Protein Alignment Zir and dock3

DIOPT Version :9

• Sequence 1: NP_608489.2
• Gene: Zir / 33165
• FlyBaseID: FBgn0031216
• Length: 2064
• Species: Drosophila melanogaster
• Sequence 2: XP_017208903.1
• Gene: dock3 / 100536057
• ZFINID: ZDB-GENE-100624-1
• Length: 2108
• Species: Danio rerio
• Alignment Length: 1925
• Identity: 351/1925 - (18%)
• Similarity: 643/1925 - (33%)
• Gaps: 635/1925 - (32%)

  Fly   191 LTPRGSWASFDLRRSVNDPLIPNLLDNVPPEHIDQSNEARRQQDRQMALFSLY----------PE 245
            :|.|..|.:..|.           ||.||.:..:..:.      .|:::..||          .:
Zfish   146 ITVRLDWGNEHLG-----------LDLVPRKEFEMVDA------DQISVSDLYKMHLSSRHSVQQ 193

  Fly   246 SEAEENIERR--LLAEIPVEHMGHRIQVNCLQLRLELEVEPIFASMAIYDAKERQKISENFYFDM 308
            |.:::...:|  ....:||.   |.:.||..........|......::||.:|.::|||.|...:
Zfish   194 STSQDGGRQRHGETCRMPVP---HHLFVNLKSFTYNTIGEDTDIFFSLYDLREGKQISEKFMVKL 255

  Fly   309 -------NADSLKRMLSSHVQCA---DISTQSHSAIFEISYPSNDLFL---VIRLEKVLQGDINN 360
                   |.:.:.|:      ||   |:|.:.         ...||::   |||..::|..|...
Zfish   256 NKNGGPKNPEKVDRL------CALFTDLSNKD---------MKRDLYIVSQVIRTGRMLLNDSKK 305

  Fly   361 SV------EPY----------------LKEDKDKYREKVKSNAVDYCERLGKYRMPFAWTGIYLT 403
            ..      .||                |||:|| :..||.:     |....:      |..|:
Zfish   306 GPPHVQYRRPYGCAVLAMSDVLQTISELKEEKD-FVLKVYT-----CNNENE------WYQIH-- 356

  Fly   404 NVFNGDNFESKDAGAAERDSFGNACGSSLGTAPSSN-----SLDRKSSTSSFDQLRRKANDMSGT 463
                 :|...|              .|:..||||:|     ||          ||
Zfish   357 -----ENIIRK--------------SSTKYTAPSTNYGLIISL----------QL---------- 382

  Fly   464 LTRRGSLERKEKHRSWSPDDFANVVENFRPITITVPSFFKQEADKMKDEDLYKILPELKRPSSVM 528
              .||.:|:..:             ||        |..|.:..         .|..:|..|..:|
Zfish   383 --LRGDMEQVRR-------------EN--------PMIFNRGV---------AITRKLGFPDVIM 415

  Fly   529 KKYKCIPGSIKLEISPCVEEAKNALTPELAPINPQSADNVRPVKEILEFPQSAIYNPHYSYRNLL 593
                  ||.|                                                   ||.|
Zfish   416 ------PGDI---------------------------------------------------RNDL 423

  Fly   594 FVSPKELNFSSRAGSA--RNIAVRVQLM--AGETPKDAVNAIYGKSSCPKFSTEAFTAVNYHNKC 654
            :::.:..:| .|.|.:  :||.|.:.::  .||..|:.::...|:.:..::.    :.|.|||..
Zfish   424 YLTLERGDF-ERGGKSVQKNIEVTMYVLYADGEILKECISLGSGEHNISEYR----SFVLYHNNS 483

  Fly   655 PSFYDEIKIALPASIKQHHHLLFTIYHVSCQKKPQDLQPSVETPIGYTWLPLLEDGKLKFGEFNL 719
            |.:.:.:|:.:|....:..||.|...|.|.:.|.:      :...|:.:.||:.:......:.:.
Zfish   484 PRWSEVVKLPIPIDRFRGSHLRFEFRHCSTKDKGE------KKLFGFAFTPLMREDGTTLSDESH 542

  Fly   720 PVMVESPPENYSFIPPNVHL------------PGIKWLDNHRAVFSINVEAVTAIHT------LD 766
            .:.|....||.:|....::|            |.|.    ...:|..:.:....|.|      |.
Zfish   543 ELYVYKCDENTTFSNHALYLGLPCCKDDFNGCPNIP----SSLIFQRSTKETLWISTQLSSTKLT 603

  Fly   767 SFLDRFFLICEYLDTRNIPSHIGENNIETELKKCLLDI----EYANREPLVRHLPLVLDKLIELL 827
            ..:|...|    |..:..|.|:             :||    .:...|.:|:.|..:||.|..:|
Zfish   604 QNVDLLAL----LKWKAHPDHV-------------MDILGRLRHVCGEEIVKFLQDILDTLFSIL 651

  Fly   828 VVTHKVGGQAMSLGSTVFEVLCLVSSLLSILNDDQYDQYGRQSLLSTYV--HFQCKIPHPFQSKQ 890
                  .......|..||:.|..:   :::|.|.::  |..:.::.||:  ||...:.:    |:
Zfish   652 ------DDNTDKYGPLVFQSLVFI---INLLRDSKF--YHFRPVMDTYIQKHFAGALAY----KE 701

  Fly   891 RLTCSRSTTEDLQLSESYTIYDNVLASGRSLD---RKELSIDVLHSMAA---RDVQVRLLHEEL- 948
            .:.|.:..   :..|......|::..:.|:|:   :..:...:|:|.|.   .:.|.|...:||
Zfish   702 LIRCLKWY---MDRSAEVVRQDHIQEAMRALEYLFKFIVQSRILYSRATCGMEEDQFRASIQELF 763

  Fly   949 -ALHWVVA------------SGKAADL--AMSNSWFLFELIVKSMIEHLHCSNTLNGPRK----- 993
             ::.:|::            .|..|..  |.:|.        .:.::.|.|    |.||.
Zfish   764 QSIRFVLSLDSRSSETLIFTQGPQATTGQASTNQ--------GNCLQPLSC----NAPRPSPLSA 816

  Fly   994 ---HRFPHQFNDDLSTLVHLVTTKVVGYHSNEPKLAQSLNASLGFFIFDILSIMDRGFVFGLIK- 1054
               :.||..|::    |:.:.|.:         ::|:.:..:||    .:.|.:..|....::|
Zfish   817 ALLNSFPAIFDE----LLQMFTVQ---------EVAEFVRGTLG----SMPSTVHIGQSMDVVKL 864

  Fly  1055 -TYTKVLISKNASIPDLMNYKIDFLRIVCSHEHFVALNLPFGTSYTMVTAPCSPTPSTTSSNSQT 1118
             :..:.:.|:..|.|:....   .|.:|..|.|   |:|.......:    ||...|:..|..::
Zfish   865 QSIARTVDSRLFSFPESRRI---LLPVVLHHIH---LHLRQQKELLI----CSGILSSIFSIIKS 919

  Fly  1119 SCGSLERALHADLSQEFLQQHFLVGLVLSDLAAVMEVPNPQLHGKAIRCIRNLMTSHDLDARYSE 1183
            |  |||.::..::.   :....|:.::|..|.|:|.....|...:..||
Zfish   920 S--SLESSVQEEVE---MMVESLLDVLLQTLLAIMSKSQSQEAVRGQRC---------------- 963

  Fly  1184 TDARARVAALYIPLLSIVMDCIPQLH-QHGLEQDRLQQIGQLEDYQGPHQTITASTINPEVAFAI 1247
            ....|.:...|:..|..::..:..:| ||           .|:::|
Zfish   964 PQCTAEITGEYVSCLLSLLRQMSDIHFQH-----------LLDNFQ------------------- 998

  Fly  1248 SGSRPYSYLNEQVKNKLPLSSENTRHLLVCFLWVLKNLERNVLY--RWLMDLSPHRVHQMLQGVN 1310
                               |.|..:..|:....|.:||.:..::  .|       .|.::|.. |
Zfish   999 -------------------SKEELKEFLLKIFCVFRNLMKLSIFPRDW-------NVMRLLTS-N 1036

  Fly  1311 VCLKTFEYTGQKNVATLKRTNTQSFRKTGSTDVKE-----KLEECIRGTNSARYDLINRRKDRNS 1370
            :.:.|.:|..    ..|.::.|.:     ..|.|.     .|........|.:.:.:...|.:..
Zfish  1037 IIVSTTQYLS----PALHKSFTDA-----DFDFKVWNSYFSLAVLFINQPSLQLETLTPAKRKKV 1092

  Fly  1371 TEKFRWRKDQMPYR--SQYADAVGKSEHELELSHFIEGSLATEVALVLLDTLEIIVHAAANLYHN 1433
            .:|:...:..|.|.  |.:.: :|:::     .|||.|.:...:.:.|:...|:         .|
Zfish  1093 FDKYGDMRVMMAYELFSMWQN-LGENK-----IHFIPGMIGPFLGVTLVPQNEV---------RN 1142

  Fly  1434 LLGTVLKVLLHSLSRNQSVLALQNLFASQRALIFKFPNLLFDDETDICADLCLILLKHCGSLLPG 1498
            ::..:...::....|...     |....:..||.|..:|:.:.:.|
Zfish  1143 IMIPIFHDMMDWEQRKNG-----NFKQVEAELIDKLDSLVSEGKGD------------------- 1183

  Fly  1499 IRSQAAASLYLLMRQNFEIGNNFARVKMQVTMSLSSLVGTSSVFSEQSLRRALKTVLVYAESDSD 1563
               :....|:.|:.|.|   ..:..:..::........|.|.|   .|:.|.::.:|.|.:.
Zfish  1184 ---ENYRELFSLLTQLF---GPYPSLLEKIEQETWRETGISFV---TSVTRLMERLLDYRDC--- 1236

  Fly  1564 LQDTSFPEQVQDLLFNLHMILSDTVKMKEYQEDPEML---LDLMNRIAKGYQNNPDLRLTWLENM 1625
                                      ||..:.:.:.:   ::|:| ..|...|..::.:.::..:
Zfish  1237 --------------------------MKGDETENKKIGCTVNLLN-FYKSEINKEEMYIRYIHKL 1274

  Fly  1626 AKKHRERANHTEAAMCYVHAASLVSEYLSMLESQKHLPVGAVSFQRISPNTLMESAVSDDVLSPG 1690
            ...|.:..|:||||...:....|:......|....|.|..: .:.|
Zfish  1275 CDMHLQAENYTEAAFTLLLYWELLHWEERPLREFLHYPAQS-EWHR------------------- 1319

  Fly  1691 EDGICLG-NHFTETGLKALLEEASNSFQVAGMYEAMNEVYKILIPIC-------EANRDFQKLSK 1747
            ::|:|.. .|:...|                      :.::..||:|       |:..|:|.||.
Zfish  1320 KEGLCRKVIHYFNKG----------------------KCWEYGIPLCRELAFQYESLYDYQSLSW 1362

  Fly  1748 VHGKLQEAF--NRISQLQGKRVFGTYFRVGFYGGKFG-DLDQQEFIYKEPTLTKLPEIFSRLQNF 1809
            :. |::.|:  |.:.|   :|:...:|||||||.||. .|..:||:.:       ...:.||:.|
Zfish  1363 IR-KMEAAYYDNIMEQ---QRLEPEFFRVGFYGRKFPFFLRNKEFVCR-------GHDYERLEAF 1416

  Fly  1810 YTERFG--PDSVHIIKDSNTVDINSLDPDKAYIQITYVEPYFETYEMRH------RETYFERNFN 1866
            .....|  |.:: .::..|..|...|..|..|:||..|....|..::..      |...|.|..|
Zfish  1417 QQRMLGEFPQAI-AMQHPNQPDEGILQGDAQYLQIYAVSAVPENMDVLQMDRVPDRIKSFYRVNN 1480

  Fly  1867 IKRFIYATPFTKNGK-AHGELNEQCKRKTILTTANHFPYVKTRIMVISRQQIVLEPIEVAIEDIQ 1930
            ::||.|..||.|..| ...|.......:|.|...:..|.:.....|..|:.:.:.|:|.||..::
Zfish  1481 VRRFRYDRPFHKGPKDRENEFKSLWIERTTLILTHPLPGISRWFEVDKRELVEVSPLENAIYVVE 1545

  Fly  1931 KKTLELAAATNQEP-----ADPKILQMVLQGCIGTTVNQG 1965
            .|..||....:|..     .:..:|.|.|.|.|...||.|
Zfish  1546 NKNQELRTLISQYQHKQLHGNINLLSMCLNGVIDAAVNGG 1585

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Zir	NP_608489.2	DUF3398	59..151	CDD:288711
		C2_Dock-C	589..769	CDD:176078	40/201 (20%)
		DHR-2	1549..2037	CDD:284365	96/445 (22%)
dock3	XP_017208903.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583535
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1997
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740