DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11374 and Pex23

DIOPT Version :9

Sequence 1:	NP_608488.3	Gene:	CG11374 / 33163	FlyBaseID:	FBgn0031214	Length:	401	Species:	Drosophila melanogaster
Sequence 2:	NP_730508.1	Gene:	Pex23 / 40229	FlyBaseID:	FBgn0052226	Length:	1350	Species:	Drosophila melanogaster

Alignment Length:	433	Identity:	80/433 - (18%)
Similarity:	139/433 - (32%)	Gaps:	136/433 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 GSEICEECDVLLQIGSRLPQNYITRNSRLKGKWGPEENS-SYLTFQLNRGKSFWMQILLTEECFF 132
            ||:...||.:|   .|.:....:|.::.....|..|:.| |.:....|..|....::...:|...
  Fly   566 GSQFWTECGIL---WSCVASGAVTVDASNMPNWFNEQTSDSKVDVNANWRKDIVNKLQRRQEKLA 627

  Fly   133 ISVNGYHFAKYFHRMPYRWLEAVDVL-----GDVSDIVIDTYYVS-------------------- 172
            .......|.|.....  .|:::.|..     |:..|.:|:..:||
  Fly   628 KLQTVAKFEKAVELS--SWVKSADARYQRPGGEFEDCIIELEWVSSGSGTDTNSSENSRSGDSGT 690

  Fly   173 -------------EYPIR-LT-------HSLPRPIPHSNKLPRDGENVE---------TEWM--- 204
                         ::|:. :|       ...||...|:..||.:...|:         .:|:
  Fly   691 FTVLSPDGAATKIQFPLSDITCVQCCSEAGAPRIAIHAPHLPVNCSPVKLQFSSDSEMEDWLSHL 755

  Fly   205 --VLSSLAKMSSKK--------------FLYQP----------------------SLPLPFYGKL 231
              |.|.:..|..|.              |::.|                      :...|:|..|
  Fly   756 SSVCSQINTMVGKPAGNAIWITSELGDVFVFDPANMKAHQTSEPSEGYVEKMDVSTCETPYYNTL 820

  Fly   232 LKENFLIEGSSLRIEGRVRLMPQRFSIAFQKGQEIWPQP-------TVSFYFSPCFLRSRHDKIG 289
            .  |.:..|:.|.|.|.|.....:.....|....:..||       .::.:.:|.|..
  Fly   821 Y--NGMPCGTELEISGCVYDDADQIRFDLQSHSAVKVQPHRVEKHRVIALHLNPRFNE------- 876

  Fly   290 TAIITRRAYLN----GDWVNCTVSRLNTSLRPGGAFVIVIACRDSYYELFVNNRSLFHFKYQMRP 350
                 |...||    .:|:: .:.....:..||..|.:.|.....:|.:.|||.....:||::.|
  Fly   877 -----RTTVLNSMKESEWLD-EIRNDKMAFAPGATFSLKIRALQDHYLIIVNNAVYTDYKYRIDP 935

  Fly   351 ECVDIVNIRGDIKLWEVAIQGNTTYKKPKVRSAMERAISAWKR 393
            |.|..:.:.|.|||:      |..|:.|.:..:|||  ..|::
  Fly   936 ESVTRLYVSGRIKLF------NVLYRCPSLIVSMER--MHWRQ 970

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11374	NP_608488.3	Gal-bind_lectin	37..162	CDD:278752	19/98 (19%)
CG11374	NP_608488.3	Gal-bind_lectin	226..369	CDD:278752	35/153 (23%)
Pex23	NP_730508.1	DysFN	64..125	CDD:214777
		Hyd_WA	210..238	CDD:283993
		Hyd_WA	257..282	CDD:283993
		TECPR	280..320	CDD:214782
		TECPR	338..371	CDD:214782
		PH-like	639..759	CDD:302622	16/121 (13%)
		Gal-bind_lectin	815..954	CDD:278752	36/159 (23%)
		TECPR	966..1000	CDD:214782	1/5 (20%)
		DysFN	1021..1081	CDD:214777
		DysFC	1092..>1113	CDD:128935
		Hyd_WA	1165..1192	CDD:283993
		Hyd_WA	1209..1237	CDD:283993
		Hyd_WA	1308..1333	CDD:283993
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3587
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810