Protein Alignment Ir21a and grik4

DIOPT Version :10

• Sequence 1: NP_001097043.1
• Gene: Ir21a / 33157
• FlyBaseID: FBgn0031209
• Length: 842
• Species: Drosophila melanogaster
• Sequence 2: XP_021322088.1
• Gene: grik4 / 556582
• ZFINID: ZDB-GENE-070821-5
• Length: 965
• Species: Danio rerio
• Alignment Length: 861
• Identity: 187/861 - (21%)
• Similarity: 302/861 - (35%)
• Gaps: 255/861 - (29%)

  Fly    35 LINHYQLNKEIFGVGMCDGNNE-----NEFRQKRRIVPTFQGNPRPRGELL--ASKFHVNS--YN 90
            |:..:.::||...|.|.|.:.:     .|.|..:........|......:|  ||:..:.|  |.
Zfish   178 LLRQFLISKETLSVRMLDDSQDPTPLLKEIRDDKTATIIVDANATMSHVILERASELGMLSVYYT 242

  Fly    91 FEQTN---SLVGL-------VNKIAQEYLNKCPPVIYYDSFVEKSDGLILENL----FKTIPIT- 140
            :..|:   ||:.|       ||.:.....|:..|  ::..||...:....||.    |...|::
Zfish   243 YILTSLEFSLLRLDDLADQRVNIVGFSVFNRTHP--FFQDFVLSLNRSWQENCDHAPFAGTPLSS 305

  Fly   141 -----FYHGEINADYEAKNKRFTSHIDCNCKS------------YILFLSDPLMTRKI----LGP 184
                 ..|..:.|..|....:.......:|||            |:..:....:|..|    .|.
Zfish   306 ALLFDAVHTVVAAVQELNRSQNVGATQLSCKSSKIWEHGTSLMNYLRMVELEGLTGHIEFNSKGQ 370

  Fly   185 QTESRVVLVSRST-------QWRLRDFLSSELSSNIVNLLVIGESLMADPMRERPYVLYTHKLYA 242
            ::...:.::..|.       ||.....||.|                    |:.|.:..|..|:
Zfish   371 RSNYALRIMQNSRDGLRQIGQWHSEQGLSME--------------------RKLPSLNVTDTLF- 414

  Fly   243 DGLGSNTPVVLTSWIKGALSRPHINLFPSKFQFGFAGHRFQISAANQPPFIFRIRTLDSSGMGQL 307
                 ||.:.:|:    .|..|::.|                 .||.       :.|:    |..
Zfish   415 -----NTTLTITT----ILENPYVML-----------------RANH-------QELE----GND 442

  Fly   308 RWDGVEFRLLTMISKRLNFSIDIT-------ETPTRSNT-RGVVDTIQEQIIERTVDIGMSGIYI 364
            |::|....:|..::..|.|...|.       ..|..:.| .|:|.    ::|.|..|:.::.:.|
Zfish   443 RYEGFCVDMLKELADILKFKYRIRLVGDGVYGVPGANGTWTGMVG----ELISRKADLAVAALTI 503

  Fly   365 TQER--LMDSAMSVGHSPDCAAFITLASKAL--------PKYRAIMGPFQWPVWVALICVYLGGI 419
            |.||  ::|.:         ..|:||....:        |.|.:.:.||...||:.::..||...
Zfish   504 TAEREKVIDFS---------KPFMTLGISIMYRVHIGRRPGYFSFLDPFSPGVWLFMLLAYLAVS 559

  Fly   420 FPIVFTDRLT-------------LSHLMGNWGEVENMFWYVFGMFTNAFSFTGKYSWSNTRKNST 471
            ..:....|||             ...|:.|...:.|.||:..|      .|..:.|....|..||
Zfish   560 CVLFLVARLTPYEWYNPHPCLKGRCSLLINQYSLGNSFWFPVG------GFMQQGSTIAPRALST 618

  Fly   472 RLLIGAYWLFTIIITSCYTGSIIAFVTLPAFPDTVDSVLDLLG-LFFRVGTLNNGGWETWFQNST 535
            |.:.|.:|.||:||.|.||.::.||:|:......::||.||.. .....||::.|...|:||||.
Zfish   619 RCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPIESVDDLADQTAIEYGTMHGGSTMTFFQNSR 683

  Fly   536 HIPTSRLYKKM------EFVGSVDEGIGNVTQSFFWNYAFLGSKAQLEYLVQSNFSDENISRRSA 594
            :....|::..|      .||.|.:|||..|..|   |||:|......||..|.|.:
Zfish   684 YQTYQRMWNFMYSKQPSVFVKSTEEGIARVLNS---NYAYLLESTMNEYYRQRNCN--------- 736

  Fly   595 LHLSEECFALFQIGFL---------FPRESVYKIKIDSMILLAQQSGLIAKINNEVSWVMQRSSS 650
                     |.|||.|         .|..|||:.:.|..||..|:...: :|.....|
Zfish   737 ---------LTQIGGLLDTKGYGIGMPLGSVYRDEFDLAILRLQEENRL-EILKRKWW------- 784

  Fly   651 GRLLQASSSNSLREIIQEERQLTTADTEGMFLLMALGYFLGATALVSEIV-------GGITNKCR 708
                  ......:|.....:.|...:..|:|:::..|..:.....|.|.|       |...:.|.
Zfish   785 ------DGGKCPKEEDHRAKGLGMENIGGIFVVLVCGLLVAIFMAVLEFVWMLRHTPGTELSVCE 843

  Fly   709 QIIK--------------RSRKSAA---------------SSWSSASSGSMLRTN--AEQLSHDK 742
            ::::              |.|:.|:               ::.:|.|:|.:....  :|.|||
Zfish   844 EMLRELQGIVLCQDSLQLRRRRGASVLRPQPLPLDERRARAAAASLSNGKLCTGTGLSEPLSH-- 906

  Fly   743 RKANRREAAEVAQKMS 758
            |.|  :|||.||:..|
Zfish   907 RLA--QEAALVARGCS 920

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir21a	NP_001097043.1	HisJ	287..>392	CDD:440596	25/114 (22%)
		Lig_chan	405..662	CDD:459656	76/285 (27%)
grik4	XP_021322088.1	Periplasmic_Binding_Protein_type1	24..401	CDD:471960	43/224 (19%)
		PBP2_iGluR_kainate_KA1	425..785	CDD:270442	107/441 (24%)