DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir21a and GLR1.4

DIOPT Version :9

Sequence 1:	NP_001097043.1	Gene:	Ir21a / 33157	FlyBaseID:	FBgn0031209	Length:	842	Species:	Drosophila melanogaster
Sequence 2:	NP_187408.2	Gene:	GLR1.4 / 819940	AraportID:	AT3G07520	Length:	861	Species:	Arabidopsis thaliana

Alignment Length:	820	Identity:	150/820 - (18%)
Similarity:	263/820 - (32%)	Gaps:	253/820 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 FTAQAFSIE--GDRSASYQEKCISRRLINHYQLNKEIFGVGMCDGNNENEFRQKRRIVPTFQGNP 73
            |...|..||  .:.|.|..|:||.::|.........||...:.:......|...||:....:|
plant   202 FQQNAIHIEYKAEFSVSSNEECIMKQLRKFKASGIRIFVAHISERIANRLFPCARRLGMMEEG-- 264

  Fly    74 RPRGELLASKFHVNSYNFEQTNSLV-----GLVN-----KIAQEYLN---------KCPPVIYYD 119
              ...:|.::   :..||:.||.|.     |::.     .:.:|..|         :...|:...
plant   265 --YAWILTAR---SMNNFQDTNYLAKEEMEGVIGFKSYIPLTEELHNFTLRWKRSLRLEEVVTRM 324

  Fly   120 SF-----------------VEKSDGLILENLFKTIPITFYHGEINADYEAKNKRFTSHIDCNCKS 167
            |.                 |.|..||.:.:|.:.||.:..|..::.|.:..:|:
plant   325 SVCSIWAHDIAWSLARAAEVAKLPGLSVYDLLEAIPESAKHKGLSGDIKFIDKK----------- 378

  Fly   168 YILFLSDPLMTRKILGPQTESRVVLVSRSTQWRLRDFLSSELSSNIVNLLVIGESLMADPMRERP 232
               |:||......::| :.|..|.|      |....|:|:.                    |.|
plant   379 ---FISDKFEIVNMIG-RGERSVGL------WNSGSFISNR--------------------RRR- 412

  Fly   233 YVLYTHKLYADGLGSNTPVVLTSWIKGALSRPHINLFPSKFQFGFAGHRFQISAANQPPFIFRIR 297
                        |.|...:....|..|:...|.|.....|........|..:.|.|..|.|..::
plant   413 ------------LSSTKALETIIWPGGSTRIPKIRSLKEKRHGKKKKLRVLVPAGNITPQILEVK 465

  Fly   298 TLDSSGMGQLRWDGVEFRLLTMISKRLNFSIDITETP-----------------TRSNTRGVVDT 345
            |              :|:  |.::....:.||:.||.                 ...|...:|.|
plant   466 T--------------DFK--TGVTAATGYCIDVFETSILPFNYEVEYIPWPGAINYKNYNDLVYT 514

  Fly   346 IQEQIIERTVDIGMSGIYITQERLMDSAMSVGHSPDCAAFITLASKALPKYRAIMGPFQWPVWVA 410
            :..|  :...|..:..|.||..|.:....::..:....|.:|...|::   ..|..|....:|:.
plant   515 LYSQ--KDKYDAAVGDITITDNRSLYVDFTLPFTDMGLAVVTAKDKSM---WIIFKPLTLSLWLT 574

  Fly   411 LICVYL--GGIFPIVFTDRLTLSHLMGN-WGEVENMFWYVFGMFTNAFSFTGKYSWSNTRKNSTR 472
            :...::  |.|..::  :|...:...|: :.::..:.  .||..|..|:..     ...:.|.:|
plant   575 IASFFILTGAIVWLI--ERHDNADFQGSCFQQIGTLL--CFGFSTLVFAHR-----ERLQHNMSR 630

  Fly   473 LLIGAYWLFTI-IITSCYTGSIIAFVTLPAFPDTVDSVLDLLGL-------FFRVGTLNNGGWET 529
            .:: ..|:|.: |:||.||.::.:.:|          |..:.||       ||......|
plant   631 FVV-IVWIFAVLILTSNYTATLTSVMT----------VQQIRGLKSNENIGFFSASIAAN----- 679

  Fly   530 WFQNSTHIPTSRLYKKMEFVGSVDEGIGNVTQSFFWNYAFLGSKAQLEYLVQSNFSDENISRRSA 594
             ..|.........||.::........:.|.|.||..:        ::.|          :....|
plant   680 -VVNDNPTFQGPRYKGLKTADDFTNALRNGTISFIVD--------EVPY----------VKLFVA 725

  Fly   595 LHLSEECFALFQ-------IGFLFPRESVYKIKIDSMILLAQQSGLIAKINNEVSWVMQRSSSGR 652
            .|.||  |.:.:       .||.|.:.|....|:...|...:::..:..|.|   |..||.::
plant   726 KHPSE--FVIVETESVTNGFGFAFQKGSPLVQKVSREIEKLRRTEKLKAIEN---WWFQRQTT-- 783

  Fly   653 LLQASSSNSLREIIQEERQLTTADTEGMFLLMALGYFLGATALVSEIVGGITNKCRQIIKRSRKS 717
              .|:|.::.       ..||.....|:|::..:.:   |.||:..::
plant   784 --SATSEDTF-------HPLTVYTFRGLFMITGVSF---AFALIVYLI----------------- 819

  Fly   718 AASSWSSASSGSMLRTNAEQ----LSHDKRKANRREAAEV 753
               .|           |.||    |.|..|..:.|.|.|:
plant   820 ---PW-----------NREQRQVVLKHFHRYVSHRFAREI 845

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir21a	NP_001097043.1	Periplasmic_Binding_Protein_Type_2	289..583	CDD:304360	56/321 (17%)
Ir21a	NP_001097043.1	Lig_chan	407..662	CDD:278489	51/272 (19%)
GLR1.4	NP_187408.2	PBP1_GABAb_receptor	47..410	CDD:107361	47/255 (18%)
		ANF_receptor	64..390	CDD:279440	40/208 (19%)
		GluR_Plant	448..778	CDD:270404	73/399 (18%)
		Periplasmic_Binding_Protein_Type_2	476..>657	CDD:304360	37/205 (18%)
		Lig_chan	570..810	CDD:278489	55/299 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910