DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir21a and GLR3.4

DIOPT Version :9

Sequence 1:	NP_001097043.1	Gene:	Ir21a / 33157	FlyBaseID:	FBgn0031209	Length:	842	Species:	Drosophila melanogaster
Sequence 2:	NP_001030971.1	Gene:	GLR3.4 / 839268	AraportID:	AT1G05200	Length:	959	Species:	Arabidopsis thaliana

Alignment Length:	472	Identity:	95/472 - (20%)
Similarity:	178/472 - (37%)	Gaps:	93/472 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   344 DTIQEQIIERTVDIGMSGIYITQER---------LMDSAMSVGHSPDCAAFITLASKALPKYRAI 399
            |.:..:::....|:.:..|.|...|         .::|.:.|         :....:|.....:.
plant   553 DNLVNEVVADNFDVAVGDITIVTNRTRYVDFTQPFIESGLVV---------VAPVKEAKSSPWSF 608

  Fly   400 MGPFQWPVWVALICVYLGGIFPIVFTDRLTLSHLMGN------WGEVENMFWYVFG-MF----TN 453
            :.||...:|..     .||.|..|......|.|....      ..::..:||:.|. ||    .|
plant   609 LKPFTIEMWAV-----TGGFFLFVGAMVWILEHRFNQEFRGPPRRQLITIFWFSFSTMFFSHREN 668

  Fly   454 AFSFTGKYSWSNTRKNSTRLLIGAYWLFTI-IITSCYTGSIIAFVTLPAFPDTVDSVLDLLGLFF 517
            ..|..|::           :||  .|||.: ||.|.||.|:.:.:|:......::.:..|:....
plant   669 TVSSLGRF-----------VLI--IWLFVVLIINSSYTASLTSILTIRQLTSRIEGIDSLVTSNE 720

  Fly   518 RVGTLNNGGWETWFQNSTHIPTSR---LYKKMEFVGSVDEG--IGNVTQSFFWNYAFLGSKAQLE 577
            .:|..:......:..|..:|..||   |..:.:::.::..|  .|.|.       |.:.....:|
plant   721 PIGVQDGTFARNYLINELNILPSRIVPLKDEEQYLSALQRGPNAGGVA-------AIVDELPYIE 778

  Fly   578 YLVQSNFSDENISRRSALHLSEECFALFQIGFLFPRESVYKIKIDSMILLAQQSGLIAKINNEVS 642
            .|:    ::.|...|:   :.:| |.....||.|.|:|...:.:.:.||...:.|.:.||:.:
plant   779 VLL----TNSNCKFRT---VGQE-FTRTGWGFAFQRDSPLAVDMSTAILQLSEEGELEKIHRK-- 833

  Fly   643 WVMQRSSSGRLLQASSSNSLREIIQEERQLTTADTEGMFLLMALGYFLGATALVSEIVGGITNKC 707
            |:..:....  :|.|:|        |:.||:.....|:||:..:..|:..|.....:........
plant   834 WLNYKHECS--MQISNS--------EDSQLSLKSFWGLFLICGITCFMALTVFFWRVFWQYQRLL 888

  Fly   708 RQIIKRSRKSAASSWSSASSGSMLRTNAEQLS-HDKRKANRREAAEVAQKMSFGMRELNLTRATL 771
            .:.....|....|..|.:..||...:..|.:. .|||:|..:|.  :.||.|   ::|..|::
plant   889 PESADEERAGEVSEPSRSGRGSRAPSFKELIKVVDKREAEIKEI--LKQKSS---KKLKSTQS-- 946

  Fly   772 REIYGSYGAPETDHGQL 788
                 :.|..::.||::
plant   947 -----AAGTSQSQHGEI 958

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir21a	NP_001097043.1	Periplasmic_Binding_Protein_Type_2	289..583	CDD:304360	50/264 (19%)
Ir21a	NP_001097043.1	Lig_chan	407..662	CDD:278489	58/271 (21%)
GLR3.4	NP_001030971.1	PBP1_GABAb_receptor_plant	62..450	CDD:380645
		Periplasmic_Binding_Protein_Type_2	<518..591	CDD:389745	5/37 (14%)
		Lig_chan	615..869	CDD:365843	64/298 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000