DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir21a and GLR1.1

DIOPT Version :9

Sequence 1:	NP_001097043.1	Gene:	Ir21a / 33157	FlyBaseID:	FBgn0031209	Length:	842	Species:	Drosophila melanogaster
Sequence 2:	NP_187061.1	Gene:	GLR1.1 / 819566	AraportID:	AT3G04110	Length:	808	Species:	Arabidopsis thaliana

Alignment Length:	749	Identity:	142/749 - (18%)
Similarity:	269/749 - (35%)	Gaps:	202/749 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 WVALVLFTAQAFSIEG---DRSASYQEKCISRRLINHY--QLNK------EIFGVGMCDGNNENE 58
            |...:....:.|..:|   .||||:   .:|....||.  ||.|      .:|.|.|
plant   174 WSESLQILVENFQDKGIYIARSASF---AVSSSGENHMMNQLRKLKVSRASVFVVHM-------- 227

  Fly    59 FRQKRRIVPTFQGNPRPRGELLASKFHVNSYNFEQTNSLVGLVNKIAQEYLNKCPPVIYYDSF-- 121
                              .|:|.|:.      |:....| ||:.: |..::.....:.|.:.|
plant   228 ------------------SEILVSRL------FQCVEKL-GLMEE-AFAWILTARTMNYLEHFAI 266

  Fly   122 VEKSDGLILENLFKT-IPITFYHGEINADYEAKNKRFTSHIDCNCKSYILFLSDPLMTRKILGPQ 185
            .....|:|   .||: ||::         .|.||  |||.:                 ||.:|..
plant   267 TRSMQGVI---GFKSYIPVS---------EEVKN--FTSRL-----------------RKRMGDD 300

  Fly   186 TE---SRVVLVSR---------------STQWRLRDFLSSELSSNIVNLL-------VIGESLMA 225
            ||   |.|::..|               |...::.  .||.:|:::::.:       :.|:..::
plant   301 TETEHSSVIIGLRAHDIACILANAVEKFSVSGKVE--ASSNVSADLLDTIRHSRFKGLSGDIQIS 363

  Fly   226 DPMRERPYVLYTHKLYADGLGSNTPVVLTSWIKGALSRPHINLFPSKFQ-------FGFAGH--- 280
            |    ..::..|.::...|......:.|  |..|:.|:....::|.:.:       ....|.
plant   364 D----NKFISETFEIVNIGREKQRRIGL--WSGGSFSQRRQIVWPGRSRKIPRHRVLAEKGEKKV 422

  Fly   281 -RFQISAANQPPFIFRIRTLDSSGMGQLRWDGVE-FRLLTMISKRLNFSIDITETPTRSNTRGVV 343
             |..::|.|:.|.:..:|....:|:..:....|| |:  |.|:.   |:.::...|.|.|...:.
plant   423 LRVLVTAGNKVPHLVSVRPDPETGVNTVSGFCVEVFK--TCIAP---FNYELEFIPYRGNNDNLA 482

  Fly   344 DTIQEQIIERTVDIGMSGIYITQERLMDSAMSVGHSPDCAAFITLASKALPKYRAIMGPFQWPVW 408
            ..:..|  ....|..:..|.||..|.:....::.::......:|:..|:...: ....||:..:|
plant   483 YLLSTQ--RDKYDAAVGDITITSNRSLYVDFTLPYTDIGIGILTVKKKSQGMW-TFFDPFEKSLW 544

  Fly   409 VALICVY-LGGIFPIVFTDRLTLSHLMGNWG-EVENMFWYVFGMFTNAFSFTGKYSWSNTRKNST 471
            :|....: |.||. :...:|.......|:|| ::..|.|  ||..|..|:...|     .:|.|:
plant   545 LASGAFFVLTGIV-VWLVERSVNPEFQGSWGQQLSMMLW--FGFSTIVFAHREK-----LQKMSS 601

  Fly   472 RLLIGAYWLFTI-IITSCYTGSIIAFVTLPAFPDTVDSVLDLLGLFFRVGTLNNGGWETWFQNST 535
            |.|: ..|:|.: |:||.|:.::.:..|:...                  .||:   :..|..||
plant   602 RFLV-IVWVFVVLILTSSYSANLTSTKTISRM------------------QLNH---QMVFGGST 644

  Fly   536 HIPTSRLYKKMEFVGSVDEGIGNVTQSFFWNYAFLGSKAQLEYLVQ---------SNFSDENISR 591
            ...|::|       ||:     |..::    ||.|.....|.:::.         .|:.::.:
plant   645 TSMTAKL-------GSI-----NAVEA----YAQLLRDGTLNHVINEIPYLSILIGNYPNDFV-- 691

  Fly   592 RSALHLSEECFALFQIGFLFPRESVYKIKIDSMILLAQQSGLIAKINNEVSWVMQRSSSGRLLQA 656
                 :::........||:|.:.|....|:...|...:..|::..:  |..|..:..|.......
plant   692 -----MTDRVTNTNGFGFMFQKGSDLVPKVSREIAKLRSLGMLKDM--EKKWFQKLDSLNVHSNT 749

  Fly   657 SSSNSLREIIQEERQLTTADTEGMFLLMALGYFL 690
            ....|..:..:..::.|..:..|:|::....:.|
plant   750 EEVASTNDDDEASKRFTFRELRGLFIIAGAAHVL 783

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir21a	NP_001097043.1	Periplasmic_Binding_Protein_Type_2	289..583	CDD:304360	63/306 (21%)
Ir21a	NP_001097043.1	Lig_chan	407..662	CDD:278489	52/266 (20%)
GLR1.1	NP_187061.1	PBP1_GABAb_receptor	31..397	CDD:107361	58/298 (19%)
		ANF_receptor	45..377	CDD:279440	53/276 (19%)
		Periplasmic_Binding_Protein_Type_2	421..737	CDD:304360	75/378 (20%)
		Lig_chan	542..781	CDD:278489	56/293 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000