DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir21a and grin2bb

DIOPT Version :9

Sequence 1:	NP_001097043.1	Gene:	Ir21a / 33157	FlyBaseID:	FBgn0031209	Length:	842	Species:	Drosophila melanogaster
Sequence 2:	NP_001121809.1	Gene:	grin2bb / 559976	ZFINID:	ZDB-GENE-061207-27	Length:	1770	Species:	Danio rerio

Alignment Length:	521	Identity:	97/521 - (18%)
Similarity:	182/521 - (34%)	Gaps:	94/521 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   316 LLTMISKRLNFSID---ITETPTRSNTRGVVDTIQEQIIERTVDIGMSGIYITQERLMDSAMSVG 377
            :|..|:|.:.|:.|   :|.........|..:.:..:::.:...:.:..:.|.:||......||.
Zfish   543 ILKKIAKSVKFTYDLYLVTNGKHGKKINGTWNGMVGEVVLKNAHMAVGSLTINEERSEVIDFSVP 607

  Fly   378 HSPDCAAFITLASKALPKYRAIMGPFQWPVW----VALICVYLGGIFPIVFTDRLTLSHLMGNWG 438
            ......:.:...|.......|.:.||...||    |.|:.|....:|...:...:..:..:.:..
Zfish   608 FIETGISVMVSRSNGTVSPSAFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGYNRCLADGR 672

  Fly   439 E-------VENMFWYVFGMFTNAFSFTGKYSWSNTRKNSTRLLIGAYWLFTIIITSCYTGSIIAF 496
            |       :....|.::|:.     |.......|.:..::::::..:..|.:|..:.||.::.||
Zfish   673 EPGGPSFTIGKAIWLLWGLV-----FNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAF 732

  Fly   497 VTLPAFPDTVDSVLDL-------LGLFFRVGTLNNGGWETWFQNSTHIPTSRLYKKM-EFVGS-- 551
            :....:.|.|..:.|.       ....||.||:.||..|...:|:        ||:| .::.|
Zfish   733 MIQEEYVDQVTGLSDKKFQHPNDFSPPFRFGTVPNGSTERNIRNN--------YKEMHSYMTSFH 789

  Fly   552 ---VDEGIGNVTQSFFWNYAFLGSKAQLEYLVQSNFSDENISRRSALHLSEECFALFQIGFLFPR 613
               |:|.:.::.....  .||:...|.|.|:...:...:.::..|..     .||....|....:
Zfish   790 QKNVNEALHSLKSGKL--DAFIYDAAVLNYMAGRDEGCKLVTIGSGY-----IFATTGYGIAIQK 847

  Fly   614 ESVYKIKIDSMILLAQQSGLIAKINNEVSWVMQRSSSGRLLQASSSNSLREIIQEERQLTTADTE 678
            :|.:|..:|..||.....|.:.::  |..|          |.....|...|::..  ||...:..
Zfish   848 DSGWKRAVDLAILQLFGDGEMEEL--EALW----------LTGICHNEKNEVMSS--QLDVDNMA 898

  Fly   679 GMFLLMALGYFLGATALVSE----------IVGGITNKCRQIIKRSRKSAASSWSSASSGSMLRT 733
            |:|.::.....|.....::|          .:|..:.|            .....|.|.|.....
Zfish   899 GVFYMLGAAMALSLITFIAEHLFYWQLRFCFMGVCSGK------------PGMTFSISRGIYSCI 951

  Fly   734 NAEQLSHDKRKANRREAAEVAQKMSFGMRELNL-----TRATLREIYGSYGAPETDHGQLDIVHT 793
            :..|:..:|...|...|   ..||:......|:     |...:..:.|..|:|   |..||..|.
Zfish   952 HGVQIEENKSALNSPSA---TMKMNMNNTHSNILRLLRTAKNMTSVPGVNGSP---HSALDYSHR 1010

  Fly   794 E 794
            |
Zfish  1011 E 1011

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir21a	NP_001097043.1	Periplasmic_Binding_Protein_Type_2	289..583	CDD:304360	55/293 (19%)
Ir21a	NP_001097043.1	Lig_chan	407..662	CDD:278489	53/278 (19%)
grin2bb	NP_001121809.1	PBP1_iGluR_NMDA_NR2	107..470	CDD:107373
		ANF_receptor	138..442	CDD:279440
		PBP2_iGluR_NMDA_Nr2	482..882	CDD:270436	68/370 (18%)
		Lig_chan	636..908	CDD:278489	58/305 (19%)
		NMDAR2_C	919..1770	CDD:287527	21/111 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810