DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir21a and CG11155

DIOPT Version :9

Sequence 1:	NP_001097043.1	Gene:	Ir21a / 33157	FlyBaseID:	FBgn0031209	Length:	842	Species:	Drosophila melanogaster
Sequence 2:	NP_651941.2	Gene:	CG11155 / 43822	FlyBaseID:	FBgn0039927	Length:	910	Species:	Drosophila melanogaster

Alignment Length:	845	Identity:	163/845 - (19%)
Similarity:	314/845 - (37%)	Gaps:	214/845 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 LINHYQLNKEIFGVGMCDGNNENEFRQKRRIVPTFQGNPRPRGELLASKF-----HVN----SYN 90
            |.:|.|...|.:.:...:|..:.|:..|.     |..|..|...||...:     ::|    :..
  Fly   119 LASHVQSICEAYDIPHIEGRIDLEYNSKE-----FSINLYPSHTLLTLAYRDIMVYLNWTKVAII 178

  Fly    91 FEQTNSLVGLVNKI----AQEYLNKCPPVIYYDSFVEKSDGLILENLFKTIPIT-------FYHG 144
            :|:...|..|::..    |:.|:.:..|    ||:.:....:..:.::|.|..|       |:..
  Fly   179 YEEDYGLFNLMHSSTETKAEMYIRQASP----DSYRQVLRAIRQKEIYKIIVDTNPSHIKSFFRS 239

  Fly   145 EINAD-----------------YEAKNKRFTS-------HIDCNCKSYILFLS----------DP 175
            .:...                 |:.::.|:.|       .:|.:.|.|:..::          |.
  Fly   240 ILQLQMNDHRYHYMFTTFDLETYDLEDFRYNSVNITAFRLVDVDSKRYLEVINQMQKLQHNGLDT 304

  Fly   176 LMTRKILGPQTESRVVLVSRSTQWRLRDFLSSELSSN--IVNLLVIGESLMADPMRERPYVLYT- 237
            :.....:  ||||.::..|.........||:.:...|  |.||....:....|.:.     ||.
  Fly   305 INGSPYI--QTESALMFDSVYAFANGLHFLNLDNHQNFYIKNLSCTSDQTWNDGIS-----LYNQ 362

  Fly   238 -HKLYADGLGSNTPVVLTSWIKGALSRPHINLFPSK------------------------FQFGF 277
             :....|||...     ..:::|..:...:::...|                        :....
  Fly   363 INAAITDGLTGT-----VQFVEGRRNIFKLDILKLKQEKIQKVGYWHPDDGVNISDPTAFYDSNI 422

  Fly   278 AGHRFQISAANQPPFIFRIRTLDSSGMGQLRWDGVEFRLLTMISKRLNFSIDITETPTRSNTRGV 342
            |.....:....:.|::. ::. |.:..|.||::|....||..|:.::.|...|...|  .|..||
  Fly   423 ANITLVVMTREERPYVM-VKE-DKNLTGNLRFEGFCIDLLKAIATQVGFQYKIELVP--DNMYGV 483

  Fly   343 V-------DTIQEQIIERTVDIGMSGIYI--TQERLMDSA---MSVGHSPDCAAFITLASKALPK 395
            .       :.|.::::||..|:.::.:.|  .:|.::|..   |::|    ......:.:....:
  Fly   484 YIPETNSWNGIVQELMERRADLAVASMTINYARESVIDFTKPFMNLG----IGILFKVPTSQPTR 544

  Fly   396 YRAIMGPFQWPVWVALICVYLGGIFPIVFTDRLT------------LSHLMGNWGEVENMFWYVF 448
            ..:.|.|....:|:.::..|:...|.:....|.:            .:.::.|...:.|.||::.
  Fly   545 LFSFMNPLAIEIWLYVLAAYILVSFALFVMARFSPYEWKNPHPCYKETDIVENQFSISNSFWFIT 609

  Fly   449 GMFTNAFSFTGKYSWSNTRKNSTRLLIGAYWLFTIIITSCYTGSIIAFVTLPAFPDTVDSVLDLL 513
            |      :|..:.|..|.:..|||::.|.::.|.:||.|.||.::.||:|:......::|..||.
  Fly   610 G------TFLRQGSGLNPKATSTRIVGGCWFFFCLIIISSYTANLAAFLTVERMISPIESASDLA 668

  Fly   514 -GLFFRVGTLNNGGWETWFQNSTHIPTSRLYKKME------FVGSVDEGIGNVTQSFFWNYAFLG 571
             ......|||..|...|:|::|......::::.||      ||.:.::||..|.:.   :||||.
  Fly   669 EQTEISYGTLEGGSTMTFFRDSKIGIYQKMWRYMENRKTAVFVKTYEDGIKRVMEG---SYAFLM 730

  Fly   572 SKAQLEYLVQSNFSDENISRRSALHLSEECFALFQIGFLFPRESVYKIKIDSMILLAQQSGLIAK 636
            ....|:|.||   .|.|:::...| |..:.:     |...|:.|.::.||...||..|:.|:| :
  Fly   731 ESTMLDYAVQ---RDCNLTQIGGL-LDSKGY-----GIATPKGSPWRDKISLAILELQEKGII-Q 785

  Fly   637 INNEVSW-----VMQRSSSGRLLQASSSNSLREIIQEERQLTTADTEGMFLLMALGYFLGATALV 696
            |..:..|     |..|....:..:|::             |...:..|:|:::..|..|.....:
  Fly   786 ILYDKWWKNTGDVCNRDDKSKESKANA-------------LGVENIGGVFVVLLCGLALAVVVAI 837

  Fly   697 SEIVGGITNKCRQIIKRSRKSAASSWSSASSGSMLRTNAEQLSHDKRKANRREAAEVAQKMSFGM 761
            .|.       |              |:|..:     .|.|         |:...:|:|:::.|.|
  Fly   838 FEF-------C--------------WNSRKN-----LNTE---------NQSLCSEMAEELRFAM 867

Fly 762 761
Fly 868 867

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir21a	NP_001097043.1	Periplasmic_Binding_Protein_Type_2	289..583	CDD:304360	76/324 (23%)
Ir21a	NP_001097043.1	Lig_chan	407..662	CDD:278489	69/278 (25%)
CG11155	NP_651941.2	PBP1_iGluR_Kainate	44..410	CDD:107377	51/311 (16%)
		ANF_receptor	61..393	CDD:279440	50/294 (17%)
		PBP2_iGluR_Kainate	424..793	CDD:270432	91/395 (23%)
		Lig_chan	555..829	CDD:278489	72/305 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910