Protein Alignment Ir21a and grid2

DIOPT Version :10

• Sequence 1: NP_001097043.1
• Gene: Ir21a / 33157
• FlyBaseID: FBgn0031209
• Length: 842
• Species: Drosophila melanogaster
• Sequence 2: NP_001004123.1
• Gene: grid2 / 448841
• ZFINID: ZDB-GENE-040913-1
• Length: 1009
• Species: Danio rerio
• Alignment Length: 1035
• Identity: 178/1035 - (17%)
• Similarity: 328/1035 - (31%)
• Gaps: 408/1035 - (39%)

  Fly    44 EIFGVGMCDGNNENEFRQKRRIVPTFQ----GNP----------RPRGELLASKFHVNSYNFEQT 94
            |:|.:.:.|.|..||..:..:|..:.:    .||          ..||.|..    |:|......
Zfish    42 EVFRMAVADLNLNNEILETEKITVSVEFVDGNNPFQAVQEACELMNRGILAL----VSSIGCMSA 102

  Fly    95 NSLVGLVNKIAQEYL-----------NKCPP---------------------------------- 114
            .||..|.:.:...:|           :.|||
Zfish   103 GSLQSLADAMHIPHLFIQRAPAGTPRSSCPPTTRAQPDDYTLFVRPPVYLNDVIFQVVMEYTWQK 167

  Fly   115 -VIYYDS------------------------FVEKSDGLILENLFKTIPITFYHGEINADYEAKN 154
             :|:||:                        .||.:..:::..:|:|:.:...|
Zfish   168 FIIFYDTDYDIRGIENFLDQTSQQGMDVSLQKVESNINMMITGMFRTMRVEELH----------- 221

  Fly   155 KRFTSHIDCNCKSYILFLSDPLMTRKILGPQTESRVVLVSRSTQWRLRDFLSSELSSNIVNLLV- 218
             |:...:    :..:||:| |...:..:....|:.  ||:...||.:   ::.|:|...|..||
Zfish   222 -RYRDTL----RRAVLFMS-PATAKAFITEVVETN--LVAFDCQWII---INEEISDMDVQELVM 275

  Fly   219 --IG--------------------------ESLMADPMRERPYVL-YTHKLYADGLGSNTPVVLT 254
              ||                          .:.:.||...:..:| .|::...|     |.::|.
Zfish   276 KSIGRLTLVRQTFPLPQNTSQRCVRNNHRINTSLCDPKDPKAQMLEITNRYIYD-----TVLLLA 335

  Fly   255 S--------------------------WIKG-----ALSRPHINLFPSKFQFGFAGH----RFQI 284
            :                          |..|     .:.:..::...|..:|...|.    .|:|
Zfish   336 NTFHRKLEDRKWHSMASLSCIRKGSKPWQGGKSMLETVKKGGVSGLTSLLEFNDNGSNPNIHFEI 400

  Fly   285 SAANQPPFIFRIRTLDSSGMGQLR---WD-------------------GVEFRLLT-------MI 320
            ...|..         :..|.|..|   ||                   ||..|::|       |:
Zfish   401 LGTNYG---------EDRGRGVSRLATWDPIHGLNGTLTDRKLENNMRGVVLRVVTVLEEPFVMV 456

  Fly   321 SKRL--------NFSIDITETPTR------------------SNTRGVVDTIQEQIIERTVDIGM 359
            |:.:        .||||:.:....                  ....|..:.:..:::.:..|:|:
Zfish   457 SENVLGKPKKYQGFSIDVLDALANYLGFKYEIYVAPDHKYGSQQADGTWNGLIGELVFKRADVGL 521

  Fly   360 SGIYITQE---------RLMDSAMSVGHSPDCAAFITLASKALPKYRAIMGPFQWPVWVALI-CV 414
            |.:.||.|         |.||.::.|        .:..|.:.:..: |.:.||...:|..:. .|
Zfish   522 SALTITPERESVVDFTTRYMDYSVGV--------LLRKAERTVDMF-ACLAPFDLSLWACIAGTV 577

  Fly   415 YLGGIFPIVFTDRLTLSHLMGNW--------GEVE-----NMFWYVFGMFTNAFSFTGKYSWSNT 466
            .|.|          ||.:|: ||        |.|.     |..|:|:|.|...   .|:..::..
Zfish   578 LLVG----------TLVYLL-NWLNPPRLPMGSVSSTTLYNSMWFVYGSFVQQ---GGEVPYTTL 628

  Fly   467 RKNSTRLLIGAYWLFTIIITSCYTGSIIAFVTLPAFPDTVDSVLDLL-GLFFRVGT--------- 521
               :||:::|.:|||.:|:.|.||.::.||:|:....:::.|:.||. ......||
Zfish   629 ---ATRMMMGVWWLFALIVISSYTANLAAFLTISRIENSIQSLQDLAKQTDLPYGTVLDSAVYDQ 690

  Fly   522 LNNGGWETWFQNSTHIPTSRLYKKMEFVGSVD-------EGIGNVTQSFFWNYAFLGSKAQLEYL 579
            :.:.|...:.::..:   |::::.:...|..:       |||..|.   :..:||:...|.|||:
Zfish   691 VRSKGMNPFERDPMY---SQMWRMINRTGGAENNVEESKEGIRKVK---YGRFAFVWDAAVLEYV 749

  Fly   580 VQSNFSDENISRRSALHLSEECFALFQIGFLFPRESVYKIKIDSMILLAQQSGLIAKINNEVSWV 644
            .   .:||:.|    |:......|....|......|.|:......||..||:|.:..:  ::.|.
Zfish   750 A---INDEDCS----LYTVSNNVADRGYGMAMQHGSPYRDIFSQRILELQQNGDMDIL--KLKWW 805

  Fly   645 MQRS-----------SSGRLLQASSSNSLREIIQEERQLTTADTEGMFLLMALGYFLGATALVSE 698
            .:.|           .||..|...|                  ..|:|.::|.|..|  :.|::.
Zfish   806 PRDSPCDLYSPVGTRKSGSALDIHS------------------FAGVFFVLAAGVVL--SCLIAT 850

  Fly   699 IVGGITNKCRQIIKRSRKSAASSWSSASSGSMLRTNAEQLSHDKRKANRREAAEVAQKMSFGMRE 763
            :                    .:|.:...||.:.:..:....|....:.|..:...:..|
Zfish   851 V--------------------ETWWTRRKGSRVPSKEDDKEIDLEHLHHRVNSLCTEDES----- 890

  Fly   764 LNLTRATLREIYGSYGAPETDHGQLDIVHTEFPNSSAKLNNIEDEESREALESLQRLDEF 823
                                       .|.:|..||..|..::.:....|.::|:::.:|
Zfish   891 ---------------------------PHKQFSTSSIDLTPLDMDSLPAARQALEQISDF 923

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir21a	NP_001097043.1	HisJ	287..>392	CDD:440596	28/168 (17%)
		Lig_chan	405..662	CDD:459656	67/298 (22%)
grid2	NP_001004123.1	PBP1_iGluR_delta_2	28..429	CDD:380614	66/426 (15%)
		PBP2_iGluR_delta_2	440..806	CDD:270449	87/406 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	989..1009