DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir21a and GLR2.8

DIOPT Version :9

Sequence 1:	NP_001097043.1	Gene:	Ir21a / 33157	FlyBaseID:	FBgn0031209	Length:	842	Species:	Drosophila melanogaster
Sequence 2:	NP_001324459.1	Gene:	GLR2.8 / 817459	AraportID:	AT2G29110	Length:	948	Species:	Arabidopsis thaliana

Alignment Length:	949	Identity:	165/949 - (17%)
Similarity:	297/949 - (31%)	Gaps:	304/949 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 FSIEGDRSASYQEKCIS--------RRLINHYQLNKEIFGVGMCDGNNENEFRQKRRIVPTFQGN 72
            :.:.|....|||.|.|:        |.::..|..|:...|:.....:...:.:..|.::|:...:
plant   142 YFVRGTIDDSYQVKAIAAIFESFGWRSVVAIYVDNELGEGIMPYLFDALQDVQVDRSVIPSEAND 206

  Fly    73 PRPRGEL------------------LASKFHVNS---------YNFEQTNSLVGLVNKIAQ-EYL 109
            .:...||                  |||:....:         |.:..||.:..::..|.. ..|
plant   207 DQILKELYKLMTRQTRVFVVHMASRLASRIFEKATEIGMMEEGYVWLMTNGMTHMMRHIHHGRSL 271

  Fly   110 NKCPPVIYYDSFVEKSDGLILENLFKTIPITFYHGEINADYEAKNKRFTSHIDCNCKSYILFLSD 174
            |....|:...|.|.||.||                   .|:..:.||       |.|....:|.|
plant   272 NTIDGVLGVRSHVPKSKGL-------------------EDFRLRWKR-------NFKKENPWLRD 310

  Fly   175 PLMTRKILGPQT-ESRVVLVSRSTQWRLRDFLSSELSSNIVNLLVIG------------ESL--- 223
            .|   .|.|... :|...|.....:..:..|..:..|.:..|:..:|            |:|
plant   311 DL---SIFGLWAYDSTTALAMAVEKTNISSFPYNNASGSSNNMTDLGTLHVSRYGPSLLEALSEI 372

  Fly   224 ----------MADPMRERPYVLYTHKLYADGLGSNTPVVLTSWIKGALSRPHINLFPSKFQFGFA 278
                      :.|...|.|      |........|...::..|..   |...:|:..:| ...|.
plant   373 RFNGLAGRFNLIDRQLESP------KFEIINFVGNEERIVGFWTP---SNGLVNVNSNK-TTSFT 427

  Fly   279 GHRFQISAANQPPFIFRIR-TLDSSGMGQLRWDGVEFRL------------------LTMISKRL 324
            |.||       .|.|:..: |:...|. ::..:|.:.::                  :|.|:...
plant   428 GERF-------GPLIWPGKSTIVPKGW-EIPTNGKKIKVGVPVKKGFFNFVEVITDPITNITTPK 484

  Fly   325 NFSIDITETPTRSNTRGVV-------------DTIQEQIIERTVDIGMSGIYITQERLMDSAMSV 376
            .::|||.|...:.....|:             |.:..::...|:|..:..:.||..|.:.:..::
plant   485 GYAIDIFEAALKKLPYSVIPQYYRFESPDDDYDDLVYKVDNGTLDAVVGDVTITAYRSLYADFTL 549

  Fly   377 GHSPD-CAAFITLASKALPKYRAIMGPFQWPVWVALICVY-LGGIFPIVFTDRLTLSHLMGNWGE 439
            .::.. .:..:.:...........:.|:...:||...|.: |.|....:|..|:..........:
plant   550 PYTESGVSMMVPVRDNENKNTWVFLKPWGLDLWVTTACFFVLIGFVVWLFEHRVNTDFRGPPHHQ 614

  Fly   440 VENMFWYVFGMFTNAFSFTGKYSWSNTRKNSTRLLIGAYWLFTIIITSCYTGSIIAFVTLPAFPD 504
            :...||:.|.  |..|:...|     ...|..|.::..:....:::|..||.::.:|:|:..|..
plant   615 IGTSFWFSFS--TMVFAHREK-----VVSNLARFVVVVWCFVVLVLTQSYTANLTSFLTVQRFQP 672

  Fly   505 TVDSVLDLLGLFFRVGTLNNGGWETWFQNSTHIPTSRLYKKMEFVGSVDEGIGNVTQSFFWNYAF 569
            ...:|.||         :.||                     ::||             :.:.||
plant   673 AAINVKDL---------IKNG---------------------DYVG-------------YQHGAF 694

  Fly   570 LGSKAQLEYLVQSNFSDENISRRSALHLSEECFALFQ---------------------------- 606
            :     .::|::..|   |:|:......||||.||..
plant   695 V-----KDFLIKEGF---NVSKLKPFGSSEECHALLSNGSISAAFDEVAYLRAILSQYCSKYAIV 751

  Fly   607 --------IGFLFPRESVYKIKIDSMILLAQQSGLIAKINNEVSWVMQRSSSGRLLQASSSNSLR 663
                    .||.|||.|.....:...||...|...:..|.|:  |.|:::.......|.|||
plant   752 EPTFKTAGFGFAFPRNSPLTGDVSKAILNVTQGDEMQHIENK--WFMKQNDCPDPKTALSSN--- 811

  Fly   664 EIIQEERQLTTADTEGMFLLMALGYFLGATALV----------------SEIVGGITNKCRQIIK 712
                   :|:.....|:||:..:..||.....|                ..|...:|:..|...:
plant   812 -------RLSLRSFWGLFLIAGIASFLALLIFVFLFLYENRHTLCDDSEDSIWRKLTSLFRNFDE 869

  Fly   713 RS------RKSAASSWSSASSGSMLRTNAEQLSHDKRKANRREAAEVAQKMSFGMRELNLTRATL 771
            :.      :.||....||..:..:...:..|::......::..|.|: :::||...|..||..|:
plant   870 KDIKSHTFKSSAVHHVSSPMTQYIPSPSTLQIAPRPHSPSQDRAFEL-RRVSFTPNEERLTTQTI 933

  Fly   772 REIYGSYGAPETDHGQLDIVHTEFPNSSAKLNNIEDEES 810
                                            :.|||||
plant   934 --------------------------------HFEDEES 940

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir21a	NP_001097043.1	Periplasmic_Binding_Protein_Type_2	289..583	CDD:304360	50/327 (15%)
Ir21a	NP_001097043.1	Lig_chan	407..662	CDD:278489	57/291 (20%)
GLR2.8	NP_001324459.1	PBP1_GABAb_receptor_plant	35..419	CDD:380645	56/314 (18%)
GLR2.8	NP_001324459.1	GluR_Plant	454..795	CDD:270404	65/400 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910