DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir21a and Ir25a

DIOPT Version :9

Sequence 1:	NP_001097043.1	Gene:	Ir21a / 33157	FlyBaseID:	FBgn0031209	Length:	842	Species:	Drosophila melanogaster
Sequence 2:	NP_001260049.1	Gene:	Ir25a / 33683	FlyBaseID:	FBgn0031634	Length:	947	Species:	Drosophila melanogaster

Alignment Length:	742	Identity:	146/742 - (19%)
Similarity:	260/742 - (35%)	Gaps:	179/742 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 FEQTNSLVGLVNKIAQEYLNKCPPV---IYYDSFVEKSDGLILENLFKTIPITFYHGEINADYEA 152
            :.|....:||:.....  ||:.|.:   .|:|        |.|.: |.||......|....|.|
  Fly   288 YTQYRDRLGLLRTTYN--LNEEPQLSSAFYFD--------LALRS-FLTIKEMLQSGAWPKDME- 340

  Fly   153 KNKRFTSHIDC------NCKSYILFLSDPLMTRKILGPQTESRVVLVSRSTQ-WRLRDFLSSELS 210
                   :::|      |.....|.|.|  ...||..|.:.....||::||| :....|:..|:.
  Fly   341 -------YLNCDDFQGGNTPQRNLDLRD--YFTKITEPTSYGTFDLVTQSTQPFNGHSFMKFEMD 396

  Fly   211 SNIVNLLVIGESLMADPMRERPYVLYTHKLYADGLGSNTPVVLTSWIKGALSRPHI-------NL 268
            .|::.:                          .|..|.....:..||.|..|...:       ||
  Fly   397 INVLQI--------------------------RGGSSVNSKSIGKWISGLNSELIVKDEEQMKNL 435

  Fly   269 FPSKFQFGFAGHRFQISAANQPPFIFRIRTLDSSGMGQLRWDGVEFRLLTMISKRLNFSIDITET 333
                    .|...::|....|.|||.|..|....      :.|....|:..|:..::|...|.|.
  Fly   436 --------TADTVYRIFTVVQAPFIMRDETAPKG------YKGYCIDLINEIAAIVHFDYTIQEV 486

  Fly   334 PT----RSNTRGVVDTIQEQIIERTVDIGMSGIYITQERLMDSAMSVGHSPDCAAFITLASKALP 394
            ..    ..:..|..:.|.::::::..|||:..:.:..||.:....:|.:.......|.:...:.|
  Fly   487 EDGKFGNMDENGQWNGIVKKLMDKQADIGLGSMSVMAEREIVIDFTVPYYDLVGITIMMQRPSSP 551

  Fly   395 ----KYRAIMGPFQWPVWVALICVYLGGIFPIVFTDRLTLSHLMGNWGE-----------VENMF 444
                |:..::   :..||:.::..|....|.:...||.:......|..:           ::...
  Fly   552 SSLFKFLTVL---ETNVWLCILAAYFFTSFLMWIFDRWSPYSYQNNREKYKDDEEKREFNLKECL 613

  Fly   445 WYVFGMFTNAFSFTGKYSWSNTRKNSTRLLIGAYWLFTIIITSCYTGSIIAFVTLPAFPDTVDSV 509
            |:..      .|.|.:......:..|.||:...:|||..||.:.||.::.||:|:......|:|
  Fly   614 WFCM------TSLTPQGGGEAPKNLSGRLVAATWWLFGFIIIASYTANLAAFLTVSRLDTPVES- 671

  Fly   510 LDLLGLFFRV--GTLNNGGWETWFQNSTHI------------------------------PTSRL 542
            ||.|...:::  ..||.....|:|:..::|                              |.|..
  Fly   672 LDDLAKQYKILYAPLNGSSAMTYFERMSNIEQMFYEIWKDLSLNDSLTAVERSKLAVWDYPVSDK 736

  Fly   543 YKKM-------EFVGSVDEGIGNVTQS-FFWNYAFLGSKAQLEYLVQSNFSDENISRRSALHLSE 599
            |.||       :...::||.:..|..| ....:||||....:.||..:|..
  Fly   737 YTKMWQAMQEAKLPATLDEAVARVRNSTAATGFAFLGDATDIRYLQLTNCD-------------- 787

  Fly   600 ECFALFQIGFLFPRESVYKIKIDSMILLAQQSGLIAKINNEVSWVMQRSSSGRLLQA--SSSNSL 662
                |..:|..|.|:. |.|.:.      |.|.|..:.||.:..::.:....:|.:.  .:..:|
  Fly   788 ----LQVVGEEFSRKP-YAIAVQ------QGSHLKDQFNNAILTLLNKRQLEKLKEKWWKNDEAL 841

  Fly   663 REIIQEERQ---LTTADTEGMFLLMALGYFLGATALVSEIVGGITNKCRQIIKRSRKSAASSWSS 724
            .:..:.|.|   ::..:..|:|:::.:|..:....||.|.......|..:||..:..:|..|.::
  Fly   842 AKCDKPEDQSDGISIQNIGGVFIVIFVGIGMACITLVFEYWWYRYRKNPRIIDVAEANAERSNAA 906

  Fly   725 ASSGSMLRTNAEQLSHDKRKANRREAA 751
            ...|.::  :...|.|...|..:.:||
  Fly   907 DHPGKLV--DGVILGHSGEKFEKSKAA 931

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir21a	NP_001097043.1	Periplasmic_Binding_Protein_Type_2	289..583	CDD:304360	71/352 (20%)
Ir21a	NP_001097043.1	Lig_chan	407..662	CDD:278489	61/307 (20%)
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	40..426	CDD:107378	38/184 (21%)
		PBP2_iGluR_putative	438..836	CDD:270435	85/438 (19%)
		Lig_chan	565..870	CDD:278489	66/336 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910