Protein Alignment Ir21a and grin2aa

DIOPT Version :9

• Sequence 1: NP_001097043.1
• Gene: Ir21a / 33157
• FlyBaseID: FBgn0031209
• Length: 842
• Species: Drosophila melanogaster
• Sequence 2: XP_021329529.1
• Gene: grin2aa / 563297
• ZFINID: ZDB-GENE-070424-129
• Length: 1460
• Species: Danio rerio
• Alignment Length: 844
• Identity: 146/844 - (17%)
• Similarity: 267/844 - (31%)
• Gaps: 244/844 - (28%)

  Fly     5 WVALVLFTAQAFSIEGDRSASYQEKCISRRLINHYQLNKEIFGVGMCDGNNENEFRQKRR----- 64
            |....:.|..|  ::||.....|.|.:...::..|           |..:......::.|
Zfish   195 WDLQHIITLDA--VDGDSRTQIQLKKVQSPVVLLY-----------CSKDEAAYILEEARSLGLT 246

  Fly    65 ------IVPTF-QGNPR------PRGELLASKFHVNSYNFE-QTNSLVGLVNKIAQEYLNK---- 111
                  |||:. .|||.      |.| :::..:....|..| :....:|::...|...|.:
Zfish   247 GFGYIWIVPSLTTGNPEITPDTFPSG-MISVSYDDWDYPLEARVRDGLGIITTAAAAMLEEFGDI 310

  Fly   112 ------CPPVIYYDSFVEKSDGLILENLFKTIPITFYHGEINADYEAKNKRFTSHIDCNCKSYIL 170
                  |     |.. :||:         |..|...:...:|..::.|:..||..
Zfish   311 PEAKTSC-----YGQ-MEKT---------KLPPSALHKYMMNVTWDGKDLSFTED---------- 350

  Fly   171 FLSDPLMTRKILGPQTESR--VVLVSRSTQW-------------------RLRDFLSSELSSNIV 214
                        |.|...:  |:::::..:|                   |...|..:|...|.:
Zfish   351 ------------GYQVHPKLVVIVLNKDREWEKMGKWENQSLTLKYPVWPRFNSFGDAETDDNHL 403

  Fly   215 NLLVIGESLMADPMRERPYVLY--THKLYADGLGSNTPVVLTSWIKGALSRPHINLFPSKFQFGF 277
            .::.         :.|:|:|:.  ..:|....:.::.|           .|.||
Zfish   404 TIVT---------LEEKPFVIVENVERLTGTCMRNSVP-----------CRKHI----------- 437

  Fly   278 AGHRFQISAANQPPFIFRIRTLDSSGMGQLR-WDGVEFRLLTMISKRLNFSID---ITETPTRSN 338
                             :..|.:..|....: ..|....:|..|::.:.|:.|   :|.......
Zfish   438 -----------------KDNTTEGGGTYIKKCCKGFCIDILKKIARNVKFTYDLYLVTNGKHGKK 485

  Fly   339 TRGVVDTIQEQIIERTVDIGMSGIYITQERLMDSAMSVGHSPDCAAFITLASKALPKYRAIMGPF 403
            ...|.:.:..:::.:...:.:..:.|.:||......||.......:.:...|.......|.:.||
Zfish   486 INNVWNGMVGEVVNKKAVMAVGSLTINEERSEVIDFSVPFVETGISVMVSRSNGTVSPSAFLEPF 550

  Fly   404 QWPVW----VALICVYLGGIF------PIVFTDRLTL-------SHLMGNWGEVENMFWYVFGMF 451
            ...||    |.|:.|....:|      |:.|...|..       |..||      ...|.::|:.
Zfish   551 SASVWVMMFVMLLLVTAMAVFMFEYISPLGFNRNLAQGKDPHGPSFTMG------KAVWLLWGLV 609

  Fly   452 TNAFSFTGKYSWSNTRKNSTRLLIGAYWLFTIIITSCYTGSIIAFVTLPAFPDTVDSVLDLLGLF 516
                 |.......|.:..:::.::..:..|.:|..:.||.::.||:....|.|.|..:.|  ..|
Zfish   610 -----FNNSVPVQNPKGTTSKFIVSVWAFFAVIFLASYTANLAAFMIQEEFVDQVTGLSD--KKF 667

  Fly   517 ---------FRVGTLNNGGWETWFQNSTHIPTSRLYK-KMEFVGSVDEGIGNVTQSFFWNYAFLG 571
                     ||.||:.||..|...:.  :.|....|. |....|..|..:...|...   .||:.
Zfish   668 QSPYSYSPPFRFGTVPNGSTERNIRK--NYPDMHQYMVKYHQTGVNDALVSLKTGKL---DAFIY 727

  Fly   572 SKAQLEYLVQSNFSDENISRRSALHLSEECFALFQIGFLFPRESVYKIKIDSMILLAQQSGLIAK 636
            ..|.|.|:...:...:.::..|..     .||....|....:.|::|..:|..||.....|.:.:
Zfish   728 DAAVLNYMAGRDEGCKLVTIGSGY-----IFATTGYGIALQKGSLWKRPVDLAILAIIGDGEMEE 787

  Fly   637 INNEVSWVMQRSSSGRLLQASSSNSLREIIQEERQLTTADTEGMFLLMA---------------- 685
            :  |..|          |.....|...|::..  ||...:..|:|.::|
Zfish   788 L--EAQW----------LTGICHNEKNEVMSS--QLDVDNMAGVFYMLATAMGLSLITFVWEHLF 838

  Fly   686 --------LGYFLGATALVSEIVGGITNKCRQI-IKRSRKSAASSWSSASSGSMLRTNAEQLSH 740
                    .|...|...|:..|..||.:....: |...:||:...:|..|:...|..:|:|:::
Zfish   839 YWRLRYCFTGVCSGTPGLLFSISRGIWSCIHGVHIDMKKKSSDLDFSPQSNMLKLIKSAKQMTN 902

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir21a	NP_001097043.1	Periplasmic_Binding_Protein_Type_2	289..583	CDD:304360	63/324 (19%)
		Lig_chan	407..662	CDD:278489	59/281 (21%)
grin2aa	XP_021329529.1	PBP1_iGluR_NMDA_NR2	33..389	CDD:107373	37/244 (15%)
		PBP2_iGluR_NMDA_Nr2	400..799	CDD:270436	85/481 (18%)
		NMDAR2_C	836..1460	CDD:313729	14/67 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900