DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir21a and grin3ba

DIOPT Version :9

Sequence 1:	NP_001097043.1	Gene:	Ir21a / 33157	FlyBaseID:	FBgn0031209	Length:	842	Species:	Drosophila melanogaster
Sequence 2:	XP_021323058.1	Gene:	grin3ba / 566411	ZFINID:	ZDB-GENE-070912-354	Length:	1118	Species:	Danio rerio

Alignment Length:	1107	Identity:	208/1107 - (18%)
Similarity:	360/1107 - (32%)	Gaps:	368/1107 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 VLFTAQAFSIEGDRSASYQEKCISRRLIN---------HYQLNKEIFGVGMCDGNNENEFR---- 60
            :|.|.|...|:|         .::|.|::         .|.|:.|:......:|:.|:.||
Zfish    49 LLPTRQQSRIQG---------ALNRALVHLRQSGNNFLPYNLSLEVLSREPLNGDPESMFRCVCQ 104

  Fly    61 ----QKRRIVPTFQGNPRPRGELLASKFHVNSY-------NFEQTNSLVGLVNKIAQEYLNKCPP 114
                |....|..|   |:...||:..:| ::|:       ..||...| ...|:...:.:.:.||
Zfish   105 DIVVQGVSAVLAF---PQSHEELIQVEF-MSSFLEIPFISIIEQGEPL-KTQNRFHLQMMTRMPP 164

  Fly   115 VIYYDSFVE------------------KSDGLILE--------------NLFKTIPITFYHGEIN 147
            ....|..:.                  .:.|::.|              :|::|:.::.....|:
Zfish   165 SGLSDLLLAVLLRGGWQGGAATVCPGGGNTGMLEELQQRGHLGLDGAHWHLWETLNLSRLEENIS 229

  Fly   148 AD--YEAKNKRFTSHIDCNCKSYILFLSDPLMTRKIL-------GPQTESRVVL----------- 192
            .|  .|..::..:........|.:||.|||..|..:|       |.......::
Zfish   230 EDKVMELLSQLLSRTPSAPASSVVLFGSDPECTATVLHCAHQLSGTLPPMHWIMGYPLSLDSLHS 294

  Fly   193 ------------VSRS-TQWRLRDFL---------------SSELSSNIVN---------LLVIG 220
                        |:|. ..:.:||.|               ...|..|:||         |...|
Zfish   295 IGSPLGLMAYGEVNRKPLNFYIRDTLQLIGRAVYAATMVRPDLALIQNMVNCFDKPNKHELPSSG 359

  Fly   221 ESL-----------MADPMR-ERPY--VLYTHK-----LYADGLGSNTPVVLTSWIKGALSRPHI 266
            :.|           :..|:| ||.:  ||.:.:     |..|.||..:.|.:.||..|.|.....
Zfish   360 QYLARFLSNTSFTGLTGPVRVERSFSRVLTSQRFHIWSLQRDPLGQPSWVTVASWQSGRLELEEQ 424

  Fly   267 NLFP----------------SKFQFGF--AGHRFQISAANQPPFIFRIRTLDSSGM---GQLRWD 310
            .|:|                .::|.|.  ||.|.::....:.||:| .|.:|..|.   |||..|
Zfish   425 GLWPGVTQHQREDGPGIRLGGRWQAGLPVAGSRLRVVTLVEHPFVF-TREVDEEGQCPAGQLCLD 488

  Fly   311 ---------------------------------GVEFRLLTMISKRLNFSID---ITETPTRSNT 339
                                             |....||..:::.::|..|   :.:....:..
Zfish   489 PQTNNSEVLNQLFRELEQTNSSSLPTDMRKCCYGYCIDLLEKLAEDMHFEFDLYIVGDGKYGAWK 553

  Fly   340 RGVVDTIQEQIIERTVDIGMSGIYI--TQERLMD-----SAMSVG---HSPDCAAFITLASKALP 394
            .|....:...::....|:.::...|  .:.|::|     .:.|:|   .|.|.||.|
Zfish   554 GGRWSGLVGDLLSGVADMAVTSFSINSARSRVIDFTSPFFSTSLGILVRSKDTAAPI-------- 610

  Fly   395 KYRAIMGPFQWPVWVAL-ICVYLGGIFPIVFTDRLTLSHLMGNWGEVENMFWYVFGMFTN----- 453
              .|.|.|..|.:||.: :.:::..:|..::           .|..       .|||..:
Zfish   611 --GAFMWPLHWSMWVGIFVALHITALFITLY-----------EWNS-------PFGMTPHGRNRI 655

  Fly   454 -AFSFT-----------GKYSWSNTRKNST-RLLIGAYWLFTIIITSCYTGSIIAFVTLPAFPDT 505
             .||::           |:...|.|.|..| |.|:..:.:|.:::.|.||.::.|.:......:.
Zfish   656 RVFSYSSALNLCYAILFGRTVASKTPKCWTGRFLMNLWAIFCLLVLSSYTANLAAVMVGEKTFEE 720

  Fly   506 VDSVLDLL----GLFFRVGTLNNGGWETWFQNSTHIPTSRLYKKMEFVGSVDEGIGNVTQSFFWN 566
            |..:.|:.    .|.||.||:.....|.:.:.|  .|....|.:.....:..:|:..:.......
Zfish   721 VSGIHDVKLHHPSLGFRFGTVRESSAEDYVKKS--FPEMHEYMRRFNKPTTPDGVSTLKTDPPQL 783

  Fly   567 YAFLGSKAQLEYLVQSNFSDENISRRSALHLSEEC--------FALFQIGFLFPRESVYKIKIDS 623
            .||:..||.|:|.|.               :..:|        ||:...|...|:.|.....:..
Zfish   784 DAFIMDKALLDYEVS---------------IDADCKLLTVGKPFAIEGYGIGLPQNSPLTRNVSE 833

  Fly   624 MILLAQQSGLIAKINNEVSWVMQRSSSGRLLQASSSNSLREIIQEERQLTTADTEGMFLLMALGY 688
            .:...:..|.:..::::  |........|:.          .:.|..|:......|:|:|:.:|.
Zfish   834 YVSRYKSDGYMDMLHDK--WYKVVPCGKRVF----------AVTETLQMGIQHFSGLFVLLCVGV 886

  Fly   689 ------FLGATALVSEIVGGITNKCR--------QIIKRS--------RKSAAS----------- 720
                  .||..|....|:..:.::.|        |.|.|:        |||.|.
Zfish   887 AGALLTLLGEHAFFRFILPHLRHQQRFKYWLHTSQKIHRAINMGCDDERKSEAESSDRCPTLCLS 951

  Fly   721 ----------SWSSASSGSMLRTNAEQLSHDKRKANRREAAEVAQKMSFGMRELNL------TRA 769
                      |.||..|.|...|...:.::...||. |||.|..:::.|.:..||.      ...
Zfish   952 ENCNLHRLPPSSSSPPSTSSTSTTTTKWNNQSVKAG-REAKEQNKRVHFNLETLNSYQLQAPPHG 1015

  Fly   770 TLREIYGSYGAPETDHGQLDIVHTEFPNSSAKL---------NNIEDEESREALESLQRLDEFMD 825
            ..|...|..|:|.|     .:.....||.|..|         ::...||....|:.  |::||..
Zfish  1016 AERGRRGLVGSPPT-----QLCSNGGPNPSLSLVLSPLTCSGHSTPWEEELHELQG--RIEEFRG 1073

  Fly   826 QM 827
            |:
Zfish  1074 QL 1075

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir21a	NP_001097043.1	Periplasmic_Binding_Protein_Type_2	289..583	CDD:304360	71/365 (19%)
Ir21a	NP_001097043.1	Lig_chan	407..662	CDD:278489	49/285 (17%)
grin3ba	XP_021323058.1	Periplasmic_Binding_Protein_Type_1	26..428	CDD:324556	73/392 (19%)
grin3ba	XP_021323058.1	PBP2_iGluR_NMDA_Nr3	457..852	CDD:270438	79/442 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810