DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir21a and Grik

DIOPT Version :9

Sequence 1:	NP_001097043.1	Gene:	Ir21a / 33157	FlyBaseID:	FBgn0031209	Length:	842	Species:	Drosophila melanogaster
Sequence 2:	NP_001262788.1	Gene:	Grik / 42476	FlyBaseID:	FBgn0038840	Length:	907	Species:	Drosophila melanogaster

Alignment Length:	739	Identity:	155/739 - (20%)
Similarity:	263/739 - (35%)	Gaps:	226/739 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 TNSLVGL---VNKIAQEY--LNKCPPVIYYDSFVEKSDGLILENLFKTIPITFYHGEINADYEAK 153
            |||:..:   |..:|:.|  :|..|..:..:.......|..|.|..|::.:....|.|..|||
  Fly   299 TNSMALVYDGVQLLAETYKHVNFRPVALSCNDDSAWDKGYTLVNYMKSLTLNGLTGPIRFDYE-- 361

  Fly   154 NKRFTSHIDCNCKSYILFLSDPLMTRKILGPQTESRVVLVSRSTQWRLRDFLSSELSSNIVNLLV 218
                                         |.:|:.::.::              ||:  :..:..
  Fly   362 -----------------------------GLRTDFKLEVI--------------ELA--VSGMQK 381

  Fly   219 IGESLMADPMRE-RPYVLYTHKLYAD--GLGSNTPVVLTSWIKGALSRPHINLFPSKFQFGFAGH 280
            ||:....|..:| ||  ...|.|..|  .|.:.:.||:|     |:|.|          :|.
  Fly   382 IGQWSGEDGFQENRP--APAHSLEPDMRSLVNKSFVVIT-----AISEP----------YGM--- 426

  Fly   281 RFQISAANQPPFIFRIRTLDSSGMGQLRWDGVEFRLLTMISKRLNFSIDITETPTRSNTRGVVDT 345
                           ::.......|..:::|....|:..:||:|.||  .|......|..|.:|.
  Fly   427 ---------------LKETSEKLEGNDQFEGFGIELIDELSKKLGFS--YTWRLQEDNKYGGIDP 474

  Fly   346 -------IQEQIIERTVDIGMSGIYITQERLMDSA-------MSVGHSPDCAAFITLASKALPKY 396
                   :..:||:...|:|::.:.:|.||  :|.       ||:|    .........|..||.
  Fly   475 KTGEWNGMLREIIDSRADMGITDLTMTSER--ESGVDFTIPFMSLG----IGILFRKPMKEPPKL 533

  Fly   397 RAIMGPFQWPVWVALICVYLGGIFPIVFTDRLTLSHLMGNWG----------EVENMF------W 445
            .:.|.||...||:.|...|:|....:....||:    ...|.          |:||.|      |
  Fly   534 FSFMSPFSGEVWLWLGLAYMGVSISMFVLGRLS----PAEWDNPYPCIEEPTELENQFSFANCLW 594

  Fly   446 YVFGMFTNAFSFTGKYSWSNTRKNSTRLLIGAYWLFTIIITSCYTGSIIAFVTLPAFPDTVDSVL 510
            :..|......|.....::      |||.:..::|.||:|:.|.||.::.||:|:.:....::...
  Fly   595 FSIGALLQQGSELAPKAY------STRAVAASWWFFTLILVSSYTANLAAFLTVESLVTPINDAD 653

  Fly   511 DLLGLFFRVGTLNNGGWE----------TWFQNSTHIPTSRLYKKME-----FVGSVDEGIGNVT 560
            ||        :.|.||..          .:|:.|.:....|:|:.|.     ...:..||:..|.
  Fly   654 DL--------SKNKGGVNYGAKIGGATFNFFKESNYPTYQRMYEFMRDNPQYMTNTNQEGVDRVE 710

  Fly   561 QSFFWNYAFLGSKAQLEYLVQSNFSDENISRRSALHLSEECFALFQIGFLFPRESV--------- 616
            .|   |||||.....:||:.:         ||        | .|.|:|.|...:..
  Fly   711 NS---NYAFLMESTTIEYITE---------RR--------C-TLTQVGALLDEKGYGIAMRKNWP 754

  Fly   617 YKIKIDSMILLAQQSGLIAKINNEVSWVMQRSSSGRLLQASSSNSLREIIQEERQLTTADTEGMF 681
            |:..:...:|..|:.||:.|:  :..|..::...|....|...:.       ...|..::..|:|
  Fly   755 YRDTLSQAVLEMQEQGLLTKM--KTKWWQEKRGGGACSDADEDSG-------AVALEISNLGGVF 810

  Fly   682 LLMALGYFLGATALVSEIVGGITNK---------------------C---RQIIKRSRKSAASSW 722
            |:|.:|.|.|....:.|:|.|:..:                     |   .:.:|..:.|:.|:.
  Fly   811 LVMGVGSFFGIFVSLLEMVLGVKERSDENQVSFKTELLDEIRFILQCSGNTKAVKYPKNSSRSNA 875

  Fly   723 SSASSGSMLRTNAEQLSHDKRKAN 746
            ||.|.||.:  :.:.|..|..:|:
  Fly   876 SSKSKGSSM--SVDSLPEDTSEAD 897

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir21a	NP_001097043.1	Periplasmic_Binding_Protein_Type_2	289..583	CDD:304360	78/338 (23%)
Ir21a	NP_001097043.1	Lig_chan	407..662	CDD:278489	65/294 (22%)
Grik	NP_001262788.1	PBP1_iGluR_Kainate	37..391	CDD:107377	24/138 (17%)
		ANF_receptor	53..374	CDD:279440	19/119 (16%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:304360	99/451 (22%)
		Lig_chan	543..816	CDD:278489	70/320 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010