DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment galectin and LGALS9C

DIOPT Version :9

Sequence 1:	NP_608487.1	Gene:	galectin / 33162	FlyBaseID:	FBgn0031213	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_001035167.2	Gene:	LGALS9C / 654346	HGNCID:	33874	Length:	356	Species:	Homo sapiens

Alignment Length:	388	Identity:	101/388 - (26%)
Similarity:	155/388 - (39%)	Gaps:	89/388 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   134 AVPKYFNDQI-GKLSEGISFTVTGN-LSVNCERFSINLVYNNDSRDVALHINPRLPQ-NYIVRNT 195
            |||  |:..| |.|.:|...||.|. ||.:..||:::........|:|.|.|||... .|:|.||
Human    14 AVP--FSGTIQGGLQDGFQITVNGAVLSCSGTRFAVDFQTGFSGNDIAFHFNPRFEDGGYVVCNT 76

  Fly   196 KVQDIWGNEEVSSALPFLLSRGEEFSIQVLVTEACYMISVNGQHFAAYTHRIPYRDVRILEVKGD 260
            :.:..||.||....:||  .:|..|.:..||..:.:.:.|||..|..|.||:|:..|..:.|.|.
Human    77 RQKGTWGPEERKMHMPF--QKGMPFDLCFLVQSSDFKVMVNGSLFVQYFHRVPFHRVDTISVNGS 139

  Fly   261 VSNVEMKRTLVLKY-----PERLPQSEANNIELHIDDGINEIDASVEETVKIPHEWCIISAPNTQ 320
            |.         |.|     |..:|...|.:                  ||......|....|..:
Human   140 VQ---------LSYISFQNPRAVPVQPAFS------------------TVPFSQPVCFPPRPRGR 177

  Fly   321 SDSSPKRNNSSNDLGLT--------------------------------LPYYGALPPNSLVDGR 353
            ....|. ...:|...:|                                :|:...: |..|...:
Human   178 RQKPPS-VRPANPAPITQTVIHTVQSASGQMFSQTPAIPPMMYPHPAYPMPFITTI-PGGLYPSK 240

  Fly   354 CLKIEGRVRLLPHSFYINLQQGQDIWPHPVIAFHLNPRFSKASSGAIGKAVVCRNAWLNGAWAQE 418
            .:.:.|.|......|:|||..|..      ||||:||||.:       .||| ||..:|.:|..|
Human   241 SIILSGTVLPSAQRFHINLCSGSH------IAFHMNPRFDE-------NAVV-RNTQINNSWGSE 291

  Fly   419 ERS-EFDTNFRPGRSFCLAIVCTKTSFEVYVNRQFMTDFKYKV-SPEVVDTVYIQGDVKLWNV 479
            ||| .....|..|:||.:.|:|.....:|.|:.|.:.::.::: :...::.:.:.||::|.:|
Human   292 ERSLPRKMPFVRGQSFSVWILCEAHCLKVAVDGQHVFEYYHRLRNLPTINKLEVGGDIQLTHV 354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
galectin	NP_608487.1	GLECT	143..262	CDD:238025	42/121 (35%)
galectin	NP_608487.1	Gal-bind_lectin	339..479	CDD:278752	41/141 (29%)
LGALS9C	NP_001035167.2	GLECT	16..146	CDD:238025	47/142 (33%)
		Beta-galactoside binding 1. /evidence=ECO:0000250	82..88		4/5 (80%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	170..190		3/20 (15%)
		Gal-bind_lectin	233..355	CDD:214904	41/136 (30%)
		Beta-galactoside binding 2. /evidence=ECO:0000250	288..294		3/5 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150760
Domainoid	1	1.000	80	1.000	Domainoid score	I8601
eggNOG	1	0.900	-	-		E1_KOG3587
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	125	1.000	Inparanoid score	I4712
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D357844at33208
OrthoFinder	1	1.000	-	-		FOG0000178
OrthoInspector	1	1.000	-	-		mtm8457
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4988
SonicParanoid	1	1.000	-	-		X133
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.830