DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11374 and LGALS9

DIOPT Version :9

Sequence 1:	NP_608488.3	Gene:	CG11374 / 33163	FlyBaseID:	FBgn0031214	Length:	401	Species:	Drosophila melanogaster
Sequence 2:	NP_033665.1	Gene:	LGALS9 / 3965	HGNCID:	6570	Length:	355	Species:	Homo sapiens

Alignment Length:	353	Identity:	86/353 - (24%)
Similarity:	148/353 - (41%)	Gaps:	56/353 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 GLCFVFHGMILMAC-EHFVIDFLTK-QGSEICEECDVLLQIGSRLPQNYITRNSRLKGKWGPEEN 106
            ||....:|.:|.:. ..|.::|.|. .|::|....:...:.|     .|:..|:|..|.|||||.
Human    28 GLQITVNGTVLSSSGTRFAVNFQTGFSGNDIAFHFNPRFEDG-----GYVVCNTRQNGSWGPEER 87

  Fly   107 SSYLTFQLNRGKSFWMQILLTEECFFISVNGYHFAKYFHRMPYRWLEAVDVLGDVSDIVIDTYYV 171
            .:::.||  :|..|.:..|:....|.:.|||..|.:||||:|:..::.:.|.|.|....|.....
Human    88 KTHMPFQ--KGMPFDLCFLVQSSDFKVMVNGILFVQYFHRVPFHRVDTISVNGSVQLSYISFQNP 150

  Fly   172 SEYPIRLTHSL----------PRP---------IPHSNKLPRDGENVETEWMVLSSLAKMSS--- 214
            ...|::...|.          |||         :..:|..|.....:.|   |.|:..:|.|
Human   151 RTVPVQPAFSTVPFSQPVCFPPRPRGRRQKPPGVWPANPAPITQTVIHT---VQSAPGQMFSTPA 212

  Fly   215 -KKFLY-QPSLPLPFYGKLLKENFLIEGSSLRIEGRVRLMPQRFSIAFQKGQEIWPQPTVSFYFS 277
             ...:| .|:.|:||...:|  ..|....|:.:.|.|....|||.|....|..|      :|:.:
Human   213 IPPMMYPHPAYPMPFITTIL--GGLYPSKSILLSGTVLPSAQRFHINLCSGNHI------AFHLN 269

  Fly   278 PCFLRSRHDKIGTAIITRRAYLNGDW--VNCTVSRLNTSLRPGGAFVIVIACRDSYYELFVNNRS 340
            |.|..:        .:.|...::..|  ...::.|....:| |.:|.:.|.|.....::.|:.:.
Human   270 PRFDEN--------AVVRNTQIDNSWGSEERSLPRKMPFVR-GQSFSVWILCEAHCLKVAVDGQH 325

  Fly   341 LFHFKYQMRP-ECVDIVNIRGDIKLWEV 367
            ||.:.:::|. ..::.:.:.|||:|..|
Human   326 LFEYYHRLRNLPTINRLEVGGDIQLTHV 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11374	NP_608488.3	Gal-bind_lectin	37..162	CDD:278752	36/119 (30%)
CG11374	NP_608488.3	Gal-bind_lectin	226..369	CDD:278752	33/145 (23%)
LGALS9	NP_033665.1	lectin domain	1..148		38/126 (30%)
		GLECT	16..146	CDD:238025	37/124 (30%)
		alternate exon	149..180		5/30 (17%)
		Peptidase_C62	<154..214	CDD:289173	12/62 (19%)
		link peptide	181..206		5/27 (19%)
		lectin domain	207..355		38/164 (23%)
		Gal-bind_lectin	233..354	CDD:214904	30/136 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150758
Domainoid	1	1.000	80	1.000	Domainoid score	I8601
eggNOG	1	0.900	-	-		E1_KOG3587
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	125	1.000	Inparanoid score	I4712
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D357844at33208
OrthoFinder	1	1.000	-	-		FOG0000178
OrthoInspector	1	1.000	-	-		mtm8457
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X133
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.800