DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir21a and GluRIIA

DIOPT Version :9

Sequence 1:	NP_001097043.1	Gene:	Ir21a / 33157	FlyBaseID:	FBgn0031209	Length:	842	Species:	Drosophila melanogaster
Sequence 2:	NP_523484.2	Gene:	GluRIIA / 33788	FlyBaseID:	FBgn0004620	Length:	907	Species:	Drosophila melanogaster

Alignment Length:	828	Identity:	164/828 - (19%)
Similarity:	293/828 - (35%)	Gaps:	215/828 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 IVPTFQGNPRPRGELLASKFHVNSYN--FEQTNSLVGLVNKIAQEYLNKCPPVIYYDSFVEKSDG 127
            :.|:.....|...|::.|.:...::.  :|....|..|.:.:..:.||              ||.
  Fly   142 VAPSLSVLSRAYFEIIKSNYEWRTFTLIYETPEGLARLQDLMNIQALN--------------SDY 192

  Fly   128 LILEN----------LFKTIPITFYHGEINADYEAKNKR------------------FTSHID-- 162
            :.|.|          |:|....||:...|..|.|.|..:                  |.:|:|
  Fly   193 VKLRNLADYADDYRILWKETDETFHEQRIILDCEPKTLKELLKVSIDFKLQGPFRNWFLTHLDTH 257

  Fly   163 -------------CNCKSYILFLSD--PLMTRK--------ILGPQT---------------ESR 189
                         .|..|..|.:.|  |...:|        |||.||               .:|
  Fly   258 NSGLRDIYNEDFKANITSVRLKVVDANPFERKKTRLTKVDQILGNQTMLPILIYDAVVLFASSAR 322

  Fly   190 VVLVS------------RSTQWRLRDFLSSE---LSSNIVNLLVIGESLMADPMRERPYVLYTHK 239
            .|:.:            .|:.|.|..|:.:|   :|.:.|......|::..|...:|  :.:..:
  Fly   323 NVIAAMQPFHPPNRHCGSSSPWMLGAFIVNEMKTISEDDVEPHFKTENMKLDEYGQR--IHFNLE 385

  Fly   240 LYADGLGSNTPVVLTSW-----IKGALSRPHINLFPSKFQFGFAGHRFQISAANQPPFIFRIRTL 299
            :|...:  |.|:::  |     ||..|....:....:...|......:.:....:.|: |.::..
  Fly   386 IYKPTV--NEPMMV--WTPDNGIKKRLLNLELESAGTTQDFSEQRKVYTVVTHYEEPY-FMMKED 445

  Fly   300 DSSGMGQLRWDGVEFRLLTMISKRLNFSIDI-------TETPTRSNTRGVVDTIQEQIIERTVDI 357
            ..:..|:.:::|....|::.:|:.:.|..:.       ...|......|::    .::|:....|
  Fly   446 HENFRGREKYEGYAVDLISKLSELMEFDYEFMIVNGNGKYNPETKQWDGII----RKLIDHHAQI 506

  Fly   358 GMSGIYITQER---------LMDSAMSVGHSPDCAAFITLASKALPKYR-AIMGPFQWPVWVALI 412
            |:..:.|||.|         .|...:|:.|         ..|...||.: |.:.||...||:.:|
  Fly   507 GVCDLTITQMRRSVVDFTVPFMQLGISILH---------YKSPPEPKNQFAFLEPFAVEVWIYMI 562

  Fly   413 CVYLGGIFPIVFTDRLTL-------------SHLMGNWGEVENMFWYVFGMFTNAFSFTGKYSWS 464
            ...|......||..||:.             ..|...| .|.|..|.:.|      |...:....
  Fly   563 FAQLIMTLAFVFIARLSYREWLPPNPAIQDPDELENIW-NVNNSTWLMVG------SIMQQGCDI 620

  Fly   465 NTRKNSTRLLIGAYWLFTIIITSCYTGSIIAFVTLPAFPDTVDSVLDLL---GLFFRVGTLNNGG 526
            ..|....|:|.|.:|.|.:::.|.||.::.||:|...:..::.|:.||:   .:.|  |::..|.
  Fly   621 LPRGPHMRILTGMWWFFALMMLSTYTANLAAFLTSNKWQSSIKSLQDLIEQDKVHF--GSMRGGS 683

  Fly   527 WETWFQNSTHIPTSRLYKKME------FVGSVDEGIGNVTQSFFWNYAFLGSKAQLEYLVQSNFS 585
            ...:|..|......|.:.:|:      |..:..||:..|.:. ...||||.....|.|.::.|..
  Fly   684 TSLFFSESNDTDYQRAWNQMKDFNPSAFTSTNKEGVARVRKE-KGGYAFLMETTSLTYNIERNCD 747

  Fly   586 DENISRRSALHLSEECFALFQIGFLFPRESVYKIKIDSMILLAQQSGLIAKINNEVSWVMQRSSS 650
            ...|..:    :.|:.:     |...|..|.|:..:...||...:.|.:.|:.|:  |....:
  Fly   748 LTQIGEQ----IGEKHY-----GLAVPLGSDYRTNLSVSILQLSERGELQKMKNK--WWKNHN-- 799

  Fly   651 GRLLQASSSNSLREIIQEERQLTTADTEGMFLLMALGYFLGATALVSEIVGGITN---------- 705
                  .:.:|..|:..:|  |:..:..|:||::|.|..:|....:.|.:..:.|
  Fly   800 ------VTCDSYHEVDGDE--LSIIELGGVFLVLAGGVLIGVILGIFEFLWNVQNVAVEERVTPW 856

  Fly   706 ---KCRQII--------KRSRKSAASSWSSASSGSMLRTNAEQLSHDK 742
               |...|.        |..|.|::|..||:...|..|.::::.|..|
  Fly   857 QAFKAELIFALKFWVRKKPMRISSSSDKSSSRRSSGSRRSSKEKSRSK 904

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir21a	NP_001097043.1	Periplasmic_Binding_Protein_Type_2	289..583	CDD:304360	72/332 (22%)
Ir21a	NP_001097043.1	Lig_chan	407..662	CDD:278489	60/276 (22%)
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..404	CDD:107377	51/281 (18%)
		ANF_receptor	46..386	CDD:279440	47/259 (18%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	85/404 (21%)
		Lig_chan	556..828	CDD:278489	68/302 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910