Protein Alignment Zir and dock9

DIOPT Version :9

• Sequence 1: NP_608489.2
• Gene: Zir / 33165
• FlyBaseID: FBgn0031216
• Length: 2064
• Species: Drosophila melanogaster
• Sequence 2: XP_031752908.1
• Gene: dock9 / 100144990
• XenbaseID: XB-GENE-987175
• Length: 2114
• Species: Xenopus tropicalis
• Alignment Length: 2288
• Identity: 644/2288 - (28%)
• Similarity: 999/2288 - (43%)
• Gaps: 523/2288 - (22%)

  Fly    16 SAADVRKNVSGCHLSKAMDPSLCGSSISPTEPLDYEEFLSQHMNIINRDPLKHILDFPQGDVTVK 80
            :|..:.:..||..:|....|.|       .||:|||..:.|....|..|.|:.:|.||..|..:.
 Frog    37 TAHSLSREDSGFTVSLLAKPKL-------IEPIDYENVIVQKKTQILNDALREMLLFPYDDFQIA 94

  Fly    81 IIPRKIRTVDHVVP-NENLSDLPHHVQECVNCYTRPWKVVEYAQRHLSSSCYIRERIDRGTISPS 144
            .:.|:.|.:...|| |.........|.||:..|...|.||.|  :|...|...|:...:| :.|.
 Frog    95 TLRRQGRYICTTVPENAEKEAQSLFVTECIRTYNSDWHVVTY--KHEDYSGDFRQLPGKG-VKPE 156

  Fly   145 -----AYQQEFEIDKD-------------------------------FSSFEEAF---------- 163
                 .|:.:.:.|||                               ..||:..|
 Frog   157 KLPVHVYEVDEDADKDEDAASLGSQKGGITKQGWLYKGNMNSAISVTMRSFKRRFFHLIQLGDGS 221

  Fly   164 ----AYKSESCTPSSRQSIASLASVSSC---------------------------TDTLTPRGSW 197
                .||.|..:...:.||    .:.||                           .|:......|
 Frog   222 YNLNFYKDEKISKEPKGSI----FLDSCMGVVQNNRVRRFAFELKMQDKSSYLLAADSDAEMEDW 282

  Fly   198 ASFDLRRSVNDPLIPNL---------------------------LDNVPPEHIDQSNEARRQQDR 235
            .|     ::|..|..|.                           ||:...|...:..|.:.:.:.
 Frog   283 IS-----TLNKILQLNFEAAMQEKRNGEAHEDDEQSKFENSSSSLDSYLQEKSPRDPETKLKNES 342

  Fly   236 QMALFSLYPESEAEENIERRLLAEI-PVEH-MGHRIQVNCLQLRLELE-------------VEPI 285
            ::.||:|  :|:.::.....:..|: |.|. .|.||.|.|..|...|:             |||.
 Frog   343 RVKLFAL--DSDTQKLDFSGIEPEVKPFEEKFGKRILVKCNDLAFNLQSCVAENEEGPTTNVEPF 405

  Fly   286 FASMAIYDAKERQKISENFYFDMNADSLKRMLSSHVQ-----CADISTQS-------------HS 332
            |.:::::|.|..:|||.:|..|:|..|:::|:.:|.|     ..|:| ||             ..
 Frog   406 FVTLSLFDIKTNRKISADFPVDLNHASVRQMICAHSQQLLNGGGDVS-QSILGSIQESMLQYPKQ 469

  Fly   333 AIFEISYPSNDLFLVIRLEKVLQGDINNSVEPYLK-EDKDKYREKVKSNAVDYCERLGKYRMPFA 396
            .||.::.|..|:|||.|:||||||.|.:..|||:| .|..|..:||..||...|.|||:||||||
 Frog   470 GIFSVTCPHTDIFLVARIEKVLQGSIAHCAEPYMKSSDSAKVAQKVLKNAKQACSRLGQYRMPFA 534

  Fly   397 WTGIYLTNVFNGDNFESKDAGAAERDSFGNACGSSLGTAPSSNSLDRKSSTSSFDQLRRKANDMS 461
            |                     |.|..|                                 .|.:
 Frog   535 W---------------------AARSLF---------------------------------KDSN 545

  Fly   462 GTLTRRGSLERKEKHRSWSPDDFANVVENFRPITITVPSFFKQEADKMKDEDLYKILPELKRPSS 526
            |||         :|:..:|                   :.::|:::|:.:||:.|:|.:.::|..
 Frog   546 GTL---------DKNARFS-------------------AIYRQDSNKISNEDMLKLLADFRKPEK 582

  Fly   527 VMKKYKCIPGSIKLEISPCVEEAKNALTPELAPINP-QSADNVRPVKEILEF----PQSAIYNPH 586
             |.|...|.|::.:.|.....:..|.:.....|:.. :::.......|:.||    |:..  .|.
 Frog   583 -MAKLPVILGNLDITIDNVSPDFPNYVNSSYIPMKQFENSAETTVTFEVEEFVPCIPKHT--QPF 644

  Fly   587 YSYRNLLFVSPKELNFSSRA--GSARNIAVRVQLM-AGETPKDAVNAIYGKSSCPKFSTEAFTAV 648
            ..|.|.|:|.||.|.:..:.  ..|||||:.::.. |.:.....:..|||:...|.|...|..:|
 Frog   645 TIYNNHLYVYPKHLKYDGQKAFAKARNIALSIEFRDADDEESQPLKCIYGRPGGPLFVKNALASV 709

  Fly   649 NYHNKCPSFYDEIKIALPASIKQHHHLLFTIYHVSCQ------KKPQDLQPSVETPIGYTWLPLL 707
            .:|.:.|.|||||||.||..:.:.||||||.:||||.      .|.:|:   :|:.:||.|||||
 Frog   710 LHHQQNPEFYDEIKIELPTQLHEKHHLLFTFFHVSCDTSSKGGTKKRDV---IESQVGYAWLPLL 771

  Fly   708 EDGKLKFGEFNLPVMVESPPE--NYSFIPPNVHL-PGIKWLDNHRAVFSINVEAVTAIHTLDSFL 769
            :||::...|.|:||....|..  .|..:....|. |.|||:|..:.:..:....|:.::..|..|
 Frog   772 KDGRVVTNEQNIPVSANLPAGYLGYQELGMGKHSGPEIKWVDGAKPLLKVATHLVSTVYAQDLHL 836

  Fly   770 DRFFLICEYLDTRNIPSHIGENNIETELKKCLLDIEYANREPLVRHLPLVLDKLIELL--VVTHK 832
            ..||..|:..::       |...:.::|.|.|..:.......::..||.||:::..:|  ....:
 Frog   837 HNFFQYCQKTES-------GVQAVGSDLVKYLKGLHAMEGHVMIAFLPTVLNQMCRVLTRATQEE 894

  Fly   833 VGGQAMSLGSTVFEVLCLVSSLLSILNDDQYDQYGRQSLLSTYVHFQCKIPHPFQSKQRLTCSRS 897
            |   |:::...:..|:.|.            .:.|.:|.|.:||.:..|
 Frog   895 V---AVNVTRVIIHVVALC------------HEEGLESYLRSYVKYVYK---------------- 928

  Fly   898 TTEDLQLSESYTIYDNVLASGRSLDRKELSIDVLHSMAARDVQVRLLHEELALHWVVASGKAADL 962
                   :|.|      :.|                      :.:.:|||||.........:||.
 Frog   929 -------AEPY------ITS----------------------ECKTMHEELAKSMTTILKPSADF 958

  Fly   963 AMSN-----SWFLFELIVKSMIEHLHCSNTLNGPRKHRFPHQFNDDLSTLVHLVTTKVVGYHSNE 1022
            ..||     |||.||:::|||.:||..::.:...|..|||..|:..:.|||:::...:...:...
 Frog   959 LTSNKLLKYSWFFFEVLIKSMAQHLVENSKVKLLRNQRFPASFHHAVETLVNMLMPHITQKYKEI 1023

  Fly  1023 PKLAQSLNASLGFFIFDILSIMDRGFVFGLIKTYTKVLISKNASIPDLMNYKIDFLRIVCSHEHF 1087
            |:.:::.|.||.|||....:.|||||||..|..|.......:..  .|..||.:|.|:||:|||:
 Frog  1024 PEASRNANHSLAFFIKRCFTFMDRGFVFKQINNYMSFFAPGDPK--TLFEYKFEFFRVVCNHEHY 1086

  Fly  1088 VALNL--PFGTSYTMVTAPCSPTPSTTSSNSQTSCGSLER----ALHADLSQEFLQQHFLVGLVL 1146
            :.|||  |||.                        |.:.|    .|...|:.:|.:.||||||:|
 Frog  1087 IPLNLPMPFGK------------------------GRIHRYQDLQLDYTLTDDFCKNHFLVGLLL 1127

  Fly  1147 SDLAAVMEVPNPQLHGKAIRCIRNLMTSHDLDARYSETDARARVAALYIPLLSIVMDCIPQLH-- 1209
            .::.:.:: ....:...||..::.||..|..|.|||....:||:|.||:||..::::.:.:::
 Frog  1128 REVGSALQ-EFRDIRQIAISVLKGLMIKHSFDDRYSSRSQQARLATLYLPLFGLLIENVQRINVK 1191

  Fly  1210 --------QHGLEQDRLQQI-------------------------GQLEDYQGPHQTITASTINP 1241
                    .:.::.:.|..:                         |.:.....||   |:||  |
 Frog  1192 DTSPFPVAHNSMKDETLSTVTSANPLVTPQKPGNTLDNNLHKDLFGVISGTASPH---TSST--P 1251

  Fly  1242 EVAFAISGSRPYSYLNEQVKNKLP--------------------------LSSENTRHLLVCFLW 1280
            .:....:.....|.::....|.||                          |.....:.||:.||.
 Frog  1252 NINSVRNADSRGSLISTDSGNSLPERNSDKSSSLDKHGGSLGNSLVRCDKLEQSEIKSLLMSFLH 1316

  Fly  1281 VLKNLERNVLYRWLMDLSPHRVHQMLQGVNVCLKTFEYTGQKNVATLKRTNTQSF------RKTG 1339
            :||::..:.|:.:....|...:........|||..|:|.|::.:|    .|.:..      ||:.
 Frog  1317 ILKSMSDDALFTYWNKASTSELMDFFTISEVCLHQFQYMGKRYIA----RNQEGLGPIVHDRKSQ 1377

  Fly  1340 STDVKEKLEECIRGTNSARYDLINRRKDRNSTEKFRWRKDQMPYRSQ---YADAVGKSEHELELS 1401
            :..|                       .||.|.....|..|:.....   :..:.|.|:.::...
 Frog  1378 TLPV-----------------------SRNRTGMMHARLQQLSSLDNSLTFNHSYGHSDADILHQ 1419

  Fly  1402 HFIEGSLATEVALVLLDTLEIIVHAAANLY-----HN-LLGTVLKVLLHSLSRNQSVLALQNLFA 1460
            ..:|.::||||.|.:||||.:...|..|..     || |:..|..|.|..|.:|||..||:|:|.
 Frog  1420 SSLEANIATEVCLTILDTLSLFTMAFKNQLLADHGHNPLMKKVFDVYLCFLQKNQSETALKNVFT 1484

  Fly  1461 SQRALIFKFPNLLFDDETDICADLCLILLKHCGSLLPGIRSQAAASLYLLMRQNFEI--GNNFAR 1523
            :.|.||:|||:..::...|:||.||..:||.|.|.|..||:.|:..||.|||.|||.  ..:|.|
 Frog  1485 ALRCLIYKFPSTFYEGRADMCAALCYEILKCCNSKLSSIRTDASQLLYFLMRNNFEYTGKKSFVR 1549

  Fly  1524 VKMQVTMSLSSLVGTSSVFSEQSLRRALKTVLVYAESDSDLQDTSFPEQVQDLLFNLHMILSDTV 1588
            ..:||.:|:|.|:...........:::|..:...|.||..::.|||...|:||...:..:|..|.
 Frog  1550 THLQVIISVSQLIADVVGIGGTRFQQSLSIINNCANSDRLIKHTSFSSDVKDLTKRIRTVLMATA 1614

  Fly  1589 KMKEYQEDPEMLLDLMNRIAKGYQNNPDLRLTWLENMAKKHRERANHTEAAMCYVHAASLVSEYL 1653
            :|||::.|||||:||...:||.|.:.|:||.|||::||:.|.:..:.:||||||||.|:||||||
 Frog  1615 QMKEHENDPEMLVDLQYSLAKSYASTPELRKTWLDSMARIHVKHGDLSEAAMCYVHVAALVSEYL 1679

  Fly  1654 SMLESQKHLPVGAVSFQRISPNTLMESAVSDDVLSPGEDGICLGNHFTETGLKALLEEASNSFQV 1718
            :.....:.   |..:|:.|:||...|:::.:||   |...:    ||.|..|..|||:.::....
 Frog  1680 TRKGMFRQ---GCSTFRVITPNIDEEASMMEDV---GMQDV----HFNEDVLMELLEQCADGLWK 1734

  Fly  1719 AGMYEAMNEVYKILIPICEANRDFQKLSKVHGKLQEAFNRISQLQ--GKRVFGTYFRVGFYG--- 1778
            |..||.:.::|||:|||.|..|||::|:.::..|..|:::::::.  |||:.||||||.|:|
 Frog  1735 AERYELIADIYKIIIPIYEKRRDFERLAHLYDTLHRAYSKVTEVMHTGKRLLGTYFRVAFFGQAA 1799

  Fly  1779 ------------GKFGDLDQQEFIYKEPTLTKLPEIFSRLQNFYTERFGPDSVHIIKDSNTVDIN 1831
                        |.|.|.|.:|:|||||.||.|.||..|||..|:::||.::|.:|:||..|:..
 Frog  1800 QYQFTDSETDVEGFFEDEDGKEYIYKEPKLTPLSEISQRLQKLYSDKFGSENVKMIQDSGKVNPK 1864

  Fly  1832 SLDPDKAYIQITYVEPYFETYEMRHRETYFERNFNIKRFIYATPFTKNGKAHGELNEQCKRKTIL 1896
            .||...||||:|:|.||||..|::.|:|.||::.||:||::..|||.:||..|.:.||.||:|||
 Frog  1865 DLDSKYAYIQVTHVTPYFEEKELQERKTEFEKSHNIRRFVFEMPFTLSGKRQGGVEEQWKRRTIL 1929

  Fly  1897 TTANHFPYVKTRIMVISRQQIVLEPIEVAIEDIQKKTLELAAATNQEPADPKILQMVLQGCIGTT 1961
            |..:.|||||.||.|:.:....|.||||||:::.||..||....:....|...||:.|||.:...
 Frog  1930 TAIHCFPYVKKRIPVMYQHHTDLNPIEVAIDEMSKKVAELRQLCSSSEVDMIKLQLKLQGSVSVQ 1994

  Fly  1962 VNQGPMEMASVFLSNLSDGTTVPTKHQNK---LRLCFREFSKRCADALKKNRNLILSDQKDYQRE 2023
            ||.||:..|.|||    |.|.......||   |:..||:|.:.|..||..|..||..:|.:||.|
 Frog  1995 VNAGPLAYARVFL----DDTNTKKYADNKIKQLKEVFRQFVEACGQALCVNERLIKENQFEYQEE 2055

  Fly  2024 LERNNDRFIERLT 2036
            ::.|....::.|:
 Frog  2056 MKANYREMVKELS 2068

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Zir	NP_608489.2	DUF3398	59..151	CDD:288711	26/97 (27%)
		C2_Dock-C	589..769	CDD:176078	67/191 (35%)
		DHR-2	1549..2037	CDD:284365	206/508 (41%)
dock9	XP_031752908.1	DUF3398	56..163	CDD:403173	33/116 (28%)
		PH_DOCK-D	180..303	CDD:270087	16/131 (12%)
		C2_Dock-D	647..836	CDD:176079	67/191 (35%)
		DHR2_DOCK9	1642..2070	CDD:212571	180/441 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	64	1.000	Domainoid score	I9945
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D20156at2759
OrthoFinder	1	1.000	-	-		FOG0000340
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X255
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.010