DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir21a and GluRIID

DIOPT Version :9

Sequence 1:	NP_001097043.1	Gene:	Ir21a / 33157	FlyBaseID:	FBgn0031209	Length:	842	Species:	Drosophila melanogaster
Sequence 2:	NP_651982.1	Gene:	GluRIID / 44483	FlyBaseID:	FBgn0028422	Length:	902	Species:	Drosophila melanogaster

Alignment Length:	989	Identity:	194/989 - (19%)
Similarity:	335/989 - (33%)	Gaps:	345/989 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSYYWVALVLFT-----AQAFSIEGDRSASYQEKCIS----------RRLINH--YQLNKEIFGV 48
            |.:.|::|::.:     ||.:......::|.|...:.          |:...|  ..:|.|: ||
  Fly     1 MHFCWISLIILSLSRVQAQFYGGNAYEASSGQSIRLGLITDDATDRIRQTFEHAISVVNNEL-GV 64

  Fly    49 GMCD-------GNNENEFRQKRRIVPTFQG---NPRPRGELLASKFHVNSYNFEQTNSLVGLVNK 103
            .:..       ||:...|.|..|::.:..|   .|..|        |.
  Fly    65 PLVGETEQVAYGNSVQAFAQLCRLMQSGVGAVFGPAAR--------HT----------------- 104

  Fly   104 IAQEYLNKCP----PVIY-YDSFVEKSDGLILENLFKTIPITFYHGEINADYEAKNK-RFTSHID 162
             |...||.|.    |.|| :.|:....||..|....:.|        .||.|:..|: .::..|.
  Fly   105 -ASHLLNACDSKDIPFIYPHLSWGSNPDGFNLHPSPEDI--------ANALYDIVNQFEWSRFIF 160

  Fly   163 CNCKSYILFLSDPLMTR-KILGP------------------------QTESRVVLVSRST----- 197
            |...:..|.:.|.|||| .|.||                        ..:||:|:|..:|
  Fly   161 CYESAEYLKILDHLMTRYGIKGPVIKVMRYDLNLNGNYKSVLRRIRKSEDSRIVVVGSTTGVAEL 225

  Fly   198 ------------------------QWRLRDFLSSELSSNIVNLLV------------------IG 220
                                    .:.|.::..||  :||..:.:                  :|
  Fly   226 LRQAQQVGIMNEDYTYIIGNLNLHTFDLEEYKYSE--ANITGIRMFSPDQEEVRDLMEKLHQELG 288

  Fly   221 ES----------------------LMADPMRERPY------------------------------ 233
            ||                      ::|:..:..||
  Fly   289 ESEPVNSGSTFITMEMALTYDAVRVIAETTKHLPYQPQMLNCSERHDNVQPDGSTFRNYMRSLEI 353

  Fly   234 --VLYTHKLYADG------------LGSNTPVVLTSWIKG---ALSRPHINLFPSKFQF------ 275
              ...|.::|.:|            |.::..|.:.:|.:|   ...||     |....|
  Fly   354 KEKTITGRIYFEGNVRKGFTFDVIELQTSGLVKVGTWEEGKDFEFQRP-----PQAVNFNDIDDG 413

  Fly   276 GFAGHRF--QISAANQPPFIFRIRTLDS-SGMGQLRWDGVEFRLLTMISKRLNFSIDITE----- 332
            ......|  .||.|.: |:...:.::|: .|..|.:..||:  |:..::.:|.|:....:
  Fly   414 SLVNKTFIVLISVATK-PYASLVESIDTLIGNNQFQGYGVD--LIKELADKLGFNFTFRDGGNDY 475

  Fly   333 ---TPTRSNTRGVVDTIQEQIIERTVDIGMSGIYITQER--LMDSA---MSVGHSPDCAAFITLA 389
               ..|.::|.|::    ::|:|...|:.::.:.||.||  ::|.:   |::|    .|......
  Fly   476 GSFNKTTNSTSGML----KEIVEGRADLAITDLTITSEREEVIDFSIPFMNLG----IAILYVKP 532

  Fly   390 SKALPKYRAIMGPFQWPVWVALICVYLGGIFPIVFTDRLTLSHLMGNWG----------EVENMF 444
            .||.|...:.|.||...||:.|...|||.........||:..    .|.          |:||.|
  Fly   533 QKAPPALFSFMDPFSSEVWLYLGIAYLGVSLCFFIIGRLSPI----EWDNPYPCIEEPEELENQF 593

  Fly   445 ------WYVFGMFTNAFSFTGKYSWSNTRKNSTRLLIGAYWLFTIIITSCYTGSIIAFVTLPAFP 503
                  |:..|......|...      .:..|||.:...:|.||:|:.|.||.::.||:|:....
  Fly   594 TINNSLWFTTGALLQQGSEIA------PKALSTRTISAIWWFFTLIMVSSYTANLAAFLTIENPT 652

  Fly   504 DTVDSVLDLLGL--FFRVGTLNNGGWETWFQNSTHIPTSRLYKKM-EFVGSVDE--------GIG 557
            ..::||.||...  ..:.|....|....:|..|    ...:|.|| |::.:..|        |:.
  Fly   653 SPINSVKDLADNKDDVQYGAKRTGSTRNFFSTS----EEPIYIKMNEYLNAHPEMLMENNQQGVD 713

  Fly   558 NVTQSFFWNYAFLGSKAQLEYLVQSNFSDENISRRSAL-----HLSEECFALFQIGFLFPRESVY 617
            .|...  ..||||.....:|:         |..|...|     .|.|:.:     |....:...|
  Fly   714 KVKSG--TKYAFLMESTSIEF---------NTVRECNLTKVGDPLDEKGY-----GIAMVKNWPY 762

  Fly   618 KIKIDSMILLAQQSGLIAKINNEVSWVMQRSSSGRLLQASSSNSLREIIQEERQLTTADTEGMFL 682
            :.|.:..:|..|:.|::|::.|:  |..:..:.  :..|.|.:      ....:|...:..|:::
  Fly   763 RDKFNKALLELQEQGVLARLKNK--WWNEVGAG--VCSAKSDD------DGPSELGVDNLSGIYV 817

  Fly   683 LMALG-------------YFLGATALVSEI--VGGITNKCRQIIK-----RSRKSAASSWS---- 723
            ::.:|             ||:...|...|:  ...:..:.|.:|:     |..|||.|.:|
  Fly   818 VLVIGSIISIIISILCWCYFVYKKAKNYEVPFCDALAEEFRIVIRFSENERPLKSAQSIYSRSRN 882

  Fly   724 SASSGSMLRTNAEQ 737
            |:.|...|:|::|:
  Fly   883 SSQSIESLKTDSEE 896

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir21a	NP_001097043.1	Periplasmic_Binding_Protein_Type_2	289..583	CDD:304360	78/334 (23%)
Ir21a	NP_001097043.1	Lig_chan	407..662	CDD:278489	65/286 (23%)
GluRIID	NP_651982.1	PBP1_iGluR_Kainate	35..397	CDD:107377	65/398 (16%)
		ANF_receptor	46..380	CDD:279440	61/370 (16%)
		PBP2_iGluR_Kainate	417..788	CDD:270432	96/413 (23%)
		Lig_chan	549..819	CDD:278489	67/309 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910