Protein Alignment Ir21a and Grid2

DIOPT Version :10

• Sequence 1: NP_001097043.1
• Gene: Ir21a / 33157
• FlyBaseID: FBgn0031209
• Length: 842
• Species: Drosophila melanogaster
• Sequence 2: NP_077355.2
• Gene: Grid2 / 79220
• RGDID: 68368
• Length: 1007
• Species: Rattus norvegicus
• Alignment Length: 1048
• Identity: 201/1048 - (19%)
• Similarity: 338/1048 - (32%)
• Gaps: 369/1048 - (35%)

  Fly     1 MSYYWV-ALVLFTAQAFSIEG---DRSASYQEKCISRRLINHYQLNKEI-------FGVGMCDGN 54
            :|::|. ...|.|:.:....|   |.||...:: :.|..:.....|:||       |.|...|||
  Rat    10 LSFWWSRTWDLATSDSIIHIGAIFDESAKKDDE-VFRTAVGDLNQNEEILQTEKITFSVTFVDGN 73

  Fly    55 NENEFRQKR---------RIVPTFQGNPRPRGELLASKFHVNSYNFEQT-----NSLVGLV--NK 103
            |..:..|:.         .:|.:.........:.||...|:.....:::     .|..||.  |:
  Rat    74 NPFQAVQEACELMNQGILALVSSIGCTSAGSLQSLADAMHIPHLFIQRSTAGTPRSGCGLTRSNR 138

  Fly   104 IAQEYLNKCPPV-------------------IYYDS---------FVEK--SDGL---------- 128
            .....|:..|||                   |:|||         |::|  ..|:
  Rat   139 NDDYTLSVRPPVYLNEVILRVVTEYAWQKFIIFYDSEYDIRGIQEFLDKVSQQGMDVALQKVENN 203

  Fly   129 ---ILENLFKTIPITFYHGEINADYEAKNKRFTSHIDCNCKSYILFLSDPLMTRKILGPQTESRV 190
               ::..||.|:.|.    |:|. |....:|            .:.:.:|...:..:....|:.
  Rat   204 INKMITTLFDTMRIE----ELNR-YRDTLRR------------AILVMNPATAKSFISEVVETN- 250

  Fly   191 VLVSRSTQW-----RLRDFLSSELSSNIVNLLVI-----------------G----ESLMADPMR 229
             ||:....|     .:.|....||....:..|.|                 |    .|.:.||
  Rat   251 -LVAFDCHWIIINEEINDVDVQELVRRSIGRLTIIRQTFPVPQNISQRCFRGNHRISSTLCDP-- 312

  Fly   230 ERPYV-------LYT-----------HKLYAD----GLGSNTPVVLTS--WIKG-----ALSRPH 265
            :.|:.       ||.           ||...|    .:.|.:.:...|  |..|     .:.:..
  Rat   313 KDPFAQNMEISNLYIYDTVLLLANAFHKKLEDRKWHSMASLSCIRKNSKPWQGGRSMLETIKKGG 377

  Fly   266 INLFPSKFQFGFAGH----RFQISAANQPPFIFR-IRTL--------------DSSGMGQLRWDG 311
            :|......:||..|.    .|:|...|....:.| :|.|              |......:|  |
  Rat   378 VNGLTGDLEFGENGGNPNVHFEILGTNYGEELGRGVRKLGCWNPVTGLNGSLTDKKLENNMR--G 440

  Fly   312 VEFRLLT-------MISKRL--------NFSIDITE---------------------TPTRSNT- 339
            |..|::|       |:|:.:        .||||:.:                     :|....|
  Rat   441 VVLRVVTVLEEPFVMVSENVLGKPKKYQGFSIDVLDALSNYLGFNYEIYVAPDHKYGSPQEDGTW 505

  Fly   340 RGVVDTIQEQIIERTVDIGMSGIYITQE---------RLMDSAMSVGHSPDCAAFITLASKALPK 395
            .|:|.    :::.:..|||:|.:.||.:         |.||.::.|        .:..|.|.:..
  Rat   506 NGLVG----ELVFKRADIGISALTITPDRENVVDFTTRYMDYSVGV--------LLRRAEKTVDM 558

  Fly   396 YRAIMGPFQWPVW---------VALICVYLGGIFPIVFTDRLTLSHLMGNWGEVENMFWYVFGMF 451
            : |.:.||...:|         |.|:...|..:.|    .||.:..:...  .:.|..|:|:|.|
  Rat   559 F-ACLAPFDLSLWACIAGTVLLVGLLVYLLNWLNP----PRLQMGSMTST--TLYNSMWFVYGSF 616

  Fly   452 TNAFSFTGKYSWSNTRKNSTRLLIGAYWLFTIIITSCYTGSIIAFVTLPAFPDTVDSVLDLLGLF 516
            ...   .|:..::..   :||:::||:|||.:|:.|.||.::.||:|:.....::.|:.||
  Rat   617 VQQ---GGEVPYTTL---ATRMMMGAWWLFALIVISSYTANLAAFLTITRIESSIQSLQDL---- 671

  Fly   517 FRVGTLNNGGWETWFQNSTHIP-----TSRLYKKMEFVG-------------------------S 551
                           ...|.||     .|.:|:.:...|                         :
  Rat   672 ---------------SKQTDIPYGTVLDSAVYQHVRMKGLNPFERDSMYSQMWRMINRSNGSENN 721

  Fly   552 VDEGIGNVTQSFFWNYAFLGSKAQLEYLVQSNFSDENISRRSALHLSEECFALFQIGFLFPRESV 616
            |.|....:.:..:.||||:...|.|||:.   .:|.:.|    .:......|....|......|.
  Rat   722 VLESQAGIQKVKYGNYAFVWDAAVLEYVA---INDPDCS----FYTVGNTVADRGYGIALQHGSP 779

  Fly   617 YKIKIDSMILLAQQSGLIAKINNEVSWVMQRSSSGRLLQASSSNSLREIIQEERQLTTADTEGMF 681
            |:......||..||||.:..:.::  |..:..      |....:|: :..|:...|......|:|
  Rat   780 YRDVFSQRILELQQSGDMDILKHK--WWPKNG------QCDLYSSV-DAKQKGGALDIKSLAGVF 835

  Fly   682 LLMALGYFLGATALVSEIVGGITNKCRQIIKRSRKSAASSWSSASSGSMLRTNAEQLSHDKRKAN 746
            .::|.|..|.....|.|                      :|.|...||.:.:..:....|....:
  Rat   836 CILAAGIVLSCLIAVLE----------------------TWWSRRKGSRVPSKEDDKEIDLEHLH 878

  Fly   747 RREAAEVAQKMSFGMRELNLTRATLREIYGSYGAPETDHGQLDIVHTEFPNSSAKLN--NIEDEE 809
            ||                             ..:..||.   |..|.:|..||..|.  :|:...
  Rat   879 RR-----------------------------VNSLCTDD---DSPHKQFSTSSIDLTPLDIDTLP 911

  Fly   810 SREALESL 817
            :|:|||.:
  Rat   912 TRQALEQI 919

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir21a	NP_001097043.1	HisJ	287..>392	CDD:440596	31/165 (19%)
		Lig_chan	405..662	CDD:459656	60/295 (20%)
Grid2	NP_077355.2	Interaction with CBLN1 homotrimer. /evidence=ECO:0000250|UniProtKB:O43424	24..345		61/342 (18%)
		Periplasmic_Binding_Protein_type1	28..429	CDD:471960	76/422 (18%)
		PBP2_iGluR_delta_2	440..806	CDD:270449	88/418 (21%)
		Interaction with AP4M1. /evidence=ECO:0000269|PubMed:14572453	921..991
		PDZ-binding. /evidence=ECO:0000250	1005..1007