DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir21a and grin3a

DIOPT Version :9

Sequence 1:	NP_001097043.1	Gene:	Ir21a / 33157	FlyBaseID:	FBgn0031209	Length:	842	Species:	Drosophila melanogaster
Sequence 2:	XP_009303361.1	Gene:	grin3a / 564832	ZFINID:	ZDB-GENE-130530-780	Length:	1111	Species:	Danio rerio

Alignment Length:	669	Identity:	124/669 - (18%)
Similarity:	222/669 - (33%)	Gaps:	162/669 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   172 LSDPLMTRKILGPQTESRVVL------VSRSTQ----WRLRDFLSSELSSNIVNLLVIGESLMAD 226
            :..|:.||  ||.....:||:      ..|.:|    ||    .||.|...:|.|:
Zfish   478 IGKPMWTR--LGSWKHGKVVMDYGVWPNKRRSQPGADWR----HSSRLHLRVVTLV--------- 527

  Fly   227 PMRERPYVLYTHKLYADGLG----------SNTPVVLTSWIKGALSRPHINLFPSKFQFGFAGHR 281
               |.|:| :|..:..:||.          :|...:|.|..:|.....  :..|.:|:....|:.
Zfish   528 ---EHPFV-FTRDVDDEGLCPAGQLCLDPLTNDTALLESLFQGLQGAN--DTVPLEFKKCCYGYC 586

  Fly   282 FQI--SAANQPPFIFRIRTLDSSGMGQL---RWDGVEFRLLTMISKRLNFSIDITETPTRSNTRG 341
            ..:  ..|....|.|.:..:.....|..   ||.|:   :..::|...:.::          |..
Zfish   587 IDLLEKLAEDMGFDFDLYIVGDGKYGAYKNGRWTGL---VGDLMSGAAHLAV----------TSF 638

  Fly   342 VVDTIQEQIIERTVDIGMS--GIYITQERLMDSAMSVGHSPDCAAFITLASKALPKYRAIMGPFQ 404
            .:::.:.|:|:.|.....:  ||.:   |..|:|..:|                    |.|.|..
Zfish   639 SINSARSQVIDFTSPFFSTSLGILV---RTRDTAAPIG--------------------AFMWPLH 680

  Fly   405 WPVWVAL-ICVYLGGIF--------PIVFTDRLTLSHLMGNWGEVENMFWYVFGMFTNAFSFTGK 460
            |.:|:.: :.:::..:|        |...|.|......:.::....|:.:.:  :|....:....
Zfish   681 WSMWLGIFVSLHVTAVFLTLYEWKSPFGMTPRGRNRDRVFSFSSALNVCYAI--LFGRTAAIKPP 743

  Fly   461 YSWSNTRKNSTRLLIGAYWLFTIIITSCYTGSIIAFV----TLPAFPDTVDSVLDLLGLFFRVGT 521
            ..|:.      |.|:..:.:|.:...|.||.::.|.:    |........|..|......||.||
Zfish   744 KCWTG------RFLMNLWAIFCLFCLSTYTANLAAVMVGEKTYEQLSGIHDPKLHHPSQGFRFGT 802

  Fly   522 LNNGGWETWFQNSTHIPTSRLYKKMEFVGSVDEGIGNVTQSFFWNYAFLGSKAQLEYLVQSNFSD 586
            :.....|.:.:.|  .|....|.:.....:..:||.::........||:..||.|:|..
Zfish   803 VRESSAEDYVKKS--FPEMHEYMRRYNAPTTPDGIDHLKDDPQKLDAFIMDKALLDYWA------ 859

  Fly   587 ENISRRSALHLSEECFALFQIGFLFPRESVYKIKIDSMILLAQQSGLIAKINNEVSWVMQRSSSG 651
                     |..:...:|...|:              .|.|.|.|.|.:.|:..||   |..|.|
Zfish   860 ---------HADKXYISLLLTGY--------------GIGLKQNSPLTSNISELVS---QYKSDG 898

  Fly   652 -------RLLQASSSNSLREIIQEERQLTTADTEGMFLLMALGYFLG-ATALVSEIVGGITNKCR 708
                   :..:..........:.|..|:......|:|:::.:|..|. .|.|...||.      |
Zfish   899 FMDMLHDKWYKVVPCGKRSFAVTETLQMGIKHFSGLFVMLCVGVALSLLTTLGEHIVH------R 957

  Fly   709 QIIKRSRKSAASSWSSASSGSMLRTNAEQLSHDKRK--ANRREAAEVAQKMSFGMRELNLTRATL 771
            .:|.|.::|....:...:|..:.|........||.:  |...::..|..........|.......
Zfish   958 WVIPRMQESTEHKYWLHTSQRLHRALNPTFKEDKLQTVAKPEKSCNVGNNQQMPWNSLGTPNCNR 1022

  Fly   772 REIYGSYGAPETDHGQLDI 790
            |::       ....||.|:
Zfish  1023 RKL-------SNQEGQNDL 1034

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir21a	NP_001097043.1	Periplasmic_Binding_Protein_Type_2	289..583	CDD:304360	55/311 (18%)
Ir21a	NP_001097043.1	Lig_chan	407..662	CDD:278489	48/274 (18%)
grin3a	XP_009303361.1	Periplasmic_Binding_Protein_Type_1	36..502	CDD:299141	7/25 (28%)
		ANF_receptor	132..452	CDD:279440
		PBP2_iGluR_NMDA_Nr3	518..908	CDD:270438	86/482 (18%)
		Lig_chan	682..941	CDD:278489	52/300 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900