Protein Alignment Zir and dock5

DIOPT Version :10

• Sequence 1: NP_608489.2
• Gene: Zir / 33165
• FlyBaseID: FBgn0031216
• Length: 2064
• Species: Drosophila melanogaster
• Sequence 2: XP_004912607.1
• Gene: dock5 / 100488768
• XenbaseID: XB-GENE-490920
• Length: 1849
• Species: Xenopus tropicalis
• Alignment Length: 1997
• Identity: 370/1997 - (18%)
• Similarity: 653/1997 - (32%)
• Gaps: 693/1997 - (34%)

  Fly   331 HSAIFEISYPSNDLFLVIR-LEKVLQGDINNSVEPYLKEDKDKYREKVKSNAVDYCERLGKYRMP 394
            |::..:.|.....:||::. ..::|.|.:.       |:|..:.|:||.:. :||..|:
 Frog   107 HNSRLQFSQIQEMMFLLMEWRSQILSGTLP-------KDDLAELRKKVTAK-IDYGNRI------ 157

  Fly   395 FAWTGIYLT------NVFNGDN------FESKDAGAAERDSFGNACGSSLGTAPSSNSLDRKSST 447
               .|:.|.      |:.:.|.      :.|.::.:...|.......|.|      ..||.:||.
 Frog   158 ---LGLDLVVRDENGNILDPDETSIITLYRSHESASRRIDERIQEEKSQL------QPLDSRSSA 213

  Fly   448 --------SSFDQLRRKANDMSGTLTRRGSLERKEKHRSWSPDDFANVVENF--------RPITI 496
                    |.:..|:....:|........||        :.|||...:.|||        .|..|
 Frog   214 ILHMAHTYSLYVNLKNFVCNMGEDAELLMSL--------YDPDDSRFISENFLVRWGSSGMPKDI 270

  Fly   497 ----TVPSFFKQEADKMKDEDLYKILPELKRPSSVM----------KKYKC---IP-GSIKLEIS 543
                .:|:.|..    :...||  |.|.:.....::          ||:.|   .| |...::||
 Frog   271 EKLNNLPAVFTD----LSCSDL--IRPRISLVCQIVRVGHMELKDGKKHTCGLRRPFGVAVMDIS 329

  Fly   544 PCV-----EEAKNALTPELAPINPQSADNVRPVKEIL------------EFPQSAIYNPHYSYRN 591
            ..:     :|.|.    ...|....:.:|:...::::            ..|.:||||.
 Frog   330 DVIHGKVDDEEKQ----HFIPFQQMNKENLISQRQLIMSPLMASRAIAENEPLTAIYNK------ 384

  Fly   592 LLFVSPKELNFSSRA-----------------------------------------GSARNIAVR 615
              .::.||:|...:.                                         |..|| .:.
 Frog   385 --VIAAKEVNHKGQGLWISLKLLPGDLAQVQKEYSHLVDRSSAVARKMGFPEIILPGDVRN-DIY 446

  Fly   616 VQLMAGE-------TPK---------DAVNAIYGKSSCPKFSTEAFT----AVNYHNKCPSFYDE 660
            :.|:.||       |||         |...|:..|:..|....|..|    .|.|..|.|.:|:.
 Frog   447 ITLIQGEFDKGKKKTPKNVEVTLSVHDPDGALIEKAIHPGAGHEGLTEYKSVVYYQVKQPCWYET 511

  Fly   661 IKIALPASIKQHHHLLFTIYHVSCQKKPQDLQPSVETPIGYTWLPLLE-DGKLKFGEFNLPVMVE 724
            :|:::|.....|.||.||..|    :..|:.:...|...|..::.|:. ||.......:..::.:
 Frog   512 VKVSIPIEDVSHCHLRFTFRH----RSSQESRDKSEKVFGMGFVRLMNPDGTTLRDRIHDLIIYK 572

  Fly   725 SPPENYSFIPPNVHLPGIKWLDN--------HRAVFSINVEAVTAIHTLDSFLDRFFLICEYLDT 781
            ...:........:.|||.|..::        |.|       ::|.  |.||| ....|||....|
 Frog   573 GDSKKSDDAKLYLLLPGTKEEEDEDGRSQRGHSA-------SITP--TKDSF-QIGTLICSTKLT 627

  Fly   782 RNIPSHIGENN-------IETELKKCLLDIEYANREPLVRHLPLVLDKLIELLVVTHKVGGQAMS 839
            :|: ..:|..|       :...|:| |::::...   :::.|...||.|..:::.|    ....|
 Frog   628 QNV-DLLGLLNWRSNSRPVSQALRK-LMEVDGGE---IMKFLQDTLDALFNIMMET----PDKES 683

  Fly   840 LGSTVFEVLCLVSSLLSILNDDQYDQYGRQSLLSTYV--HFQCKIPHPFQSKQRLTCSRSTTEDL 902
            ....||:.|..:.||::   |.::..:  ..:|.||:  ||...:.:     :||         :
 Frog   684 CDVLVFDALVFIISLIA---DIKFQHF--NPVLETYITKHFSTTLAY-----ERL---------I 729

  Fly   903 QLSESYTIYDNVLASGRSLD---RKELSIDVLHSMAARDVQVRLLHEELALHWVVASGKAADLAM 964
            ::...|.         ||.|   |:|:....|.::.
 Frog   730 KVLSWYV---------RSADDPCRQEMLFSSLKAIK----------------------------- 756

  Fly   965 SNSWFLFELIVKSMIEHLHCSNTLNGPRKHRFPHQFNDDLSTLVHLVTTKVVGYHSNEPKLAQSL 1029
                :||..||:|.|.:|.    ..|..:.|  .||||.:.                  :|..||
 Frog   757 ----YLFRFIVQSRILYLR----FYGQGEGR--DQFNDSIR------------------QLFLSL 793

  Fly  1030 NASLGFFIFDILSIMDRGF-----VFGLIKTYTKVLISKNASIPDLMNYKIDFLRIVCSHEHFVA 1089
            |           .:|||..     :......|...:|:...::.|.:...:.|.:.|.|
 Frog   794 N-----------ELMDRPLDKAVKIKAAALKYLPGIINDLKTVFDPVELSVLFAKFVQS------ 841

  Fly  1090 LNLPFGTSYTMVTAPCSPTPSTTSSNSQTSCGSLERALHADLSQEFLQ----------------- 1137
                              .|:....:...:|  :.:.:.:||   |||
 Frog   842 ------------------VPADQLVHQTLTC--MSKVVESDL---FLQPECRDALQPLLIDQLSG 883

  Fly  1138 ---------QHFLVGLVLSDLAAVM---EVPNPQLHGKAI--RCIRNLMTSHDLDARYSETDARA 1188
                     .|...|.:||::..|:   ||....||.:.|  |.:|.:..:....:|.|
 Frog   884 QLDDNYAKPDHEACGHLLSNIIEVLQSKEVGETSLHIQLIMERLLRRINRTVIGMSRQS------ 942

  Fly  1189 RVAALYIPLLSIVMDCIPQLHQHGLEQDRLQQIGQLEDYQGPHQTITASTINPEVAFAISGSRPY 1253
                   |.:...:.|:..|            :.|::||.                        |
 Frog   943 -------PHIGCFVACMTAL------------LRQMDDYH------------------------Y 964

  Fly  1254 SYLNEQVKNKLPLSSENTRHLLVCFLWVLKNLERNVLYRWLMDLSPHRVHQMLQGVNVCLKTFEY 1318
            .|.         :|:..||..::.||     :|..:|::   ||...||:
 Frog   965 DYY---------ISTFRTRQDIIDFL-----METFILFK---DLIGKRVY--------------- 997

  Fly  1319 TGQKNVATLKRTNTQSFRK--TGSTDVKEKLEECIRGTNSARYDLINRRKDRNSTEKFRWRKDQM 1381
              .|:...:..|..:.|.:  |....|..||                 ..|.:|.|...|
 Frog   998 --PKDWMLMTMTQNKVFLRAMTRFAAVLNKL-----------------FLDESSFELQLW----- 1038

  Fly  1382 PYRSQYADAVGKSEHE-LELSHFIE----------GSLATEVALVLLDTLEIIVHAAANLYHNL- 1434
              .:.:..||....|| |:|..|.|          |.:..|:.|.:.|           :::||
 Frog  1039 --NNFFHLAVSFLTHESLQLHRFSEEKRKKILSKYGDMRKEIGLKIRD-----------MWYNLG 1090

  Fly  1435 ----------LGTVLKVLLHSLSRNQSVLALQNLFASQRALIFKFPNLLFDDETDICADLCLILL 1489
                      :|.:|:|.|                               ..|||:
 Frog  1091 PHKIKFIPSMVGPILEVTL-------------------------------TPETDL--------- 1115

  Fly  1490 KHCGSLLPGIRSQAAASLYLLMRQ---NFEIGNNFARVKMQVTMSLSSLVGTSSVFSEQSLRRAL 1551
                       .:|...::..|.|   ||....:|...:.::...|...|....  .::..:..|
 Frog  1116 -----------RKATIPIFFDMMQHEHNFSGSGHFHMFENELITRLDQEVEGGR--GDRQYKDLL 1167

  Fly  1552 KTVLV-------YAESDSDLQDTSFPEQVQDLLFNLHMILSDTVKMKEYQED-PEMLLDLMNRIA 1608
            :.:|:       |.....::    |...|..||.||  :...|:...|.:|: ....::|:|...
 Frog  1168 ERLLLENCRKHKYLSGSGEV----FTLLVSSLLENL--LDYRTIANDESEENRMSCTVNLLNFYK 1226

  Fly  1609 KGYQNNPDLRLTWLENMAKKHRERANHTEAAMCYVHAASLVSEYLSMLESQKHLPVGAVSFQRIS 1673
            :  :...|:.:.:|..:...|..:.|:||||    :|..|.:|.|...|.    |......||.|
 Frog  1227 E--KKREDIYIRYLYKLRDLHLRKENYTEAA----YALLLHAELLQWSEK----PCAPHLLQRDS 1281

  Fly  1674 PNTLMESAVSD----DVLSPGEDGICLGNHFTETGLKALLEEA-SNSFQVAGMYEAMNEVYKILI 1733
            .....:..:.:    :::|           |.:.|  .:.|:| .:|.::..|||  |:::
 Frog  1282 YTVYTQQELKERLYHEIIS-----------FFDKG--KMWEQAIIHSKELLDMYE--NQIF---- 1327

  Fly  1734 PICEANRDFQKLSKVHGKLQEAFNRISQLQGKRVFGTYFRVGFYGGKFGD-LDQQEFIYKEPTLT 1797
                   .::.||.:..|....:..|  ::..|:...||.||:||..|.. |..:.|||:.....
 Frog  1328 -------HYEALSVLLNKQAGFYQNI--MRSLRLQSEYFAVGYYGQGFPSFLRNKIFIYRGKEYE 1383

  Fly  1798 KLPEIFSRLQNFYTERFGPDSVHIIKDSNTVDINSLDPDKAYIQITYVEPYFETYEMRHRET--- 1859
            :|.:....|.|.:     |:...:...|...| ...:..|.|:|...|:|.. ....|::|.
 Frog  1384 RLEDFNLWLLNQF-----PNGEKLSSSSPPGD-EIRNSTKQYVQCFSVKPLM-NLPSRYKEKLVP 1441

  Fly  1860 -----YFERNFNIKRFIYATPFTKNGK-AHGELNEQCKRKTILTTANHFPYVKTRIMVISRQQIV 1918
                 |:..| .::||.|:.||.:..| ...|.......:|..|||...|.:.....|.......
 Frog  1442 EQILGYYRYN-EVQRFSYSRPFRRGEKDPDNEFATMWIERTTFTTAYKLPGILKWFEVKHFDTEE 1505

  Fly  1919 LEPIEVAIEDIQKKTLELAAATNQEPADPKI----LQMVLQGCIGTTVNQGPMEMASVFLSNLSD 1979
            :.|::.|||.::....:::....|..||..:    |.|:|.|.:...|..|.......|.:.
 Frog  1506 ISPLQNAIETMELTNEKISHLVQQHRADQSLPLHPLSMLLSGIVDPAVMGGFSNYEKAFFTE--- 1567

  Fly  1980 GTTVPTKH---QNKLRLC--------------FREFSKRCADALKKNRNLILSDQKDYQRELER- 2026
              ....:|   |:||.|.              .|...::..|.|:.....::|..||.:.::|:
 Frog  1568 --RYLQEHPMDQDKLELLKQLIALQMPLLAQGIRIHGEKLTDNLRPLHERLVSCFKDLRSKVEKL 1630

  Fly  2027 ---------NNDRFIER----LTPFITLTSVQNHGVVKANAYNNKST 2060
                     ..||.:.|    :.|:||..:::....|..::..:.|:
 Frog  1631 YGTITLPASLTDRKLSRAGSVVVPYITSATLRRLSSVSTSSSGSSSS 1677

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Zir	NP_608489.2	DOCK_C-D_N	46..153	CDD:463380
		C2_Dock-C	589..769	CDD:176078	47/249 (19%)
		DHR2_DOCK_C	1614..2035	CDD:212568	100/470 (21%)
dock5	XP_004912607.1	SH3	12..67	CDD:473055
		DOCK_N	74..433	CDD:465040	64/374 (17%)
		C2	441..632	CDD:472691	49/206 (24%)
		DHR2_DOCK5	1232..1631	CDD:212581	97/447 (22%)