Protein Alignment Zir and dock11

DIOPT Version :9

• Sequence 1: NP_608489.2
• Gene: Zir / 33165
• FlyBaseID: FBgn0031216
• Length: 2064
• Species: Drosophila melanogaster
• Sequence 2: XP_031747276.1
• Gene: dock11 / 100498640
• XenbaseID: XB-GENE-921713
• Length: 2072
• Species: Xenopus tropicalis
• Alignment Length: 2264
• Identity: 668/2264 - (29%)
• Similarity: 1043/2264 - (46%)
• Gaps: 451/2264 - (19%)

  Fly     3 SAQRSFVQKVSKQ-SAADVRKNVSGCHLSKAMDPSLCGSSISPTEPLDYEEFLSQHMNIINRDPL 66
            |..|.|.:::|:. :||::|::|     |:|:..|:........||||||..:||....|..||.
 Frog     2 SEVRKFTKRLSRPGTAAELRQSV-----SEAVRSSVILEKARVVEPLDYEAVISQRKAQIYSDPH 61

  Fly    67 KHILDFPQGDVTVKIIPRKIRTVDHVVPNENLSDLPH-HVQECVNCYTRPWKVVEYAQRHLSSSC 130
            :.:|.||..||.:.|:.|:.|||..:||::..::... .|:||:..||..||||.|.....|.
 Frog    62 RDMLMFPMEDVFISIVDRQWRTVQSMVPDDAENEARSLFVKECIKYYTSDWKVVNYKYEEYSG-- 124

  Fly   131 YIRERIDRGTISPSAYQQE------FEIDKDFSSFEEAF-------------------------- 163
                  |...:...:::.|      ||||:||...|::.
 Frog   125 ------DFRALPCKSFRPEKIPNHIFEIDEDFDKDEDSASICSQKGGVIKQGWLNKANIGTTIPV 183

  Fly   164 -----------------------AYKSESCTPSSRQSIASLASVSSCTDT-LTPRGSWASFDLRR 204
                                   :||.|..:..|:..|    .:.||.|. |.|:....:|:||.
 Frog   184 TMKVFRRRYFYLTQLPDGSYILNSYKDEKNSKDSKGCI----FLDSCIDVILCPKMRRNAFELRM 244

  Fly   205 ---------------------------SVN-DPLIPNLLDNVPPEHIDQSNEARRQQDRQMALF- 240
                                       .:| |.|:....|.|.|...|:::..:.:.:..|...
 Frog   245 LDKSSHYLAAETEQEMEEWLLTLKKIIQINADSLVQEKKDTVDPVQDDEASSGQGKSENIMESLE 309

  Fly   241 -SLYPE----------------SEAEENI-------ERRLLAEI-----PVEHMG-HRIQVNCLQ 275
             |::||                ||..:||       :|...:.|     |.|..| .|....|..
 Frog   310 RSMHPELMKYGKETEHLNKLSRSEGRQNIFSFDSEVQRLDFSFIEPDIRPFEEKGSQRFIAKCQD 374

  Fly   276 LRLEL-------------EVEPIFASMAIYDAKERQKISENFYFDMNADSLKRMLSSHVQCADIS 327
            |...:             .|||.|.::|::|.|...|||.:|:.|:|..:::.||.:....:|..
 Frog   375 LVFSVLGNVNDKPDGPLTNVEPFFVTLALFDVKNNCKISADFHVDLNPPAVREMLPNISVQSDKG 439

  Fly   328 TQSHSA---------------------IFEISYPSNDLFLVIRLEKVLQGDINNSVEPYLK-EDK 370
            ..|..|                     :|.::.|..::|||.|:||||||:|.:..|||:| .|.
 Frog   440 NNSRRASVSENLIHGIPELHFLDIKEGVFSVTNPHPEIFLVARVEKVLQGNITHCAEPYMKNSDP 504

  Fly   371 DKYREKVKSNAVDYCERLGKYRMPFAWTGIYLTNVFNGDNFESKDAGAAERDSFGNACGSSLGTA 435
            .|..:||..||...|.|||:||||.||                     |.|..|
 Frog   505 TKTAQKVLKNAKLACSRLGQYRMPLAW---------------------AARQVF----------- 537

  Fly   436 PSSNSLDRKSSTSSFDQLRRKANDMSGTLTRRGSLERKEKHRSWSPDDFANVVENFRPITITVPS 500
                                  .|..|||    ..|.|                 |.|:
 Frog   538 ----------------------KDTQGTL----DTEAK-----------------FSPL------ 553

  Fly   501 FFKQEADKMKDEDLYKILPELKRPSSVMKKYKCIPGSIKLEISPCVEEAKNALTPELAPINPQSA 565
             :||::.|:..|||.::|.|.::|..  .|.:.|||.:.:.:.....:..|.:|....||.|.:.
 Frog   554 -YKQDSSKLSTEDLLRLLTEYRKPEK--SKLQVIPGQLIVSVDCIPIDFSNCVTSSYVPIKPYNT 615

  Fly   566 DNVRPVKEILEF-PQSAIY-NPHYSYRNLLFVSPKELNFSSRA--GSARNIAVRVQLMAGETPK- 625
            ::.....|:.|| |:...| .|..||:|..:|.|..|.:.::.  ..||||||.::....:.|.
 Frog   616 ESPGIAVEVEEFVPEITKYCYPFTSYKNHFYVYPLHLKYDNQKTFAKARNIAVLIEFRDSDEPDC 680

  Fly   626 DAVNAIYGKSSCPKFSTEAFTAVNYHNKCPSFYDEIKIALPASIKQHHHLLFTIYHVSCQ---KK 687
            .|:..||||...|.|:..|:..|.:||:.|.||||||:.||..:.|.||||||.|||||.   |.
 Frog   681 QALKCIYGKPGVPVFTRNAYAVVLHHNQSPEFYDEIKLELPLHLHQKHHLLFTFYHVSCDISAKG 745

  Fly   688 PQDLQPSVETPIGYTWLPLLEDGKLKFGEFNLPVMVESPPENYSFIPPNVHLPG--IKWLDNHRA 750
            ......:.|||:||:|:|||:||::...|..|||....|....|...|:....|  |||:|..:.
 Frog   746 SSKKNENPETPVGYSWVPLLKDGRIMTSEQQLPVSANLPAGYLSCCNPDAKKVGGDIKWVDGAKP 810

  Fly   751 VFSINVEAVTAIHTLDSFLDRFFLICEYLD--TRNIPSHIGENNIETELKKCLLDIEYANREP-L 812
            :|.|.....:.::|.|..|..||..|:.:.  ::::|..:      .:..|||    :|...| :
 Frog   811 LFKIRSHLKSTVYTQDLHLHNFFNYCQLVQSGSKDLPGEM------VKYLKCL----HAMEVPVM 865

  Fly   813 VRHLPLVLDKLIELL-VVTHKVGGQAMSLGSTVFEVLCLVSSLLSILNDDQYDQYGRQSLLSTYV 876
            ::.||::|.:|.::| .|:|:   ..::|..|:     ::..::|..:::..|.|     |.:|:
 Frog   866 IQFLPVILTQLFQVLTTVSHE---DEVALNCTL-----VLLHIVSKCHEEGLDHY-----LRSYL 917

  Fly   877 HFQCKIPHPFQSKQRLTCSRSTTEDLQLSESYTIYDNVLASGRSLDRKELSIDVLHSMAARDVQV 941
            .:..:|       ::.:.|.|
 Frog   918 KYVFRI-------EKSSSSNS-------------------------------------------- 931

  Fly   942 RLLHEELALHWVVASGKAADLAMSN-----SWFLFELIVKSMIEHLHCSNTLNGPRKHRFPHQFN 1001
            |.:||.||:..:....::||....|     |||.||.:.|:|...|...|.:..||..|||..:.
 Frog   932 RPMHEILAITMITVLKQSADFLAINKLLKYSWFFFEALAKAMALFLIEENKIKTPRPQRFPEAYQ 996

  Fly  1002 DDLSTLVHLVTTKVVGYHSNEPKLAQSLNASLGFFIFDILSIMDRGFVFGLIKTYTKVLISKNAS 1066
            :.|.:|:..:...|...:....:.::::|.||..||...|:.|||||||.||..|......|:..
 Frog   997 NVLHSLLLSIIPHVTIRYGEIQEESRNVNFSLANFIKRCLTFMDRGFVFNLINDYMSGFSLKDPK 1061

  Fly  1067 IPDLMNYKIDFLRIVCSHEHFVALNLPFGTSYTMVTAPCSPTPSTTSSNSQTSCGSLERALHADL 1131
            |  |..||.:||:.:||||||:.||||...:.|.:.     ......|.:.....||:..|...|
 Frog  1062 I--LAEYKFEFLQTICSHEHFIPLNLPMVFAKTKLL-----RVQDLLSYAVERFTSLDINLECSL 1119

  Fly  1132 SQEFLQQHFLVGLVLSDLAAVMEVPNPQLHGKAIRCIRNLMTSHDLDARYSETDARARVAALYIP 1196
            :.::.:.||||||:|.::..|:: .|..:...||..::.::..|..|.||...:.:|::|.||:|
 Frog  1120 TDDYCRNHFLVGLLLREVQQVLQ-ENYDIRYIAISTLKQILIKHAFDNRYQHKNQQAKIAQLYLP 1183

  Fly  1197 LLSIVMDCIPQL----------------------------HQHGLEQDRLQQIGQL--------E 1225
            |:::::..:.:.                            ::..|..|:......:        |
 Frog  1184 LIAMLLGNVSRFAGRDTLYHCAAMSTSVSRDSFICNFTSSNRSSLIMDKDTGCSSISNGYILNRE 1248

  Fly  1226 DYQG-------PHQTITASTINPEVAFAISGSRPYSYLNEQVKNKLPLSSENTRHLLVCFLWVLK 1283
            |.:|       ..||.|..  |.......|....||.|:          |...:.||:|:|::.|
 Frog  1249 DSRGSLYIDGATEQTATGE--NMRRCSTKSSVSQYSRLD----------SYEIKSLLICYLYIAK 1301

  Fly  1284 NLERNVLYRWLMDLSPHRVHQMLQGVNVCLKTFEYTGQKNVATLKRTNTQSFRKTGSTDVKEKLE 1348
            .:..::|..:...::|..:...|..:.|||..|.|||::|:|   |.......|..:.|.|.:..
 Frog  1302 VISDDLLVSYWNKITPPELLSFLTLLEVCLFHFRYTGKRNIA---RVQDVWMSKHFAGDRKSQTM 1363

  Fly  1349 ECIRGTNSARYDLINRRKDRNSTEKFRWRKDQMPYRSQYADAVGKSEHELELSH--FIEGSLATE 1411
            ..:|....|    |..|....|:           ..|.:...:..|..|.::.|  .:||:.|||
 Frog  1364 PALRSRTGA----IQARLQHLSS-----------LESSFTLNLSSSTTEADIIHQALLEGNCATE 1413

  Fly  1412 VALVLLDTLEIIVHAAANLY-----HN-LLGTVLKVLLHSLSRNQSVLALQNLFASQRALIFKFP 1470
            |:|.:|||:...........     || |:..:|.:.|..|...||.:.|:::|||.|:.|.|||
 Frog  1414 VSLTVLDTISFFTQTFRTQLLNTECHNPLMKKILDIYLAFLKNGQSEMCLKHVFASLRSFISKFP 1478

  Fly  1471 NLLFDDETDICADLCLILLKHCGSLLPGIRSQAAASLYLLMRQNFEI--GNNFARVKMQVTMSLS 1533
            :..|....::|:..|..:||.|.|.|...|::|:|.||||||.|||.  ...|.|..:|:.:::|
 Frog  1479 SAFFKGRVNMCSAFCYEVLKCCTSKLSSTRNEASALLYLLMRNNFEFTKRKTFLRTHLQIIIAVS 1543

  Fly  1534 SLVGTSSVFSEQSLRRALKTVLVYAESDSDLQDTSFPEQVQDLLFNLHMILSDTVKMKEYQEDPE 1598
            .|:...::......:.:|..:..:|.||..::.||||.:|:||...:..::..|.:|||:::|||
 Frog  1544 QLIADVALSGGSRFQESLSIINNFANSDKAMKATSFPSEVKDLTKKIRTVIMATAQMKEHEKDPE 1608

  Fly  1599 MLLDLMNRIAKGYQNNPDLRLTWLENMAKKHRERANHTEAAMCYVHAASLVSEYLSMLESQKHLP 1663
            ||:||...:||.|.:.|:||.||||:|||.|.:..:::|||||.:|.|:||:|:|.   .:|...
 Frog  1609 MLIDLQYSLAKSYASTPELRKTWLESMAKIHTKNGDYSEAAMCSIHVAALVAEFLL---RKKLFH 1670

  Fly  1664 VGAVSFQRISPNTLMESAVSDDVLSPGEDGICLGNHFTETGLKALLEEASNSFQVAGMYEAMNEV 1728
            .|..:|::|:||...|:|:.       ||...:..:::|..|..|||:..:....|..||.::||
 Frog  1671 CGCSAFKKITPNIDEEAAMK-------EDAGMMDVYYSEEVLVELLEQCVDGLWKAERYETISEV 1728

  Fly  1729 YKILIPICEANRDFQKLSKVHGKLQEAFNRISQLQ--GKRVFGTYFRVGFYG-GKFGDLDQQEFI 1790
            .|:||||.|..|:|:||::::..|..|:.:|.::.  |||:.||||||.||| ..|.|.|.:|:|
 Frog  1729 SKLLIPIYEKKREFEKLTQLYRTLHGAYTKILEVMQTGKRLLGTYFRVAFYGQAFFEDEDGKEYI 1793

  Fly  1791 YKEPTLTKLPEIFSRLQNFYTERFGPDSVHIIKDSNTVDINSLDPDKAYIQITYVEPYFETYEMR 1855
            ||||.||.|.||..||.|.|.|:||.::|.||:|||.|:...||...|:||:|||:||||.:::.
 Frog  1794 YKEPKLTGLSEISLRLLNLYGEKFGTETVKIIQDSNKVNAKDLDLKFAHIQVTYVKPYFEEHDLS 1858

  Fly  1856 HRETYFERNFNIKRFIYATPFTKNGKAHGELNEQCKRKTILTTANHFPYVKTRIMVISRQQIVLE 1920
            .|.|.||:|.||.||::.||:|.:||.||.:.||||::|||||:|.|||||.||.||...|:.|.
 Frog  1859 DRRTDFEKNHNIARFVFETPYTLSGKKHGCVEEQCKKRTILTTSNSFPYVKKRIPVIYEHQVDLM 1923

  Fly  1921 PIEVAIEDIQKKTLELAAATNQEPADPKILQMVLQGCIGTTVNQGPMEMASVFLSNLSDGTTVPT 1985
            |::|||::|::||.:|.........|...||:.||||:...||.||:..|..||.: |..:..|.
 Frog  1924 PVDVAIDEIKEKTADLQKICASPDIDMIQLQLKLQGCVSVQVNAGPLAYARAFLED-SQSSKYPN 1987

  Fly  1986 KHQNKLRLCFREFSKRCADALKKNRNLILSDQKDYQRELERNNDRFIERLTPFI 2039
            |...:|:..|:.|.:.|:.||..|..||..||.:||..|:.|....::.|:..|
 Frog  1988 KKIKELKDIFKHFIQACSIALDLNERLIKDDQIEYQEGLKSNFRDMVKELSEII 2041

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Zir	NP_608489.2	DUF3398	59..151	CDD:288711	28/98 (29%)
		C2_Dock-C	589..769	CDD:176078	72/187 (39%)
		DHR-2	1549..2037	CDD:284365	210/490 (43%)
dock11	XP_031747276.1	DUF3398	39..147	CDD:403173	38/115 (33%)
		PH_DOCK-D	161..283	CDD:270087	16/125 (13%)
		C2_Dock-D	641..829	CDD:176079	72/187 (39%)
		DHR2_DOCK	1625..2037	CDD:414667	184/422 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	64	1.000	Domainoid score	I9945
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55633
OrthoDB	1	1.010	-	-		D20156at2759
OrthoFinder	1	1.000	-	-		FOG0000340
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X255
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.930