ||.|..|..|||:.::....|..||.:.::||::|||.|..|||::|:.::..|..|:::
Mouse  1742 V----HFNEDVLMELLEQCADGLWKAERYELIADIYKLIIPIYEKRRDFERLAHLYDTLHRAYSK 1802

  Fly  1759 ISQL--QGKRVFGTYFRVGFYG---------------GKFGDLDQQEFIYKEPTLTKLPEIFSRL 1806
            ::::  .|:|:.||||||.|:|               |.|.|.|.:|:|||||.||.|.||..||
Mouse  1803 VTEVMHSGRRLLGTYFRVAFFGQAAQYQFTDSETDVEGFFEDEDGKEYIYKEPKLTPLSEISQRL 1867

  Fly  1807 QNFYTERFGPDSVHIIKDSNTVDINSLDPDKAYIQITYVEPYFETYEMRHRETYFERNFNIKRFI 1871
            ...|:::||.::|.:|:||..|:...||...||||:|:|.|:|:..|::.|.|.|||..||:||:
Mouse  1868 LKLYSDKFGSENVKMIQDSGKVNPKDLDSKFAYIQVTHVTPFFDEKELQERRTEFERCHNIRRFM 1932

  Fly  1872 YATPFTKNGKAHGELNEQCKRKTILTTANHFPYVKTRIMVISRQQIVLEPIEVAIEDIQKKTLEL 1936
            :..|||:.||..|.:.|||||:||||..:.|||||.||.|:.:....|.||||||:::.||..||
Mouse  1933 FEMPFTQTGKRQGGVEEQCKRRTILTAIHCFPYVKKRIPVMYQHHTDLNPIEVAIDEMSKKVAEL 1997

  Fly  1937 AAATNQEPADPKILQMVLQGCIGTTVNQGPMEMASVFLSNLSDGTTVPTKHQNKLRL---CFREF 1998
            ....:....|...||:.|||.:...||.||:..|..||    |.|.......||::|   .||:|
Mouse  1998 RQLCSSAEVDMIKLQLKLQGSVSVQVNAGPLAYARAFL----DDTNTKRYPDNKVKLLKEVFRQF 2058

  Fly  1999 SKRCADALKKNRNLILSDQKDYQRELERN--------NDRFIERLTPFITLTSVQNHGVVKANAY 2055
            .:.|..||..|..||..||.:||.|::.|        :|...|::.|....|||..:.:...||.
Mouse  2059 VEACGQALAVNERLIKEDQLEYQEEMKANYREMAKELSDIMREQICPLEEKTSVLPNSLHIFNAI 2123

  Fly  2056 NNKST 2060
            :...|
Mouse  2124 SGTPT 2128

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zir	NP_608489.2	DUF3398	59..151	CDD:288711	25/100 (25%)
		C2_Dock-C	589..769	CDD:176078	70/191 (37%)
		DHR-2	1549..2037	CDD:284365	205/538 (38%)
Dock9	XP_006518407.1	DUF3398	57..167	CDD:371776	34/122 (28%)
		PH_DOCK-D	181..304	CDD:270087	16/126 (13%)
		C2_Dock-D	648..837	CDD:176079	70/191 (37%)
		DHR2_DOCK9	1644..2098	CDD:212571	177/464 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839420
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1997
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55633
OrthoDB	1	1.010	-	-		D20156at2759
OrthoFinder	1	1.000	-	-		FOG0000340
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100358
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X255
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.660