Protein Alignment Ir21a and Gria1

DIOPT Version :10

• Sequence 1: NP_001097043.1
• Gene: Ir21a / 33157
• FlyBaseID: FBgn0031209
• Length: 842
• Species: Drosophila melanogaster
• Sequence 2: NP_113796.1
• Gene: Gria1 / 50592
• RGDID: 621531
• Length: 907
• Species: Rattus norvegicus
• Alignment Length: 862
• Identity: 163/862 - (18%)
• Similarity: 295/862 - (34%)
• Gaps: 233/862 - (27%)

  Fly     3 YYWVALVLFTAQAFSIEGDRSASYQEKCISRRLINHYQLNKEIFGVGMCDGNNENEFRQKRRIVP 67
            |.|...|      :..:.||..|    .:.|.|....:.|.::..|.:.. ..|..:|.
  Rat   140 YKWQTFV------YIYDADRGLS----VLQRVLDTAAEKNWQVTAVNILT-TTEEGYRM------ 187

  Fly    68 TFQGNPRPRGELLASKFHVNSYNFEQTNSLVGLV-----NKIAQEY-----------LNKCPPVI 116
            .||...:.:..|:     |.....|:.|:::|.:     |.|...|           |||
  Rat   188 LFQDLEKKKERLV-----VVDCESERLNAILGQIVKLEKNGIGYHYILANLGFMDIDLNK----- 242

  Fly   117 YYDSFVEKS---DGLILENLFKTIPITFYHGEINADYEAKNKRFTSHIDCNCKSYILFLS----- 173
                |.|..   .|..|.|...|||     ..|...:...:.|..:.:|.....|...|:
  Rat   243 ----FKESGANVTGFQLVNYTDTIP-----ARIMQQWRTSDSRDHTRVDWKRPKYTSALTYDGVK 298

  Fly   174 ------DPLMTRKI-LGPQTESRVVLVSRSTQW--------RLRDFLSSELSSNIVNLLVIGESL 223
                  ..|..::| :..:..:...|.:.:..|        .|:......|:.|:         .
  Rat   299 VMAEAFQSLRRQRIDISRRGNAGDCLANPAVPWGQGIDIQRALQQVRFEGLTGNV---------Q 354

  Fly   224 MADPMRERPYVLYTHKLYADGL----------------------GSNTPVVLTSWI-KGALSRPH 265
            ..:..|...|.|:..::..||:                      |.|:.|...::| ...|..|:
  Rat   355 FNEKGRRTNYTLHVIEMKHDGIRKIGYWNEDDKFVPAATDAQAGGDNSSVQNRTYIVTTILEDPY 419

  Fly   266 INLFPSKFQFGFAGHRFQISAANQPPFIFRIRTLDSSGMGQLRWDGVEFRLLTMISKRLNFSIDI 330
            :.|..:..||                            .|..|::|....|...|:|.:.:|..:
  Rat   420 VMLKKNANQF----------------------------EGNDRYEGYCVELAAEIAKHVGYSYRL 456

  Fly   331 ---------TETPTRSNTRGVVDTIQEQIIERTVDIGMSGIYIT--QERLMDSA---MSVGHSPD 381
                     ...|......|:|.    :::....|:.::.:.||  :|.::|.:   ||:|.|
  Rat   457 EIVSDGKYGARDPDTKAWNGMVG----ELVYGRADVAVAPLTITLVREEVIDFSKPFMSLGIS-- 515

  Fly   382 CAAFITLASKALPKYRAIMGPFQWPVWVALICVYLGGIFPIVFTDRL----------------TL 430
              ..|....|:.|...:.:.|..:.:|:.::..|:|....:....|.                |.
  Rat   516 --IMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHSEEFEEGRDQTT 578

  Fly   431 SHLMGNWGEVENMFWYVFGMFTNAFSFTGKYSWSNTRKNSTRLLIGAYWLFTIIITSCYTGSIIA 495
            |.....:| :.|..|:..|      :|..:....:.|..|.|::.|.:|.||:||.|.||.::.|
  Rat   579 SDQSNEFG-IFNSLWFSLG------AFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAA 636

  Fly   496 FVTLPAFPDTVDSVLDLL-GLFFRVGTLNNGGWETWFQNSTHIPTSRLYKKME------FVGSVD 553
            |:|:......::|..||. ......|||..|..:.:|:.|......:::..|:      ||.:.:
  Rat   637 FLTVERMVSPIESAEDLAKQTEIAYGTLEAGSTKEFFRRSKIAVFEKMWTYMKSAEPSVFVRTTE 701

  Fly   554 EGIGNVTQSFFWNYAFLGSKAQLEYLVQSNFSDE-----NISRRSALHLSEECFALFQIGFLFPR 613
            ||:..|.:| ...||:|......||:.|....|.     |:..:.             .|...|:
  Rat   702 EGMIRVRKS-KGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKG-------------YGIATPK 752

  Fly   614 ESVYKIKIDSMILLAQQSGLIAKINNEVSWVMQRSSSGRLLQASSSNSLREIIQEERQLTTADTE 678
            .|..:..::..:|...:.||:.|:.|:  |...:...|     |.....::   :...|:.::..
  Rat   753 GSALRNPVNLAVLKLNEQGLLDKLKNK--WWYDKGECG-----SGGGDSKD---KTSALSLSNVA 807

  Fly   679 GMFLLMALGYFLGATALV------------SEIVGGITNKCRQIIKRSRKSAA---SSWSSASSG 728
            |:|.::..|  ||...||            |:.:.|.....:|.|..:.:::.   :|.:.||.|
  Rat   808 GVFYILIGG--LGLAMLVALIEFCYKSRSESKRMKGFCLIPQQSINEAIRTSTLPRNSGAGASGG 870

  Fly   729 SMLRTNAEQLSHDKRKA 745
            .....|...:|.|..|:
  Rat   871 GGSGENGRVVSQDFPKS 887

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir21a	NP_001097043.1	HisJ	287..>392	CDD:440596	20/118 (17%)
		Lig_chan	405..662	CDD:459656	61/284 (21%)
Gria1	NP_113796.1	PBP1_iGluR_AMPA_GluR1	26..392	CDD:380613	50/296 (17%)
		PBP2_iGluR_AMPA_GluR1	406..787	CDD:270447	88/439 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	857..881		5/23 (22%)
		PDZ-binding	904..907