DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment galectin and Lgals9

DIOPT Version :9

Sequence 1:	NP_608487.1	Gene:	galectin / 33162	FlyBaseID:	FBgn0031213	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_001375428.1	Gene:	Lgals9 / 25476	RGDID:	3005	Length:	354	Species:	Rattus norvegicus

Alignment Length:	383	Identity:	106/383 - (27%)
Similarity:	172/383 - (44%)	Gaps:	77/383 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   136 PKYFNDQI-------GKLSEGISFTVTGNLSVNCERFSINLVYNNDSRDVALHINPRLPQ-NYIV 192
            |.|.|..|       |.|..|:..|:.|.:.....|.::|........|:|.|.|||..: .|:|
  Rat     8 PPYMNPVIPFTGIIQGGLQNGLQITLQGTVHPFPNRIAVNFQTGFSGNDIAFHFNPRFEEGGYVV 72

  Fly   193 RNTKVQDIWGNEEVSSALPFLLSRGEEFSIQVLVTEACYMISVNGQHFAAYTHRIPYRDVRILEV 257
            .|||....||.||....:||  .:|..|.:..||..:.:.:.||...|..|:||:||..|..:.|
  Rat    73 CNTKQNGKWGPEERKMQMPF--QKGMPFELCFLVQRSEFKVMVNKNFFVQYSHRVPYHLVDTISV 135

  Fly   258 KG--DVSNVEMKRTLV---------------LKYPERLPQSEANNIE----LHIDDGINEIDASV 301
            .|  .:|.:..:.:..               :::| |:|:......:    .|        .|.|
  Rat   136 SGCLHLSFINFQNSTAAPVQPVFSTMQFSQPVQFP-RMPKGRKQRTQGFQPAH--------QAPV 191

  Fly   302 EETV-----KIPHEWCIISAPNTQSDSSPKRNNSSNDLGLTLPYYGALPPNSLVDGRCLKIEGRV 361
            .:|:     .||.:  ::|.|.....:.|..       ..|:|::.:: ||.....:.:.|.|.|
  Rat   192 AQTIIHTVHSIPGQ--MLSTPGIPPMAYPTP-------AYTIPFFTSI-PNGFYPSKSINISGVV 246

  Fly   362 RLLPHS--FYINLQQGQDIWPHPVIAFHLNPRFSKASSGAIGKAVVCRNAWLNGAWAQEERS-EF 423
              ||.:  |:|||:.|.|      |||||||||:        :.||.||..:|.:|..|||| ..
  Rat   247 --LPDAKRFHINLRCGGD------IAFHLNPRFN--------EKVVVRNTQINNSWGPEERSLPG 295

  Fly   424 DTNFRPGRSFCLAIVCTKTSFEVYVNRQFMTDFKYKVS--PEVVDTVYIQGDVKLWNV 479
            ...|..|:||.:.|:|....|:|.|:.|.:.::.:::.  |: ::|:.:.||::|.:|
  Rat   296 RMPFNRGQSFSVWILCEGHCFKVAVDGQHICEYYHRLKNLPD-INTLEVAGDIQLTHV 352

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
galectin	NP_608487.1	GLECT	143..262	CDD:238025	40/128 (31%)
galectin	NP_608487.1	Gal-bind_lectin	339..479	CDD:278752	48/144 (33%)
Lgals9	NP_001375428.1	Gal-bind_lectin	22..145	CDD:214904	40/124 (32%)
		Beta-galactoside binding 1. /evidence=ECO:0000250	81..87		4/5 (80%)
		Gal-bind_lectin	231..353	CDD:214904	48/139 (35%)
		Beta-galactoside binding 2. /evidence=ECO:0000250	286..292		3/5 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	86	1.000	Domainoid score	I7884
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H134662
Inparanoid	1	1.050	119	1.000	Inparanoid score	I4689
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D357844at33208
OrthoFinder	1	1.000	-	-		FOG0000178
OrthoInspector	1	1.000	-	-		mtm8932
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X133
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.970