DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir21a and Ir7c

DIOPT Version :9

Sequence 1:	NP_001097043.1	Gene:	Ir21a / 33157	FlyBaseID:	FBgn0031209	Length:	842	Species:	Drosophila melanogaster
Sequence 2:	NP_001245572.1	Gene:	Ir7c / 31692	FlyBaseID:	FBgn0029966	Length:	625	Species:	Drosophila melanogaster

Alignment Length:	524	Identity:	102/524 - (19%)
Similarity:	203/524 - (38%)	Gaps:	84/524 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   213 IVNLLVIGESLMADPMRERPYVLYTHKLYA-DGLGSNTPVVLTSWIKGA-------LSRPHINLF 269
            ::|:.|:..::..  .|:....|||:..|. ....|:.||..|::...|       |::|   ||
  Fly   145 LLNMYVLNVNVFL--QRDGTVHLYTYYPYGPHHCQSSLPVYYTAFQDLAAPANGFGLTKP---LF 204

  Fly   270 PSKFQFGFAGHRFQISAANQPPFIFRIRTLDSSGMGQLRWDGVEFRLLTMISKRLNFSIDITETP 334
            |.|.. ...|....::.....|::  |...|....|.....|:|..:...:::|:||:|.:.|..
  Fly   205 PRKLT-NMHGCEMVVATFEHRPYV--IIEDDPKTPGGRSIHGIEGLIFRSLAERMNFTIKLVEQK 266

  Fly   335 TRSNTRGVVDTIQEQIIERTVD--IGMSGIYITQERLMDSAM--SVGHSPDCAAFITLASKALPK 395
            .::....:.|.....|::..||  :.::.:.....:.....|  |..::......:..:..::..
  Fly   267 DKNRGEILPDGNFTGILKMMVDGEVNLTFVCFMYSKARSDLMLPSTSYTSFPIVLVVPSGGSISP 331

  Fly   396 YRAIMGPFQWPVWVALICVYLGGIFPIVFTDRLTLSHLMGNWGEVENMFWYVFGMFTNAFSFTGK 460
            ...:..||::.:|   .|:.:..||..|....|.::.|.|    :.|:   |.|. .|...|.|
  Fly   332 MGRLTRPFRYIIW---SCILVSLIFGFVLICLLKITALPG----LRNL---VLGR-RNRLPFMG- 384

  Fly   461 YSWS---------NTRKNSTRLLIGAYWLFTIIITSCYTGSIIAFVTLPAFPDTVDSVLDLLGLF 516
             .|:         |.::|..|.::..:.|.|:|:.:.|||.:...:........:.|:.::|...
  Fly   385 -MWASLLGGLALYNPQRNFARYILVMWLLQTLILRAAYTGQLYLLLQDVEMRSPIKSLSEVLAKD 448

  Fly   517 FRVGTLNNGGWETWFQNSTHIPTSRLYKKMEFVGSV-------DEGIGNVTQSFFWNYAFLGSKA 574
            :....|  ....|.|::|  :||:..:..:....|:       |.||               :.|
  Fly   449 YEFRIL--PALRTIFKDS--MPTTNFHAVLSLEESLYRLRDEDDPGI---------------TVA 494

  Fly   575 QLEYLVQSNFSDENISRRSALHLSEECFALFQIGFLFPRESVYKIKIDSMILLAQQSGLIAKINN 639
            .|:..| :.|...:...:..|.:..:......:.|.....|.:|.:||.:|:....||::|:
  Fly   495 LLQPTV-NQFDFRSGPNKRHLTVLPDPLMTAPLTFYMRPHSYFKRRIDRLIMAMMSSGIVAR--- 555

  Fly   640 EVSWVMQRSSSGRLLQASSSNSLREIIQEERQLTTADTEGMFLLMALGYFLGATALVSEIVGGIT 704
                 .::....|:.:.|...:|     |.:.|:.....|:|:..|..|.:.....:.||:  .|
  Fly   556 -----YRKMYMDRIKRVSKRRNL-----EPKPLSIWRLSGIFVCCAGLYLVALIVFILEIL--TT 608

  Fly   705 NKCR 708
            |..|
  Fly   609 NHRR 612

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir21a	NP_001097043.1	Periplasmic_Binding_Protein_Type_2	289..583	CDD:304360	58/313 (19%)
Ir21a	NP_001097043.1	Lig_chan	407..662	CDD:278489	52/270 (19%)
Ir7c	NP_001245572.1	Lig_chan-Glu_bd	225..287	CDD:214911	13/63 (21%)
Ir7c	NP_001245572.1	Lig_chan	343..593	CDD:278489	58/295 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810