DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir21a and grid1a

DIOPT Version :9

Sequence 1:	NP_001097043.1	Gene:	Ir21a / 33157	FlyBaseID:	FBgn0031209	Length:	842	Species:	Drosophila melanogaster
Sequence 2:	XP_021323097.1	Gene:	grid1a / 793756	ZFINID:	ZDB-GENE-120411-28	Length:	1044	Species:	Danio rerio

Alignment Length:	548	Identity:	119/548 - (21%)
Similarity:	210/548 - (38%)	Gaps:	123/548 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   201 LRDFLSSELSSNIVNLLVIGESLMADPMRERPYVLYTHKLYADGLGSNTPVVLTSW-----IKGA 260
            |.||.|:..:|: |...::|.|                  |::..|.:.. .|.:|     :.|:
Zfish   381 LMDFRSNGANSH-VQFEILGTS------------------YSETFGKDVK-RLATWDSDRGLNGS 425

  Fly   261 LSRPHINLFPSKFQFGFAGHRFQISAANQPPFIFRIRTLDSSGMGQ-LRWDGVEFRLLTMISKRL 324
            |..       ::...|..|...::....:.||:.....:    :|| .|:.|....:|..::|.|
Zfish   426 LRE-------NRADHGMQGITLKVVTLLEEPFVMVAENI----LGQPKRYKGFSIDVLDALAKIL 479

  Fly   325 NFSIDITET--------PTRSNTRGVVDTIQEQIIERTVDIGMSGIYITQER--LMDSA-----M 374
            .|..::.:.        .|..:..|::.    ::|.:..|:.:|.|.||.||  ::|.:     .
Zfish   480 GFKYEMYQVADAKYGSPQTNGSWNGMIG----ELIGKRADVAISAITITPERENVVDFSKRYLDY 540

  Fly   375 SVGHSPDCAAFITLASKALPKYRAIMGPFQWPVWVALICVYLGGIFPIVFTDRLTLSHLMGN--- 436
            |||      ..:|...:.|..: :::.||...|| |.|...:..:..:||..|...|....|
Zfish   541 SVG------ILMTKTEERLNIF-SLLAPFDLAVW-ACIAAAIPVVGVMVFLLRRVQSVRSQNPPG 597

  Fly   437 -------WGEVENMFWYVFGMFTNAFSFTGKYSWSNTRKNSTRLLIGAYWLFTIIITSCYTGSII 494
                   ....::..|.|:|    ||...|..|:.::.  :.|:.:|::||||:|:.|.||.::.
Zfish   598 PHQPASVTTSFQSAIWIVYG----AFVQQGGESFMSSM--ALRIAMGSWWLFTLIVCSSYTANLA 656

  Fly   495 AFVTLPAFPDTVDSVLDL---------------LGLFFRVGTLNNGGWETWFQNSTHIPTSRLYK 544
            |::|:....:.:.:..||               :..:|||     .|.....|:||.....|...
Zfish   657 AYLTVSRMDNAIRTFQDLSKQSEINYGTVRESAVFEYFRV-----KGTNPLEQDSTFAELWRTIN 716

  Fly   545 KME----FVGSVDEGIGNVTQSFFWNYAFLGSKAQLEYLVQSNFSDENISRRSALHLSEECFALF 605
            |.:    .|.|..|||..|.:.   .||||...|.|||   :..:|::.:    |.::....:..
Zfish   717 KNQGQDNSVTSPAEGIRKVKRD---PYAFLWDMAVLEY---AALTDDDCT----LVVTGNGMSSK 771

  Fly   606 QIGFLFPRESVYKIKIDSMILLAQQSGLIAKINNEVSWVMQRSSSGRLLQASSSNSLREIIQEER 670
            ..|......|.|:......||..|:.|.:..:..:  |..::   ||    ...:...|...|.|
Zfish   772 GYGLALQHGSPYRDLFSQKILDLQEKGDLDILKQK--WWPRK---GR----CDLDKHAEPQTEGR 827

  Fly   671 QLTTADTEGMFLLMALGYFLGATALVSE 698
            .|......|:|.::|.|..|.......|
Zfish   828 ALRLHSFAGVFCILAAGLLLACLVAALE 855

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir21a	NP_001097043.1	Periplasmic_Binding_Protein_Type_2	289..583	CDD:304360	81/338 (24%)
Ir21a	NP_001097043.1	Lig_chan	407..662	CDD:278489	65/283 (23%)
grid1a	XP_021323097.1	Periplasmic_Binding_Protein_Type_1	25..424	CDD:324556	12/62 (19%)
		PBP2_iGluR_delta_1	437..809	CDD:270448	92/410 (22%)
		DNA_pol3_gamma3	<915..1044	CDD:331207
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810