DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment galectin and LGALS9

DIOPT Version :9

Sequence 1:	NP_608487.1	Gene:	galectin / 33162	FlyBaseID:	FBgn0031213	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_033665.1	Gene:	LGALS9 / 3965	HGNCID:	6570	Length:	355	Species:	Homo sapiens

Alignment Length:	401	Identity:	109/401 - (27%)
Similarity:	168/401 - (41%)	Gaps:	95/401 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   124 FKASFYEY-ADAVPKYFNDQI-GKLSEGISFTVTGN-LSVNCERFSINLVYNNDSRDVALHINPR 185
            |..|...| :.|||  |:..| |.|.:|:..||.|. ||.:..||::|........|:|.|.|||
Human     3 FSGSQAPYLSPAVP--FSGTIQGGLQDGLQITVNGTVLSSSGTRFAVNFQTGFSGNDIAFHFNPR 65

  Fly   186 LPQ-NYIVRNTKVQDIWGNEEVSSALPFLLSRGEEFSIQVLVTEACYMISVNGQHFAAYTHRIPY 249
            ... .|:|.||:....||.||..:.:||  .:|..|.:..||..:.:.:.|||..|..|.||:|:
Human    66 FEDGGYVVCNTRQNGSWGPEERKTHMPF--QKGMPFDLCFLVQSSDFKVMVNGILFVQYFHRVPF 128

  Fly   250 RDVRILEVKGDVS----NVEMKRTLVLK-------------YPERLPQSEANNIELHIDDGINEI 297
            ..|..:.|.|.|.    :.:..||:.::             :|.| |:....
Human   129 HRVDTISVNGSVQLSYISFQNPRTVPVQPAFSTVPFSQPVCFPPR-PRGRRQ------------- 179

  Fly   298 DASVEETVKIPHEWCIISAPNTQS-----DSSPKRNNSSNDLGLTLPYYGALPP----------- 346
                    |.|..|....||.||:     .|:|.:..|:          .|:||
Human   180 --------KPPGVWPANPAPITQTVIHTVQSAPGQMFST----------PAIPPMMYPHPAYPMP 226

  Fly   347 ------NSLVDGRCLKIEGRVRLLPHSFYINLQQGQDIWPHPVIAFHLNPRFSKASSGAIGKAVV 405
                  ..|...:.:.:.|.|......|:|||..|..      |||||||||.:       .|||
Human   227 FITTILGGLYPSKSILLSGTVLPSAQRFHINLCSGNH------IAFHLNPRFDE-------NAVV 278

  Fly   406 CRNAWLNGAWAQEERS-EFDTNFRPGRSFCLAIVCTKTSFEVYVNRQFMTDFKYKV-SPEVVDTV 468
             ||..::.:|..|||| .....|..|:||.:.|:|.....:|.|:.|.:.::.::: :...::.:
Human   279 -RNTQIDNSWGSEERSLPRKMPFVRGQSFSVWILCEAHCLKVAVDGQHLFEYYHRLRNLPTINRL 342

  Fly   469 YIQGDVKLWNV 479
            .:.||::|.:|
Human   343 EVGGDIQLTHV 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
galectin	NP_608487.1	GLECT	143..262	CDD:238025	43/121 (36%)
galectin	NP_608487.1	Gal-bind_lectin	339..479	CDD:278752	42/158 (27%)
LGALS9	NP_033665.1	lectin domain	1..148		51/148 (34%)
		GLECT	16..146	CDD:238025	46/133 (35%)
		alternate exon	149..180		5/52 (10%)
		Peptidase_C62	<154..214	CDD:289173	14/91 (15%)
		link peptide	181..206		8/24 (33%)
		lectin domain	207..355		44/171 (26%)
		Gal-bind_lectin	233..354	CDD:214904	40/135 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150757
Domainoid	1	1.000	80	1.000	Domainoid score	I8601
eggNOG	1	0.900	-	-		E1_KOG3587
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	125	1.000	Inparanoid score	I4712
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D357844at33208
OrthoFinder	1	1.000	-	-		FOG0000178
OrthoInspector	1	1.000	-	-		mtm8457
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4988
SonicParanoid	1	1.000	-	-		X133
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.830