Protein Alignment Ir21a and gria1b

DIOPT Version :10

• Sequence 1: NP_001097043.1
• Gene: Ir21a / 33157
• FlyBaseID: FBgn0031209
• Length: 842
• Species: Drosophila melanogaster
• Sequence 2: NP_991293.1
• Gene: gria1b / 403044
• ZFINID: ZDB-GENE-020125-2
• Length: 917
• Species: Danio rerio
• Alignment Length: 915
• Identity: 172/915 - (18%)
• Similarity: 315/915 - (34%)
• Gaps: 292/915 - (31%)

  Fly     1 MSYYWVALVLFTAQAFSIEGDRS------ASYQEKCISRRLINHYQLNKEIFGVGMCDGNNENEF 59
            ||:.....|.|...:|.|:.:..      ...|:..|:  |:.||:.||.::..     ::::..
Zfish    97 MSFCGALHVCFVTPSFPIDTNNQFVIQLRPELQDALIA--LVEHYKWNKFVYMY-----SSDSGL 154

  Fly    60 RQKRRIVPTFQGNPRPRGELLASK-FHVNSYNFEQTNSLVGLVNKIAQEYLNKCPPVIYYDSFVE 123
            ...::|:.|           .|.| :.|.|.||:.......|  |..|:..||....|..|..:|
Zfish   155 TVLQKILDT-----------AAEKTWQVTSINFDTLTEAAFL--KAIQDLDNKKEFKIILDCELE 206

  Fly   124 KSDGLILENLFKTIPITFYHGEINADYEAKNKRFTSHIDCNCKSYILFLSDPLMTRKILG----P 184
            :.:.::  ||.                 |..|:       |.|:|...|::       ||    .
Zfish   207 RLNSIL--NLI-----------------AAQKK-------NLKNYHYILAN-------LGFLDLN 238

  Fly   185 QTESRVVLVSRSTQWRLRDFLSSELSSNIVNLLVIGESLMADPMRERPYVLYTHKLYADGLG--- 246
            .||.|.. .:..|.::|.::.:..:|..|.:.|......:..|.|.   :.||..|..||:.
Zfish   239 LTEFRKG-GANVTGFQLMNYTNPTVSRTIQDWLEFDSKDLKSPKRR---LKYTGALTYDGVTVMA 299

  Fly   247 -----------------------SNTPVVLTSW-----IKGALSRPHINLFPSKFQFGFAGHR-- 281
                                   :|.|   ..|     |:.||.:..........||...|||
Zfish   300 TAFQNLRKQRIDISRRGNAGECLANPP---APWGQGIDIQRALQQVQFEGLTGHVQFNDKGHRTN 361

  Fly   282 FQISAAN---------------------------------------------QPPFIFRIRTLDS 301
            |.:|...                                             :.|::. ::....
Zfish   362 FTVSVMEFGPSGPKKVGYWNQREKYVSTATYSNMLNETFGLQNRTYVVTTILEAPYVM-LKKNHE 425

  Fly   302 SGMGQLRWDGVEFRLLTMISKRLNFSIDI------------TETPTRSNTRGVVDTIQEQIIERT 354
            ..:|..:::|....|...|:|.:.:|..:            .||...:...|       :::...
Zfish   426 QLVGNDKYEGYCVELAAEIAKHVGYSYRLELVGDGKYGARDAETMMWNGMVG-------ELVYGK 483

  Fly   355 VDIGMSGIYIT--QERLMDSA---MSVGHSPDCAAFITLASKALPKYRAIMGPFQWPVWVALICV 414
            .|:.::.:.||  :|.::|.:   ||:|.|    ..|...:|:.|...:.:.|..:.:|:.::..
Zfish   484 ADVAVAPLTITLVREEVIDFSKPFMSLGIS----IMIKKPTKSKPGVFSFLDPLAYEIWMCIVFA 544

  Fly   415 YLGGIFPIVFTDRLTLSHLMGNWGEVENMFWYV-------------------------------- 447
            |: |:..::|        |:..:...|   |:.
Zfish   545 YI-GVSVVLF--------LVSRFSPYE---WHADDEEETADQQNQNQPPSPEPNQSPNQSQNQRE 597

  Fly   448 ------------FGMFTNAFSFTGKYSWS----NTRKNSTRLLIGAYWLFTIIITSCYTGSIIAF 496
                        ||:|.:.:...|.:...    :.|..|.|::.|.:|.||:||.|.||.::.||
Zfish   598 EKQEKQPEHTNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAF 662

  Fly   497 VTLPAFPDTVDSVLDLL-GLFFRVGTLNNGGWETWFQNSTHIPTSRLYKKME------FVGSVDE 554
            :|:......::|..||. ......|||:.|..:.:|:.|......:::..|:      ||.:.||
Zfish   663 LTVERMVSPIESAEDLAKQTEIAYGTLDGGSTKEFFRRSKIAVFEKMWSYMKSAEPTVFVKTTDE 727

  Fly   555 GIGNVTQSFFWNYAFLGSKAQLEYLVQSNFSDE-----NISRRSALHLSEECFALFQIGFLFPRE 614
            |:..|.:| ...||:|......||:.|....|.     |:..:.             .|...|:.
Zfish   728 GVVRVRKS-KGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKG-------------YGVATPKG 778

  Fly   615 SVYKIKIDSMILLAQQSGLIAKINNEVSWVMQRSSSGRLLQASSSNSLREIIQEERQLTTADTEG 679
            |..:..::..:|...:.||:.|:.|:  |...:...|     |.....::   :...|:.::..|
Zfish   779 SALRNPVNLAVLKLNEQGLLDKLKNK--WWYDKGECG-----SGGGDSKD---KTSALSLSNVAG 833

  Fly   680 MFLLMALGYFLGATALV--------SEIVGGITNKCRQIIKRSRKSAASSWSSASSGSMLRTNAE 736
            :|.::..|  ||...||        |.|.   :.:.:|||..:..|  |:.:...||.   .|..
Zfish   834 VFYILIGG--LGLAMLVALVEFCYKSRIE---SRRMKQIIDAAMLS--STLTRMGSGG---ENGR 888

  Fly   737 QLSHD 741
            .::||
Zfish   889 VMAHD 893

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir21a	NP_001097043.1	HisJ	287..>392	CDD:440596	20/166 (12%)
		Lig_chan	405..662	CDD:459656	62/316 (20%)
gria1b	NP_991293.1	PBP1_iGluR_AMPA_GluR1	26..390	CDD:380613	67/352 (19%)
		PBP2_iGluR_AMPA_GluR1	404..812	CDD:270447	83/447 (19%)