DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir21a and GluRIIC

DIOPT Version :9

Sequence 1:	NP_001097043.1	Gene:	Ir21a / 33157	FlyBaseID:	FBgn0031209	Length:	842	Species:	Drosophila melanogaster
Sequence 2:	NP_608557.4	Gene:	GluRIIC / 33275	FlyBaseID:	FBgn0046113	Length:	940	Species:	Drosophila melanogaster

Alignment Length:	896	Identity:	169/896 - (18%)
Similarity:	309/896 - (34%)	Gaps:	247/896 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VALVLFTAQA-----------------FSIEGD----RSASYQEKCISRRLINHYQLNKEIFGVG 49
            :.|.|:.|||                 |:|..|    |:|:..:..:..|.:::..:....|
  Fly   133 MTLNLYPAQAILSKAYADIVQNFGWRKFTIVYDADDARAAARLQDLLQLREVHNDVVRVRKF--- 194

  Fly    50 MCDGNNENEF-------RQKRRIVPTFQGNPRPRGELLASKF---------HVNSYNFE-QTNSL 97
                :.:::|       |.:||:|  ....|....|||.|..         |:...|.| .|:.|
  Fly   195 ----HKDDDFRVMWKSIRGERRVV--LDCEPNMLVELLNSSTEFGLTGQYNHIFLTNLETYTDHL 253

  Fly    98 VGL--------VNKIAQEYL-NKCPPVIYYD---SFVEKSDGLILENLFKTIPITFYHGEI---- 146
            ..|        ||..|...| |..||.  |.   .:|.:.|.::.|:  ...|.|..|..|
  Fly   254 EELAADNETFAVNITAARLLVNPDPPP--YSLPYGYVTQRDNIVYES--SDPPRTLIHDLIHDAL 314

  Fly   147 --------NADYEAKNKRFTSHIDCNCKSYILFLSDPLMTRKILGPQTESRVVLVSRSTQWRLRD 203
                    ||.:...::.....|.|:                          ...|....|.:..
  Fly   315 QLFAQSWRNASFFYPDRMVVPRITCD--------------------------FAASGGRTWAMGR 353

  Fly   204 FLSSEL--SSNIVNLLVIGESLMADPMRERPYVLYTHKLY--ADGLGSNTPVVLTSW-IKGALSR 263
            :|:..:  :|.:.|.......|..|...:|  :.:..::|  .||:|      :..| .:|.:::
  Fly   354 YLARLMKGTSGVNNTNFRTSILQFDEDGQR--ITFNIEVYDPLDGIG------IAIWDPRGQITQ 410

  Fly   264 PHINLFPSKFQFGFAGHRFQISAANQPPFIFRIRTLDSSGM-GQLRWDGVEFRLLTMISKRLNFS 327
            .::::...|...      ::::....||:.....|.....: |...:.|....|:..|::.:.|
  Fly   411 LNVDVKAQKKMI------YRVATRIGPPYFSYNETARELNLTGNALYQGYAVDLIDAIARHVGF- 468

  Fly   328 IDITETPTRSNTRGVVDTIQEQ-------IIERTVDIGMSGIYITQER---------LMDSAMSV 376
             :....|......|.:|...:|       ||.....:|:..:.|||.|         .|...:|:
  Fly   469 -EYVFVPVADQQYGKLDKETKQWNGIIGEIINNDAHMGICDLTITQARKTAVDFTVPFMQLGVSI 532

  Fly   377 --GHSPDCAAFITLASKALPKYRAIMGPFQWPVWVALICVYLGGIFPIVFTDRLTLSHLMGNWGE 439
              ..||.       ..|.|..|   :.||...||:.::.    .:|.:.|...:.......:|..
  Fly   533 LAYKSPH-------VEKTLDAY---LAPFGGEVWIWILI----SVFVMTFLKTIVARISKMDWEN 583

  Fly   440 ----------VENMFWYVF--GMFTNAFSFTGKYSWSNTRKNSTRLLIGAYWLFTIIITSCYTGS 492
                      :||. |.:.  |..|.|...|.... ...|....|:....:|:|.|||.:.||.:
  Fly   584 PHPCNRDPEVLENQ-WRIHNTGWLTVASIMTAGCD-ILPRSPQVRMFEATWWIFAIIIANSYTAN 646

  Fly   493 IIAFVTLPAFPDTVDSVLDLLG-LFFRVGTLNNGGW--------ETWFQNSTHI-----PTSRLY 543
            :.||:|......::.::.||.. ...:.||:..|..        ||.::.:.::     |::...
  Fly   647 LAAFLTSSKMEGSIANLKDLSAQKKVKFGTIYGGSTYNLLADSNETVYRLAFNLMNNDDPSAYTK 711

  Fly   544 KKMEFVGSVDEGIGNVTQSFFWNYAFLGSKAQLEYLVQSNFSDENISRRSALHLSEECFALFQIG 608
            ..:|.|..|.:..|        :|.||.....|||..:.|....::..:    ..|:.:|:
  Fly   712 DNLEGVDRVRKNRG--------DYMFLMETTTLEYHREQNCDLRSVGEK----FGEKHYAI---- 760

  Fly   609 FLFPRESVYKIKIDSMILLAQQSGLIAKINNEVSWVMQRSSSGRLLQASSSNSLREIIQEERQLT 673
             ..|..:.|:..:...||...:.|.:..:..:  |  .::.:....:....::..::..||
  Fly   761 -AVPFGAEYRSNLSVAILKLSERGELYDLKQK--W--WKNPNASCFEEPDPDATPDMTFEE---- 816

  Fly   674 TADTEGMFLLMALGYFLGATALVSEIVGGITN--------------KCRQIIKRSRKSAASSWSS 724
               ..|:|      |.|.|..|::.:: |||.              ..:...|:..:.....|::
  Fly   817 ---LRGIF------YTLYAGILIAFLI-GITEFLVYVQQVALEERLTFKDAFKKEIRFVLCVWNN 871

  Fly   725 AS---SG---SMLRTNAEQLSHDKR-----KANRREAAEVAQKMSFGMREL 764
            ..   :|   |.:||...: |.||.     |::||   .|..:.|..|||:
  Fly   872 RKPIVAGTPISSVRTTPRR-SLDKSLDRTPKSSRR---VVIGRSSEEMREM 918

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir21a	NP_001097043.1	Periplasmic_Binding_Protein_Type_2	289..583	CDD:304360	70/338 (21%)
Ir21a	NP_001097043.1	Lig_chan	407..662	CDD:278489	51/280 (18%)
GluRIIC	NP_608557.4	PBP1_iGluR_Kainate	26..404	CDD:107377	60/317 (19%)
		Periplasmic_Binding_Protein_Type_1	<279..363	CDD:299141	16/113 (14%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	79/409 (19%)
		Lig_chan	554..828	CDD:278489	58/313 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010