Protein Alignment Ir21a and gria4a

DIOPT Version :10

• Sequence 1: NP_001097043.1
• Gene: Ir21a / 33157
• FlyBaseID: FBgn0031209
• Length: 842
• Species: Drosophila melanogaster
• Sequence 2: NP_999971.1
• Gene: gria4a / 407735
• ZFINID: ZDB-GENE-020125-7
• Length: 898
• Species: Danio rerio
• Alignment Length: 721
• Identity: 137/721 - (19%)
• Similarity: 251/721 - (34%)
• Gaps: 206/721 - (28%)

  Fly   125 SDGLILENLFKTIPITFYHGEINADYEAKNKRFTSHIDCNCKSYILFLSDPLMTRKILGPQTESR 189
            :.|:.:|...|.:.|....|.|..|:..:...:|..:      :.|..:.|   |||.......:
Zfish   335 NQGIDMERTLKQVRIQGLTGNIQFDHYGRRVNYTMDV------FELKSNGP---RKIGYWNDLDK 390

  Fly   190 VVLVSRSTQWRLRDFLSSELSSNIVNLLVIGESLMADPMRERPYVLYTHKLYADGLGSNTPVVLT 254
            :|||...        ||....|.:.|..||..::|     |.|||:                :..
Zfish   391 LVLVQNE--------LSMGNDSAMENRTVIVTTIM-----EGPYVM----------------LKK 426

  Fly   255 SWIKGALSRPHINLFPSKFQF-GFAGHRFQISAANQPPFIFRIRTLDSSGMGQLRWDGVEFRLLT 318
            :|          .::....|| |:.     :..|::                ..:..|:::::..
Zfish   427 NW----------EMYEGNEQFEGYC-----VDLASE----------------VAKHIGIKYKISI 460

  Fly   319 MISKRLNFSIDITETPTRSNTRGVVDTIQEQIIERTVDIGMSGIYIT--QERLMDSA---MSVGH 378
            ::..:..     ...|......|:|.    :::....:|.::.:.||  :|.::|.:   ||:|.
Zfish   461 VLDGKYG-----ARDPETKIWNGMVG----ELVYGKAEIAVAPLAITLVREEVIDFSKPFMSLGI 516

  Fly   379 SPDCAAFITLASKALPKYRAIMGPFQWPVWVALICVYLGGIFPIVFTDRL------TLSHLMGNW 437
            |    ..|....|:.|...:.:.|..:.:|:.::..|:|....:....|.      |.....|:.
Zfish   517 S----IMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEPEEGSD 577

  Fly   438 GE----------VENMFWYVFGMF-TNAFSFTGKYSWSNTRKNSTRLLIGAYWLFTIIITSCYTG 491
            |.          :.|..|:..|.| .....||       .|..|.|::.|.:|.||:||.|.||.
Zfish   578 GPPSDQPPNEFGIFNSLWFSLGAFMQQGCDFT-------PRSLSGRIVGGVWWFFTLIIISSYTA 635

  Fly   492 SIIAFVTLPAFPDTVDSVLDLL-GLFFRVGTLNNGGWETWFQNSTHIPTSRLYKKME------FV 549
            ::.||:|:......::|..||. ......|||::|..:.:|:.|......:::..|:      |.
Zfish   636 NLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPTVFT 700

  Fly   550 GSVDEGIGNVTQSFFWNYAFLGSKAQLEYLVQSNFSDE-----NISRRSALHLSEECFALFQIGF 609
            .:..||:..|.:| ...||||......||..|....|.     |:..:.             .|.
Zfish   701 KTTAEGVARVRKS-KGKYAFLLESTMNEYTEQRKPCDTMKVGGNLDSKG-------------YGV 751

  Fly   610 LFPRESVYKIKIDSMILLAQQSGLIAKINNEVSWVMQRSSSGRLLQASSSNSLREIIQEERQLTT 674
            ..|:.|.....::..:|...::|::.|:.|:  |...:...|.....|...|       .:.|:.
Zfish   752 ATPKGSQLGTPVNLAVLKLSEAGVLDKLKNK--WWYDKGECGPKDSGSKDKS-------SQALSL 807

  Fly   675 ADTEGMFLLMALGYFLGATALVSEIVGGITNKCRQIIKRSRKSAASSWSSASSGSMLRTNAEQLS 739
            ::..|:|.::..|  ||...||:            :::...||              |..|::|
Zfish   808 SNVAGVFYILVGG--LGLAMLVA------------LVEFCYKS--------------RAEAKKL- 843

  Fly   740 HDKRKANRREAAEVAQKMSFGMRELNLTRATLREIYGSYG-------------APETDHG-QLDI 790
                            |::|.....|..|.::....|..|             .|...|| .|.:
Zfish   844 ----------------KLTFSEAMRNKARLSITGSLGENGRVLTPDCPKAVHSGPSYRHGPALAV 892

  Fly   791 VHTEFP 796
            |.::.|
Zfish   893 VSSDLP 898

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir21a	NP_001097043.1	HisJ	287..>392	CDD:440596	15/109 (14%)
		Lig_chan	405..662	CDD:459656	62/285 (22%)
gria4a	NP_999971.1	PBP1_iGluR_AMPA_GluR4	23..395	CDD:380611	15/68 (22%)
		PBP2_iGluR_AMPA_GluR4	408..790	CDD:270445	90/469 (19%)