DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir21a and grik5

DIOPT Version :9

Sequence 1:	NP_001097043.1	Gene:	Ir21a / 33157	FlyBaseID:	FBgn0031209	Length:	842	Species:	Drosophila melanogaster
Sequence 2:	NP_001315085.1	Gene:	grik5 / 798791	ZFINID:	ZDB-GENE-070821-6	Length:	1067	Species:	Danio rerio

Alignment Length:	848	Identity:	181/848 - (21%)
Similarity:	312/848 - (36%)	Gaps:	190/848 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 RSASY--------QEKCISR--RLINHYQLNKEIFGVGMCDGNNE-----NEFRQKRRIVPTFQG 71
            ||.||        :.:|:.|  .||..:.:::|...:.|.|.|.:     .|.|..:........
Zfish   167 RSFSYPSASLVCAKAECLLRLEELIRRFLISRETLSIRMLDDNLDPTPLLKEIRDDKIATIIIDA 231

  Fly    72 NPRPRGELLASKFHVNSYNFEQTNSLVGLVNKIAQEYLNKCP-PVIYYDSFVEKSDGLILENLFK 135
            |        ||    .||...:..|.:|:.:...:..|.... |:::.|..|::...::..::|.
Zfish   232 N--------AS----ISYLILKKASELGMTSAFYKYILTTMDFPLLWLDDIVDEQSNIVGFSMFN 284

  Fly   136 TIPITFYHGEINADYEAKNKRFTSHIDCNCKSYILFLSDPLMTRKILGPQTE---SRVVLVSRST 197
            |.. .||...|      ::...:....|:...|    ..|.::..:|.....   |.|..::||.
Zfish   285 TTH-PFYLEFI------RSLNLSWREGCDINPY----PGPALSSALLFDAVHVVVSAVQELNRSQ 338

  Fly   198 QWRLRDFLSSELSSNIVNLLVIGESLMADPMRERPYVLYTHKLYADGLGSNTPVVLTSWIKGALS 262
            :..::     .||.....:...|.||| :.:|...|...|.::..:..|..|...|....|....
Zfish   339 EIGVK-----PLSCTSPQIWQHGTSLM-NYLRMVEYDGLTGRVEFNSKGQRTNYTLHILEKHRGG 397

  Fly   263 RPHINLFPS-------------KFQFGFAGHRFQISAANQPPFIFR-IRTLDSSGMGQLRWDGVE 313
            ...|.::.|             ......|.....|:...:.|::.| |...:..|..|  ::|..
Zfish   398 HKEIGIWYSNNTLLMNSTSLDINVSETLANKSLIITTILENPYVMRKINYQEFEGNEQ--YEGFC 460

  Fly   314 FRLLTMISKRLNFSIDI---------TETPTRSNTRGVVDTIQEQIIERTVDIGMSGIYITQER- 368
            ..:|..:|..|.|:..|         ...|..|.| |:|.    ::|.|..|:.::...||.||
Zfish   461 VDMLRELSDILKFTYRIKLVDDGLYGAPEPNGSWT-GMVG----ELINRKADLAVAAFTITSERE 520

  Fly   369 -LMDSAMSVGHSPDCAAFITLASKAL--------PKYRAIMGPFQWPVWVALICVYLGGIFPIVF 424
             ::|.:         ..|:||....|        |.|.:.:.||...||:.::..||.....:..
Zfish   521 KVIDFS---------KPFMTLGISILYRVHIGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFL 576

  Fly   425 TDRLT-------------LSHLMGNWGEVENMFWYVFGMFTNAFSFTGKYSWSNTRKNSTRLLIG 476
            :.||:             ...|:.|...:.|..|:..|      .|..:.|....|..|||.:.|
Zfish   577 SARLSPYEWYNPHPCLRERRDLLENQYTLGNSLWFPVG------GFMQQGSEIMPRALSTRCVSG 635

  Fly   477 AYWLFTIIITSCYTGSIIAFVTLPAFPDTVDSVLDLLG-LFFRVGTLNNGGWETWFQNSTHIPTS 540
            .:|.||:||.|.||.::.||:|:......::|..||.. ...:.||::.|...|:|.||.:....
Zfish   636 VWWAFTLIIISSYTANLAAFLTVQRMEVPIESPDDLADQTNIQYGTIHGGSTMTFFMNSRYQTYQ 700

  Fly   541 RLYKKM------EFVGSVDEGIGNVTQSFFWNYAFLGSKAQLEYLVQSNFSDENISRRSALHLSE 599
            |::..|      .||.|.:|||..|..|   .||||......||                 |.|.
Zfish   701 RMWNYMYSKQPSVFVKSTEEGIARVVNS---KYAFLLESTMNEY-----------------HRSL 745

  Fly   600 ECFALFQIGFL---------FPRESVYKIKIDSMILLAQQSGLIAKINNEVSWVMQRSSSGRLLQ 655
            .| .|.|||.|         .|..|.::.::...:|..|:       ||.:..:.:|...|
Zfish   746 NC-NLTQIGGLLDTKGYGIGMPLGSPFRDELSLAVLQLQE-------NNRLEILKRRWWEG---- 798

  Fly   656 ASSSNSLREIIQEERQLTTADTEGMFLLMALGYFLGATALVSEIV-----GGITNKCRQIIKRSR 715
               ....:|.....:.|...:..|:|:::..|..:.....|.|.|     ...|::.|.:
Zfish   799 ---GKCPKEEDHRAKGLGMENIGGIFVVLICGLIIAVFVAVMEFVWSTRRSAETDEVRPL----- 855

  Fly   716 KSAASSWSSASSGSMLRTNAEQLSHDKRKANRREAAEVAQK--MSFGMRELNLTRATLREIYGSY 778
             |....:.|.::.|:.:   |.|:..:...:.::::.:.::  :|..:...:.||.||
Zfish   856 -SCDRQYHSHTTVSVCQ---EMLTEFRNAVSCKKSSRLRRRRPLSSSLALRHPTRITL------- 909

  Fly   779 GAP 781
            |||
Zfish   910 GAP 912

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir21a	NP_001097043.1	Periplasmic_Binding_Protein_Type_2	289..583	CDD:304360	87/333 (26%)
Ir21a	NP_001097043.1	Lig_chan	407..662	CDD:278489	71/283 (25%)
grik5	NP_001315085.1	PBP1_iGluR_Kainate_KA1_2	38..412	CDD:107389	53/273 (19%)
		ANF_receptor	55..392	CDD:279440	50/253 (20%)
		Periplasmic_Binding_Protein_Type_1	<313..383	CDD:299141	16/75 (21%)
		Periplasmic_Binding_Protein_Type_2	427..797	CDD:304360	103/419 (25%)
		Lig_chan	558..828	CDD:278489	75/310 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910