DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11374 and Lgals9

DIOPT Version :9

Sequence 1:	NP_608488.3	Gene:	CG11374 / 33163	FlyBaseID:	FBgn0031214	Length:	401	Species:	Drosophila melanogaster
Sequence 2:	NP_001375428.1	Gene:	Lgals9 / 25476	RGDID:	3005	Length:	354	Species:	Rattus norvegicus

Alignment Length:	355	Identity:	75/355 - (21%)
Similarity:	143/355 - (40%)	Gaps:	61/355 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 GLCFVFHGMILMACEHFVIDFLTKQGSEICEECDVLLQIGSRLPQ-NYITRNSRLKGKWGPEENS 107
            ||.....|.:........::|.|.....     |:......|..: .|:..|::..|||||||..
  Rat    28 GLQITLQGTVHPFPNRIAVNFQTGFSGN-----DIAFHFNPRFEEGGYVVCNTKQNGKWGPEERK 87

  Fly   108 SYLTFQLNRGKSFWMQILLTEECFFISVNGYHFAKYFHRMPYRWLEAVDVLGDVSDIVIDTYYVS 172
            ..:.||  :|..|.:..|:....|.:.||...|.:|.||:||..::.:.|.|.:....|:....:
  Rat    88 MQMPFQ--KGMPFELCFLVQRSEFKVMVNKNFFVQYSHRVPYHLVDTISVSGCLHLSFINFQNST 150

  Fly   173 EYPIR-----LTHSLPRPIPHSNKLPRDGENVETEWMVLSSLAKMSSK----------KFLYQPS 222
            ..|::     :..|.|...|   ::|: |....|:....:..|.::..          :.|..|.
  Rat   151 AAPVQPVFSTMQFSQPVQFP---RMPK-GRKQRTQGFQPAHQAPVAQTIIHTVHSIPGQMLSTPG 211

  Fly   223 LP----------LPFYGKLLKENFLIEGSSLRIEGRVRLMPQRFSIAFQKGQEIWPQPTVSFYFS 277
            :|          :||:..:  .|......|:.|.|.|....:||.|..:.|.:|      :|:.:
  Rat   212 IPPMAYPTPAYTIPFFTSI--PNGFYPSKSINISGVVLPDAKRFHINLRCGGDI------AFHLN 268

  Fly   278 PCFLRSRHDKIGTAIITRRAYLNGDW---VNCTVSRLNTSLRPGGAFVIVIACRDSYYELFVNNR 339
            |.|    ::|    ::.|...:|..|   ......|:  ....|.:|.:.|.|....:::.|:.:
  Rat   269 PRF----NEK----VVVRNTQINNSWGPEERSLPGRM--PFNRGQSFSVWILCEGHCFKVAVDGQ 323

  Fly   340 SLFHFKYQMR--PECVDIVNIRGDIKLWEV 367
            .:..:.::::  |: ::.:.:.|||:|..|
  Rat   324 HICEYYHRLKNLPD-INTLEVAGDIQLTHV 352

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11374	NP_608488.3	Gal-bind_lectin	37..162	CDD:278752	32/118 (27%)
CG11374	NP_608488.3	Gal-bind_lectin	226..369	CDD:278752	31/147 (21%)
Lgals9	NP_001375428.1	Gal-bind_lectin	22..145	CDD:214904	32/123 (26%)
		Beta-galactoside binding 1. /evidence=ECO:0000250	81..87		5/5 (100%)
		Gal-bind_lectin	231..353	CDD:214904	29/139 (21%)
		Beta-galactoside binding 2. /evidence=ECO:0000250	286..292		1/5 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	86	1.000	Domainoid score	I7884
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	119	1.000	Inparanoid score	I4689
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D357844at33208
OrthoFinder	1	1.000	-	-		FOG0000178
OrthoInspector	1	1.000	-	-		mtm8932
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X133
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.970