DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir21a and Nmdar1

DIOPT Version :9

Sequence 1:	NP_001097043.1	Gene:	Ir21a / 33157	FlyBaseID:	FBgn0031209	Length:	842	Species:	Drosophila melanogaster
Sequence 2:	NP_730940.1	Gene:	Nmdar1 / 40665	FlyBaseID:	FBgn0010399	Length:	997	Species:	Drosophila melanogaster

Alignment Length:	1010	Identity:	191/1010 - (18%)
Similarity:	337/1010 - (33%)	Gaps:	360/1010 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 YWVALVLFTA--------------QAFSIEGDRSASYQEKCISR-------------RLINHYQL 41
            :.:|:||..|              ..::|.|..|.|..|:..|.             |.:.:|..
  Fly    13 FGLAIVLLVAPIDAAQRHTASDNPSTYNIGGVLSNSDSEEHFSTTIKHLNFDQQYVPRKVTYYDK 77

  Fly    42 N--------KEIFGVGMCDGNNENEFRQKRRIVPTFQGNPRPRGEL--LASKFHVNSYNFEQTNS 96
            .        |.:|.|  ||...||      |:......:.:..|:|  .|..:....|:.    .
  Fly    78 TIRMDKNPIKTVFNV--CDKLIEN------RVYAVVVSHEQTSGDLSPAAVSYTSGFYSI----P 130

  Fly    97 LVGLVNK--------IAQEYLNKCPPVIYY---DSFVE----------------KSDGLILENLF 134
            ::|:.::        |...:|...||  ||   |.::|                .:||..:...|
  Fly   131 VIGISSRDAAFSDKNIHVSFLRTVPP--YYHQADVWLEMLSHFAYTKVIIIHSSDTDGRAILGRF 193

  Fly   135 KTIPITFYHG-------EINADYEAKNKRFTSHI----DCNCKSYILFLSDP------------- 175
            :|...|:|..       |:..::|.|.:.||.|:    ....:.|:::.|..
  Fly   194 QTTSQTYYDDVDVRATVELIVEFEPKLESFTEHLIDMKTAQSRVYLMYASTEDAQVIFRDAGEYN 258

  Fly   176 --------LMTRK----------ILGPQTESRVVLVSRSTQWRLRDFLSSELSSNIVNLLVIGES 222
                    ::|.:          :||.|.|.     :.|.:..:||  |..:.::.:..::..|:
  Fly   259 MTGEGHVWIVTEQALFSNNTPDGVLGLQLEH-----AHSDKGHIRD--SVYVLASAIKEMISNET 316

  Fly   223 LMADP-------------------MRERPYVLYTHKLYADGLGS---------NTPVVLTSWIKG 259
            :...|                   ::.|.....|.::..|..|.         |........:.|
  Fly   317 IAEAPKDCGDSAVNWESGKRLFQYLKSRNITGETGQVAFDDNGDRIYAGYDVINIREQQKKHVVG 381

  Fly   260 ALS--------RPHIN----LFPSKFQFGFAG----HRFQISAANQPPFIFRIRTLDSSGMGQLR 308
            ..|        |..||    ::|.|.:....|    ...::....:.||::..|..|.
  Fly   382 KFSYDSMRAKMRMRINDSEIIWPGKQRRKPEGIMIPTHLRLLTIEEKPFVYVRRMGDD------- 439

  Fly   309 WDGVEFR-----------------------------LLTMISKRLNFSIDITETP--------TR 336
                |||                             ||..:|||:||:.|:..:|        .|
  Fly   440 ----EFRCEPDERPCPLFNNSDATANEFCCRGYCIDLLIELSKRINFTYDLALSPDGQFGHYILR 500

  Fly   337 SNTRGVVDTIQE------QIIERTVDIGMSGIYITQERLMDSAMSVGHSPDCAAFITLASKALPK 395
            :|| |.:...:|      :::....|:.::.:.|..||              |.:|.. ||.. |
  Fly   501 NNT-GAMTLRKEWTGLIGELVNERADMIVAPLTINPER--------------AEYIEF-SKPF-K 548

  Fly   396 YRAI----------------MGPFQWPVW---------VALICVYLGGIFPIVFTDRLTLSHLMG 435
            |:.|                :.||...:|         |||:...|....|.   .|..|||...
  Fly   549 YQGITILEKKPSRSSTLVSFLQPFSNTLWILVMVSVHVVALVLYLLDRFSPF---GRFKLSHSDS 610

  Fly   436 NWGEVENM---FWYVFGMFTNAFSFTGKYSWSNTRKNSTRLLIGAYWL-FTIIITSCYTGSIIAF 496
            |..:..|:   .|:.:|:..|:....|     ..|..|.|:| |..|. |.:||.:.||.::.||
  Fly   611 NEEKALNLSSAVWFAWGVLLNSGIGEG-----TPRSFSARVL-GMVWAGFAMIIVASYTANLAAF 669

  Fly   497 VTLPAFPDTVDSVLDLLGLFFRVGTLNNGGWETWFQNST---------------HIPTSRLYKKM 546
            :.|.. |.|            ::..:|:.......:|.|               .:..|.:|:.|
  Fly   670 LVLER-PKT------------KLSGINDARLRNTMENLTCATVKGSSVDMYFRRQVELSNMYRTM 721

  Fly   547 EF--VGSVDEGIGNVTQSFFWNYAFLGSKAQLEYLVQSNFSDENISRRSALHLSEECFALFQIGF 609
            |.  ..:.::.|.:|.:...  .||:...::|||         ..|:...|..:.|.|.....|.
  Fly   722 EANNYATAEQAIQDVKKGKL--MAFIWDSSRLEY---------EASKDCELVTAGELFGRSGYGI 775

  Fly   610 LFPRESVYKIKIDSMILLAQQSGLIAKINNEVSWVMQRSSSGRLLQASSSNSLREIIQE-ERQLT 673
            ...:.|.:...:...||...:||.:.|::.:  |:..    |.:.|..      |:.:: ...|.
  Fly   776 GLQKGSPWTDAVTLAILEFHESGFMEKLDKQ--WIFH----GHVQQNC------ELFEKTPNTLG 828

  Fly   674 TADTEGMFLLMALGYFLGATALVSEIVGGITNKCRQIIKRSR----KSAASSWSSASSGSMLRTN 734
            ..:..|:|:|:.:|...|...::.|::    .|..|:.|:.|    :.||..|    .|::
  Fly   829 LKNMAGVFILVGVGIAGGVGLIIIEVI----YKKHQVKKQKRLDIARHAADKW----RGTI---- 881

  Fly   735 AEQLSHDKRKANRREAAEVAQKMSFGMRELNLTRA 769
                  :|||..|   |.:|.:..:.: .||.|.|
  Fly   882 ------EKRKTIR---ASLAMQRQYNV-GLNSTHA 906

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir21a	NP_001097043.1	Periplasmic_Binding_Protein_Type_2	289..583	CDD:304360	80/382 (21%)
Ir21a	NP_001097043.1	Lig_chan	407..662	CDD:278489	60/284 (21%)
Nmdar1	NP_730940.1	PBP1_iGluR_NMDA_NR1	12..405	CDD:107374	68/412 (17%)
		ANF_receptor	58..371	CDD:279440	52/333 (16%)
		PBP2_iGluR_NMDA_Nr1	417..818	CDD:270437	94/473 (20%)
		HisJ	451..>558	CDD:223904	25/123 (20%)
		Periplasmic_Binding_Protein_Type_2	<516..651	CDD:304360	34/159 (21%)
		Lig_chan	575..838	CDD:278489	64/307 (21%)
		CaM_bdg_C0	854..882	CDD:287524	8/45 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010