DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir21a and KaiR1D

DIOPT Version :9

Sequence 1:	NP_001097043.1	Gene:	Ir21a / 33157	FlyBaseID:	FBgn0031209	Length:	842	Species:	Drosophila melanogaster
Sequence 2:	NP_650925.1	Gene:	KaiR1D / 42473	FlyBaseID:	FBgn0038837	Length:	853	Species:	Drosophila melanogaster

Alignment Length:	876	Identity:	180/876 - (20%)
Similarity:	307/876 - (35%)	Gaps:	275/876 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 DGNNENEFRQ-------KRRIVP---------------TFQGNPRPRGEL---LASKF------- 84
            |.:.|..|||       .|.|:|               :|....|..|.|   :|:.|
  Fly    40 DDHQELAFRQAVDRINADRSILPRSKLVAQIERISPFDSFHAGKRVCGLLNIGVAAIFGPQSSHT 104

  Fly    85 --HVNS---------------YNFEQTNSLVGLV---NKIAQEYLN-------KCPPVIYYDSFV 122
              ||.|               |...:.:.||.|.   |.:::.|::       |...:||
  Fly   105 ASHVQSICDNMEIPHLENRWDYRLRRESCLVNLYPHPNTLSKAYVDIVRHWGWKTFTIIY----- 164

  Fly   123 EKSDGLI-LENLFKT-----IPITFYHGEINADY-----EAKNKRFTSHI--DCNCKSYILFLSD 174
            |.:||:: |:.|.|.     .|||......:.||     :.||.. .:||  ||:.:.    :.:
  Fly   165 ENNDGIVRLQELLKAHGMTPFPITVRQLSDSGDYRPLLKQIKNSA-EAHIVLDCSTER----IHE 224

  Fly   175 PLMTRKILGPQTESRVVLVSRSTQWRLRDFLSSEL---SSNIVNLLVIGESLMADPMRE------ 230
            .|...:.:|..::....||   |...|......|.   .:||....:|.|.:::|.:|:
  Fly   225 VLKQAQQIGMMSDYHSYLV---TSLDLHTVNLDEFRYGGTNITGFRLINEKIVSDVVRQWSIDEK 286

  Fly   231 -------------RPYVLY--------------------THKLYADGLGSNTPVVLTSWIKGALS 262
                         ...::|                    .|.:..||        .::|..|...
  Fly   287 GLLRSANLTTVRSETALMYDAVHLFAKALHDLDTSQQIDIHPISCDG--------QSTWQHGFSL 343

  Fly   263 RPHINLFPSK-----FQFGFAGHR--FQISAAN-QPPFIFRIRTLDSS---GM------------ 304
            ..::.:...|     .:|...|.|  |.:.... .|..|.:|.|.:|:   |:
  Fly   344 INYMKIVEMKGLTNVIKFDHQGFRTDFMLDIVELTPAGIRKIGTWNSTLPDGINFTRTFSQKQQE 408

  Fly   305 -------------------------------GQLRWDGVEFRLLTMISKRLNFSIDITETPTRS- 337
                                           |..:::|....|:..|||.|.|:..|...|..|
  Fly   409 IEANLKNKTLVVTTILSNPYCMRKESAIPLSGNDQFEGYAVDLIHEISKSLGFNYKIQLVPDGSY 473

  Fly   338 ----NTRGVVDTIQEQIIERTVDIGMSGIYITQERLMDSAMSVGHSPDCAAFITLASKAL----- 393
                ...|..:.:..:::|:..|:.::.:.||.||  :.|:..     ...|:.|....|
  Fly   474 GSLNKLTGEWNGMIRELLEQRADLAIADLTITFER--EQAVDF-----TTPFMNLGVSILYRKPI 531

  Fly   394 ---PKYRAIMGPFQWPVWVALICVYLGG---IFPIV-FTDRLTLSHLMGNWGEVENMF------W 445
               |...:.:.|....||:.:...|||.   :|.:. ||.....::...:..:||:.|      |
  Fly   532 KQPPNLFSFLSPLSLDVWIYMATAYLGVSVLLFILAKFTPYEWPAYTDAHGEKVESQFTLLNCMW 596

  Fly   446 YVFG-MFTNAFSFTGKYSWSNTRKNSTRLLIGAYWLFTIIITSCYTGSIIAFVTLPAFPDTVDSV 509
            :..| :......|..|       ..|||::.|.:|.||:|:.|.||.::.||:|:......::|.
  Fly   597 FAIGSLMQQGCDFLPK-------ALSTRMVAGIWWFFTLIMISSYTANLAAFLTVERMDSPIESA 654

  Fly   510 LDLL-GLFFRVGTLNNGGWETWFQNSTHIPTSRLYKKME------FVGSVDEGIGNVTQSFFWNY 567
            .||. ....:.|.|..|....:|::|......|::..||      |..|..||:..|.:. ..:|
  Fly   655 EDLAKQTRIKYGALKGGSTAAFFRDSKISTYQRMWSFMESARPSVFTASNGEGVERVAKG-KGSY 718

  Fly   568 AFLGSKAQLEYLVQSNFSDENISRRSALHLSEECFALFQIGFLF---------PRESVYKIKIDS 623
            |||.....:||:.:.|                 | .|.|:|.:.         |..|.|:..|:|
  Fly   719 AFLMESTSIEYVTERN-----------------C-ELTQVGGMLDTKSYGIATPPNSPYRTAINS 765

  Fly   624 MILLAQQSGLIAKINNEVSWVMQRSSSGRL-LQASSSNSLREIIQEERQLTTADTEGMFLLMALG 687
            :||..|:.|.:..:  :..|..::...|:. ::.|.|:|      ...:|..|:..|:|:::..|
  Fly   766 VILKLQEEGKLHIL--KTKWWKEKRGGGKCRVETSKSSS------AANELGLANVGGVFVVLMGG 822

  Fly   688 YFLGATALVSEIVGGITNKCRQIIKRSRKSA 718
            ..:.....|.|.|.    |.|::....|.||
  Fly   823 MGVACVIAVCEFVW----KSRKVAVEERLSA 849

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir21a	NP_001097043.1	Periplasmic_Binding_Protein_Type_2	289..583	CDD:304360	81/370 (22%)
Ir21a	NP_001097043.1	Lig_chan	407..662	CDD:278489	69/282 (24%)
KaiR1D	NP_650925.1	PBP1_iGluR_Kainate	31..397	CDD:107377	73/377 (19%)
		ANF_receptor	42..378	CDD:279440	66/356 (19%)
		Periplasmic_Binding_Protein_Type_2	415..785	CDD:304360	90/404 (22%)
		Lig_chan	547..823	CDD:278489	74/309 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910