DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir21a and Ir7d

DIOPT Version :9

Sequence 1:	NP_001097043.1	Gene:	Ir21a / 33157	FlyBaseID:	FBgn0031209	Length:	842	Species:	Drosophila melanogaster
Sequence 2:	NP_001138175.1	Gene:	Ir7d / 7354416	FlyBaseID:	FBgn0259190	Length:	594	Species:	Drosophila melanogaster

Alignment Length:	738	Identity:	133/738 - (18%)
Similarity:	233/738 - (31%)	Gaps:	243/738 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 SASYQEKCISRRLINHYQLNKEIFGVGMCDGNNENEFRQKRRIVPTFQGNPRPRGELLASKFHVN 87
            |.||:|....|.::.|..||:.::                   .|.|     |...:||||.:
  Fly    57 STSYEEMDRDRVILVHQVLNRNLY-------------------PPNF-----PVAVVLASKMN-- 95

  Fly    88 SYNFEQTNSLVGLVNKIAQEYLNKCPPVIYYDSFVEKSDGLILENLFKTIPITFYHGEINADYEA 152
                          .||..:...:.               |.::|..:.|.|.          |.
  Fly    96 --------------RKITAQVFTQL---------------LFVQNAEQAIAIA----------EG 121

  Fly   153 KNKRFTSHIDCNCKSYILFLSDPLMTRKILGPQTESRVVLVSRSTQWRLRDFLSSELSSNIVNLL 217
            .|:.....|       :|..|.|            .|.::....|.     |:....:.|:|.|:
  Fly   122 VNRNGLCVI-------VLLTSQP------------ERPIMTKIFTY-----FMQERYNINVVILV 162

  Fly   218 VIGESLMADPMRERPYVLYTHKLYADGLGSNTPVVLTS-------------WIKGALSRPHINLF 269
            .....:.|  ...|||               ||...:|             |          ::|
  Fly   163 PRLHGVQA--FNVRPY---------------TPTSCSSLEPVEIDIKDGDLW----------DVF 200

  Fly   270 PSKFQFGFAGHRFQISAANQPPFIFRIRTLDSSGMGQLRWDGVEFRLLTMISKRLNFSIDITETP 334
            |.:.: ...|....:...:.||:: ||....|..|..|  ||::..||.::::::||::.:  .|
  Fly   201 PRRLK-NLHGCPLSVIVWDIPPYM-RINWKSSDPMDGL--DGLDGLLLRIVARKMNFTLKL--IP 259

  Fly   335 TRSN--------TRGVVDTIQEQIIERTVDIGMSGIYITQERLMDSAMSVGHSPDCAAFITLASK 391
            ...|        ..|......:.:.||..:|.:.....|.||......:..:|......:..|..
  Fly   260 NEPNGLIGGSSFMNGTFTGAYKMLRERRANITIGCAACTPERSTFLEATSPYSQMSYIIVLQARG 324

  Fly   392 ALPKYRAIMGPFQWPVWVALICVYLGGIFPIVFTDRLTLSHLMGNWGEVENMFWYVFGMFTNAFS 456
            ....|..::.||:...|                   |.||.::|       :.|.|
  Fly   325 GYSIYEVMLFPFEKYTW-------------------LLLSTILG-------LHWIV--------- 354

  Fly   457 FTGKYSWSNTRKNSTRLLIGAYWLFTIIITSCYTGSIIAFV---TLPAFPDTVDSVLDLLGLFFR 518
                  .|..|..|..|.....|:|  :|.:.|..|:..|:   .:...|.|:|..|
  Fly   355 ------GSRWRMPSPILAGWMLWIF--VIRASYEASVFNFIQNSPVKPSPRTLDQAL-------- 403

  Fly   519 VGTLNNGGWETWFQNSTHIPTSRLYKKM-EFVGSVDEGIGNVTQSFF------WNYAFLGSKAQL 576
                 :||    |:..|...:.|:..|: .|.|......|.....|.      |......|:|.|
  Fly   404 -----SGG----FRFITDHASYRMTLKIPSFQGKTLISAGQPVDVFDALLKAPWKTGAFTSRAFL 459

  Fly   577 -EYLVQSNFSDENISRRSALHLSEECFALFQIGFLFPRESVYKIKIDSMILLAQQSGLIAKINNE 640
             ::||:..      ..|:.|.:..|......:...||..|.:..:|:.::...:..|:....:..
  Fly   460 ADHLVRHR------KHRNQLVILAEKIVDNMLCMYFPHGSYFAWEINKLLFNMRSFGIFQHHSQI 518

  Fly   641 VSW-----VMQRSSSGRLLQASSSNSLREIIQEERQLTTADTEGM-FLLMALGYFLGATALVSEI 699
            ::|     .....:.|:.:.:|:.:           :.|...|.| |::.||...:||.. :|.:
  Fly   519 LAWDNLPTTTDTDTPGKRIHSSTES-----------VATGFAESMSFVVAALNCLMGALC-ISIV 571

  Fly   700 VGGITNKCRQIIKRSRKSAASSW 722
            |.|:     :::.|.|......|
  Fly   572 VFGL-----ELLSRRRHWTGLEW 589

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir21a	NP_001097043.1	Periplasmic_Binding_Protein_Type_2	289..583	CDD:304360	64/312 (21%)
Ir21a	NP_001097043.1	Lig_chan	407..662	CDD:278489	48/270 (18%)
Ir7d	NP_001138175.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810