DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir21a and clumsy

DIOPT Version :9

Sequence 1:	NP_001097043.1	Gene:	Ir21a / 33157	FlyBaseID:	FBgn0031209	Length:	842	Species:	Drosophila melanogaster
Sequence 2:	NP_001036373.1	Gene:	clumsy / 35394	FlyBaseID:	FBgn0026255	Length:	1002	Species:	Drosophila melanogaster

Alignment Length:	823	Identity:	174/823 - (21%)
Similarity:	313/823 - (38%)	Gaps:	211/823 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 EQTNSLVGLVNKIAQEYLNKCPPVIYYDS--FVEKSDGLILENLFKTI----PITFYHGEINADY 150
            :|.|.|     |:..||.:...|::...|  |.|.|.   :|....|:    |..|:...:..|:
  Fly   224 QQANEL-----KMLGEYQSVFIPLLDTHSIDFGELSG---VEANITTVRLMDPSDFHVKNVVHDW 280

  Fly   151 EAKNKRFTSH--IDCN-CKSYILFLSDPL-----------MTRKILGPQTESRVVLVSRSTQW-- 199
            |.:.||...:  :|.| .||.::.|:|.:           :..::..|..|.|     |...|
  Fly   281 EEREKREGRYFKVDPNRVKSQMILLNDAVWLFSKGLTELGIFEELTAPDLECR-----RKKPWPF 340

  Fly   200 --RLRDFL---SSELSSNIVNLLVIGESLMADPMRERPYVLYTHKLYADGLGSNTPVVLTSW--I 257
              |:.:|:   |.|.|:..::....|:...        :.|...:|.:||.     :.|.:|  :
  Fly   341 GKRIIEFIKARSEETSTGRIDFNENGQRSF--------FTLRFMELNSDGF-----LDLATWDPV 392

  Fly   258 KG--ALSRPHINLFPSKFQFG--FAGHRFQISAANQPPFIFRIRTLDSSGMGQL-----RWDGVE 313
            .|  .|:...    .|:.:.|  .:...|.:|:....||:    ||.....|::     |::|..
  Fly   393 NGLDVLNDDE----ESEKRVGQKLSNKTFIVSSRLGAPFL----TLREPQEGEILTGNSRYEGYS 449

  Fly   314 FRLLTMISKRLNFSIDITETP-----TRSNTRGVVDTIQEQIIERTVDIGMSGIYITQERLMDSA 373
            ..|:..|:|.|||..:...:|     ..:......|.|..|:|:...|:|:..:.:|..|    .
  Fly   450 IDLINEIAKMLNFKFEFRMSPDGKYGALNKVTQTWDGIVRQLIDGNADLGICDLTMTSSR----R 510

  Fly   374 MSVGHSPDCAAFITLASKAL--------PKYRAIMGPFQWPVWVALICVYLGGIFPIVFTDRLTL 430
            .:|..:|   .|:||....|        ....:.:.||...||     :|:|..:..:......|
  Fly   511 QAVDFTP---PFMTLGISILFSKPPTPPTDLFSFLSPFSLDVW-----IYMGSAYLFISLLLFAL 567

  Fly   431 SHLM-GNW---------GEVENMF------WYVFGMFTNAFSFTGKYSWSNTRKNSTRLLIGAYW 479
            :.:. .:|         .||||::      |...|      |..|:......:..||||:.|.:|
  Fly   568 ARMAPDDWENPHPCKEPEEVENIWSIMNTTWLSIG------SLMGQGCDILPKAASTRLVTGMWW 626

  Fly   480 LFTIIITSCYTGSIIAFVTLPAFPDTVDSVLDLLGLF-FRVGTLNNGGWETWFQNSTHIPTSRLY 543
            .|.:::.:.||.::.||:|.....::::|..||.... .:.|.:..|....:|::|......:::
  Fly   627 FFALMMLNSYTANLAAFLTNSRQANSINSAEDLAAQSKIKYGAMAGGSTMGFFRDSNFSTYQKMW 691

  Fly   544 KKME------FVGSVDEGIGNVTQSFFWN-YAFLGSKAQLEYLVQSNFSDENISRRSALHLSEEC 601
            ..||      |..:.|||:..|.:.  .| ||||.....|||         |:.|:        |
  Fly   692 TAMESASPSVFTKTNDEGVERVQKG--KNLYAFLMESTTLEY---------NVERK--------C 737

  Fly   602 FALFQI---------GFLFPRESVYKIKIDSMILLAQQSGLIAKINNEVSWVMQRSSSGRLLQAS 657
             .|.||         |...|..|.|:.:|.:.:|...:.|.:|::..:  |..:....|...::.
  Fly   738 -DLVQIGGWLDYKSYGIAMPFNSPYRKQISAAVLKLGELGQLAELKRK--WWKEMHGGGNCEKSD 799

  Fly   658 SSNSLREIIQEERQLTTADTEGMFLLMALGYFLGATALVSEIVGGITN--------------KCR 708
            ....      :..:|...:..|:||::.||       |:|.:|.|.|.              ..:
  Fly   800 EDGG------DTPELGLENVGGVFLVLGLG-------LLSAMVLGCTEFLWNVKSVAIEEKISLK 851

  Fly   709 QIIKRSRKSAASSW-------SSASSGSMLRTNAEQLSHDKRKAN-RREAAEVAQKMSFGMRELN 765
            :..|.....||..|       :|:.|||   :|:...|..:.|.: :.:...:....|.|.:::.
  Fly   852 EAFKSEALFAARIWITTKPVHTSSESGS---SNSSSSSSSRSKHSFKSQGLSMKSLKSSGYQDVE 913

  Fly   766 LT-RATLREIYGSYG-------APETDHG-------QLDIVHT 793
            .: .:.|::|...:.       .|..:.|       |:|:|.|
  Fly   914 ASVHSKLKKIGSMFSLKSQKTVTPPPEIGWKLDKSTQIDVVPT 956

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir21a	NP_001097043.1	Periplasmic_Binding_Protein_Type_2	289..583	CDD:304360	78/335 (23%)
Ir21a	NP_001097043.1	Lig_chan	407..662	CDD:278489	64/287 (22%)
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	26..396	CDD:107377	43/197 (22%)
		ANF_receptor	39..379	CDD:279440	37/175 (21%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	95/416 (23%)
		Lig_chan	548..812	CDD:278489	65/302 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910